Identification of hepatoprotective flavonolignans from silymarin

scientific article

Identification of hepatoprotective flavonolignans from silymarin is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2010PNAS..107.5995P
P356DOI10.1073/PNAS.0914009107
P3181OpenCitations bibliographic resource ID3226562
P932PMC publication ID2851903
P698PubMed publication ID20231449
P5875ResearchGate publication ID41969101

P50authorTyler N. GrafQ55189281
Volker LohmannQ37839024
Nicholas H. OberliesQ54796381
P2093author name stringStephen J Polyak
Yanze Liu
Sampa Pal
David Y W Lee
Chihiro Morishima
P2860cites workIkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domainQ22010650
Robust hepatitis C virus infection in vitroQ27470013
Gram-Scale Purification of Flavonolignan Diastereoisomers from Silybum marianum (Milk Thistle) Extract in Support of Preclinical in vivo Studies for Prostate Cancer ChemopreventionQ57268417
Are herbals as safe as their advocates believe?Q82646858
Relationships between Hepatitis C Virus Replication and CXCL-8 Production In VitroQ27477464
Regulation of CXCL-8 (Interleukin-8) Induction by Double-Stranded RNA Signaling Pathways during Hepatitis C Virus InfectionQ27478028
Identification of Determinants Involved in Initiation of Hepatitis C Virus RNA Synthesis by Using Intergenotypic Replicase ChimerasQ27480357
Silymarin inhibits in vitro T-cell proliferation and cytokine production in hepatitis C virus infectionQ27490911
Production of infectious hepatitis C virus in tissue culture from a cloned viral genomeQ27860899
Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infectionQ27860901
Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trialQ27860949
Host-pathogen interactions: subversion and utilization of the NF-kappa B pathway during infectionQ28386446
Shaping the nuclear action of NF-kappaBQ29614600
Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core proteinQ29620682
Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B.Q33933056
Silibinin and related compounds are direct inhibitors of hepatitis C virus RNA-dependent RNA polymeraseQ34020427
The use of silymarin in the treatment of liver diseasesQ34104302
Interleukin-8: an expanding universe beyond neutrophil chemotaxis and activationQ34150617
Use of complementary and alternative medicine in patients with liver diseaseQ34152596
Milk thistle.Q34459546
Molecular Structure and Stereochemistry of Silybin A, Silybin B, Isosilybin A, and Isosilybin B, Isolated from Silybum marianum (Milk Thistle)Q34542212
Inhibition of T-cell inflammatory cytokines, hepatocyte NF-kappaB signaling, and HCV infection by standardized SilymarinQ34626058
Milk thistle nomenclature: why it matters in cancer research and pharmacokinetic studiesQ34634347
An updated systematic review with meta-analysis for the clinical evidence of silymarinQ34760909
Milk thistle for the treatment of liver disease: a systematic review and meta-analysisQ34994556
Silybin and silymarin--new and emerging applications in medicineQ36737890
Toward the definition of the mechanism of action of silymarin: activities related to cellular protection from toxic damage induced by chemotherapyQ36840439
Virus associated innate immunity in liverQ37175673
Multiple effects of silymarin on the hepatitis C virus lifecycleQ39698364
Projecting future complications of chronic hepatitis C in the United StatesQ40594872
Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy.Q42981378
Increased prooxidant production and enhanced susceptibility to glutathione depletion in HepG2 cells co-expressing HCV core protein and CYP2E1.Q42982113
Hepatitis C drug development at a crossroadsQ42991359
HCV natural history: the retrospective and prospective in perspectiveQ42994353
Hepatitis C virus proteins: direct link to hepatic oxidative stress, steatosis, carcinogenesis and moreQ43036470
Silibinin inhibits constitutive and TNFalpha-induced activation of NF-kappaB and sensitizes human prostate carcinoma DU145 cells to TNFalpha-induced apoptosisQ43919085
The NF-kappa B activation pathway: its regulation and role in inflammation and cell survivalQ46171001
Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial.Q46834318
P433issue13
P407language of work or nameEnglishQ1860
P304page(s)5995-9
P577publication date2010-03-30
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleIdentification of hepatoprotective flavonolignans from silymarin
P478volume107

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