scholarly article | Q13442814 |
P50 | author | Tyler N. Graf | Q55189281 |
Volker Lohmann | Q37839024 | ||
Nicholas H. Oberlies | Q54796381 | ||
P2093 | author name string | Stephen J Polyak | |
Yanze Liu | |||
Sampa Pal | |||
David Y W Lee | |||
Chihiro Morishima | |||
P2860 | cites work | IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain | Q22010650 |
Robust hepatitis C virus infection in vitro | Q27470013 | ||
Gram-Scale Purification of Flavonolignan Diastereoisomers from Silybum marianum (Milk Thistle) Extract in Support of Preclinical in vivo Studies for Prostate Cancer Chemoprevention | Q57268417 | ||
Are herbals as safe as their advocates believe? | Q82646858 | ||
Relationships between Hepatitis C Virus Replication and CXCL-8 Production In Vitro | Q27477464 | ||
Regulation of CXCL-8 (Interleukin-8) Induction by Double-Stranded RNA Signaling Pathways during Hepatitis C Virus Infection | Q27478028 | ||
Identification of Determinants Involved in Initiation of Hepatitis C Virus RNA Synthesis by Using Intergenotypic Replicase Chimeras | Q27480357 | ||
Silymarin inhibits in vitro T-cell proliferation and cytokine production in hepatitis C virus infection | Q27490911 | ||
Production of infectious hepatitis C virus in tissue culture from a cloned viral genome | Q27860899 | ||
Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection | Q27860901 | ||
Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial | Q27860949 | ||
Host-pathogen interactions: subversion and utilization of the NF-kappa B pathway during infection | Q28386446 | ||
Shaping the nuclear action of NF-kappaB | Q29614600 | ||
Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein | Q29620682 | ||
Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B. | Q33933056 | ||
Silibinin and related compounds are direct inhibitors of hepatitis C virus RNA-dependent RNA polymerase | Q34020427 | ||
The use of silymarin in the treatment of liver diseases | Q34104302 | ||
Interleukin-8: an expanding universe beyond neutrophil chemotaxis and activation | Q34150617 | ||
Use of complementary and alternative medicine in patients with liver disease | Q34152596 | ||
Milk thistle. | Q34459546 | ||
Molecular Structure and Stereochemistry of Silybin A, Silybin B, Isosilybin A, and Isosilybin B, Isolated from Silybum marianum (Milk Thistle) | Q34542212 | ||
Inhibition of T-cell inflammatory cytokines, hepatocyte NF-kappaB signaling, and HCV infection by standardized Silymarin | Q34626058 | ||
Milk thistle nomenclature: why it matters in cancer research and pharmacokinetic studies | Q34634347 | ||
An updated systematic review with meta-analysis for the clinical evidence of silymarin | Q34760909 | ||
Milk thistle for the treatment of liver disease: a systematic review and meta-analysis | Q34994556 | ||
Silybin and silymarin--new and emerging applications in medicine | Q36737890 | ||
Toward the definition of the mechanism of action of silymarin: activities related to cellular protection from toxic damage induced by chemotherapy | Q36840439 | ||
Virus associated innate immunity in liver | Q37175673 | ||
Multiple effects of silymarin on the hepatitis C virus lifecycle | Q39698364 | ||
Projecting future complications of chronic hepatitis C in the United States | Q40594872 | ||
Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy. | Q42981378 | ||
Increased prooxidant production and enhanced susceptibility to glutathione depletion in HepG2 cells co-expressing HCV core protein and CYP2E1. | Q42982113 | ||
Hepatitis C drug development at a crossroads | Q42991359 | ||
HCV natural history: the retrospective and prospective in perspective | Q42994353 | ||
Hepatitis C virus proteins: direct link to hepatic oxidative stress, steatosis, carcinogenesis and more | Q43036470 | ||
Silibinin inhibits constitutive and TNFalpha-induced activation of NF-kappaB and sensitizes human prostate carcinoma DU145 cells to TNFalpha-induced apoptosis | Q43919085 | ||
The NF-kappa B activation pathway: its regulation and role in inflammation and cell survival | Q46171001 | ||
Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. | Q46834318 | ||
P433 | issue | 13 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 5995-9 | |
P577 | publication date | 2010-03-30 | |
P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
P1476 | title | Identification of hepatoprotective flavonolignans from silymarin | |
P478 | volume | 107 |
Q38588143 | A comprehensive overview of hepatoprotective natural compounds: mechanism of action and clinical perspectives |
Q27012998 | A current update on the rule of alternative and complementary medicine in the treatment of liver diseases |
Q36971126 | A validated UHPLC-tandem mass spectrometry method for quantitative analysis of flavonolignans in milk thistle (Silybum marianum) extracts |
Q36750919 | Absolute configuration of isosilybin A by X-ray crystallography of the heavy atom analogue 7-(4-Bromobenzoyl)isosilybin A |
Q36672710 | Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4B. |
Q40375330 | Anti-HCV Activity from Semi-purified Methanolic Root Extracts of Valeriana wallichii. |
Q98771123 | Anti-oxidant and anti-inflammatory potential of aqueous extracts of leaves, barks and roots of Bixa orellana L. (Bixaceae) on acetaminophen-induced liver damage in mice |
Q35050214 | Antioxidant oils and Salmonella enterica Typhimurium reduce tumor in an experimental model of hepatic metastasis |
Q35585469 | Antioxidants as therapeutic agents for liver disease |
Q64249929 | Antiviral Activities of Silymarin and Derivatives |
Q91950284 | Antiviral activity of silymarin in comparison with baicalein against EV-A71 |
Q33657624 | Antiviral natural products and herbal medicines |
Q35958261 | Beneficial effects of fucoidan in patients with chronic hepatitis C virus infection. |
Q28065998 | Botanicals and Their Bioactive Phytochemicals for Women's Health |
Q57268361 | Chemoselective fluorination and chemoinformatic analysis of griseofulvin: Natural vs fluorinated fungal metabolites |
Q53314962 | Curcumin, Silybin Phytosome(®) and α-R-Lipoic Acid Mitigate Chronic Hepatitis in Rat by Inhibiting Oxidative Stress and Inflammatory Cytokines Production. |
Q52713011 | Dehydrosilybin attenuates the production of ROS in rat cardiomyocyte mitochondria with an uncoupler-like mechanism. |
Q45328822 | Dietary supplementation of silymarin is associated with decreased cell proliferation, increased apoptosis, and activation of detoxification system in hepatocellular carcinoma |
Q30997889 | Differential in vitro effects of intravenous versus oral formulations of silibinin on the HCV life cycle and inflammation |
Q46240649 | Dihydroquercetin ameliorated acetaminophen-induced hepatic cytotoxicity via activating JAK2/STAT3 pathway and autophagy. |
Q54359675 | Effect of silybin on high-fat-induced fatty liver in rats. |
Q36933129 | Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial |
Q40821539 | Effects of Silymarin, Glycyrrhizin, and Oxymatrine on the Pharmacokinetics of Ribavirin and Its Major Metabolite in Rats |
Q36778757 | Enhanced bioactivity of silybin B methylation products |
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Q40900220 | Gallic acid decreases hepatitis C virus expression through its antioxidant capacity. |
Q38064280 | Hepatitis C virus and natural compounds: a new antiviral approach? |
Q36993948 | Hepatitis C virus-induced mitochondrial dysfunctions |
Q92591667 | Hepatoprotective Activity of Some Medicinal Plants in Sudan |
Q36675737 | Hepatoprotective and antiviral functions of silymarin components in hepatitis C virus infection |
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Q37646391 | Hepatoprotective effect of silymarin |
Q92801892 | Hepatoprotective effects of silymarin on CCl4-induced hepatic damage in broiler chickens model |
Q59351879 | Herbal management of hepatocellular carcinoma through cutting the pathways of the common risk factors |
Q36330277 | Herbal plants and plant preparations as remedial approach for viral diseases. |
Q36807240 | HiFSA fingerprinting applied to isomers with near-identical NMR spectra: the silybin/isosilybin case |
Q39268320 | Identification and evaluation of anti hepatitis C virus phytochemicals from Eclipta alba |
Q24567657 | Identification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gamma |
Q42725611 | Improvement of cerebellum redox states and cholinergic functions contribute to the beneficial effects of silymarin against manganese-induced neurotoxicity. |
Q41539117 | In silico studies of medicinal compounds against hepatitis C capsid protein from north India |
Q41262487 | In vitro effects on biofilm viability and antibacterial and antiadherent activities of silymarin |
Q54155433 | In vivo assessment of an industrial waste product as a feed additive in dairy cows: Effects of larch (Larix decidua L.) sawdust on blood parameters and milk composition |
Q89315057 | In-Vitro Activity of Silybin and Related Flavonolignans against Leishmania infantum and L. donovani |
Q34620898 | Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D(3). |
Q37539831 | Inhibition of HIV by Legalon-SIL is independent of its effect on cellular metabolism |
Q55228735 | Inhibitory effect of silibinin on hepatitis B virus entry. |
Q51507299 | Investigating the potential for toxicity from long-term use of the herbal products, goldenseal and milk thistle. |
Q39560356 | Legalon-SIL downregulates HCV core and NS5A in human hepatocytes expressing full-length HCV. |
Q44948899 | Liver exhibits thermal variations according to the stage of fibrosis progression: A novel use of modulated-differential scanning calorimetry for research in hepatology. |
Q35113499 | Manganese induces oxidative stress, redox state unbalance and disrupts membrane bound ATPases on murine neuroblastoma cells in vitro: protective role of silymarin. |
Q28476811 | Mechanism of inhibition of enveloped virus membrane fusion by the antiviral drug arbidol |
Q26775036 | Natural Products as Tools for Defining How Cellular Metabolism Influences Cellular Immune and Inflammatory Function during Chronic Infection |
Q35087842 | Natural compounds isolated from Brazilian plants are potent inhibitors of hepatitis C virus replication in vitro. |
Q38895458 | Nature and Implications of Oxidative and Nitrosative Stresses in Autoimmune Hepatitis |
Q38193220 | New insights into antioxidant strategies against paraquat toxicity |
Q38866384 | Non-alcoholic Fatty Liver Disease: Beneficial Effects of Flavonoids. |
Q41918847 | Null anticarcinogenic effect of silymarin on diethylnitrosamine-induced hepatocarcinogenesis in rats |
Q38006957 | Oxidative stress and benefits of antioxidant agents in acute and chronic hepatitis |
Q48134300 | Pannorin B, a new naphthopyrone from an endophytic fungal isolate of Penicillium sp. |
Q35535691 | Phylogenetic and chemical diversity of fungal endophytes isolated from Silybum marianum (L) Gaertn. (milk thistle) |
Q38735010 | Phytochemistry and Pharmacological Activities of the Genus Gentiana (Gentianaceae). |
Q49197977 | Plant-derived antivirals against hepatitis c virus infection |
Q26753151 | Potential Effects of Silymarin and Its Flavonolignan Components in Patients with β-Thalassemia Major: A Comprehensive Review in 2015 |
Q41045039 | Protective Role of Silymarin on Hepatic and Renal Toxicity Induced by MTX Based Chemotherapy in Children with Acute Lymphoblastic Leukemia |
Q35025699 | Protective activity of Panduratin A against thioacetamide-induced oxidative damage: demonstration with in vitro experiments using WRL-68 liver cell line |
Q35800747 | Rationale, challenges, and participants in a Phase II trial of a botanical product for chronic hepatitis C |
Q38166445 | Review article: management of chronic hepatitis C in patients with contraindications to anti-viral therapy |
Q50947917 | Role of UDP-Glucuronosyltransferase 1A1 in the Metabolism and Pharmacokinetics of Silymarin Flavonolignans in Patients with HCV and NAFLD. |
Q37374001 | Semisynthesis, cytotoxicity, antiviral activity, and drug interaction liability of 7-O-methylated analogues of flavonolignans from milk thistle |
Q90452530 | Silibinin Ameliorates O-GlcNAcylation and Inflammation in a Mouse Model of Nonalcoholic Steatohepatitis |
Q49830490 | Silibinin alleviates inflammation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes and has a therapeutic effect on arthritis in rats |
Q26740421 | Silibinin and colorectal cancer chemoprevention: a comprehensive review on mechanisms and efficacy |
Q34359120 | Silibinin inhibits HIV-1 infection by reducing cellular activation and proliferation |
Q34652154 | Silibinin inhibits hepatitis C virus entry into hepatocytes by hindering clathrin-dependent trafficking |
Q39406731 | Silibinin regulates gene expression, production and secretion of mucin from cultured airway epithelial cells |
Q41426862 | Silybin-vitamin E-phospholipids complex reduces liver fibrosis in patients with chronic hepatitis C treated with pegylated interferon α and ribavirin |
Q36435673 | Silymarin Suppresses Cellular Inflammation By Inducing Reparative Stress Signaling |
Q40116615 | Silymarin alleviates hepatic oxidative stress and protects against metabolic disorders in high-fat diet-fed mice |
Q38988551 | Silymarin and Its Role in Chronic Diseases |
Q53514982 | Silymarin and lycopene administration in periparturient dairy cows: effects on milk production and oxidative status. |
Q26851453 | Silymarin for HCV infection |
Q36269639 | Silymarin suppresses basal and stimulus-induced activation, exhaustion, differentiation, and inflammatory markers in primary human immune cells |
Q37286270 | Silymarin's Protective Effects and Possible Mechanisms on Alcoholic Fatty Liver for Rats |
Q39104518 | Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years. |
Q94069115 | Single Laboratory Validation of a Quantitative Core Shell-Based LC Separation for the Evaluation of Silymarin Variability and Associated Antioxidant Activity of Pakistani Ecotypes of Milk Thistle ( L.). |
Q47589563 | Spatial organization of silybin biosynthesis in milk thistle [Silybum marianum (L.) Gaertn]. |
Q35215333 | Synergistic antibacterial effect between silibinin and antibiotics in oral bacteria |
Q36883450 | Talarolutins A-D: Meroterpenoids from an endophytic fungal isolate of Talaromyces minioluteus. |
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Q34354947 | The emerging role of hepatitis B virus pre-S2 deletion mutant proteins in HBV tumorigenesis. |
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