Targeting cell entry of enveloped viruses as an antiviral strategy.

scientific article published on 30 December 2010

Targeting cell entry of enveloped viruses as an antiviral strategy. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3390/MOLECULES16010221
P932PMC publication ID6259279
P698PubMed publication ID21193846
P5875ResearchGate publication ID49716989

P2093author name stringEve-Isabelle Pécheur
François Penin
Elodie Teissier
P2860cites workHIV-1 neutralization profile and plant-based recombinant expression of actinohivin, an Env glycan-specific lectin devoid of T-cell mitogenic activityQ21076115
Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infectionQ21245138
Mechanisms of viral entry: sneaking in the front doorQ22252690
A small-molecule dengue virus entry inhibitorQ22309806
Design, synthesis, and biological evaluation of antiviral agents targeting flavivirus envelope proteinsQ22570477
Antiviral compounds discovered by virtual screening of small-molecule libraries against dengue virus E proteinQ22808780
A small molecule fusion inhibitor of dengue virusQ22808782
Identification of hepatoprotective flavonolignans from silymarinQ24600492
HIV-1 entry inhibitors: an overviewQ24645525
Biochemical mechanism of hepatitis C virus inhibition by the broad-spectrum antiviral arbidolQ24653452
Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusionQ24656213
Assembly of endocytic machinery around individual influenza viruses during viral entryQ24669815
Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexesQ24673768
Potent anti-influenza activity of cyanovirin-N and interactions with viral hemagglutininQ24680353
Peptide inhibitors of dengue virus and West Nile virus infectivityQ24813811
Preclinical Evaluation of Two Neutralizing Human Monoclonal Antibodies against Hepatitis C Virus (HCV): a Potential Treatment To Prevent HCV Reinfection in Liver Transplant PatientsQ27473046
Hepatitis C Virus Entry Depends on Clathrin-Mediated EndocytosisQ27473290
A ligand-binding pocket in the dengue virus envelope glycoproteinQ27477685
Structural basis of viral invasion: lessons from paramyxovirus FQ27481675
Domain III from class II fusion proteins functions as a dominant-negative inhibitor of virus membrane fusionQ27485039
A virocidal amphipathic -helical peptide that inhibits hepatitis C virus infection in vitroQ27485575
The CD81 Partner EWI-2wint Inhibits Hepatitis C Virus EntryQ27485588
Hepatitis C virus NS5A anchor peptide disrupts human immunodeficiency virusQ27485703
Viral membrane fusionQ27486639
Structures and Mechanisms of Viral Membrane Fusion Proteins: Multiple Variations on a Common ThemeQ27487974
Low pH-dependent Hepatitis C Virus Membrane Fusion Depends on E2 Integrity, Target Lipid Composition, and Density of Virus ParticlesQ27489056
Human occludin is a hepatitis C virus entry factor required for infection of mouse cellsQ27490169
Amphipathic DNA Polymers Inhibit Hepatitis C Virus Infection by Blocking Viral EntryQ27490785
The Disulfide Bonds in Glycoprotein E2 of Hepatitis C Virus Reveal the Tertiary Organization of the MoleculeQ27490948
A broad-spectrum antiviral targeting entry of enveloped virusesQ27491286
Peptide Inhibitors of Dengue-Virus Entry Target a Late-Stage Fusion IntermediateQ27491339
Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformationQ27643140
Mechanism by which the lectin actinohivin blocks HIV infection of target cellsQ27657228
Inhibition of human immunodeficiency virus (HIV-1) infection in human peripheral blood leucocytes-SCID reconstituted mice by rapamycinQ39303806
Respiratory syncytial virus-neutralizing monoclonal antibodies motavizumab and palivizumab inhibit fusionQ39697277
Multiple effects of silymarin on the hepatitis C virus lifecycleQ39698364
Mapping of the hepatitis B virus attachment site by use of infection-inhibiting preS1 lipopeptides and tupaia hepatocytesQ39723280
Anti-CD81 antibodies can prevent a hepatitis C virus infection in vivoQ39912694
EWI-2wint--a host cell factor inhibiting hepatitis C virus entry.Q39914715
Cyanovirin-N inhibits hepatitis C virus entry by binding to envelope protein glycansQ40261250
Phosphorothioate oligonucleotides inhibit human immunodeficiency virus type 1 fusion by blocking gp41 core formationQ40298802
Antiviral activity of chondroitin sulphate E targeting dengue virus envelope proteinQ40348272
Hepatitis C virus glycoproteins mediate low pH-dependent membrane fusion with liposomesQ40364883
Inhibition of West Nile virus entry by using a recombinant domain III from the envelope glycoprotein.Q40468928
Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A.Q40536971
Putative role of membranes in the HIV fusion inhibitor enfuvirtide mode of action at the molecular levelQ42065660
Gumming up the works: DNA polymers as HCV entry inhibitorsQ42426768
Actinohivin: specific amino acid residues essential for anti-HIV activityQ42907167
Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy.Q42981378
Lamiridosins, hepatitis C virus entry inhibitors from Lamium album.Q42992652
A randomized, open-label study to evaluate the safety and pharmacokinetics of human hepatitis C immune globulin (Civacir) in liver transplant recipientsQ42993950
Monoclonal anti-claudin 1 antibodies prevent hepatitis C virus infection of primary human hepatocytesQ42999009
Hepatitis C virus cell-cell transmission in hepatoma cells in the presence of neutralizing antibodiesQ43041465
Clarithromycin inhibits type a seasonal influenza virus infection in human airway epithelial cellsQ43205377
Discovery of 4-benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (R)-methylpiperazine (BMS-378806): a novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactionsQ44488145
Successful prevention of hepatitis C virus (HCV) liver graft reinfection by silibinin mono-therapyQ45376579
Palivizumab utilization and compliance: trends in respiratory syncytial virus prophylaxis in FloridaQ45378078
Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein.Q45396940
Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial.Q46834318
Adamantane resistance among influenza A viruses isolated early during the 2005-2006 influenza season in the United StatesQ46925884
Adamantane resistance in influenza A.Q46956251
Rapamycin reduces CCR5 mRNA levels in macaques: potential applications in HIV-1 prevention and treatmentQ46989111
Binding of a potent small-molecule inhibitor of six-helix bundle formation requires interactions with both heptad-repeats of the RSV fusion proteinQ27658463
Production of infectious hepatitis C virus in tissue culture from a cloned viral genomeQ27860899
Replication of hepatitis C virusQ27860957
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entryQ28131832
The structural biology of type I viral membrane fusionQ28188215
HIV entry and its inhibitionQ28273919
Arbidol: a broad-spectrum antiviral compound that blocks viral fusionQ28275353
Influenza M2 proton channelsQ28281767
Identification of terfenadine as an inhibitor of human CD81-receptor HCV-E2 interaction: synthesis and structure optimizationQ28284214
Characteristics of arbidol-resistant mutants of influenza virus: implications for the mechanism of anti-influenza action of arbidolQ28301644
Inhibition of neuraminidase inhibitor-resistant influenza virus by DAS181, a novel sialidase fusion proteinQ28471835
HIV-1 fusion inhibitor peptides enfuvirtide and T-1249 interact with erythrocyte and lymphocyte membranesQ28473380
A Novel Small Molecule Inhibitor of Hepatitis C Virus EntryQ28475468
Mechanism of inhibition of enveloped virus membrane fusion by the antiviral drug arbidolQ28476811
Distribution and three-dimensional structure of AIDS virus envelope spikesQ29617562
An amino-terminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5AQ29620628
Virus membrane-fusion proteins: more than one way to make a hairpinQ29620769
Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza virusesQ30229199
Antiviral chemotherapeutic agents against respiratory viruses: where are we now and what's in the pipeline?Q30341187
Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infection.Q30353535
Inhibition of influenza virus infection by a novel antiviral peptide that targets viral attachment to cellsQ30357092
Identification and characterisation of a novel anti-viral peptide against avian influenza virus H9N2.Q30377821
Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitorsQ30386796
Actinohivin, a novel anti-human immunodeficiency virus protein from an actinomycete, inhibits viral entry to cells by binding high-mannose type sugar chains of gp120.Q30909988
Mode of action of an antiviral peptide from HIV-1. Inhibition at a post-lipid mixing stageQ31454800
A peptide derived from hepatitis C virus E2 envelope protein inhibits a post-binding step in HCV entryQ33531362
Targeting the proteolytic processing of the viral glycoprotein precursor is a promising novel antiviral strategy against arenavirusesQ33558767
Efficient inhibition of hepatitis B virus infection by acylated peptides derived from the large viral surface proteinQ33717942
Anti-HIV-1 activity of weekly or biweekly treatment with subcutaneous PRO 140, a CCR5 monoclonal antibodyQ33798442
Novel inhibitors of influenza virus fusion: structure-activity relationship and interaction with the viral hemagglutininQ33826751
The molecular basis of the specific anti-influenza action of amantadineQ33931939
Viral entry inhibitors targeted to the membrane site of action.Q33990602
Entry of hepatitis C virus and human immunodeficiency virus is selectively inhibited by carbohydrate-binding agents but not by polyanionsQ34004118
Silibinin and related compounds are direct inhibitors of hepatitis C virus RNA-dependent RNA polymeraseQ34020427
A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells.Q34051627
Influenza A: understanding the viral life cycleQ34089400
Rigid amphipathic fusion inhibitors, small molecule antiviral compounds against enveloped virusesQ34182763
Pharmacokinetic properties and bioequivalence of two formulations of arbidol: an open-label, single-dose, randomized-sequence, two-period crossover study in healthy Chinese male volunteersQ34607768
Milk thistle nomenclature: why it matters in cancer research and pharmacokinetic studiesQ34634347
Class III viral membrane fusion proteinsQ34789408
Drug-drug interactions of silymarin on the perspective of pharmacokineticsQ34890751
Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide developmentQ35137168
Orally active fusion inhibitor of respiratory syncytial virusQ35547902
Class II virus membrane fusion proteinsQ36346783
Cell entry of hepatitis C virusQ36385222
Biochemical and genetic characterizations of a novel human immunodeficiency virus type 1 inhibitor that blocks gp120-CD4 interactionsQ36525116
Herbal medicine in the treatment of liver diseasesQ36748782
Current pharmacotherapeutic treatment options in Parkinson's diseaseQ36857140
Lipids as modulators of membrane fusion mediated by viral fusion proteinsQ36946651
Hepatitis C virus entry into host cellsQ36959983
Distribution and dynamics of adamantanes in a lipid bilayerQ37008274
Addition of a cholesterol group to an HIV-1 peptide fusion inhibitor dramatically increases its antiviral potencyQ37153758
The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activityQ37448171
Evolution of prophylaxis: MoAb, siRNA, vaccine, and small moleculesQ37570954
Targeting a binding pocket within the trimer-of-hairpins: small-molecule inhibition of viral fusionQ37585515
The hepatitis C virus and its hepatic environment: a toxic but finely tuned partnershipQ37609487
Viral entry mechanisms: the increasing diversity of paramyxovirus entryQ37624858
Development of novel therapies for hepatitis C.Q37736815
Viral proteins function as ion channels.Q37755567
New perspectives in HCV therapy: entry inhibitors.Q37760237
Essential regions for antiviral activities of actinohivin, a sugar-binding anti-human immunodeficiency virus protein from an actinomyceteQ38327540
Actinohivin, a broadly neutralizing prokaryotic lectin, inhibits HIV-1 infection by specifically targeting high-mannose-type glycans on the gp120 envelopeQ38343814
Actinohivin, a novel anti-HIV protein from an actinomycete that inhibits syncytium formation: isolation, characterization, and biological activitiesQ38943968
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectanti-HIV agentsQ50377208
P304page(s)221-250
P577publication date2010-12-30
P1433published inMoleculesQ151332
P1476titleTargeting cell entry of enveloped viruses as an antiviral strategy
P478volume16

Reverse relations

cites work (P2860)
Q39152233"Fusion and binding inhibition" key target for HIV-1 treatment and pre-exposure prophylaxis: targets, drug delivery and nanotechnology approaches.
Q397889935-(Perylen-3-yl)ethynyl-arabino-uridine (aUY11), an arabino-based rigid amphipathic fusion inhibitor, targets virion envelope lipids to inhibit fusion of influenza virus, hepatitis C virus, and other enveloped viruses
Q39156048A Review of Functional Motifs Utilized by Viruses.
Q35956838A generic screening platform for inhibitors of virus induced cell fusion using cellular electrical impedance
Q30422931A new player in the puzzle of filovirus entry
Q36297991A suite of modular fluorescence assays interrogate the human immunodeficiency virus glycoprotein-41 coiled coil and assist in determining binding mechanism of low molecular weight fusion inhibitors
Q37685760Acid phosphatase 2 (ACP2) is required for membrane fusion during influenza virus entry
Q37951610Amphipathic properties of HIV-1 gp41 fusion inhibitors
Q95290815Antiviral Peptides: Identification and Validation
Q40307920Antiviral agents targeting glycans on dengue virus E-glycoprotein
Q40143919Antiviral and Antioxidant Activities of Sulfated Galactomannans from Plants of Caatinga Biome
Q30391416Antivirals for Respiratory Viral Infections: Problems and Prospects
Q34040731Arbidol as a broad-spectrum antiviral: an update
Q33696539Blocking interaction of viral gp120 and CD4-expressing T cells by single-stranded DNA aptamers
Q37065151Cell surface assembly of HIV gp41 six-helix bundles for facile, quantitative measurements of hetero-oligomeric interactions
Q38107673Chikungunya virus: an update on antiviral development and challenges
Q40288667Computational identification of self-inhibitory peptides from envelope proteins
Q36946831Design of Small Molecules with HIV Fusion Inhibitory Property Based on Gp41 Interaction Assay
Q34253013Discovery and SAR study of piperidine-based derivatives as novel influenza virus inhibitors
Q34522341Entry of hepatitis B and hepatitis D virus into hepatocytes: Basic insights and clinical implications.
Q36842185Gardiquimod: a Toll-like receptor-7 agonist that inhibits HIV type 1 infection of human macrophages and activated T cells
Q99201268How can nanotechnology help to combat COVID-19? Opportunities and urgent need
Q35860797Identification of Peptide Inhibitors of Enveloped Viruses Using Support Vector Machine
Q40159006Identification of sequence motifs involved in Dengue virus-host interactions
Q22337991Inhibitors of tick-borne flavivirus reproduction from structure-based virtual screening
Q40189080Interaction of Flaviviruses with Reproduction Inhibitors Binding in β-OG Pocket: Insights from Molecular Dynamics Simulations
Q38524164Interactions of HIV-1 proteins as targets for developing anti-HIV-1 peptides.
Q27026314Multiscale perspectives of virus entry via endocytosis
Q53601817Naïve Human Antibody Libraries for Infectious Diseases.
Q84315466Peptide-Protein Interaction Studies of Antimicrobial Peptides Targeting Middle East Respiratory Syndrome Coronavirus Spike Protein: An In Silico Approach
Q40218035Prediction of HBF-0259 interactions with hepatitis B Virus receptors and surface antigen secretory factors
Q92983162Rice stripe virus hitchhikes the vector insect vitellogenin ligand-receptor pathway for ovary entry
Q98389656SARS-CoV-2 Entry Inhibitors: Small Molecules and Peptides Targeting Virus or Host Cells
Q90737186Structure-Based Design of Antivirals against Envelope Glycoprotein of Dengue Virus
Q59355547Surfactin Inhibits Membrane Fusion during Invasion of Epithelial Cells by Enveloped Viruses
Q55084371The Antiviral Drug Arbidol Inhibits Zika Virus.
Q40026277The Location of the Protonated and Unprotonated Forms of Arbidol in the Membrane: A Molecular Dynamics Study.
Q28271798The Synthetic Antiviral Drug Arbidol Inhibits Globally Prevalent Pathogenic Viruses

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