Actinohivin, a broadly neutralizing prokaryotic lectin, inhibits HIV-1 infection by specifically targeting high-mannose-type glycans on the gp120 envelope

scientific article published on 24 May 2010

Actinohivin, a broadly neutralizing prokaryotic lectin, inhibits HIV-1 infection by specifically targeting high-mannose-type glycans on the gp120 envelope is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AAC.00254-10
P932PMC publication ID2916299
P698PubMed publication ID20498311

P50authorKristel Van LaethemQ28743837
Dominique ScholsQ47698773
Jan BalzariniQ31332118
P2093author name stringHaruo Tanaka
Atsushi Takahashi
Katrien O François
Dana Huskens
Geoffrey Férir
Bart Hoorelbeke
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Crystal structure of cyanovirin-N, a potent HIV-inactivating protein, shows unexpected domain swappingQ27618183
Solution structure of a cyanovirin-N:Man alpha 1-2Man alpha complex: structural basis for high-affinity carbohydrate-mediated binding to gp120Q27635270
Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high mannose oligosaccharidesQ27639344
Structural improvement of unliganded simian immunodeficiency virus gp120 core by normal-mode-based X-ray crystallographic refinementQ27654249
Mechanism by which the lectin actinohivin blocks HIV infection of target cellsQ27657228
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibodyQ27759364
Solution structure of cyanovirin-N, a potent HIV-inactivating proteinQ27764577
DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cellsQ28138968
Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cellsQ28288205
Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responsesQ28616569
A simple screening system for anti-HIV drugs: syncytium formation assay using T-cell line tropic and macrophage tropic HIV env expressing cell lines--establishment and validation.Q38943963
Actinohivin, a novel anti-HIV protein from an actinomycete that inhibits syncytium formation: isolation, characterization, and biological activitiesQ38943968
Identification of replication-competent strains of simian immunodeficiency virus lacking multiple attachment sites for N-linked carbohydrates in variable regions 1 and 2 of the surface envelope protein.Q39581340
Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.Q39756219
Resistance of HIV-1 to the broadly HIV-1-neutralizing, anti-carbohydrate antibody 2G12.Q40204965
Carbohydrate-binding agents efficiently prevent dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN)-directed HIV-1 transmission to T lymphocytesQ40216885
Carbohydrates of human immunodeficiency virus. Structures of oligosaccharides linked to the envelope glycoprotein 120.Q41986204
Molecular cloning of actinohivin, a novel anti-HIV protein from an actinomycete, and its expression in Escherichia coliQ42644711
Determining the structure of an unliganded and fully glycosylated SIV gp120 envelope glycoprotein.Q44104909
A genotypic resistance assay for the detection of drug resistance in the human immunodeficiency virus type 1 envelope geneQ45176343
Cyanovirin-N inhibits AIDS virus infections in vaginal transmission modelsQ45670260
HIV/SIV glycoproteins: structure-function relationshipsQ48042571
Safety concerns for the potential use of cyanovirin-N as a microbicidal anti-HIV agentQ56763406
Cyanovirin-N gel as a topical microbicide prevents rectal transmission of SHIV89.6P in macaquesQ73814670
AIDS models: microbicides could learn from vaccinesQ78029025
Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1Q29619512
Actinohivin, a novel anti-human immunodeficiency virus protein from an actinomycete, inhibits viral entry to cells by binding high-mannose type sugar chains of gp120.Q30909988
Llama antibody fragments with cross-subtype human immunodeficiency virus type 1 (HIV-1)-neutralizing properties and high affinity for HIV-1 gp120Q33374701
Antibodies against Manalpha1,2-Manalpha1,2-Man oligosaccharide structures recognize envelope glycoproteins from HIV-1 and SIV strainsQ33627537
Whither or wither microbicides?Q33715907
Resistance of human immunodeficiency virus type 1 to the high-mannose binding agents cyanovirin N and concanavalin A.Q33842989
Animal model for the therapy of acquired immunodeficiency syndrome with reverse transcriptase inhibitorsQ33957283
Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapyQ34005185
Beyond receptor expression: the influence of receptor conformation, density, and affinity in HIV-1 infectionQ34065091
The mannose-dependent epitope for neutralizing antibody 2G12 on human immunodeficiency virus type 1 glycoprotein gp120.Q34341843
The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120.Q34342352
Mutational pathways, resistance profile, and side effects of cyanovirin relative to human immunodeficiency virus type 1 strains with N-glycan deletions in their gp120 envelopesQ35024164
Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide developmentQ35137168
Pradimicin A, a carbohydrate-binding nonpeptidic lead compound for treatment of infections with viruses with highly glycosylated envelopes, such as human immunodeficiency virusQ35634404
Inhibiting sexual transmission of HIV-1 infectionQ35709090
High-mannose-specific deglycosylation of HIV-1 gp120 induced by resistance to cyanovirin-N and the impact on antibody neutralizationQ36237904
Exploiting the defensive sugars of HIV-1 for drug and vaccine designQ36802333
Profile of resistance of human immunodeficiency virus to mannose-specific plant lectinsQ37511474
Mannose-specific plant lectins from the Amaryllidaceae family qualify as efficient microbicides for prevention of human immunodeficiency virus infectionQ37568901
Essential regions for antiviral activities of actinohivin, a sugar-binding anti-human immunodeficiency virus protein from an actinomyceteQ38327540
Carbohydrate binding properties of the stinging nettle (Urtica dioica) rhizome lectinQ38350612
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)3287-3301
P577publication date2010-05-24
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleActinohivin, a broadly neutralizing prokaryotic lectin, inhibits HIV-1 infection by specifically targeting high-mannose-type glycans on the gp120 envelope
P478volume54

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cites work (P2860)
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