The high mannose-type glycan binding lectin actinohivin: dimerization greatly improves anti-HIV activity

scientific article published on 22 June 2011

The high mannose-type glycan binding lectin actinohivin: dimerization greatly improves anti-HIV activity is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1022325035
P356DOI10.1038/JA.2011.51
P698PubMed publication ID21694730
P5875ResearchGate publication ID51239904

P50authorSatoshi ŌmuraQ21061207
P2093author name stringHaruo Tanaka
Atsushi Takahashi
Shinichi Oka
Atsuko Hachiya
Junji Inokoshi
P2860cites workHIV-1 neutralization profile and plant-based recombinant expression of actinohivin, an Env glycan-specific lectin devoid of T-cell mitogenic activityQ21076115
Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in womenQ24629582
Crystal structures of the sugar complexes of Streptomyces olivaceoviridis E-86 xylanase: sugar binding structure of the family 13 carbohydrate binding moduleQ27637656
Mechanism by which the lectin actinohivin blocks HIV infection of target cellsQ27657228
HIV entry and its inhibitionQ28273919
beta-Trefoil fold. Patterns of structure and sequence in the Kunitz inhibitors interleukins-1 beta and 1 alpha and fibroblast growth factorsQ28294610
Proteins that bind high-mannose sugars of the HIV envelopeQ28295811
Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug targetQ28369397
Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and diseaseQ29616432
Structure of ricin B-chain at 2.5 A resolution.Q30372288
Actinohivin, a novel anti-human immunodeficiency virus protein from an actinomycete, inhibits viral entry to cells by binding high-mannose type sugar chains of gp120.Q30909988
Rapid and simple phenotypic assay for drug susceptibility of human immunodeficiency virus type 1 using CCR5-expressing HeLa/CD4(+) cell clone 1-10 (MAGIC-5)Q33981401
Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapyQ34005185
Targeting therapeutics to an exposed and conserved binding element of the HIV-1 fusion proteinQ34981730
Inhibition of HIV entry by carbohydrate-binding proteinsQ36434175
Microbicides: a new frontier in HIV preventionQ36649988
Essential regions for antiviral activities of actinohivin, a sugar-binding anti-human immunodeficiency virus protein from an actinomyceteQ38327540
Actinohivin, a broadly neutralizing prokaryotic lectin, inhibits HIV-1 infection by specifically targeting high-mannose-type glycans on the gp120 envelopeQ38343814
A simple screening system for anti-HIV drugs: syncytium formation assay using T-cell line tropic and macrophage tropic HIV env expressing cell lines--establishment and validation.Q38943963
Actinohivin, a novel anti-HIV protein from an actinomycete that inhibits syncytium formation: isolation, characterization, and biological activitiesQ38943968
Glycosylation: heterogeneity and the 3D structure of proteinsQ40914186
Unwelcomed guests with master keys: how HIV uses chemokine receptors for cellular entryQ41583314
Molecular cloning of actinohivin, a novel anti-HIV protein from an actinomycete, and its expression in Escherichia coliQ42644711
Actinohivin: specific amino acid residues essential for anti-HIV activityQ42907167
A bifunctional fusion protein containing Fc-binding fragment B of staphylococcal protein A amino terminal to antidigoxin single-chain Fv.Q43691134
Structure and evolution of ricin B chainQ47397814
β-Trefoil foldQ56339973
Targeting the glycans of gp120: a novel approach aimed at the Achilles heel of HIVQ81410989
P433issue8
P304page(s)551-557
P577publication date2011-06-22
P1433published inThe Journal of AntibioticsQ7743552
P1476titleThe high mannose-type glycan binding lectin actinohivin: dimerization greatly improves anti-HIV activity
P478volume64