High-mannose-specific deglycosylation of HIV-1 gp120 induced by resistance to cyanovirin-N and the impact on antibody neutralization

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High-mannose-specific deglycosylation of HIV-1 gp120 induced by resistance to cyanovirin-N and the impact on antibody neutralization is …
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scholarly articleQ13442814

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P356DOI10.1016/J.VIROL.2007.06.029
P932PMC publication ID2121147
P698PubMed publication ID17658575
P5875ResearchGate publication ID6179604

P50authorRobin ShattockQ84767097
P2093author name stringNaheed Mahmood
Qinxue Hu
P2860cites workThe HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and ImmunogensQ22242262
Solution structure of a cyanovirin-N:Man alpha 1-2Man alpha complex: structural basis for high-affinity carbohydrate-mediated binding to gp120Q27635270
Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high mannose oligosaccharidesQ27639344
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibodyQ27759364
The antigenic structure of the HIV gp120 envelope glycoproteinQ28274698
Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cellsQ28288205
Proteins that bind high-mannose sugars of the HIV envelopeQ28295811
Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia spQ28299555
GP120: target for neutralizing HIV-1 antibodiesQ28303124
Nonrandom distribution of gp120 N-linked glycosylation sites important for infectivity of human immunodeficiency virus type 1Q28646731
Antibody neutralization and escape by HIV-1Q29547345
Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1Q29619512
Cyanovirin-N binds to gp120 to interfere with CD4-dependent human immunodeficiency virus type 1 virion binding, fusion, and infectivity but does not affect the CD4 binding site on gp120 or soluble CD4-induced conformational changes in gp120.Q33648180
Multiple antiviral activities of cyanovirin-N: blocking of human immunodeficiency virus type 1 gp120 interaction with CD4 and coreceptor and inhibition of diverse enveloped virusesQ33804363
Evolution of the human immunodeficiency virus type 1 envelope during infection reveals molecular corollaries of specificity for coreceptor utilization and AIDS pathogenesisQ33813025
Resistance of human immunodeficiency virus type 1 to the high-mannose binding agents cyanovirin N and concanavalin A.Q33842989
The mannose-dependent epitope for neutralizing antibody 2G12 on human immunodeficiency virus type 1 glycoprotein gp120.Q34341843
The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120.Q34342352
Mutational pathways, resistance profile, and side effects of cyanovirin relative to human immunodeficiency virus type 1 strains with N-glycan deletions in their gp120 envelopesQ35024164
Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide developmentQ35137168
Inhibiting sexual transmission of HIV-1 infectionQ35709090
The entry of entry inhibitors: a fusion of science and medicineQ35976966
Blockade of attachment and fusion receptors inhibits HIV-1 infection of human cervical tissueQ36399466
Inhibition of HIV entry by carbohydrate-binding proteinsQ36434175
Cyanovirin-N defines a new class of antiviral agent targeting N-linked, high-mannose glycans in an oligosaccharide-specific mannerQ38301855
Selective interactions of the human immunodeficiency virus-inactivating protein cyanovirin-N with high-mannose oligosaccharides on gp120 and other glycoproteins.Q38301990
The N-terminal V3 loop glycan modulates the interaction of clade A and B human immunodeficiency virus type 1 envelopes with CD4 and chemokine receptorsQ39597685
Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120Q39612212
Resistance of HIV-1 to the broadly HIV-1-neutralizing, anti-carbohydrate antibody 2G12.Q40204965
The rational design of an AIDS vaccineQ40348550
Modified HIV envelope proteins with enhanced binding to neutralizing monoclonal antibodiesQ40484043
Carbohydrate structures of the human-immunodeficiency-virus (HIV) recombinant envelope glycoprotein gp120 produced in Chinese-hamster ovary cellsQ42163960
An N-glycan within the human immunodeficiency virus type 1 gp120 V3 loop affects virus neutralizationQ43451743
Structure-based, targeted deglycosylation of HIV-1 gp120 and effects on neutralization sensitivity and antibody recognition.Q44572417
Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusionQ45422914
Cyanovirin-N inhibits AIDS virus infections in vaginal transmission modelsQ45670260
Restricted variable residues in the C-terminal segment of HIV-1 V3 loop regulate the molecular anatomy of CCR5 utilizationQ46553841
The C-type lectin superfamily in the immune systemQ46835986
A role for carbohydrates in immune evasion in AIDS.Q47982875
A general model for the surface glycoproteins of HIV and other retroviruses.Q49281404
Isolation and characterization of a lectin with exclusive specificity towards mannose from snowdrop (Galanthus nivalis ) bulbsQ61551531
Analysis of the interaction between the HIV-inactivating protein cyanovirin-N and soluble forms of the envelope glycoproteins gp120 and gp41Q73097938
Cyanovirin-N gel as a topical microbicide prevents rectal transmission of SHIV89.6P in macaquesQ73814670
Targeting the glycans of gp120: a novel approach aimed at the Achilles heel of HIVQ81410989
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
P304page(s)145-154
P577publication date2007-07-23
P1433published inVirologyQ7934867
P1476titleHigh-mannose-specific deglycosylation of HIV-1 gp120 induced by resistance to cyanovirin-N and the impact on antibody neutralization
P478volume368

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cites work (P2860)
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