Homologous recombination in DNA repair and DNA damage tolerance

scientific article

Homologous recombination in DNA repair and DNA damage tolerance is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1040825790
P356DOI10.1038/CR.2008.1
P3181OpenCitations bibliographic resource ID2772012
P932PMC publication ID3087377
P698PubMed publication ID18166982
P5875ResearchGate publication ID5682700

P50authorWolf-Dietrich HeyerQ63309380
P2093author name stringXuan Li
P2860cites workCellular roles of dna topoisomerases: a molecular perspectiveQ22121990
Evidence for simultaneous protein interactions between human Rad51 paralogsQ22253453
Identification and purification of two distinct complexes containing the five RAD51 paralogsQ24292055
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repairQ24299313
Analysis of the DNA substrate specificity of the human BACH1 helicase associated with breast cancerQ24301530
Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosisQ24301697
RAD51C is required for Holliday junction processing in mammalian cellsQ24304325
Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeatsQ24306511
Insights into DNA recombination from the structure of a RAD51-BRCA2 complexQ24319669
Multiple heterologies increase mitotic double-strand break-induced allelic gene conversion tract lengths in yeast.Q34607778
Maintenance of genome stability in Saccharomyces cerevisiaeQ34762852
Translesion DNA synthesis in eukaryotes: a one- or two-polymerase affairQ34770150
Rad54: the Swiss Army knife of homologous recombination?Q35100612
Rad54, a Jack of all trades in homologous recombinationQ35162506
Holliday junctions in the eukaryotic nucleus: resolution in sight?Q35559727
The Mus81 solution to resolution: generating meiotic crossovers without Holliday junctionsQ35643073
Emerging functions of BRCA2 in DNA recombinationQ35846734
Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differencesQ36037736
BLM ortholog, Sgs1, prevents aberrant crossing-over by suppressing formation of multichromatid joint moleculesQ36082370
Recombination mediator and Rad51 targeting activities of a human BRCA2 polypeptide.Q36143372
The Fanconi Anemia/BRCA pathway: new faces in the crowdQ36343120
Loss of heterozygosity induced by a chromosomal double-strand breakQ36546233
Exonuclease I of Saccharomyces cerevisiae functions in mitotic recombination in vivo and in vitroQ36568265
DNA interstrand cross-link repair in Saccharomyces cerevisiae.Q36649807
Fanconi anemia and DNA replication repairQ36811854
Chromosome fragility: molecular mechanisms and cellular consequencesQ36849639
RAD54 controls access to the invading 3'-OH end after RAD51-mediated DNA strand invasion in homologous recombination in Saccharomyces cerevisiaeQ37077426
Sws1 is a conserved regulator of homologous recombination in eukaryotic cellsQ24337352
The Stability of Broken Ends of Chromosomes in Zea Mays.Q24533277
Structure of the single-strand annealing domain of human RAD52 proteinQ24536071
BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediatesQ24544999
Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiaeQ24548535
Damage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1Q24551095
The Rad51 paralog Rad51B promotes homologous recombinational repairQ24551864
Disruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin CQ24554173
The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamilyQ24555147
The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repairQ24556631
Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchangeQ24599514
A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group MQ24654206
The hSNM1 protein is a DNA 5'-exonucleaseQ24671253
Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repairQ24685928
Differential and collaborative actions of Rad51 paralog proteins in cellular response to DNA damageQ24812447
BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structureQ27639649
Rad52 forms ring structures and co-operates with RPA in single-strand DNA annealingQ27930553
In vivo roles of Rad52, Rad54, and Rad55 proteins in Rad51-mediated recombination.Q27930596
Rad52 associates with RPA and functions with rad55 and rad57 to assemble meiotic recombination complexesQ27931495
A ubiquitin-binding motif in the translesion DNA polymerase Rev1 mediates its essential functional interaction with ubiquitinated proliferating cell nuclear antigen in response to DNA damageQ27931627
Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replicationQ27932084
Break-induced replication and telomerase-independent telomere maintenance require Pol32.Q27933035
Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexesQ27933322
Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like proteinQ27933995
The S. cerevisiae Rrm3p DNA helicase moves with the replication fork and affects replication of all yeast chromosomesQ27934054
The yeast Snm1 protein is a DNA 5'-exonucleaseQ27934200
The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments.Q27934939
The beta-lactamase motif in Snm1 is required for repair of DNA double-strand breaks caused by interstrand crosslinks in S. cerevisiaeQ27935474
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.Q27937465
Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast RAD51 proteinQ27937922
Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promote DNA strand exchange by Rad51 recombinaseQ27938070
DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1Q27938100
CeBRC-2 stimulates D-loop formation by RAD-51 and promotes DNA single-strand annealingQ33250311
Topoisomerase IIIalpha and Bloom's helicase can resolve a mobile double Holliday junction substrate through convergent branch migrationQ33250631
Rad52-mediated DNA annealing after Rad51-mediated DNA strand exchange promotes second ssDNA captureQ33263102
FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding proteinQ33289084
A surfeit of RAD51-like genes?Q33633019
Targeted inactivation of mouse RAD52 reduces homologous recombination but not resistance to ionizing radiationQ33781473
DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparabilityQ34164868
Tumor cell death induced by topoisomerase-targeting drugs.Q34192665
Crystal structure of a Rad51 filamentQ34331322
Efficient copying of nonhomologous sequences from ectopic sites via P-element-induced gap repairQ34336201
Repair of DNA interstrand cross-linksQ34343361
Recombination and recombination-dependent DNA replication in bacteriophage T4.Q34490524
Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.Q34541051
DNA double-strand break repair: all's well that ends wellQ34555274
Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance.Q34571928
Double-strand breaks and translocations in cancerQ34578131
Mobile D-loops are a preferred substrate for the Bloom's syndrome helicase.Q34588305
Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancerQ34597168
Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.Q34597176
Double-strand break repair in the absence of RAD51 in yeast: a possible role for break-induced DNA replicationQ37490114
Mutations in XRS2 and RAD50 delay but do not prevent mating-type switching in Saccharomyces cerevisiaeQ38308503
The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaksQ38774142
Phosphorylation of Rad55 on serines 2, 8, and 14 is required for efficient homologous recombination in the recovery of stalled replication forksQ39126666
Defining the roles of nucleotide excision repair and recombination in the repair of DNA interstrand cross-links in mammalian cellsQ39456389
DNA replication is required To elicit cellular responses to psoralen-induced DNA interstrand cross-links.Q39456549
The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway.Q40382206
Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cellsQ40643885
Telomere maintenance by recombination in human cells.Q40839283
Frequent chromosomal translocations induced by DNA double-strand breaksQ40872179
DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: bleomycin, neocarzinostatin and other enediynesQ41090666
Shu proteins promote the formation of homologous recombination intermediates that are processed by Sgs1-Rmi1-Top3.Q41312383
Sgs1 regulates gene conversion tract lengths and crossovers independently of its helicase activityQ41493782
The F-Box DNA helicase Fbh1 prevents Rhp51-dependent recombination without mediator proteins.Q42107587
Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2.Q42152324
Rad54, a Swi2/Snf2-like recombinational repair protein, disassembles Rad51:dsDNA filamentsQ44230461
Rad54p is a chromatin remodeling enzyme required for heteroduplex DNA joint formation with chromatinQ44270140
ATP-dependent and ATP-independent roles for the Rad54 chromatin remodeling enzyme during recombinational repair of a DNA double strand breakQ45226582
The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junctionQ45345099
Rad54 protein is targeted to pairing loci by the Rad51 nucleoprotein filamentQ46189017
Visualization of Rad54, a chromatin remodeling protein, translocating on single DNA moleculesQ46202156
The DNA binding properties of Saccharomyces cerevisiae Rad51 proteinQ46561573
Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2pQ46576875
Replication fork reactivation downstream of a blocked nascent leading strandQ46923728
Drosophila BLM in double-strand break repair by synthesis-dependent strand annealingQ47071772
Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM.Q47074397
DNA strand exchange proteins: a biochemical and physical comparison.Q47956058
High-frequency P element loss in Drosophila is homolog dependent.Q52449709
Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination.Q52524907
The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends.Q53657324
BRCA2-dependent and independent formation of RAD51 nuclear foci.Q53939630
RMPs: recombination/replication mediator proteinsQ56896449
Similarity of the yeast RAD51 filament to the bacterial RecA filamentQ56937925
Multiple Mechanisms Control Chromosome Integrity after Replication Fork Uncoupling and Restart at Irreparable UV LesionsQ58883733
Antitumour drugs impede DNA uncoiling by topoisomerase IQ59092676
Rad54 dissociates homologous recombination intermediates by branch migrationQ64387873
Synapsis and the formation of paranemic joints by E. coli RecA proteinQ70168677
Superhelicity-driven homologous DNA pairing by yeast recombination factors Rad51 and Rad54Q73074482
A novel function of Rad54 protein. Stabilization of the Rad51 nucleoprotein filamentQ78882309
The BRCA2-Interacting Protein DSS1 Is Vital for DNA Repair, Recombination, and Genome Stability in Ustilago maydisQ79212406
Homology-driven chromatin remodeling by human RAD54Q80119033
Rad54 protein possesses chromatin-remodeling activity stimulated by the Rad51-ssDNA nucleoprotein filamentQ27938152
A genetic screen for top3 suppressors in Saccharomyces cerevisiae identifies SHU1, SHU2, PSY3 and CSM2: four genes involved in error-free DNA repairQ27939159
In vivo assembly and disassembly of Rad51 and Rad52 complexes during double-strand break repairQ27939283
MUS81 encodes a novel helix-hairpin-helix protein involved in the response to UV- and methylation-induced DNA damage in Saccharomyces cerevisiaeQ27939646
Genome maintenance mechanisms for preventing cancerQ28131737
Molecular views of recombination proteins and their controlQ28207872
Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defectsQ28216078
SWI2/SNF2 and related proteins: ATP-driven motors that disrupt protein-DNA interactions?Q28236020
Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2Q28236543
Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolismQ28245231
Rad54 protein promotes branch migration of Holliday junctionsQ28253660
SUMO-modified PCNA recruits Srs2 to prevent recombination during S phaseQ28254244
Mechanism of homologous recombination: mediators and helicases take on regulatory functionsQ28259452
Stimulation by Rad52 of yeast Rad51-mediated recombinationQ28260489
Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein AQ28260499
The double-strand-break repair model for recombinationQ28267259
Replisome assembly and the direct restart of stalled replication forksQ28276681
Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cellsQ28511551
DSS1 is required for RAD51 focus formation and genomic stability in mammalian cellsQ28586983
The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaksQ28592473
A single-stranded DNA-binding protein is needed for efficient presynaptic complex formation by the Saccharomyces cerevisiae Rad51 proteinQ28647553
The Bloom's syndrome helicase suppresses crossing over during homologous recombinationQ29547237
Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteinsQ29615270
Recombination proteins in yeastQ29617872
DNA helicase Srs2 disrupts the Rad51 presynaptic filamentQ29618305
RecQ helicases: caretakers of the genomeQ29618390
Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeastQ29618612
Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugationQ29619155
Recombinational repair of DNA damage in Escherichia coli and bacteriophage lambdaQ29619755
Function of yeast Rad52 protein as a mediator between replication protein A and the Rad51 recombinaseQ29620205
Rad52 partially substitutes for the Rad51 paralog XRCC3 in maintaining chromosomal integrity in vertebrate cellsQ30453366
Rad52 protein associates with replication protein A (RPA)-single-stranded DNA to accelerate Rad51-mediated displacement of RPA and presynaptic complex formationQ30736645
Studies of the interaction between Rad52 protein and the yeast single-stranded DNA binding protein RPA.Q32060621
DNA annealing by RAD52 protein is stimulated by specific interaction with the complex of replication protein A and single-stranded DNAQ32062848
Catalysis of homologous DNA pairing by yeast Rad51 and Rad54 proteinsQ32063619
The Rad51-dependent pairing of long DNA substrates is stabilized by replication protein A.Q32186835
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectDNA damageQ5205747
cell biologyQ7141
P304page(s)99-113
P577publication date2008-01-01
P1433published inCell ResearchQ1524018
P1476titleHomologous recombination in DNA repair and DNA damage tolerance
P478volume18

Reverse relations

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Q34657712Mystery of DNA repair: the role of the MRN complex and ATM kinase in DNA damage repair
Q33842009Nanobiomotors of archaeal DNA repair machineries: current research status and application potential
Q39019557Nascent DNA synthesis during homologous recombination is synergistically promoted by the rad51 recombinase and DNA homology
Q57491394Network Analysis of RAD51 Proteins in Metazoa and the Evolutionary Relationships With Their Archaeal Homologs
Q38789155New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress
Q90224455Nickel Carcinogenesis Mechanism: DNA Damage
Q37021526Nonsense-mediated decay regulates key components of homologous recombination
Q37302669Novel insights into RAD51 activity and regulation during homologous recombination and DNA replication
Q38220992Nuclease delivery: versatile functions of SLX4/FANCP in genome maintenance
Q26822478Nucleases in homologous recombination as targets for cancer therapy
Q36288503O6-methylguanine DNA methyltransferase as a promising target for the treatment of temozolomide-resistant gliomas
Q49836867Observation and Analysis of RAD51 Nucleation Dynamics at Single-Monomer Resolution.
Q28307657Oligo/polynucleotide-based gene modification: strategies and therapeutic potential
Q54588181Opposite modifying effects of HR and NHEJ deficiency on cancer risk in Ptc1 heterozygous mouse cerebellum.
Q37194752Oxidative damage and mutagenesis in Saccharomyces cerevisiae: genetic studies of pathways affecting replication fidelity of 8-oxoguanine
Q47131342PARP2 controls double-strand break repair pathway choice by limiting 53BP1 accumulation at DNA damage sites and promoting end-resection
Q30921143PCNA is required for initiation of recombination-associated DNA synthesis by DNA polymerase delta
Q97540196Pamiparib is a potent and selective PARP inhibitor with unique potential for the treatment of brain tumor
Q42793326Pathways for Holliday junction processing during homologous recombination in Saccharomyces cerevisiae.
Q40801597Pathways for double-strand break repair in genetically unstable Z-DNA-forming sequences
Q38223676Pathways for genome integrity in G2 phase of the cell cycle
Q41857124Peptide aptamer mimicking RAD51-binding domain of BRCA2 inhibits DNA damage repair and survival in Trypanosoma brucei
Q47205384Photosynthetic functions of Synechococcus in the ocean microbiomes of diverse salinity and seasons
Q91802196Platinum Salts in Patients with Breast Cancer: A Focus on Predictive Factors
Q40404211PolDIP2 interacts with human PrimPol and enhances its DNA polymerase activities.
Q64387964Polymorphism of DNA Repair Genes via Homologous Recombination (HR) in Ovarian Cancer
Q36936978Preferential D-loop extension by a translesion DNA polymerase underlies error-prone recombination
Q24308876PrimPol bypasses UV photoproducts during eukaryotic chromosomal DNA replication
Q38866687PrimPol-A new polymerase on the block
Q34025948Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes
Q37613647Programmable Genome Editing Tools and their Regulation for Efficient Genome Engineering
Q30450792Purification of FANCD2 sub-complexes
Q40997100RAD51 haploinsufficiency causes congenital mirror movements in humans
Q37800769RAD51C: a novel cancer susceptibility gene is linked to Fanconi anemia and breast cancer
Q42635196RDM1 gene overexpression represents a therapeutic target in papillary thyroid carcinoma.
Q40988187REPLACR-mutagenesis, a one-step method for site-directed mutagenesis by recombineering
Q39167940RNAi silencing targeting RNF8 enhances radiosensitivity of a non-small cell lung cancer cell line A549.
Q24309568RTEL1 maintains genomic stability by suppressing homologous recombination
Q36097164Rad51 Expression in Nasopharyngeal Carcinoma and Its Association with Tumor Reduction: A Preliminary Study in Indonesia
Q34071842Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs
Q39503969Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death.
Q34058338Rad52 SUMOylation affects the efficiency of the DNA repair
Q33652233Rad52/Rad59-dependent recombination as a means to rectify faulty Okazaki fragment processing.
Q41607544Rad54 is not essential for any geminiviral replication mode in planta
Q93035884Radiation resistance of normal human astrocytes: the role of non-homologous end joining DNA repair activity
Q33792899Radiation-generated short DNA fragments may perturb non-homologous end-joining and induce genomic instability
Q33900056RecA maintains the integrity of chloroplast DNA molecules in Arabidopsis
Q30366224RecO protein initiates DNA recombination and strand annealing through two alternative DNA binding mechanisms.
Q37166694Recognition of double strand breaks by a mutator protein (MU2) in Drosophila melanogaster
Q37254288Recombination-dependent oligomerization of human papillomavirus genomes upon transient DNA replication
Q52723083Recruitment kinetics of the homologous recombination pathway in procyclic forms of Trypanosoma brucei after ionizing radiation treatment.
Q34516867Reduced proficiency in homologous recombination underlies the high sensitivity of embryonal carcinoma testicular germ cell tumors to Cisplatin and poly (adp-ribose) polymerase inhibition
Q92709516Regulation of gene expression by altered promoter methylation using a CRISPR/Cas9-mediated epigenetic editing system
Q33966065Regulation of homologous recombination in eukaryotes
Q38559892Regulation of recombination and genomic maintenance
Q36879506Regulation of therapeutic resistance in cancers by receptor tyrosine kinases
Q35200273Regulators of homologous recombination repair as novel targets for cancer treatment.
Q28755375RepPop: a database for repetitive elements in Populus trichocarpa
Q37775586Repair of DNA interstrand cross-links during S phase of the mammalian cell cycle
Q37346254Repair of DNA lesions associated with triplex-forming oligonucleotides
Q39969993Repair of I-SceI induced DSB at a specific site of chromosome in human cells: influence of low-dose, low-dose-rate gamma-rays
Q37938603Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair.
Q37993652Replication fork dynamics and the DNA damage response.
Q33509264Replication protein A (RPA1a) is required for meiotic and somatic DNA repair but is dispensable for DNA replication and homologous recombination in rice
Q38768243Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides
Q48162485Revolutionizing male fertility factor research in mice by using the genome editing tool CRISPR/Cas9.
Q61799067Robust and efficient knock-in in embryonic stem cells and early-stage embryos of the common marmoset using the CRISPR-Cas9 system
Q37775588Role of homologous recombination in DNA interstrand crosslink repair
Q35069570Role of lamin b1 in chromatin instability
Q53687949Role of long non-coding RNA in drug resistance in non-small cell lung cancer.
Q24646853Roles of RECQ helicases in recombination based DNA repair, genomic stability and aging
Q38048886Sequence and structural basis for chromosomal fragility during translocations in cancer
Q49354543Single-molecule live-cell imaging of bacterial DNA repair and damage tolerance.
Q35841330Single-nucleotide polymorphisms in DNA bypass polymerase genes and association with breast cancer and breast cancer subtypes among African Americans and Whites.
Q35835383Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers.
Q37171001Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells
Q34339095Spatiotemporal recruitment of human DNA polymerase delta to sites of UV damage
Q35764178Spindle Checkpoint Factors Bub1 and Bub2 Promote DNA Double-Strand Break Repair by Nonhomologous End Joining
Q27938895Srs2 disassembles Rad51 filaments by a protein-protein interaction triggering ATP turnover and dissociation of Rad51 from DNA.
Q34517593Structural and functional insights from the metagenome of an acidic hot spring microbial planktonic community in the Colombian Andes.
Q35961942Structural basis for substrate recognition and processive cleavage mechanisms of the trimeric exonuclease PhoExo I.
Q46237274Studies of lncRNAs in DNA double strand break repair: what is new?
Q38630696Sunitinib induces genomic instability of renal carcinoma cells through affecting the interaction of LC3-II and PARP-1.
Q37226478Synthetic genetic targeting of genome instability in cancer.
Q34671726Synthetic lethality between gene defects affecting a single non-essential molecular pathway with reversible steps
Q64077863TLP-mediated global transcriptional repression after double-strand DNA breaks slows down DNA repair and induces apoptosis
Q35731289TODRA, a lncRNA at the RAD51 Locus, Is Oppositely Regulated to RAD51, and Enhances RAD51-Dependent DSB (Double Strand Break) Repair
Q50088140TP53 Haploinsufficiency Rescues Emergency Granulopoiesis in FANCC-/- Mice.
Q64058293Tailoring Ovarian Cancer Treatment: Implications of Mutations
Q35757980Targeted inhibition of histone deacetylases and hedgehog signaling suppress tumor growth and homologous recombination in aerodigestive cancers.
Q47308626Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy
Q39383614Targeting PI3K and RAD51 in Barrett's adenocarcinoma: impact on DNA damage checkpoints, expression profile and tumor growth
Q37019392Targeting cancer with a lupus autoantibody
Q37769804Targeting inflammatory pathways for tumor radiosensitization.
Q38651063The Association of Low-Penetrance Variants in DNA Repair Genes with Colorectal Cancer: A Systematic Review and Meta-Analysis
Q37272458The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange
Q38821634The Changing Landscape of Genetic Testing for Inherited Breast Cancer Predisposition
Q60922544The DNA damage response is developmentally regulated in the African trypanosome
Q54209627The HTLV-1 basic leucine zipper factor (HBZ) attenuates repair of double-stranded DNA breaks via non-homologous end joining (NHEJ).
Q37526483The MRE11 complex: starting from the ends.
Q24616365The Role of PCNA Posttranslational Modifications in Translesion Synthesis
Q33948571The Smc5/6 complex and Esc2 influence multiple replication-associated recombination processes in Saccharomyces cerevisiae
Q95839849The bromodomain containing protein BRD-9 orchestrates RAD51-RAD54 complex formation and regulates homologous recombination-mediated repair
Q39835877The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry
Q28115800The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cells
Q33720883The cohesin-like RecN protein stimulates RecA-mediated recombinational repair of DNA double-strand breaks.
Q90645627The correction of ETV6/RUNX1 translocation in acute lymphocytic leukemia cells: a new gene targeting system by homologous recombination mechanism
Q92214210The current state of molecular testing in the treatment of patients with solid tumors, 2019
Q39179722The enigmatic oncogene and tumor suppressor-like properties of RAD54B: Insights into genome instability and cancer
Q53775795The functional status of DNA repair pathways determines the sensitization effect to cisplatin in non-small cell lung cancer cells.
Q24599645The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells
Q38233068The potential of PARP inhibitors in neuro-oncology
Q28272384The rice RAD51C gene is required for the meiosis of both female and male gametocytes and the DNA repair of somatic cells
Q38064172The role of BRCA1 in DNA double-strand repair: past and present
Q37781516The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers
Q35113821Top3-Rmi1 dissolve Rad51-mediated D loops by a topoisomerase-based mechanism
Q37174956Triapine potentiates platinum-based combination therapy by disruption of homologous recombination repair
Q39781851Two modules in the BRC repeats of BRCA2 mediate structural and functional interactions with the RAD51 recombinase.
Q36145592Tyrosine phosphorylation stimulates activity of human RAD51 recombinase through altered nucleoprotein filament dynamics
Q54231304Unveiling benznidazole's mechanism of action through overexpression of DNA repair proteins in Trypanosoma cruzi.
Q64254541Women's cancers: how the discovery of BRCA genes is driving current concepts of cancer biology and therapeutics
Q95728259XRCC4 c.1394G>T Single Nucleotide Polymorphisms and Breast Cancer Risk among Filipinos
Q35031979YAP regulates S-phase entry in endothelial cells
Q38858838hCAS/CSE1L regulates RAD51 distribution and focus formation for homologous recombinational repair
Q36228025mRNA and DNA selection via protein multimerization: YB-1 as a case study.
Q36874139mTOR Inhibitors Suppress Homologous Recombination Repair and Synergize with PARP Inhibitors via Regulating SUV39H1 in BRCA-Proficient Triple-Negative Breast Cancer
Q36394957tRNA processing defects induce replication stress and Chk2-dependent disruption of piRNA transcription.

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