Inhibition of calpain prevents NMDA-induced cell death and beta-amyloid-induced synaptic dysfunction in hippocampal slice cultures

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Inhibition of calpain prevents NMDA-induced cell death and beta-amyloid-induced synaptic dysfunction in hippocampal slice cultures is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1476-5381.2010.00652.X
P932PMC publication ID2850408
P698PubMed publication ID20233208
P5875ResearchGate publication ID42108291

P2093author name stringK G Reymann
A Hahn
G Gross
H Schoemaker
A Möller
V Nimmrich
K Wicke
M Strassburger
U H Schöder
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Progressive incorporation of propidium iodide in cultured mouse neurons correlates with declining electrophysiological status: a fluorescence scale of membrane integrityQ34452978
Calpain inhibitors, but not caspase inhibitors, prevent actin proteolysis and DNA fragmentation during apoptosisQ34457040
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Inhibition of Calpain Prevents N-Methyl-D-aspartate-Induced Degeneration of the Nucleus Basalis and Associated Behavioral DysfunctionQ42440226
beta-amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalisQ42492837
The novel calpain inhibitor A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 and tau cleavage in hippocampal neurons.Q43213857
Stage-dependent and sector-specific neuronal loss in hippocampus during Alzheimer's diseaseQ43924252
Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice.Q45251288
Calpain and N-methyl-d-aspartate (NMDA)-induced excitotoxicity in rat retinasQ46476462
Calpain-mediated mGluR1alpha truncation: a key step in excitotoxicityQ46769581
Calpain-cleaved collapsin response mediator protein-3 induces neuronal death after glutamate toxicity and cerebral ischemia.Q46958346
Cdk5 is a key factor in tau aggregation and tangle formation in vivoQ48300530
beta-Amyloid-induced dynamin 1 degradation is mediated by N-methyl-D-aspartate receptors in hippocampal neurons.Q48463841
Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease.Q48963534
Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment.Q48970270
Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease.Q50455488
Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus.Q53245545
Neuronal loss in primary long-term cortical culture involves neurodegeneration-like cell death via calpain and p35 processing, but not developmental apoptosis or aging.Q53576708
Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's diseaseQ57132920
Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase asQ79851539
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectcell deathQ2383867
P304page(s)1523-31
P577publication date2010-04-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleInhibition of calpain prevents NMDA-induced cell death and beta-amyloid-induced synaptic dysfunction in hippocampal slice cultures
P478volume159

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cites work (P2860)
Q38014513Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine--searching for the connections
Q38099671Amyloid β, glutamate, excitotoxicity in Alzheimer's disease: are we on the right track?
Q39004902Calpain research for drug discovery: challenges and potential
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Q36881509Differential roles for caspase-mediated and calpain-mediated cell death in 1- and 3-week-old rat cortical cultures
Q64998890Involvement of calpain in the neuropathogenesis of Alzheimer's disease.
Q47120381Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers.
Q34493905Proteolysis of calcineurin is increased in human hippocampus during mild cognitive impairment and is stimulated by oligomeric Abeta in primary cell culture
Q44516795Tat-collapsin response mediator protein 2 (CRMP2) increases the survival of neurons after NMDA excitotoxity by reducing the cleavage of CRMP2.
Q36208482Temporal dependence of cysteine protease activation following excitotoxic hippocampal injury
Q37845675The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease

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