| scholarly article | Q13442814 |
| review article | Q7318358 |
| P50 | author | Hey-Kyoung Lee | Q37841582 |
| Alfredo Kirkwood | Q86847004 | ||
| P2093 | author name string | Hui Wang | |
| Kaiwen He | |||
| Andrea Megill | |||
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| Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations | Q24301868 | ||
| Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease | Q24316501 | ||
| Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path | Q24538964 | ||
| Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade | Q24561819 | ||
| Antisense oligodeoxynucleotide-mediated disruption of hippocampal cAMP response element binding protein levels impairs consolidation of memory for water maze training | Q24564996 | ||
| Inhibition of calpain prevents NMDA-induced cell death and beta-amyloid-induced synaptic dysfunction in hippocampal slice cultures | Q24603101 | ||
| Natural patterns of activity and long-term synaptic plasticity | Q24616717 | ||
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| NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo | Q24679444 | ||
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| Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro | Q34049813 | ||
| Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo | Q34063772 | ||
| Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice | Q34067152 | ||
| Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease | Q34107259 | ||
| NMDA-mediated Ca(2+) influx drives aberrant ryanodine receptor activation in dendrites of young Alzheimer's disease mice | Q34149384 | ||
| Role of AMPA receptor endocytosis in synaptic plasticity | Q34238072 | ||
| Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex | Q34277494 | ||
| A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory | Q34324150 | ||
| Developmental regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor subunit expression in forebrain and relationship to regional susceptibility to hypoxic/ischemic injury. II. Human cerebral white matter and cortex | Q34330653 | ||
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| Strategies for disease modification in Alzheimer's disease | Q34342498 | ||
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| Phosphorylation of the alpha-amino-3-hydroxy-5-methylisoxazole4-propionic acid receptor GluR1 subunit by calcium/calmodulin-dependent kinase II. | Q34450034 | ||
| Potential treatment opportunities for Alzheimer's disease through inhibition of secretases and Abeta immunization | Q34509815 | ||
| Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease | Q34543713 | ||
| Synaptic incorporation of AMPA receptors during LTP is controlled by a PKC phosphorylation site on GluR1. | Q34548349 | ||
| Dendritic protein synthesis, synaptic plasticity, and memory | Q34571206 | ||
| Insights into immediate-early gene function in hippocampal memory consolidation using antisense oligonucleotide and fluorescent imaging approaches | Q34579339 | ||
| Reduced sodium channel Na(v)1.1 levels in BACE1-null mice | Q34624269 | ||
| Nicotine activates immature "silent" connections in the developing hippocampus | Q34763285 | ||
| Reactive oxygen species in the regulation of synaptic plasticity and memory | Q34805998 | ||
| Alzheimer's disease: treatments in discovery and development | Q34982289 | ||
| Amyloid β-induced impairments in hippocampal synaptic plasticity are rescued by decreasing mitochondrial superoxide | Q34982983 | ||
| Neuronal activity regulates the regional vulnerability to amyloid-β deposition | Q35009626 | ||
| BDNF regulates the intrinsic excitability of cortical neurons | Q35039394 | ||
| Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models | Q35070000 | ||
| A physiological mechanism for Hebb's postulate of learning | Q35100243 | ||
| Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex | Q35105866 | ||
| Introduction. Long-term potentiation and structure of the issue | Q35124797 | ||
| Soluble oligomers of amyloid-β peptide disrupt membrane trafficking of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor contributing to early synapse dysfunction. | Q35144851 | ||
| Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning | Q48189640 | ||
| Visually driven regulation of intrinsic neuronal excitability improves stimulus detection in vivo | Q48213051 | ||
| Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis | Q48217048 | ||
| Hypersensitivity to seizures in beta-amyloid precursor protein deficient mice | Q48236519 | ||
| Strengthening of horizontal cortical connections following skill learning | Q48243844 | ||
| Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein + presenilin-1 transgenic mice. | Q48267298 | ||
| Mechanisms of calcium influx into hippocampal spines: heterogeneity among spines, coincidence detection by NMDA receptors, and optical quantal analysis. | Q48270437 | ||
| NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus | Q48327089 | ||
| Defects in expression of genes related to synaptic vesicle trafficking in frontal cortex of Alzheimer's disease | Q48350194 | ||
| Multiple forms of synaptic plasticity triggered by selective suppression of activity in individual neurons. | Q48435334 | ||
| Potentiation of cortical inhibition by visual deprivation. | Q48438986 | ||
| Nicotinic modulation of network and synaptic transmission in the immature hippocampus investigated with genetically modified mice. | Q48449811 | ||
| beta-Amyloid-induced dynamin 1 degradation is mediated by N-methyl-D-aspartate receptors in hippocampal neurons. | Q48463841 | ||
| Incidence of dementia after ischemic stroke: results of a longitudinal study. | Q48491561 | ||
| Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice. | Q48546084 | ||
| Blockade of long-term potentiation in rat hippocampal CA1 region by inhibitors of protein synthesis. | Q48594719 | ||
| Anisomycin blocks the late phase of long-term potentiation in the dentate gyrus of freely moving rats | Q48654971 | ||
| Tracking the fear engram: the lateral amygdala is an essential locus of fear memory storage. | Q48716253 | ||
| Blockade of gamma-secretase activity within the hippocampus enhances long-term memory. | Q48718666 | ||
| Temporary occlusion of associative motor cortical plasticity by prior dynamic motor training. | Q48874202 | ||
| Hippocampal synaptic transmission enhanced by low concentrations of nicotine. | Q48887721 | ||
| Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease. | Q48920532 | ||
| Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization | Q40885683 | ||
| Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation | Q41103770 | ||
| Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating. | Q41256595 | ||
| Exploring the etiology of Alzheimer disease using molecular genetics | Q41366388 | ||
| Beta-amyloid disrupted synaptic vesicle endocytosis in cultured hippocampal neurons. | Q41437626 | ||
| NSAIDs: How they Work and their Prospects as Therapeutics in Alzheimer's Disease | Q41512953 | ||
| Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes | Q41609588 | ||
| Impairment of hippocampal long-term potentiation by Alzheimer amyloid beta-peptides | Q41725623 | ||
| CREB and memory | Q41733280 | ||
| Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory. | Q41736768 | ||
| Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors | Q41825065 | ||
| The production of amyloid beta peptide is a critical requirement for the viability of central neurons. | Q42170170 | ||
| Beta-amyloid-induced dynamin 1 depletion in hippocampal neurons. A potential mechanism for early cognitive decline in Alzheimer disease. | Q42274064 | ||
| Oral treatment with a gamma-secretase inhibitor improves long-term potentiation in a mouse model of Alzheimer's disease | Q42465497 | ||
| alpha7 Nicotinic acetylcholine receptor as a target to rescue deficit in hippocampal LTP induction in beta-amyloid infused rats | Q42487269 | ||
| Amyloid peptide Abeta(1-42) binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors | Q42491766 | ||
| beta-Amyloid(1-42) peptide directly modulates nicotinic receptors in the rat hippocampal slice. | Q42498248 | ||
| beta-Amyloid selectively augments NMDA receptor-mediated synaptic transmission in rat hippocampus. | Q42521332 | ||
| Are NSAIDs useful to treat Alzheimer's disease or mild cognitive impairment? | Q42659546 | ||
| Activity deprivation reduces miniature IPSC amplitude by decreasing the number of postsynaptic GABA(A) receptors clustered at neocortical synapses. | Q42670226 | ||
| Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice. | Q42675168 | ||
| Ameliorative effects of a non-competitive BACE1 inhibitor TAK-070 on Aβ peptide levels and impaired learning behavior in aged rats | Q42904574 | ||
| Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses. | Q43236403 | ||
| Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain | Q43516537 | ||
| Neuregulins increase alpha7 nicotinic acetylcholine receptors and enhance excitatory synaptic transmission in GABAergic interneurons of the hippocampus. | Q43683723 | ||
| Suppressed expression of nicotinic acetylcholine receptors by nanomolar beta-amyloid peptides in PC12 cells. | Q43865953 | ||
| Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease. | Q43941772 | ||
| Alzheimer amyloid beta-peptide inhibits the late phase of long-term potentiation through calcineurin-dependent mechanisms in the hippocampal dentate gyrus | Q43980897 | ||
| Dark rearing alters the development of GABAergic transmission in visual cortex. | Q44132598 | ||
| alpha- and betaCaMKII. Inverse regulation by neuronal activity and opposing effects on synaptic strength | Q44258612 | ||
| Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampus | Q44524418 | ||
| Beta-amyloid regulation of presynaptic nicotinic receptors in rat hippocampus and neocortex. | Q44532497 | ||
| Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease. | Q44557611 | ||
| BACE1 Suppression by RNA Interference in Primary Cortical Neurons | Q44643912 | ||
| BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes | Q44686140 | ||
| BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease | Q44722202 | ||
| Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability. | Q44728737 | ||
| Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice | Q44884968 | ||
| Gamma-secretase: proteasome of the membrane? | Q44918417 | ||
| Subunit rules governing the sorting of internalized AMPA receptors in hippocampal neurons | Q44984032 | ||
| Deviant ryanodine receptor-mediated calcium release resets synaptic homeostasis in presymptomatic 3xTg-AD mice. | Q45916530 | ||
| Modulation of synaptic transmission and long-term potentiation: effects on paired pulse facilitation and EPSC variance in the CA1 region of the hippocampus | Q46152163 | ||
| Selective reconfiguration of layer 4 visual cortical circuitry by visual deprivation | Q46229886 | ||
| Regulation of NMDA receptors by neuregulin signaling in prefrontal cortex. | Q46497163 | ||
| Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice. | Q46610675 | ||
| Adaptation to synaptic inactivity in hippocampal neurons | Q46616710 | ||
| The synaptic Abeta hypothesis of Alzheimer disease | Q46621202 | ||
| Amyloid beta prevents activation of calcium/calmodulin-dependent protein kinase II and AMPA receptor phosphorylation during hippocampal long-term potentiation | Q46641415 | ||
| Enhanced caffeine-induced Ca2+ release in the 3xTg-AD mouse model of Alzheimer's disease | Q46698220 | ||
| Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease. | Q46726652 | ||
| NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production. | Q46750110 | ||
| Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses | Q46768341 | ||
| Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1. | Q46899478 | ||
| Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice. | Q47593587 | ||
| Abeta oligomer-mediated long-term potentiation impairment involves protein phosphatase 1-dependent mechanisms. | Q48103179 | ||
| Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations | Q48134209 | ||
| Common molecular mechanisms in explicit and implicit memory | Q28248948 | ||
| Translational control by MAPK signaling in long-term synaptic plasticity and memory | Q28249953 | ||
| Identification of the Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate-type glutamate receptor | Q28257288 | ||
| Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein | Q28260479 | ||
| Activity-dependent scaling of quantal amplitude in neocortical neurons | Q28264163 | ||
| Control of peripheral nerve myelination by the beta-secretase BACE1 | Q28264800 | ||
| Metaplasticity: the plasticity of synaptic plasticity | Q28281044 | ||
| Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit | Q28282250 | ||
| Deficiency of the Copper Chaperone for Superoxide Dismutase Increases Amyloid-β Production | Q28289956 | ||
| Candidate gene for the chromosome 1 familial Alzheimer's disease locus | Q28295424 | ||
| Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency | Q28505078 | ||
| Regulation of NMDA receptor trafficking by amyloid-beta | Q28506085 | ||
| Mice lacking both presenilin genes exhibit early embryonic patterning defects | Q28508946 | ||
| The neuregulin-1 receptor erbB4 controls glutamatergic synapse maturation and plasticity. | Q28568657 | ||
| Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization | Q28571556 | ||
| PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity | Q28574179 | ||
| Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons | Q28579011 | ||
| Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm | Q28585594 | ||
| Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein | Q28586098 | ||
| Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory | Q28588695 | ||
| Presenilin-1 regulates neuronal differentiation during neurogenesis | Q28590604 | ||
| Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration | Q28590719 | ||
| Mossy fiber long-term potentiation deficits in BACE1 knock-outs can be rescued by activation of alpha7 nicotinic acetylcholine receptors | Q28590874 | ||
| APP processing and synaptic plasticity in presenilin-1 conditional knockout mice | Q28591914 | ||
| Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus | Q28592777 | ||
| Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease | Q28854273 | ||
| Alzheimer's disease is a synaptic failure | Q29547670 | ||
| AMPA receptor trafficking and synaptic plasticity | Q29547876 | ||
| Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease | Q29614374 | ||
| Neuronal calcium signaling | Q29614727 | ||
| AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss | Q29614850 | ||
| APP processing and synaptic function | Q29615873 | ||
| Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction | Q29617044 | ||
| Long-term potentiation--a decade of progress? | Q29619421 | ||
| Learning induces long-term potentiation in the hippocampus | Q29619482 | ||
| Synaptic plasticity and memory: an evaluation of the hypothesis | Q29619840 | ||
| Presenilin 1 regulates homeostatic synaptic scaling through Akt signaling | Q35190094 | ||
| Presenilins in memory, Alzheimer's disease, and therapy | Q35748755 | ||
| Beta-secretase inhibition for the treatment of Alzheimer's disease--promise and challenge | Q35753298 | ||
| Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity. | Q35768842 | ||
| SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer's disease amyloidosis and improves synaptic function | Q35838771 | ||
| Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels | Q35879583 | ||
| Molecular mechanisms underlying emotional learning and memory in the lateral amygdala | Q35902483 | ||
| Deciphering the molecular basis of memory failure in Alzheimer's disease | Q35902501 | ||
| Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss | Q35918370 | ||
| BACE1 activity is modulated by cell-associated sphingosine-1-phosphate. | Q35945545 | ||
| Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity | Q35985945 | ||
| A synaptic basis for memory storage in the cerebral cortex | Q35997034 | ||
| Synaptic plasticity at hippocampal mossy fibre synapses | Q36302353 | ||
| Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice | Q36327027 | ||
| Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices | Q36342500 | ||
| Neuregulin-1 and myelination | Q36416058 | ||
| The distribution and targeting of neuronal voltage-gated ion channels | Q36514764 | ||
| Physiological roles for amyloid beta peptides | Q36523591 | ||
| Elements of a neurobiological theory of hippocampal function: the role of synaptic plasticity, synaptic tagging and schemas | Q36527016 | ||
| Synaptic plasticity and phosphorylation | Q36564122 | ||
| Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing | Q36579740 | ||
| Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression | Q36609033 | ||
| Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo | Q36666647 | ||
| Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium. | Q36695036 | ||
| Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease | Q36934762 | ||
| Activity of gamma-secretase on substrates other than APP. | Q37066678 | ||
| {beta}-Amyloid impairs AMPA receptor trafficking and function by reducing Ca2+/calmodulin-dependent protein kinase II synaptic distribution | Q37155459 | ||
| Inhibition and modulation of gamma-secretase for Alzheimer's disease | Q37215842 | ||
| beta-Secretase as a therapeutic target for Alzheimer's disease | Q37215845 | ||
| CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease. | Q37230760 | ||
| BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampus | Q37309641 | ||
| BACE1 regulates voltage-gated sodium channels and neuronal activity | Q37355641 | ||
| Presynaptic type III neuregulin 1 is required for sustained enhancement of hippocampal transmission by nicotine and for axonal targeting of alpha7 nicotinic acetylcholine receptors | Q37369416 | ||
| Alternative Abeta immunotherapy approaches for Alzheimer's disease | Q37438255 | ||
| Increased levels of NMDA receptor NR2A subunits at pre- and postsynaptic sites of the hippocampal CA1: an early response to conditional double knockout of presenilin 1 and 2. | Q37485390 | ||
| Developing novel immunogens for a safe and effective Alzheimer's disease vaccine | Q37574391 | ||
| Alzheimer's disease: synaptic dysfunction and Abeta | Q37636545 | ||
| The dysregulation of intracellular calcium in Alzheimer disease | Q37676636 | ||
| The upside of APP at synapses | Q37825632 | ||
| Therapeutic intervention for Alzheimer's disease with γ-secretase inhibitors: still a viable option? | Q37827490 | ||
| Novel γ-secretase modulators: a review of patents from 2008 to 2010. | Q37828163 | ||
| The role of CREB signaling in Alzheimer's disease and other cognitive disorders. | Q37863146 | ||
| Hippocampal synaptic plasticity in Alzheimer's disease: what have we learned so far from transgenic models? | Q37898103 | ||
| Amyloid-beta-(1-42) increases ryanodine receptor-3 expression and function in neurons of TgCRND8 mice | Q38308416 | ||
| cAMP response element-binding protein in the amygdala is required for long- but not short-term conditioned taste aversion memory | Q38342475 | ||
| Facilitation of currents through rat Ca2+-permeable AMPA receptor channels by activity-dependent relief from polyamine block | Q39445641 | ||
| Surface trafficking of sodium channels in cells and in hippocampal slices | Q39474750 | ||
| Effects of conjugated linoleic acid on cleavage of amyloid precursor protein via PPARγ. | Q39498646 | ||
| PPARγ co-activator-1α (PGC-1α) reduces amyloid-β generation through a PPARγ-dependent mechanism | Q39584769 | ||
| Nicotine decreases beta-amyloid through regulating BACE1 transcription in SH-EP1-α4β2 nAChR-APP695 cells | Q39588913 | ||
| A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease. | Q39665939 | ||
| Effects of galantamine on β-amyloid release and beta-site cleaving enzyme 1 expression in differentiated human neuroblastoma SH-SY5Y cells | Q39684627 | ||
| 2,2',4'-trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice | Q39711842 | ||
| Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis | Q39789741 | ||
| Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease | Q39813744 | ||
| Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation | Q40061988 | ||
| 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity. | Q40076266 | ||
| Protein synthesis and memory: a review | Q40079699 | ||
| Specific suppression of beta-secretase gene expression by short interfering RNA in SK-N-SH cells. | Q40181362 | ||
| Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo | Q40199218 | ||
| Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model | Q40379114 | ||
| Contrasting properties of two forms of long-term potentiation in the hippocampus. | Q40482872 | ||
| Presenilin 1 is involved in maturation and trafficking of N‐cadherin to the plasma membrane | Q40630606 | ||
| Ca(2+) stores and capacitative Ca(2+) entry in human neuroblastoma (SH-SY5Y) cells expressing a familial Alzheimer's disease presenilin-1 mutation | Q40706362 | ||
| Enhanced ryanodine-mediated calcium release in mutant PS1-expressing Alzheimer's mouse models. | Q50690364 | ||
| The γ-secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice. | Q51019775 | ||
| Memory in mice as affected by intracerebral puromycin. | Q51285018 | ||
| Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure. | Q51770733 | ||
| Oligomers of beta-amyloid peptide inhibit BDNF-induced arc expression in cultured cortical Neurons. | Q51967760 | ||
| A physiological basis for a theory of synapse modification. | Q52255807 | ||
| Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. | Q53274559 | ||
| Alzheimer disease: presenilin springs a leak. | Q53281601 | ||
| Presenilins and Alzheimer disease: the calcium conspiracy. | Q53382538 | ||
| Bace1 modulates myelination in the central and peripheral nervous system. | Q53588736 | ||
| Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity | Q59065408 | ||
| Role for Rapid Dendritic Protein Synthesis in Hippocampal mGluR-Dependent Long-Term Depression | Q60141744 | ||
| Requirement of translation but not transcription for the maintenance of long-term depression in the CA1 region of freely moving rats | Q61896447 | ||
| Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors | Q71768164 | ||
| Presenilin-mediated modulation of capacitative calcium entry | Q73133100 | ||
| Calcium signals in long-term potentiation and long-term depression | Q73194908 | ||
| Hippocampal LTD expression involves a pool of AMPARs regulated by the NSF-GluR2 interaction | Q73203901 | ||
| NMDA receptor-mediated subthreshold Ca(2+) signals in spines of hippocampal neurons | Q73469653 | ||
| A novel role for {gamma}-secretase: selective regulation of spontaneous neurotransmitter release from hippocampal neurons | Q83238745 | ||
| beta -Amyloid peptide blocks the response of alpha 7-containing nicotinic receptors on hippocampal neurons | Q95721074 | ||
| Amyloid beta oligomers (A beta(1-42) globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents. | Q30179416 | ||
| SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production | Q30482542 | ||
| BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. | Q30483997 | ||
| Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis | Q30486959 | ||
| Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations | Q30491040 | ||
| Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice | Q30493115 | ||
| BACE1 deficiency causes altered neuronal activity and neurodegeneration | Q30495458 | ||
| Beta-secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice | Q30497942 | ||
| Beta-secretase (BACE) as a drug target for Alzheimer's disease | Q30749785 | ||
| Use-dependent effects of amyloidogenic fragments of (beta)-amyloid precursor protein on synaptic plasticity in rat hippocampus in vivo. | Q31840196 | ||
| Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation | Q32063777 | ||
| BACE1 is the major beta-secretase for generation of Abeta peptides by neurons | Q32063781 | ||
| beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase | Q33213947 | ||
| Synaptic targeting by Alzheimer's-related amyloid beta oligomers. | Q33288786 | ||
| Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice | Q33291589 | ||
| Specific roles of AMPA receptor subunit GluR1 (GluA1) phosphorylation sites in regulating synaptic plasticity in the CA1 region of hippocampus | Q33593591 | ||
| Activation of immediate early genes and memory formation | Q33651838 | ||
| Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease | Q33687945 | ||
| Alzheimer's disease: from pathogenesis to disease-modifying approaches | Q33790299 | ||
| Functional deprivation promotes amyloid plaque pathogenesis in Tg2576 mouse olfactory bulb and piriform cortex | Q33818653 | ||
| Synaptic plasticity: taming the beast | Q33929019 | ||
| PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. | Q33932164 | ||
| Cadherins in embryonic and neural morphogenesis | Q33938474 | ||
| Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression. | Q33944873 | ||
| P275 | copyright license | Creative Commons Attribution 3.0 Unported | Q14947546 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P921 | main subject | cell | Q7868 |
| protein precursor | Q258658 | ||
| membrane protein | Q423042 | ||
| enzyme inhibitor | Q427492 | ||
| neuroplasticity | Q849491 | ||
| mechanism of action | Q3271540 | ||
| nervous system | Q9404 | ||
| P304 | page(s) | 272374 | |
| P577 | publication date | 2012-06-26 | |
| P1433 | published in | Neural Plasticity | Q15716605 |
| P1476 | title | Consequences of inhibiting amyloid precursor protein processing enzymes on synaptic function and plasticity | |
| P478 | volume | 2012 |
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