| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1040646247 |
| P356 | DOI | 10.1038/NCB1602 |
| P932 | PMC publication ID | 2747787 |
| P698 | PubMed publication ID | 17576410 |
| P5875 | ResearchGate publication ID | 232754565 |
| P50 | author | Clifford J. Woolf | Q5132981 |
| P2093 | author name string | Ping He | |
| Haibin Wang | |||
| Virginia M-Y Lee | |||
| Bryce W Carey | |||
| Doo Yeon Kim | |||
| Dora M Kovacs | |||
| Warren H Pettingell | |||
| Alexander M Binshtok | |||
| Laura A M Ingano | |||
| Mary H Wertz | |||
| P2860 | cites work | Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1). | Q44243372 |
| Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease | Q44270458 | ||
| A novel method for monitoring surface membrane trafficking on hippocampal acute slice preparation | Q44451261 | ||
| BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes | Q44686140 | ||
| High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease | Q45286392 | ||
| Type I and type II Na(+) channel alpha-subunit polypeptides exhibit distinct spatial and temporal patterning, and association with auxiliary subunits in rat brain | Q48140249 | ||
| Biosynthesis and processing of the alpha subunit of the voltage-sensitive sodium channel in rat brain neurons | Q48319338 | ||
| Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain. | Q48678268 | ||
| Dementia and adult-onset unprovoked seizures. | Q49103438 | ||
| Seizures and myoclonus in patients with Alzheimer's disease. | Q53191262 | ||
| Seizures in Alzheimer's disease: clinicopathologic study. | Q53203295 | ||
| Bace1 modulates myelination in the central and peripheral nervous system. | Q53588736 | ||
| Upregulation of the Voltage-Gated Sodium Channel 2 Subunit in Neuropathic Pain Models: Characterization of Expression in Injured and Non-Injured Primary Sensory Neurons | Q57990434 | ||
| Distribution of voltage-gated sodium channel ?-subunit and ?-subunit mRNAs in human hippocampal formation, cortex, and cerebellum | Q60513667 | ||
| Distribution of voltage-gated sodium channel alpha-subunit and beta-subunit mRNAs in human hippocampal formation, cortex, and cerebellum | Q73863923 | ||
| Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE | Q22010705 | ||
| Purification and cloning of amyloid precursor protein beta-secretase from human brain | Q22010914 | ||
| De novo mutations in the sodium-channel gene SCN1A cause severe myoclonic epilepsy of infancy | Q24533495 | ||
| Sodium channel beta subunits mediate homophilic cell adhesion and recruit ankyrin to points of cell-cell contact | Q28141221 | ||
| From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels | Q28143653 | ||
| Functional effects of two voltage-gated sodium channel mutations that cause generalized epilepsy with febrile seizures plus type 2 | Q28188391 | ||
| Sodium channel beta subunits: anything but auxiliary | Q28210938 | ||
| Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration | Q28245447 | ||
| Control of peripheral nerve myelination by the beta-secretase BACE1 | Q28264800 | ||
| Clinical phenotypic heterogeneity of Alzheimer's disease associated with mutations of the presenilin-1 gene | Q28280248 | ||
| Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits | Q30476942 | ||
| BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. | Q30483997 | ||
| Molecular mechanisms of gating and drug block of sodium channels | Q30668670 | ||
| beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase | Q33213947 | ||
| Changes in the mRNAs encoding voltage-gated sodium channel types II and III in human epileptic hippocampus. | Q34092030 | ||
| Identification of epilepsy genes in human and mouse | Q34432267 | ||
| Neuropsychiatric symptoms in the dementias | Q34769198 | ||
| Seizures in elderly patients with dementia: epidemiology and management | Q35215650 | ||
| Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration. | Q35844774 | ||
| BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo | Q36321125 | ||
| The human heart and rat brain IIA Na+ channels interact with different molecular regions of the beta1 subunit | Q36436600 | ||
| The distribution and targeting of neuronal voltage-gated ion channels | Q36514764 | ||
| Molecular properties of voltage-sensitive sodium channels | Q38165670 | ||
| Sodium channel beta1 subunits promote neurite outgrowth in cerebellar granule neurons | Q40510241 | ||
| In vivo inhibition of Abeta production by memapsin 2 (beta-secretase) inhibitors | Q40547178 | ||
| The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1. | Q40631641 | ||
| Sodium channel mRNA in the B104 neuroblastoma cell line | Q41206431 | ||
| Activation of protein kinase A modulates trafficking of the human cardiac sodium channel in Xenopus oocytes | Q41921498 | ||
| Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease | Q44132132 | ||
| alpha- and beta-secretase: profound changes in Alzheimer's disease. | Q44225451 | ||
| P433 | issue | 7 | |
| P921 | main subject | sodium | Q658 |
| voltage | Q25428 | ||
| P304 | page(s) | 755-764 | |
| P577 | publication date | 2007-06-18 | |
| P1433 | published in | Nature Cell Biology | Q1574111 |
| P1476 | title | BACE1 regulates voltage-gated sodium channels and neuronal activity | |
| P478 | volume | 9 |
| Q36352123 | "Untangling" Alzheimer's disease and epilepsy |
| Q37183730 | A novel adhesion molecule in human breast cancer cells: voltage-gated Na+ channel beta1 subunit. |
| Q41582196 | APP mouse models for Alzheimer's disease preclinical studies |
| Q36030499 | Adaptor protein 2-mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing. |
| Q37785311 | Alzheimer's secretases regulate voltage-gated sodium channels |
| Q37529350 | Amyloid precursor protein modulates Nav1.6 sodium channel currents through a Go-coupled JNK pathway |
| Q89971236 | An alternative mechanism of early nodal clustering and myelination onset in GABAergic neurons of the central nervous system |
| Q36049612 | An emerging role for voltage-gated Na+ channels in cellular migration: regulation of central nervous system development and potentiation of invasive cancers |
| Q28087661 | An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels |
| Q36236517 | Analyzing and Modeling the Dysfunction of Inhibitory Neurons in Alzheimer's Disease |
| Q38493207 | Application of a Bioinformatics-Based Approach to Identify Novel Putative in vivo BACE1 Substrates |
| Q39177527 | Arabidopsis B-cell lymphoma2 (Bcl-2)-associated athanogene 7 (BAG7)-mediated heat tolerance requires translocation, sumoylation and binding to WRKY29. |
| Q37905121 | Axon-glial disruption: the link between vascular disease and Alzheimer's disease? |
| Q35142894 | Axonal and Schwann cell BACE1 is equally required for remyelination of peripheral nerves |
| Q47658329 | BACE1 Function and Inhibition: Implications of Intervention in the Amyloid Pathway of Alzheimer's Disease Pathology. |
| Q52720530 | BACE1 Mediates HIV-Associated and Excitotoxic Neuronal Damage Through an APP-Dependent Mechanism. |
| Q93152965 | BACE1 Translation: At the Crossroads Between Alzheimer's Disease Neurodegeneration and Memory Consolidation |
| Q37506870 | BACE1 activity regulates cell surface contactin-2 levels |
| Q36860349 | BACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels |
| Q30495458 | BACE1 deficiency causes altered neuronal activity and neurodegeneration |
| Q36447042 | BACE1 elevation is associated with aberrant limbic axonal sprouting in epileptic CD1 mice |
| Q38332419 | BACE1 inhibitor drugs in clinical trials for Alzheimer's disease |
| Q33740069 | BACE1 is necessary for experience-dependent homeostatic synaptic plasticity in visual cortex |
| Q37309641 | BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampus |
| Q86436522 | BACE1 modulates gating of KCNQ1 (Kv7.1) and cardiac delayed rectifier KCNQ1/KCNE1 (IKs) |
| Q30496432 | BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization |
| Q26765999 | Beta-Amyloid and Tau-Protein: Structure, Interaction, and Prion-Like Properties |
| Q37112626 | CRMP2 protein SUMOylation modulates NaV1.7 channel trafficking |
| Q101574226 | Changes in neuronal excitability and synaptic transmission in nucleus accumbens in a transgenic Alzheimer's disease mouse model |
| Q34012785 | Combinations of SNPs related to signal transduction in bipolar disorder |
| Q39051111 | Consecutive Analysis of BACE1 Function on Developing and Developed Neuronal Cells. |
| Q38026045 | Consequences of inhibiting amyloid precursor protein processing enzymes on synaptic function and plasticity |
| Q48159136 | Consolidation of object recognition memory requires HRI kinase-dependent phosphorylation of eIF2α in the hippocampus |
| Q64247928 | Contribution of voltage-gated sodium channel β-subunits to cervical cancer cells metastatic behavior |
| Q97570180 | Critical analysis of the use of β-site amyloid precursor protein-cleaving enzyme 1 inhibitors in the treatment of Alzheimer's disease |
| Q28081678 | Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways |
| Q90229547 | Differential regulation of ion channels function by proteolysis |
| Q38408049 | Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease |
| Q34094449 | Divalent cation tolerance protein binds to β-secretase and inhibits the processing of amyloid precursor protein |
| Q26796239 | Diverse impact of acute and long-term extracellular proteolytic activity on plasticity of neuronal excitability |
| Q48109704 | Do sodium channel proteolytic fragments regulate sodium channel expression? |
| Q38502153 | Dual roles of voltage-gated sodium channels in development and cancer |
| Q35175125 | Early onset of hypersynchronous network activity and expression of a marker of chronic seizures in the Tg2576 mouse model of Alzheimer's disease |
| Q37719047 | Early-Onset Network Hyperexcitability in Presymptomatic Alzheimer's Disease Transgenic Mice Is Suppressed by Passive Immunization with Anti-Human APP/Aβ Antibody and by mGluR5 Blockade. |
| Q37769877 | Electrophysiology and beyond: multiple roles of Na+ channel β subunits in development and disease |
| Q64901250 | Emerging roles for multifunctional ion channel auxiliary subunits in cancer. |
| Q33635210 | Enhanced red-emitting railroad worm luciferase for bioassays and bioimaging |
| Q91636820 | Exercise-Induced Cognitive Improvement Is Associated with Sodium Channel-Mediated Excitability in APP/PS1 Mice |
| Q92373855 | Exploring the molecular basis of neuronal excitability in a vocal learner |
| Q57165578 | Expression analysis of beta-secretase 1 (BACE1) and its naturally occurring antisense (BACE1-AS) in blood of epileptic patients |
| Q35379630 | Fluorescent nanoparticles for the measurement of ion concentration in biological systems |
| Q36773970 | Focal Scn1a knockdown induces cognitive impairment without seizures |
| Q33862796 | Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects |
| Q37329676 | Functions of the Alzheimer's Disease Protease BACE1 at the Synapse in the Central Nervous System. |
| Q35972878 | Future Therapeutics in Alzheimer's Disease: Development Status of BACE Inhibitors. |
| Q89576661 | Genetic and molecular basis of epilepsy-related cognitive dysfunction |
| Q37633601 | Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease |
| Q92659597 | GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models |
| Q90732192 | Going Too Far Is the Same as Falling Short†: Kinesin-3 Family Members in Hereditary Spastic Paraplegia |
| Q37415435 | High activities of BACE1 in brains with mild cognitive impairment |
| Q37961866 | Identification and biology of β-secretase |
| Q41839372 | Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit |
| Q33521280 | Identification of beta-secretase (BACE1) substrates using quantitative proteomics |
| Q36385951 | Identification of the cysteine residue responsible for disulfide linkage of Na+ channel α and β2 subunits |
| Q36869427 | Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease |
| Q34007475 | Inhibition of BACE1 for therapeutic use in Alzheimer's disease |
| Q50998138 | Intrinsic neuronal excitability: implications for health and disease. |
| Q38851332 | Ion channel regulation by β-secretase BACE1 - enzymatic and non-enzymatic effects beyond Alzheimer's disease. |
| Q37152732 | Ion channels: functional expression and therapeutic potential in cancer. Colloquium on Ion Channels and Cancer |
| Q37781814 | Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions |
| Q34006919 | Knock-in of human BACE1 cleaves murine APP and reiterates Alzheimer-like phenotypes |
| Q36375702 | Linking vascular disorders and Alzheimer's disease: potential involvement of BACE1 |
| Q46121560 | Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes |
| Q35110927 | Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein |
| Q83225902 | Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs isogenic controls |
| Q92669442 | MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties |
| Q35933018 | MicroRNA-9 induces defective trafficking of Nav1.1 and Nav1.2 by targeting Navβ2 protein coding region in rat with chronic brain hypoperfusion |
| Q35235909 | Na Channel β Subunits: Overachievers of the Ion Channel Family |
| Q37960093 | Na+ channelopathies and epilepsy: recent advances and new perspectives. |
| Q37139045 | Nardilysin convertase regulates the function of the maxi-K channel isoform mK44 in human myometrium |
| Q42142611 | Natural Modulators of Amyloid-Beta Precursor Protein Processing. |
| Q52689780 | Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease. |
| Q47147189 | Navβ2 knockdown improves cognition in APP/PS1 mice by partially inhibiting seizures and APP amyloid processing |
| Q38796950 | Network abnormalities and interneuron dysfunction in Alzheimer disease |
| Q96431671 | Neuregulin 1: an intriguing therapeutic target for neurodevelopmental disorders |
| Q37066557 | Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system. |
| Q36804007 | Neurological dysfunctions associated with altered BACE1-dependent Neuregulin-1 signaling |
| Q36053924 | Neuronal β-amyloid generation is independent of lipid raft association of β-secretase BACE1: analysis with a palmitoylation-deficient mutant |
| Q97531640 | Nodes of Ranvier during development and repair in the CNS |
| Q39435580 | Overexpression of the VSSC-associated CAM, β-2, enhances LNCaP cell metastasis associated behavior |
| Q37032450 | Palmitoylation of amyloid precursor protein regulates amyloidogenic processing in lipid rafts |
| Q33575863 | Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2 |
| Q43237740 | Physiological and behavioral effects of amphetamine in BACE1(-/-) mice |
| Q37961473 | Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and presenilin |
| Q37143124 | Plasticity of intrinsic neuronal properties in CNS disorders |
| Q33696172 | Predicting memapsin 2 (β-secretase) hydrolytic activity |
| Q34509439 | Processing of the synaptic cell adhesion molecule neurexin-3beta by Alzheimer disease alpha- and gamma-secretases |
| Q36108414 | Progressive effect of beta amyloid peptides accumulation on CA1 pyramidal neurons: a model study suggesting possible treatments |
| Q34101110 | Protein aggregation diseases: pathogenicity and therapeutic perspectives |
| Q38966192 | Proteinases, Their Extracellular Targets, and Inflammatory Signaling. |
| Q36715710 | Recapitulating amyloid β and tau pathology in human neural cell culture models: clinical implications |
| Q50089415 | Reduced cooperativity of voltage-gated sodium channels in the hippocampal interneurons of an aged mouse model of Alzheimer's disease. |
| Q34624269 | Reduced sodium channel Na(v)1.1 levels in BACE1-null mice |
| Q27675616 | Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor |
| Q47736002 | Scn1b deletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts |
| Q45991966 | Scn2b Deletion in Mice Results in Ventricular and Atrial Arrhythmias. |
| Q24651316 | Scn3b knockout mice exhibit abnormal ventricular electrophysiological properties |
| Q37583653 | Shared cognitive and behavioral impairments in epilepsy and Alzheimer's disease and potential underlying mechanisms |
| Q35883077 | Significance of transcytosis in Alzheimer's disease: BACE1 takes the scenic route to axons |
| Q41841425 | Silencing of amyloid precursor protein expression using a new engineered delta ribozyme |
| Q45927250 | Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer's disease. |
| Q28082122 | Sodium channel β subunits: emerging targets in channelopathies |
| Q24310498 | Sodium channel β1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans |
| Q42976628 | Sodium channel β2 subunit promotes filopodia-like processes and expansion of the dendritic tree in developing rat hippocampal neurons |
| Q38121847 | Soluble amyloid precursor protein 770 is a novel biomarker candidate for acute coronary syndrome |
| Q38059094 | Splice variants of the Alzheimer's disease beta-secretase, BACE1. |
| Q37030825 | Structure-activity relationship of memapsin 2: implications on physiological functions and Alzheimer's disease |
| Q39474750 | Surface trafficking of sodium channels in cells and in hippocampal slices |
| Q34405667 | Targeting the β secretase BACE1 for Alzheimer's disease therapy |
| Q28833244 | Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer's disease-related pathogenesis |
| Q55385303 | Tau-Induced Pathology in Epilepsy and Dementia: Notions from Patients and Animal Models. |
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| Q39755143 | The Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques. |
| Q35717366 | The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb |
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| Q37349066 | The voltage-gated Na+ channel beta3 subunit does not mediate trans homophilic cell adhesion or associate with the cell adhesion molecule contactin |
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