| review article | Q7318358 |
| scholarly article | Q13442814 |
| P2093 | author name string | Ilya Bezprozvanny | |
| Elena Popugaeva | |||
| Polina Egorova | |||
| P2860 | cites work | Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans | Q21092490 |
| Nuclear localization or inclusion body formation of ataxin-2 are not necessary for SCA2 pathogenesis in mouse or human | Q24290184 | ||
| Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations | Q24301868 | ||
| Machado-Joseph disease gene product is a cytoplasmic protein widely expressed in brain | Q24317460 | ||
| Neuronal calcium sensor-1 enhancement of InsP3 receptor activity is inhibited by therapeutic levels of lithium | Q24547141 | ||
| The synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degeneration | Q27000356 | ||
| Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor | Q27675616 | ||
| Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1 | Q28236674 | ||
| Control of peripheral nerve myelination by the beta-secretase BACE1 | Q28264800 | ||
| Ataxin-3 represses transcription via chromatin binding, interaction with histone deacetylase 3, and histone deacetylation | Q28566835 | ||
| Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3 | Q28575230 | ||
| Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein | Q28586098 | ||
| Ataxia and Purkinje cell degeneration in mice lacking the CAMTA1 transcription factor | Q28591066 | ||
| Store-operated calcium channels | Q29617459 | ||
| Therapeutic prospects for spinocerebellar ataxia type 2 and 3. | Q30410969 | ||
| BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. | Q30483997 | ||
| Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice | Q30493115 | ||
| Presenilin-mediated modulation of capacitative calcium entry | Q73133100 | ||
| Spinocerebellar ataxia type 2 in southern Italy: a clinical and molecular study of 30 families | Q78081110 | ||
| Spinocerebellar ataxia type 15 | Q84729510 | ||
| The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease | Q30594530 | ||
| Calcium stores in hippocampal synaptic boutons mediate short-term plasticity, store-operated Ca2+ entry, and spontaneous transmitter release. | Q31965193 | ||
| The molecular biology of Huntington's disease | Q31997579 | ||
| The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity | Q33292521 | ||
| Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice | Q33554241 | ||
| Compensatory regulation of Cav2.1 Ca2+ channels in cerebellar Purkinje neurons lacking parvalbumin and calbindin D-28k | Q33593543 | ||
| Intracellular inclusions, pathological markers in diseases caused by expanded polyglutamine tracts? | Q33607537 | ||
| Dysregulated phosphorylation of Ca(2+) /calmodulin-dependent protein kinase II-α in the hippocampus of subjects with mild cognitive impairment and Alzheimer's disease | Q33615147 | ||
| Sequencing analysis of the ITPR1 gene in a pure autosomal dominant spinocerebellar ataxia series | Q33831290 | ||
| Clinical and molecular advances in autosomal dominant cerebellar ataxias: from genotype to phenotype and physiopathology | Q33860898 | ||
| Pulling complexes out of complex diseases: Spinocerebellar Ataxia 7. | Q33879684 | ||
| Mutagenesis mapping of the presenilin 1 calcium leak conductance pore | Q33885492 | ||
| Progressive age-related impairment of the late long-term potentiation in Alzheimer's disease presenilin-1 mutant knock-in mice | Q33939994 | ||
| Calcineurin links Ca2+ dysregulation with brain aging | Q33947530 | ||
| A store-operated Ca(2+) influx pathway in the bag cell neurons of Aplysia | Q33952324 | ||
| Dantrolene--a review of its pharmacology, therapeutic use and new developments | Q33976686 | ||
| Role of presenilins in neuronal calcium homeostasis | Q34003214 | ||
| 'New' functions for 'old' proteins: the role of the calcium-binding proteins calbindin D-28k, calretinin and parvalbumin, in cerebellar physiology. Studies with knockout mice | Q34216909 | ||
| Computational analysis of calcium signaling and membrane electrophysiology in cerebellar Purkinje neurons associated with ataxia | Q34306449 | ||
| Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2. | Q34405223 | ||
| Targeting the β secretase BACE1 for Alzheimer's disease therapy | Q34405667 | ||
| Caffeine-induced inhibition of inositol(1,4,5)-trisphosphate-gated calcium channels from cerebellum | Q34439930 | ||
| Stabilizing ER Ca2+ channel function as an early preventative strategy for Alzheimer's disease | Q34532864 | ||
| Do thin spines learn to be mushroom spines that remember? | Q34627910 | ||
| Autosomal dominant system degeneration in Portuguese families of the Azores Islands. A new genetic disorder involving cerebellar, pyramidal, extrapyramidal and spinal cord motor functions | Q34704996 | ||
| Role of inositol 1,4,5-trisphosphate receptors in pathogenesis of Huntington's disease and spinocerebellar ataxias | Q34981549 | ||
| Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex | Q35105866 | ||
| SCA15 due to large ITPR1 deletions in a cohort of 333 white families with dominant ataxia | Q35125192 | ||
| Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease | Q35177900 | ||
| Abnormalities in the climbing fiber-Purkinje cell circuitry contribute to neuronal dysfunction in ATXN1[82Q] mice | Q35227534 | ||
| Deranged calcium signaling in Purkinje cells and pathogenesis in spinocerebellar ataxia 2 (SCA2) and other ataxias | Q35670193 | ||
| The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb | Q35717366 | ||
| Orai proteins interact with TRPC channels and confer responsiveness to store depletion. | Q35721728 | ||
| Autosomal dominant cerebellar ataxias: clinical features, genetics, and pathogenesis | Q35751839 | ||
| Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels | Q35879583 | ||
| Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer's disease mice | Q36158722 | ||
| Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease | Q36279483 | ||
| Chronic suppression of inositol 1,4,5-triphosphate receptor-mediated calcium signaling in cerebellar purkinje cells alleviates pathological phenotype in spinocerebellar ataxia 2 mice | Q36315976 | ||
| Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice | Q36327027 | ||
| Human ataxias: a genetic dissection of inositol triphosphate receptor (ITPR1)-dependent signaling | Q36384774 | ||
| β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects | Q36385744 | ||
| Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor. | Q36788552 | ||
| Transient receptor potential channels in Alzheimer's disease. | Q36816373 | ||
| β-Secretase: its biology as a therapeutic target in diseases | Q36951145 | ||
| Spinocerebellar ataxia 2 (SCA2). | Q37140787 | ||
| Familial Alzheimer's disease mutations in presenilins: effects on endoplasmic reticulum calcium homeostasis and correlation with clinical phenotypes | Q37201294 | ||
| BACE1 regulates voltage-gated sodium channels and neuronal activity | Q37355641 | ||
| Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2. | Q37359666 | ||
| The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease | Q37884646 | ||
| Dentatorubral-pallidoluysian atrophy | Q37914437 | ||
| Calcium-dependent regulation of climbing fibre synapse elimination during postnatal cerebellar development | Q38077528 | ||
| Structure-based design of β-site APP cleaving enzyme 1 (BACE1) inhibitors for the treatment of Alzheimer's disease | Q38091104 | ||
| Presenilins and calcium signaling-systems biology to the rescue | Q38120346 | ||
| Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond | Q38257864 | ||
| Safety profile of semagacestat, a gamma-secretase inhibitor: IDENTITY trial findings | Q39166771 | ||
| Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3. | Q40135127 | ||
| The precision of axon targeting of mouse olfactory sensory neurons requires the BACE1 protease | Q40534733 | ||
| Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating. | Q41256595 | ||
| Regulators of calcium homeostasis identified by inference of kinetic model parameters from live single cells perturbed by siRNA. | Q41881898 | ||
| Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice | Q41979914 | ||
| The prevalence and wide clinical spectrum of the spinocerebellar ataxia type 2 trinucleotide repeat in patients with autosomal dominant cerebellar ataxia | Q42037666 | ||
| Functional Annotation of Small Noncoding RNAs Target Genes Provides Evidence for a Deregulated Ubiquitin-Proteasome Pathway in Spinocerebellar Ataxia Type 1 | Q42425932 | ||
| A phase 3 trial of semagacestat for treatment of Alzheimer's disease | Q42710153 | ||
| Ataxin-2 associates with rough endoplasmic reticulum | Q43709275 | ||
| Gating of long-term depression by Ca2+/calmodulin-dependent protein kinase II through enhanced cGMP signalling in cerebellar Purkinje cells. | Q44136854 | ||
| Deviant ryanodine receptor-mediated calcium release resets synaptic homeostasis in presymptomatic 3xTg-AD mice. | Q45916530 | ||
| Total deletion and a missense mutation of ITPR1 in Japanese SCA15 families | Q46519046 | ||
| Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice | Q46574998 | ||
| A role for the protein phosphatase 2B in altered hippocampal synaptic plasticity in the aged rat. | Q46916235 | ||
| Pharmacological inhibition of BACE1 impairs synaptic plasticity and cognitive functions | Q47685980 | ||
| Alterations in the ryanodine receptor calcium release channel correlate with Alzheimer's disease neurofibrillary and beta-amyloid pathologies | Q48161187 | ||
| A new humanized ataxin-3 knock-in mouse model combines the genetic features, pathogenesis of neurons and glia and late disease onset of SCA3/MJD. | Q48491103 | ||
| Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice. | Q48546084 | ||
| Autosomal dominant cerebellar ataxia type I clinical features and MRI in families with SCA1, SCA2 and SCA3. | Q48898409 | ||
| Calcium, membranes, aging, and Alzheimer's disease. Introduction and overview. | Q53188131 | ||
| Bace1 modulates myelination in the central and peripheral nervous system. | Q53588736 | ||
| The type 1 inositol 1,4,5-trisphosphate receptor gene is altered in the opisthotonos mouse | Q71954986 | ||
| P921 | main subject | Alzheimer's disease | Q11081 |
| P304 | page(s) | 127-133 | |
| P577 | publication date | 2015-04-04 | |
| P1433 | published in | Seminars in Cell & Developmental Biology | Q14330411 |
| P1476 | title | Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease | |
| P478 | volume | 40 |
| Q33608642 | Analyzing the genes related to Alzheimer's disease via a network and pathway-based approach |
| Q39336233 | Calcium signaling, PKC gamma, IP3R1 and CAR8 link spinocerebellar ataxias and Purkinje cell dendritic development. |
| Q48713195 | Circulating microRNAs in Neurodegenerative Diseases. |
| Q39195180 | Dynamic Nature of presenilin1/γ-Secretase: Implication for Alzheimer's Disease Pathogenesis. |
| Q39456024 | Huntington's Disease: Calcium Dyshomeostasis and Pathology Models |
| Q89017844 | In Vivo Analysis of the Climbing Fiber-Purkinje Cell Circuit in SCA2-58Q Transgenic Mouse Model |
| Q37042016 | In vivo analysis of cerebellar Purkinje cell activity in SCA2 transgenic mouse model |
| Q49666213 | Inositol 1,4,5-trisphosphate receptors and neurodegenerative disorders |
| Q26765782 | Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer's Disease |
| Q28076174 | Motor Dysfunctions and Neuropathology in Mouse Models of Spinocerebellar Ataxia Type 2: A Comprehensive Review |
| Q36222731 | Mouse polyQ database: a new online resource for research using mouse models of neurodegenerative diseases. |
| Q40410650 | Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's Disease |
| Q47593443 | P2X receptor overexpression induced by soluble oligomers of amyloid beta peptide potentiates synaptic failure and neuronal dyshomeostasis in cellular models of Alzheimer's disease. |
| Q37503765 | Regulation of Store-Operated Ca2+ Entry by Septins. |
| Q27314944 | Store-independent modulation of Ca(2+) entry through Orai by Septin 7. |
| Q52722816 | The role of septin 7 in physiology and pathological disease: A systematic review of current status. |
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