In Vivo Analysis of the Climbing Fiber-Purkinje Cell Circuit in SCA2-58Q Transgenic Mouse Model

scientific article published on 01 October 2018

In Vivo Analysis of the Climbing Fiber-Purkinje Cell Circuit in SCA2-58Q Transgenic Mouse Model is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S12311-018-0951-4
P932PMC publication ID6281806
P698PubMed publication ID29876801

P50authorIlya B BezprozvannyQ89017842
P2093author name stringPolina A Egorova
Alexandra V Gavrilova
P2860cites workNuclear localization or inclusion body formation of ataxin-2 are not necessary for SCA2 pathogenesis in mouse or humanQ24290184
The excitatory synaptic action of climbing fibres on the Purkinje cells of the cerebellumQ24540328
Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxiaQ28586378
The therapeutic mode of action of 4-aminopyridine in cerebellar ataxiaQ30495678
Disruption of the olivo-cerebellar circuit by Purkinje neuron-specific ablation of BK channelsQ33982019
Modulation of Purkinje cell complex spike waveform by synchrony levels in the olivocerebellar systemQ34426274
Ionic currents underlying spontaneous action potentials in isolated cerebellar Purkinje neurons.Q34502373
Early changes in cerebellar physiology accompany motor dysfunction in the polyglutamine disease spinocerebellar ataxia type 3Q35205602
Abnormalities in the climbing fiber-Purkinje cell circuitry contribute to neuronal dysfunction in ATXN1[82Q] miceQ35227534
Chronic suppression of inositol 1,4,5-triphosphate receptor-mediated calcium signaling in cerebellar purkinje cells alleviates pathological phenotype in spinocerebellar ataxia 2 miceQ36315976
Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2Q36354944
Changes in Purkinje cell firing and gene expression precede behavioral pathology in a mouse model of SCA2Q36477656
Effects of climbing fiber driven inhibition on Purkinje neuron spikingQ36495681
In vivo analysis of cerebellar Purkinje cell activity in SCA2 transgenic mouse modelQ37042016
Spinocerebellar ataxia 2 (SCA2).Q37140787
The dynamic relationship between cerebellar Purkinje cell simple spikes and the spikelet number of complex spikesQ37545066
Consensus paper: pathological mechanisms underlying neurodegeneration in spinocerebellar ataxiasQ37619548
Spatiotemporal firing patterns in the cerebellum.Q37872197
Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's diseaseQ38408049
Climbing fibers in spinocerebellar ataxia: A mechanism for the loss of motor controlQ38705074
Climbing Fiber Regulation of Spontaneous Purkinje Cell Activity and Cerebellum-Dependent Blink Responses(1,2,3).Q40028806
The Modifiable Neuronal Network of the CerebellumQ40080645
Neuronal Atrophy Early in Degenerative Ataxia Is a Compensatory Mechanism to Regulate Membrane Excitability.Q41486765
Mechanisms of Spontaneous Climbing Fiber Discharge-Evoked Pauses and Output Modulation of Cerebellar Purkinje Cell in MiceQ41526935
Spinocerebellar ataxia type 6 protein aggregates cause deficits in motor learning and cerebellar plasticity.Q41679065
Activity patterns of cerebellar cortical neurones and climbing fibre afferents in the awake catQ41691504
The origin of the complex spike in cerebellar Purkinje cellsQ41824973
The prevalence and wide clinical spectrum of the spinocerebellar ataxia type 2 trinucleotide repeat in patients with autosomal dominant cerebellar ataxiaQ42037666
Climbing fiber input shapes reciprocity of Purkinje cell firing.Q44670248
Harmaline attenuates voltage--sensitive Ca(2+) currents in neurons of the inferior olive.Q45028152
Effect of harmaline on firing pattern of rat cerebellar Purkinje cells in ontogenesisQ46645483
The secondary spikes of climbing fibre responses recorded from Purkinje cell somata in cat cerebellumQ48312298
Cerebellar ataxia by enhanced Ca(V)2.1 currents is alleviated by Ca2+-dependent K+-channel activators in Cacna1a(S218L) mutant mice.Q48312857
Effects of electrical stimulation and reversible lesions of the olivocerebellar pathway on Purkinje cell activity in the flocculus of the cat.Q48444392
The olivo-cerebellar system: Functional properties as revealed by harmaline-induced tremorQ48636937
Inferior olive and oculomotor systemQ48733103
Autosomal dominant cerebellar ataxia type I clinical features and MRI in families with SCA1, SCA2 and SCA3.Q48898409
Increased noise level of purkinje cell activities minimizes impact of their modulation during sensorimotor control.Q48950773
Inositol 1,4,5-trisphosphate receptors and neurodegenerative disordersQ49666213
Spontaneous and harmaline-stimulated Purkinje cell activity in rats with a genetic movement disorderQ67934547
P433issue5
P921main subjectPurkinje cellQ1570272
P304page(s)590-600
P577publication date2018-10-01
P1433published inThe CerebellumQ7721969
P1476titleIn Vivo Analysis of the Climbing Fiber-Purkinje Cell Circuit in SCA2-58Q Transgenic Mouse Model
P478volume17

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cites work (P2860)
Q92131811Ataxic Symptoms in Huntington's Disease Transgenic Mouse Model Are Alleviated by Chlorzoxazone
Q92000696Cerebellar Development and Circuit Maturation: A Common Framework for Spinocerebellar Ataxias

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