| scholarly article | Q13442814 |
| review article | Q7318358 |
| P356 | DOI | 10.1111/FEBS.14366 |
| P698 | PubMed publication ID | 29253316 |
| P2093 | author name string | Ilya B Bezprozvanny | |
| Polina A Egorova | |||
| P2860 | cites work | Carboxyl-terminal sequences critical for inositol 1,4,5-trisphosphate receptor subunit assembly | Q44177977 |
| Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability. | Q44728737 | ||
| Aβ and NMDAR activation cause mitochondrial dysfunction involving ER calcium release | Q45850701 | ||
| Total deletion and a missense mutation of ITPR1 in Japanese SCA15 families | Q46519046 | ||
| Endogenous signalling pathways and caged IP3 evoke Ca2+ puffs at the same abundant immobile intracellular sites. | Q47097739 | ||
| A novel gain-of-function mutation in the ITPR1 suppressor domain causes spinocerebellar ataxia with altered Ca2+ signal patterns. | Q48269069 | ||
| Sporadic infantile-onset spinocerebellar ataxia caused by missense mutations of the inositol 1,4,5-triphosphate receptor type 1 gene | Q48270136 | ||
| Revisiting channel allostery: a coherent mechanism in IP₃ and ryanodine receptors | Q48496001 | ||
| The attribution of human infections with antimicrobial resistant Salmonella bacteria in Denmark to sources of animal origin | Q50068407 | ||
| Mutations in the IRBIT domain of ITPR1 are a frequent cause of autosomal dominant nonprogressive congenital ataxia. | Q50521784 | ||
| Aβ42 oligomers selectively disrupt neuronal calcium release. | Q50767005 | ||
| Highly Sensitive Measurement of Inositol 1,4,5-Trisphosphate by Using a New Fluorescent Ligand and Ligand Binding Domain Combination. | Q51725336 | ||
| Differential deregulation of astrocytic calcium signalling by amyloid-β, TNFα, IL-1β and LPS. | Q53462673 | ||
| Apoptosis induced by Aβ25-35 peptide is Ca(2+) -IP3 signaling-dependent in murine astrocytes. | Q53464414 | ||
| Calcium - a life and death signal | Q56836038 | ||
| Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans | Q21092490 | ||
| Huntingtin interacting proteins are genetic modifiers of neurodegeneration | Q21145230 | ||
| Nuclear localization or inclusion body formation of ataxin-2 are not necessary for SCA2 pathogenesis in mouse or human | Q24290184 | ||
| Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations | Q24301868 | ||
| Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1 | Q24302464 | ||
| Molecular cloning of a cDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant | Q24304421 | ||
| Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1 | Q24310249 | ||
| Machado-Joseph disease gene product is a cytoplasmic protein widely expressed in brain | Q24317460 | ||
| Neuronal calcium sensor-1 enhancement of InsP3 receptor activity is inhibited by therapeutic levels of lithium | Q24547141 | ||
| ATP-dependent adenophostin activation of inositol 1,4,5-trisphosphate receptor channel gating: kinetic implications for the durations of calcium puffs in cells | Q24644630 | ||
| Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model | Q24647950 | ||
| Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand | Q27639992 | ||
| Apo and InsP3-bound crystal structures of the ligand-binding domain of an InsP3 receptor | Q27673043 | ||
| Structural and functional conservation of key domains in InsP3 and ryanodine receptors | Q27676937 | ||
| The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics | Q27860914 | ||
| The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage | Q28115007 | ||
| Huntington's disease | Q28284355 | ||
| Ataxin-3 represses transcription via chromatin binding, interaction with histone deacetylase 3, and histone deacetylation | Q28566835 | ||
| Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3 | Q28575230 | ||
| HAP1 facilitates effects of mutant huntingtin on inositol 1,4,5-trisphosphate-induced Ca release in primary culture of striatal medium spiny neurons | Q28592352 | ||
| Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective | Q29614702 | ||
| Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues | Q30989369 | ||
| The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity | Q33292521 | ||
| Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis. | Q33605796 | ||
| Sequencing analysis of the ITPR1 gene in a pure autosomal dominant spinocerebellar ataxia series | Q33831290 | ||
| Expression of inositol trisphosphate receptors. | Q33834374 | ||
| Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease. | Q33850154 | ||
| Clinical and molecular advances in autosomal dominant cerebellar ataxias: from genotype to phenotype and physiopathology | Q33860898 | ||
| Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons | Q33966472 | ||
| Inositol trisphosphate receptor Ca2+ release channels. | Q33983069 | ||
| Toward a high-resolution structure of IP₃R channel | Q34173862 | ||
| Functional characterization of the type 1 inositol 1,4,5-trisphosphate receptor coupling domain SII(+/-) splice variants and the Opisthotonos mutant form | Q34177631 | ||
| Functional and biochemical analysis of the type 1 inositol (1,4,5)-trisphosphate receptor calcium sensor | Q34181907 | ||
| Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptors | Q34281322 | ||
| Computational analysis of calcium signaling and membrane electrophysiology in cerebellar Purkinje neurons associated with ataxia | Q34306449 | ||
| Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2. | Q34405223 | ||
| Caffeine-induced inhibition of inositol(1,4,5)-trisphosphate-gated calcium channels from cerebellum | Q34439930 | ||
| IP3 receptor/Ca2+ channel: from discovery to new signaling concepts | Q34662801 | ||
| Autosomal dominant system degeneration in Portuguese families of the Azores Islands. A new genetic disorder involving cerebellar, pyramidal, extrapyramidal and spinal cord motor functions | Q34704996 | ||
| Molecular characterization of the inositol 1,4,5-trisphosphate receptor pore-forming segment | Q34715202 | ||
| Role of inositol 1,4,5-trisphosphate receptors in pathogenesis of Huntington's disease and spinocerebellar ataxias | Q34981549 | ||
| Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia | Q34990974 | ||
| Direct association of ligand-binding and pore domains in homo- and heterotetrameric inositol 1,4,5-trisphosphate receptors | Q35116636 | ||
| SCA15 due to large ITPR1 deletions in a cohort of 333 white families with dominant ataxia | Q35125192 | ||
| Inositol 1,4,5-trisphosphate receptor localized to endoplasmic reticulum in cerebellar Purkinje neurons | Q35453195 | ||
| Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400. | Q35534135 | ||
| A Point Mutation in the Ubiquitin Ligase RNF170 That Causes Autosomal Dominant Sensory Ataxia Destabilizes the Protein and Impairs Inositol 1,4,5-Trisphosphate Receptor-mediated Ca2+ Signaling | Q35662322 | ||
| Deranged calcium signaling in Purkinje cells and pathogenesis in spinocerebellar ataxia 2 (SCA2) and other ataxias | Q35670193 | ||
| Autosomal dominant cerebellar ataxias: clinical features, genetics, and pathogenesis | Q35751839 | ||
| Analyzing and Quantifying the Gain-of-Function Enhancement of IP3 Receptor Gating by Familial Alzheimer's Disease-Causing Mutants in Presenilins. | Q35800316 | ||
| Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs | Q35906130 | ||
| Bcl-2 family in inter-organelle modulation of calcium signaling; roles in bioenergetics and cell survival | Q35928205 | ||
| The inositol 1,4,5-trisphosphate receptors | Q36231356 | ||
| Chronic suppression of inositol 1,4,5-triphosphate receptor-mediated calcium signaling in cerebellar purkinje cells alleviates pathological phenotype in spinocerebellar ataxia 2 mice | Q36315976 | ||
| Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate. | Q36322335 | ||
| Human ataxias: a genetic dissection of inositol triphosphate receptor (ITPR1)-dependent signaling | Q36384774 | ||
| ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT. | Q36411728 | ||
| Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse Model. | Q36431970 | ||
| Identification of functionally critical residues in the channel domain of inositol trisphosphate receptors | Q36481838 | ||
| Gating machinery of InsP3R channels revealed by electron cryomicroscopy | Q36721050 | ||
| Biphasic regulation of InsP3 receptor gating by dual Ca2+ release channel BH3-like domains mediates Bcl-xL control of cell viability | Q36770769 | ||
| Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor. | Q36788552 | ||
| CaBP1, a neuronal Ca2+ sensor protein, inhibits inositol trisphosphate receptors by clamping intersubunit interactions. | Q36884135 | ||
| Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease | Q36934762 | ||
| In vivo analysis of cerebellar Purkinje cell activity in SCA2 transgenic mouse model | Q37042016 | ||
| Aggregation of expanded huntingtin in the brains of patients with Huntington disease. | Q37079417 | ||
| Spinocerebellar ataxia 2 (SCA2). | Q37140787 | ||
| Alzheimer's disease-associated peptide Aβ42 mobilizes ER Ca(2+) via InsP3R-dependent and -independent mechanisms. | Q37280639 | ||
| Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2. | Q37359666 | ||
| Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation. | Q37365504 | ||
| Impaired mitochondrial function due to familial Alzheimer's disease-causing presenilins mutants via Ca(2+) disruptions | Q37383808 | ||
| Bcl-2 family on guard at the ER. | Q37412841 | ||
| The role of intracellular calcium stores in synaptic plasticity and memory consolidation | Q38103722 | ||
| IRBIT: a regulator of ion channels and ion transporters. | Q38187237 | ||
| Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease | Q38408049 | ||
| IP3 receptor mutations and brain diseases in human and rodents. | Q39140608 | ||
| Calcium signaling, PKC gamma, IP3R1 and CAR8 link spinocerebellar ataxias and Purkinje cell dendritic development. | Q39336233 | ||
| An ITPR1 gene deletion causes spinocerebellar ataxia 15/16: a genetic, clinical and radiological description | Q39673940 | ||
| Biochemical and Immunological Studies on the P<sub>400</sub> Protein, a Protein Characteristic of the Purkinje Cell from Mouse and Rat Cerebellum | Q39718189 | ||
| Putative receptor for inositol 1,4,5-trisphosphate similar to ryanodine receptor | Q39755978 | ||
| The gain-of-function enhancement of IP3-receptor channel gating by familial Alzheimer's disease-linked presenilin mutants increases the open probability of mitochondrial permeability transition pore | Q39762857 | ||
| Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3. | Q40135127 | ||
| Intracellular channels | Q40392897 | ||
| Three-dimensional Rearrangements within Inositol 1,4,5-Trisphosphate Receptor by Calcium | Q40620855 | ||
| Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating. | Q41256595 | ||
| Heterotetrameric complex formation of inositol 1,4,5-trisphosphate receptor subunits | Q41334433 | ||
| Recessive and Dominant De Novo ITPR1 Mutations Cause Gillespie Syndrome | Q41368463 | ||
| Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes | Q41609588 | ||
| Amyloid-β and Alzheimer's disease type pathology differentially affects the calcium signalling toolkit in astrocytes from different brain regions | Q41880646 | ||
| Regulators of calcium homeostasis identified by inference of kinetic model parameters from live single cells perturbed by siRNA. | Q41881898 | ||
| Nuclear ALG-2 protein interacts with Ca2+ homeostasis endoplasmic reticulum protein (CHERP) Ca2+-dependently and participates in regulation of alternative splicing of inositol trisphosphate receptor type 1 (IP3R1) pre-mRNA. | Q42135943 | ||
| Identification of novel and hotspot mutations in the channel domain of ITPR1 in two patients with Gillespie syndrome. | Q42361619 | ||
| Analysis of calcium homeostasis in fresh lymphocytes from patients with sporadic Alzheimer's disease or mild cognitive impairment | Q42519895 | ||
| Mechanism of ER stress-induced brain damage by IP(3) receptor | Q42781656 | ||
| IP3-mediated gating mechanism of the IP3 receptor revealed by mutagenesis and X-ray crystallography | Q43083585 | ||
| Type 1 inositol trisphosphate receptor regulates cerebellar circuits by maintaining the spine morphology of purkinje cells in adult mice | Q43506578 | ||
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | neurodegeneration | Q1755122 |
| P577 | publication date | 2017-12-18 | |
| P1433 | published in | FEBS Journal | Q1388041 |
| P1476 | title | Inositol 1,4,5-trisphosphate receptors and neurodegenerative disorders |
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