Abnormalities in the climbing fiber-Purkinje cell circuitry contribute to neuronal dysfunction in ATXN1[82Q] mice

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Abnormalities in the climbing fiber-Purkinje cell circuitry contribute to neuronal dysfunction in ATXN1[82Q] mice is …
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scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.2579-11.2011
P932PMC publication ID3178465
P698PubMed publication ID21900557

P50authorHarry T. OrrQ47823272
P2093author name stringGang Chen
Timothy J Ebner
Lisa A Duvick
Wangcai Gao
Blake A Ebner
Justin A Barnes
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Effects of insulin-like growth factor I on climbing fibre synapse elimination during cerebellar developmentQ48390262
The anatomy of the cerebellumQ48396422
Cerebellar cortical molecular layer inhibition is organized in parasagittal zones.Q48450767
Purkinje cell expression of a mutant allele of SCA1 in transgenic mice leads to disparate effects on motor behaviors, followed by a progressive cerebellar dysfunction and histological alterations.Q48628376
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Topography and nociceptive receptive fields of climbing fibres projecting to the cerebellar anterior lobe in the catQ48663020
Neurological Deficit in Cats With Lesions of the Olivocerebellar SystemQ48849350
Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar Purkinje cellsQ48969810
Parallel fibre stimulation and the responses induced thereby in the Purkinje cells of the cerebellumQ51242484
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The spinocerebellar ataxia type 1 protein, ataxin-1, has RNA-binding activity that is inversely affected by the length of its polyglutamine tractQ24290683
Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1Q24310249
RORalpha-mediated Purkinje cell development determines disease severity in adult SCA1 miceQ24316105
RNA association and nucleocytoplasmic shuttling by ataxin-1Q24329112
The excitatory synaptic action of climbing fibres on the Purkinje cells of the cerebellumQ24540328
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Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1Q28272543
Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factorsQ28472246
The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7Q28505609
Mice lacking ataxin-1 display learning deficits and decreased hippocampal paired-pulse facilitationQ28511494
P/Q-type Ca2+ channel alpha1A regulates synaptic competition on developing cerebellar Purkinje cellsQ28513023
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3Q28575230
Bidirectional alterations in cerebellar synaptic transmission of tottering and rolling Ca2+ channel mutant miceQ28589656
Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunitQ28592875
Trinucleotide Repeat DisordersQ29038716
SCA1-like disease in mice expressing wild-type ataxin-1 with a serine to aspartic acid replacement at residue 776.Q30496777
Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1.Q33887926
In vivo two-photon calcium imaging of neuronal networksQ34201683
Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brainQ34244887
Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1.Q34353488
Organization and remodeling of the olivocerebellar climbing fiber projectionQ36417573
Flavoprotein autofluorescence imaging in the cerebellar cortex in vivoQ36829860
Low-frequency oscillations in the cerebellar cortex of the tottering mouseQ37086565
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2.Q37359666
Long-term potentiation of the responses to parallel fiber stimulation in mouse cerebellar cortex in vivoQ37387251
Functional relations of cerebellar modules of the catQ37397916
A reevaluation of the role of mitochondria in neuronal Ca2+ homeostasisQ39416351
Calcium dynamics and electrophysiological properties of cerebellar Purkinje cells in SCA1 transgenic miceQ43565393
Harmaline-induced rhythmic activity of cerebellar and lower brain stem neuronsQ43602920
The entire trajectories of single olivocerebellar axons in the cerebellar cortex and their contribution to Cerebellar compartmentalization.Q43744870
Gene profiling links SCA1 pathophysiology to glutamate signaling in Purkinje cells of transgenic miceQ45022856
Molecular, topographic, and functional organization of the cerebellar cortex: a study with combined aldolase C and olivocerebellar labeling.Q45094898
In vivo calcium imaging of circuit activity in cerebellar cortexQ46633521
ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathologyQ47072817
P433issue36
P407language of work or nameEnglishQ1860
P921main subjectPurkinje cellQ1570272
P304page(s)12778-12789
P577publication date2011-09-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleAbnormalities in the climbing fiber-Purkinje cell circuitry contribute to neuronal dysfunction in ATXN1[82Q] mice
P478volume31

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