| scholarly article | Q13442814 |
| P50 | author | Thomas C. Südhof | Q97270 |
| P2093 | author name string | Qiming Li | |
| P2860 | cites work | Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE | Q22010705 |
| Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity | Q22010912 | ||
| Purification and cloning of amyloid precursor protein beta-secretase from human brain | Q22010914 | ||
| Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis | Q24290159 | ||
| The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus | Q24292016 | ||
| A secreted form of human ADAM9 has an alpha-secretase activity for APP | Q24299257 | ||
| The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein | Q24315811 | ||
| MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains | Q24316013 | ||
| Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor | Q24317632 | ||
| Molecular cloning of the cDNA for a human amyloid precursor protein homolog: evidence for a multigene family | Q24328904 | ||
| Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein | Q24336515 | ||
| Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin | Q24337780 | ||
| Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications | Q24561689 | ||
| Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein | Q24650599 | ||
| Phosphorylation regulates intracellular trafficking of beta-secretase | Q40816653 | ||
| A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor | Q40890347 | ||
| Expression of the chondroitin sulfate proteoglycans of amyloid precursor (appican) and amyloid precursor-like protein 2. | Q41319306 | ||
| Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's beta-secretase | Q41875693 | ||
| Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. | Q42495065 | ||
| The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture | Q43735231 | ||
| Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1). | Q44243372 | ||
| Effects of PS1 deficiency on membrane protein trafficking in neurons | Q48327056 | ||
| APP gene family. Alternative splicing generates functionally related isoforms | Q49162225 | ||
| Studies on the metabolism and biological function of APLP2 | Q71064813 | ||
| Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 | Q25938983 | ||
| Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa | Q27861105 | ||
| It all sticks together--the APP-related family of proteins and Alzheimer's disease | Q28138947 | ||
| Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription | Q28201680 | ||
| BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics | Q28201876 | ||
| A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60 | Q28205099 | ||
| A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid | Q28207898 | ||
| gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins | Q28207962 | ||
| Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein | Q28216526 | ||
| Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms | Q28219134 | ||
| SynCAM, a synaptic adhesion molecule that drives synapse assembly | Q28219424 | ||
| The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system | Q28299173 | ||
| Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch | Q28346677 | ||
| The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner | Q28510317 | ||
| Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor | Q28588379 | ||
| Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase | Q29042710 | ||
| The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor | Q29618322 | ||
| The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease | Q30432239 | ||
| Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains | Q30728721 | ||
| Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases | Q31032457 | ||
| Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production | Q31816667 | ||
| BACE1 is the major beta-secretase for generation of Abeta peptides by neurons | Q32063781 | ||
| The presenilins in Alzheimer's disease--proteolysis holds the key. | Q33763282 | ||
| A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. | Q34049859 | ||
| The Role of presenilins in gamma-secretase activity | Q34116345 | ||
| Notch and presenilin: a proteolytic mechanism emerges | Q34360633 | ||
| Nuclear signaling: a common function of presenilin substrates? | Q34509780 | ||
| Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice. | Q35846021 | ||
| Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease | Q36415791 | ||
| Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity | Q36415795 | ||
| The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein | Q36788339 | ||
| The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1. | Q40631641 | ||
| P433 | issue | 11 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 10542-50 | |
| P577 | publication date | 2004-03-12 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1 | |
| P478 | volume | 279 |
| Q34469761 | A peptide binding to the β-site of APP improves spatial memory and attenuates Aβ burden in Alzheimer's disease transgenic mice |
| Q36674481 | A two decade contribution of molecular cell biology to the centennial of Alzheimer's disease: are we progressing toward therapy? |
| Q40234658 | APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission. |
| Q36393290 | APLP1 as a cerebrospinal fluid biomarker for γ-secretase modulator treatment |
| Q48138450 | APLP1 is endoproteolytically cleaved by γ-secretase without previous ectodomain shedding |
| Q50597609 | APLP1 promotes dFoxO-dependent cell death in Drosophila. |
| Q33617218 | Alteration of Aβ metabolism-related molecules in predementia induced by AlCl3 and D-galactose |
| Q38749991 | Alternative Processing of the Amyloid Precursor Protein Family by Rhomboid Protease RHBDL4. |
| Q28504667 | Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts |
| Q26829267 | Alzheimer's therapeutics: translation of preclinical science to clinical drug development |
| Q48954585 | Amyloid precursor-like protein 1 (APLP1) exhibits stronger zinc-dependent neuronal adhesion than amyloid precursor protein and APLP2. |
| Q40340767 | Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein |
| Q53550119 | Amyloid-beta precursor-like protein APLP1 is a novel p53 transcriptional target gene that augments neuroblastoma cell death upon genotoxic stress. |
| Q35809939 | An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1. |
| Q35084401 | An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease |
| Q35822309 | An antibody to the beta-secretase cleavage site on amyloid-beta-protein precursor inhibits amyloid-beta production. |
| Q55041213 | Analyzing the Behavior of Neuronal Pathways in Alzheimer's Disease Using Petri Net Modeling Approach. |
| Q38493207 | Application of a Bioinformatics-Based Approach to Identify Novel Putative in vivo BACE1 Substrates |
| Q28658612 | Asynchronous evolutionary origins of Aβ and BACE1 |
| Q37598601 | BACE and gamma-secretase characterization and their sorting as therapeutic targets to reduce amyloidogenesis |
| Q38120669 | BACE1 as a therapeutic target in Alzheimer's disease: rationale and current status |
| Q30495458 | BACE1 deficiency causes altered neuronal activity and neurodegeneration |
| Q39705874 | BACE1 gene promoter single-nucleotide polymorphisms in Alzheimer's disease |
| Q33740069 | BACE1 is necessary for experience-dependent homeostatic synaptic plasticity in visual cortex |
| Q37309641 | BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampus |
| Q30483997 | BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. |
| Q30496432 | BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization |
| Q37352319 | BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate. |
| Q24315799 | BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2 |
| Q53588736 | Bace1 modulates myelination in the central and peripheral nervous system. |
| Q24323262 | Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin |
| Q46980143 | Beta-galactoside alpha2,6-sialyltransferase I cleavage by BACE1 enhances the sialylation of soluble glycoproteins. A novel regulatory mechanism for alpha2,6-sialylation |
| Q34066765 | Beta-secretase: structure, function, and evolution |
| Q48217048 | Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis |
| Q35361462 | Calpain dysregulation in Alzheimer's disease |
| Q37416750 | Cell biology, regulation and inhibition of beta-secretase (BACE-1). |
| Q53397736 | Click chemistry-mediated biotinylation reveals a function for the protease BACE1 in modulating the neuronal surface glycoproteome. |
| Q41762167 | Complex translational regulation of BACE1 involves upstream AUGs and stimulatory elements within the 5' untranslated region |
| Q39051111 | Consecutive Analysis of BACE1 Function on Developing and Developed Neuronal Cells. |
| Q28504488 | Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members |
| Q97570180 | Critical analysis of the use of β-site amyloid precursor protein-cleaving enzyme 1 inhibitors in the treatment of Alzheimer's disease |
| Q36401406 | Current concepts in therapeutic strategies targeting cognitive decline and disease modification in Alzheimer's disease |
| Q34113857 | Cyclin-dependent kinase 5, a node protein in diminished tauopathy: a systems biology approach. |
| Q33939218 | Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase |
| Q35940403 | Development of a specific ELISA to measure BACE1 levels in human tissues |
| Q40504171 | Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme |
| Q47665585 | Direct evidence of amyloid precursor-like protein 1 trans interactions in cell-cell adhesion platforms investigated via fluorescence fluctuation spectroscopy |
| Q47880848 | Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation |
| Q38408049 | Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease |
| Q58785711 | Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer's Disease |
| Q48797327 | Effects of aluminium on β-amyloid (1-42) and secretases (APP-cleaving enzymes) in rat brain |
| Q41210086 | Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory |
| Q46818675 | Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis. |
| Q33635210 | Enhanced red-emitting railroad worm luciferase for bioassays and bioimaging |
| Q33307832 | Extracting unrecognized gene relationships from the biomedical literature via matrix factorizations |
| Q28573687 | FE65 as a link between VLDLR and APP to regulate their trafficking and processing |
| Q28486102 | Ferulic acid is a nutraceutical β-secretase modulator that improves behavioral impairment and alzheimer-like pathology in transgenic mice |
| Q37329676 | Functions of the Alzheimer's Disease Protease BACE1 at the Synapse in the Central Nervous System. |
| Q34947624 | Gadd153 and NF-κB crosstalk regulates 27-hydroxycholesterol-induced increase in BACE1 and β-amyloid production in human neuroblastoma SH-SY5Y cells |
| Q38431696 | Global gene expression profiling and senescence biomarker analysis of hESC exposed to H2O2 induced non-cytotoxic oxidative stress. |
| Q40537045 | Human BACE forms dimers and colocalizes with APP. |
| Q35214758 | Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression |
| Q40170952 | IGF-1-induced processing of the amyloid precursor protein family is mediated by different signaling pathways |
| Q37961866 | Identification and biology of β-secretase |
| Q33521280 | Identification of beta-secretase (BACE1) substrates using quantitative proteomics |
| Q36904004 | Identification of brain-enriched proteins in the cerebrospinal fluid proteome by LC-MS/MS profiling and mining of the Human Protein Atlas |
| Q28388232 | Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese-exposed non-human primates |
| Q30530899 | Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes |
| Q40286287 | Intracellular domains of amyloid precursor-like protein 2 interact with CP2 transcription factor in the nucleus and induce glycogen synthase kinase-3beta expression |
| Q38633186 | Involvement of Insulin Signaling Disturbances in Bisphenol A-Induced Alzheimer's Disease-like Neurotoxicity |
| Q37781814 | Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions |
| Q36939128 | Is the amyloid hypothesis of Alzheimer's disease therapeutically relevant? |
| Q42492935 | Keratinocytes from APP/APLP2-deficient mice are impaired in proliferation, adhesion and migration in vitro |
| Q36133947 | Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo |
| Q48141439 | Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains |
| Q42091639 | Leaky scanning and reinitiation regulate BACE1 gene expression |
| Q36375702 | Linking vascular disorders and Alzheimer's disease: potential involvement of BACE1 |
| Q96640603 | Matriptase processing of APLP1 ectodomain alters its homodimerization |
| Q36870561 | Mechanisms of disease: new therapeutic strategies for Alzheimer's disease--targeting APP processing in lipid rafts |
| Q24338963 | Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signalling |
| Q37715176 | Membrane rafts in Alzheimer's disease beta-amyloid production |
| Q38123911 | Metabolism of amyloid β peptide and pathogenesis of Alzheimer's disease |
| Q34430920 | Methylene blue modulates β-secretase, reverses cerebral amyloidosis, and improves cognition in transgenic mice |
| Q37596385 | MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of Alzheimer disease subjects |
| Q35898639 | Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation |
| Q41913198 | Novel zinc-binding site in the E2 domain regulates amyloid precursor-like protein 1 (APLP1) oligomerization. |
| Q24292718 | PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein |
| Q34575001 | PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2. |
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| Q47593479 | Perspectives of Alzheimer's disease treatments |
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| Q27001550 | Platelets and Alzheimer's disease: Potential of APP as a biomarker |
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| Q33696172 | Predicting memapsin 2 (β-secretase) hydrolytic activity |
| Q36300032 | Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease |
| Q34110227 | Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process |
| Q34101110 | Protein aggregation diseases: pathogenicity and therapeutic perspectives |
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| Q38109402 | Redundancy and divergence in the amyloid precursor protein family |
| Q42241167 | Regulation of amyloid-β production by the prion protein |
| Q50693394 | Regulation of heparan sulfate 6-O-sulfation by beta-secretase activity. |
| Q36350742 | Relevance of amyloid precursor-like protein 2 C-terminal fragments in pancreatic cancer cells |
| Q38154621 | Research status of the regulation of miRNA on BACE1. |
| Q36740945 | Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1. |
| Q37030825 | Structure-activity relationship of memapsin 2: implications on physiological functions and Alzheimer's disease |
| Q37073568 | Substrate specificity of gamma-secretase and other intramembrane proteases |
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| Q36397690 | The Alzheimer's disease beta-secretase enzyme, BACE1. |
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| Q39755143 | The Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques. |
| Q37108142 | The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimer's Disease |
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