Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase

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Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2011PLoSO...621337H
P356DOI10.1371/JOURNAL.PONE.0021337
P932PMC publication ID3117885
P698PubMed publication ID21695060
P5875ResearchGate publication ID51240223

P50authorStefan F LichtenthalerQ63092222
P2093author name stringPeer-Hendrik Kuhn
Alessio Colombo
Sebastian Hogl
P2860cites workAPP binds DR6 to trigger axon pruning and neuron death via distinct caspasesQ22251088
The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor proteinQ24308011
A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor proteinQ24312803
BACE (beta-secretase) modulates the processing of APLP2 in vivoQ24336570
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APPQ26269904
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeuticsQ27860914
Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloproteaseQ28140038
Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humansQ28145545
Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1Q28236674
The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylationQ28245707
Control of peripheral nerve myelination by the beta-secretase BACE1Q28264800
Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of NotchQ74306590
Amyloid precursor-like protein 2 (APLP2) is modified by the addition of chondroitin sulfate glycosaminoglycan at a single site.Q41443062
Cleavage of amyloid beta peptide during constitutive processing of its precursorQ41852594
Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor proteinQ42045819
Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substratesQ42226899
Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.Q42495065
Sheddases and intramembrane-cleaving proteases: RIPpers of the membrane. Symposium on regulated intramembrane proteolysisQ42541972
Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brainQ43516537
The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predictedQ44231100
Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis.Q45041133
Similar alternative splicing of a non-homologous domain in beta A4-amyloid protein precursor-like proteins.Q48082624
Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretaseQ48269632
Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neuronsQ49158635
Functional and quantitative proteomics using SILACQ57369727
Novel regulation of chondroitin sulfate glycosaminoglycan modification of amyloid precursor protein and its homologue, APLP2Q71921071
Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretaseQ74105290
The ADAM metalloproteinasesQ28292696
A practical recipe for stable isotope labeling by amino acids in cell culture (SILAC)Q28296386
Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-alpha converting enzymeQ28344424
Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of NotchQ28346677
Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family membersQ28504488
Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein geneQ28586800
Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO miceQ28590025
beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activityQ28593175
The proprotein convertasesQ28609903
In-gel digestion for mass spectrometric characterization of proteins and proteomesQ29547583
Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.Q30336360
Maturation and pro-peptide cleavage of beta-secretaseQ30868782
Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteasesQ31032457
Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10Q33498106
beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins.Q33762857
The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domainQ34009371
A disintegrin and metalloprotease 10 activity sheds the ectodomain of the amyloid precursor-like protein 2 and regulates protein expression in proximal tubule cellsQ35055620
The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous systemQ36042072
Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules.Q36074351
Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice.Q36530142
Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's diseaseQ36564159
Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP).Q36761978
The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometryQ36835366
The "a disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functionsQ37339450
Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptorsQ37427458
α-secretase in Alzheimer's disease: molecular identity, regulation and therapeutic potentialQ37806286
Regulated intramembrane proteolysis--lessons from amyloid precursor protein processingQ37854085
Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.Q39659066
ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neuronsQ39672952
Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.Q39686420
Insulin-like growth factor-1 (IGF-1)-induced processing of amyloid-beta precursor protein (APP) and APP-like protein 2 is mediated by different metalloproteinasesQ40074092
The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.Q40106778
Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor proteinQ40340767
Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinasesQ40352720
Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).Q40482942
The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.Q40631641
ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signallingQ41107179
Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domainQ41156869
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectproteolysisQ33123
P304page(s)e21337
P577publication date2011-06-17
P1433published inPLOS OneQ564954
P1476titleDetermination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase
P478volume6

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cites work (P2860)
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