scholarly article | Q13442814 |
P819 | ADS bibcode | 2011PLoSO...621337H |
P356 | DOI | 10.1371/JOURNAL.PONE.0021337 |
P932 | PMC publication ID | 3117885 |
P698 | PubMed publication ID | 21695060 |
P5875 | ResearchGate publication ID | 51240223 |
P50 | author | Stefan F Lichtenthaler | Q63092222 |
P2093 | author name string | Peer-Hendrik Kuhn | |
Alessio Colombo | |||
Sebastian Hogl | |||
P2860 | cites work | APP binds DR6 to trigger axon pruning and neuron death via distinct caspases | Q22251088 |
The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein | Q24308011 | ||
A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein | Q24312803 | ||
BACE (beta-secretase) modulates the processing of APLP2 in vivo | Q24336570 | ||
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Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1 | Q28236674 | ||
The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation | Q28245707 | ||
Control of peripheral nerve myelination by the beta-secretase BACE1 | Q28264800 | ||
Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch | Q74306590 | ||
Amyloid precursor-like protein 2 (APLP2) is modified by the addition of chondroitin sulfate glycosaminoglycan at a single site. | Q41443062 | ||
Cleavage of amyloid beta peptide during constitutive processing of its precursor | Q41852594 | ||
Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein | Q42045819 | ||
Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates | Q42226899 | ||
Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. | Q42495065 | ||
Sheddases and intramembrane-cleaving proteases: RIPpers of the membrane. Symposium on regulated intramembrane proteolysis | Q42541972 | ||
Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain | Q43516537 | ||
The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted | Q44231100 | ||
Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis. | Q45041133 | ||
Similar alternative splicing of a non-homologous domain in beta A4-amyloid protein precursor-like proteins. | Q48082624 | ||
Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase | Q48269632 | ||
Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons | Q49158635 | ||
Functional and quantitative proteomics using SILAC | Q57369727 | ||
Novel regulation of chondroitin sulfate glycosaminoglycan modification of amyloid precursor protein and its homologue, APLP2 | Q71921071 | ||
Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase | Q74105290 | ||
The ADAM metalloproteinases | Q28292696 | ||
A practical recipe for stable isotope labeling by amino acids in cell culture (SILAC) | Q28296386 | ||
Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-alpha converting enzyme | Q28344424 | ||
Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch | Q28346677 | ||
Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members | Q28504488 | ||
Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene | Q28586800 | ||
Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice | Q28590025 | ||
beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity | Q28593175 | ||
The proprotein convertases | Q28609903 | ||
In-gel digestion for mass spectrometric characterization of proteins and proteomes | Q29547583 | ||
Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation. | Q30336360 | ||
Maturation and pro-peptide cleavage of beta-secretase | Q30868782 | ||
Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases | Q31032457 | ||
Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10 | Q33498106 | ||
beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins. | Q33762857 | ||
The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain | Q34009371 | ||
A disintegrin and metalloprotease 10 activity sheds the ectodomain of the amyloid precursor-like protein 2 and regulates protein expression in proximal tubule cells | Q35055620 | ||
The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system | Q36042072 | ||
Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules. | Q36074351 | ||
Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice. | Q36530142 | ||
Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease | Q36564159 | ||
Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP). | Q36761978 | ||
The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry | Q36835366 | ||
The "a disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functions | Q37339450 | ||
Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors | Q37427458 | ||
α-secretase in Alzheimer's disease: molecular identity, regulation and therapeutic potential | Q37806286 | ||
Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing | Q37854085 | ||
Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1. | Q39659066 | ||
ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons | Q39672952 | ||
Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms. | Q39686420 | ||
Insulin-like growth factor-1 (IGF-1)-induced processing of amyloid-beta precursor protein (APP) and APP-like protein 2 is mediated by different metalloproteinases | Q40074092 | ||
The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. | Q40106778 | ||
Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein | Q40340767 | ||
Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases | Q40352720 | ||
Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1). | Q40482942 | ||
The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1. | Q40631641 | ||
ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling | Q41107179 | ||
Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain | Q41156869 | ||
P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
P6216 | copyright status | copyrighted | Q50423863 |
P433 | issue | 6 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | proteolysis | Q33123 |
P304 | page(s) | e21337 | |
P577 | publication date | 2011-06-17 | |
P1433 | published in | PLOS One | Q564954 |
P1476 | title | Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase | |
P478 | volume | 6 |
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Q53460407 | Combined deletions of amyloid precursor protein and amyloid precursor-like protein 2 reveal different effects on mouse brain metal homeostasis. |
Q39287009 | Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines |
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Q36419261 | Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases |
Q34979489 | Regulated intramembrane proteolysis and degradation of murine epithelial cell adhesion molecule mEpCAM. |
Q35355728 | Regulation of major histocompatibility complex class I molecule expression on cancer cells by amyloid precursor-like protein 2. |
Q36350742 | Relevance of amyloid precursor-like protein 2 C-terminal fragments in pancreatic cancer cells |
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Q36103683 | Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons |
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