| P2093 | author name string | Donat Kögel | |
| | Thomas Deller | |
| | Christian Behl | |
| P2860 | cites work | BAG3 and friends: co-chaperones in selective autophagy during aging and disease | Q84381212 |
| | APP binds DR6 to trigger axon pruning and neuron death via distinct caspases | Q22251088 |
| | c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK | Q24291602 |
| | Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism | Q24297873 |
| | Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3 | Q24312870 |
| | Homo- and heterodimerization of APP family members promotes intercellular adhesion | Q24337232 |
| | Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts | Q24675729 |
| | The amyloid precursor protein: beyond amyloid | Q24680465 |
| | Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory | Q28202553 |
| | Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival | Q28216349 |
| | The amyloid precursor protein is developmentally regulated and correlated with synaptogenesis | Q72787226 |
| | Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis | Q74516844 |
| | The unsolved relationship of brain aging and late-onset Alzheimer disease | Q37562196 |
| | Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells | Q37576797 |
| | Amyloid-independent mechanisms in Alzheimer's disease pathogenesis | Q37808579 |
| | The Role of the anti-amyloidogenic secretase ADAM10 in shedding the APP-like proteins | Q37878504 |
| | The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway | Q39641837 |
| | A macromolecular complex involving the amyloid precursor protein (APP) and the cytosolic adapter FE65 is a negative regulator of axon branching | Q39739662 |
| | Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway | Q39796401 |
| | The intracellular domain of amyloid precursor protein induces neuron-specific apoptosis | Q39947889 |
| | The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. | Q40106778 |
| | Amyloid precursor protein modulates ERK-1 and -2 signaling | Q40154388 |
| | Amyloid precursor protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK 1,2 signaling | Q40168518 |
| | IGF-1-induced processing of the amyloid precursor protein family is mediated by different signaling pathways | Q40170952 |
| | The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis | Q40217478 |
| | Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation. | Q40340003 |
| | Down-regulation of endogenous amyloid precursor protein processing due to cellular aging | Q40348451 |
| | Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells | Q40483602 |
| | Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production | Q40645886 |
| | A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1. | Q40660368 |
| | Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein. | Q41240734 |
| | Secreted forms of beta-amyloid precursor protein protect against ischemic brain injury | Q41451125 |
| | Disruption of brain cell ion homeostasis in Alzheimer's disease by oxy radicals, and signaling pathways that protect therefrom | Q41485834 |
| | The expression of amyloid beta protein precursor protects nerve cells from beta-amyloid and glutamate toxicity and alters their interaction with the extracellular matrix | Q41509726 |
| | Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives | Q41630805 |
| | Trophic effect of beta-amyloid precursor protein on cerebral cortical neurons in culture | Q41656266 |
| | Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain | Q42263336 |
| | Impaired calcium homeostasis in aged hippocampal neurons | Q42446302 |
| | Regulation of gene expression by the amyloid precursor protein: inhibition of the JNK/c-Jun pathway. | Q42471712 |
| | Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. | Q42495065 |
| | Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer m | Q42737591 |
| | sAPPalpha antagonizes dendritic degeneration and neuron death triggered by proteasomal stress | Q43062510 |
| | The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells | Q44007451 |
| | Phosphatidylinositol-3-kinase-Akt kinase and p42/p44 mitogen-activated protein kinases mediate neurotrophic and excitoprotective actions of a secreted form of amyloid precursor protein | Q44025529 |
| | JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis | Q44485247 |
| | The amyloid precursor protein protects PC12 cells against endoplasmic reticulum stress-induced apoptosis | Q44581792 |
| | Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis. | Q45041133 |
| | Cytoprotective function of sAppalpha in human keratinocytes | Q45243239 |
| | Reduction of neurological damage by a peptide segment of the amyloid beta/A4 protein precursor in a rabbit spinal cord ischemia model | Q46736730 |
| | Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury | Q48092228 |
| | Upregulation of amyloid precursor protein messenger RNA in response to traumatic brain injury: an ovine head impact model | Q48100956 |
| | Hypersensitivity to seizures in beta-amyloid precursor protein deficient mice | Q48236519 |
| | Experimental brain injury induces expression of amyloid precursor protein, which may be related to neuronal loss in the hippocampus | Q48335641 |
| | Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein | Q48342880 |
| | Anti-apoptotic wild-type Alzheimer amyloid precursor protein signaling involves the p38 mitogen-activated protein kinase/MEF2 pathway | Q48427045 |
| | Secreted amyloid precursor protein alpha selectively suppresses N-methyl-D-aspartate currents in hippocampal neurons: involvement of cyclic GMP. | Q48538138 |
| | Soluble amyloid precursor protein alpha reduces neuronal injury and improves functional outcome following diffuse traumatic brain injury in rats | Q48541352 |
| | Expression of amyloid precursor protein, tau and presenilin RNAs in rat hippocampus following deafferentation lesions | Q48826927 |
| | Amyloid precursor protein family-induced neuronal death is mediated by impairment of the neuroprotective calcium/calmodulin protein kinase IV-dependent signaling pathway. | Q52545476 |
| | The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains. | Q53277046 |
| | C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression. | Q53651998 |
| | Liposome-incorporated DHA increases neuronal survival by enhancing non-amyloidogenic APP processing | Q54636930 |
| | Soluble derivatives of the beta amyloid protein precursor in cerebrospinal fluid: alterations in normal aging and in Alzheimer's disease | Q67298810 |
| | Amino-terminal region of the beta-amyloid precursor protein activates mitogen-activated protein kinase | Q70921280 |
| | Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members | Q28504488 |
| | Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction | Q28574751 |
| | Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene | Q28586800 |
| | The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity | Q28587197 |
| | beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity | Q28593175 |
| | The APP intracellular domain (AICD) potentiates ER stress-induced apoptosis | Q28771721 |
| | Amyloid precursor protein trafficking, processing, and function | Q29617429 |
| | Neuroprotective secreted amyloid precursor protein acts by disrupting amyloid precursor protein dimers | Q30487766 |
| | Characterization of the neurotrophic interaction between nerve growth factor and secreted alpha-amyloid precursor protein | Q32063601 |
| | The beta-amyloid precursor protein controls a store-operated Ca2+ entry in cortical neurons | Q33207345 |
| | Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP). | Q33289346 |
| | Signaling events regulating the neurodevelopmental triad. Glutamate and secreted forms of beta-amyloid precursor protein as examples | Q33758906 |
| | Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase | Q33939218 |
| | The amyloid precursor protein and its homologues: structural and functional aspects of native and pathogenic oligomerization | Q34175222 |
| | The APP family of proteins: similarities and differences | Q34610073 |
| | Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease | Q34988301 |
| | Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis. | Q35000938 |
| | Targeting the JNK pathway for therapeutic benefit in CNS disease | Q35137435 |
| | Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor | Q35638734 |
| | Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations | Q35745983 |
| | Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases | Q35934211 |
| | Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices | Q36342500 |
| | Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis | Q36400886 |
| | Unraveling in vivo functions of amyloid precursor protein: insights from knockout and knockdown studies. | Q36586320 |
| | The functions of mammalian amyloid precursor protein and related amyloid precursor-like proteins | Q36626425 |
| | Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1. | Q36740945 |
| | Neurotrophic and neuroprotective effects of hAPP in transgenic mice | Q36798319 |
| | Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo. | Q36858269 |
| | APP at a glance | Q36945313 |
| | Alpha-secretase as a therapeutic target | Q36956821 |
| | Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease | Q37178375 |
| | The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease | Q37207978 |
| | Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors | Q37427458 |
| | Bridging physiology and pathology in AD. | Q37518549 |
| P433 | issue | 3-4 | |
| P921 | main subject | protein family | Q417841 |
| P1104 | number of pages | 9 | |
| P304 | page(s) | 471-479 | |
| P577 | publication date | 2011-11-16 | |
| P1433 | published in | Experimental Brain Research | Q13358841 |
| P1476 | title | Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging | |
| P478 | volume | 217 | |