| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.M108357200 |
| P8608 | Fatcat ID | release_nocvmemigrdt3adai7f6orsa4m |
| P698 | PubMed publication ID | 11724784 |
| P50 | author | Luciano D'Adamio | Q52350188 |
| Peter Lopez | Q55247052 | ||
| Meir H Scheinfeld | Q44548937 | ||
| P2093 | author name string | Pasquale Vito | |
| Mona Abdallah | |||
| Roberta Roncarati | |||
| P2860 | cites work | Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease | Q49017768 |
| JNK activation is associated with intracellular beta-amyloid accumulation | Q49105677 | ||
| Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and -8. | Q53229491 | ||
| Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases. | Q53333732 | ||
| Filamentous nerve cell inclusions in neurodegenerative diseases | Q77540879 | ||
| The JIP group of mitogen-activated protein kinase scaffold proteins | Q22010547 | ||
| Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE | Q22010705 | ||
| Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations | Q22254363 | ||
| Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing | Q24290265 | ||
| Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules | Q24290899 | ||
| The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein | Q24315811 | ||
| Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease | Q24316501 | ||
| Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3 | Q24554324 | ||
| MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines | Q24601753 | ||
| Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1 | Q28118975 | ||
| The beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocation | Q28138194 | ||
| A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain | Q28141707 | ||
| Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I | Q28141879 | ||
| Signal transduction by the JNK group of MAP kinases | Q28142592 | ||
| Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation | Q28143624 | ||
| Mammalian MAP kinase signalling cascades | Q28204140 | ||
| A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60 | Q28205099 | ||
| Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease | Q28241772 | ||
| Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases | Q28242035 | ||
| Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein | Q28260479 | ||
| Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain | Q28273268 | ||
| A mammalian scaffold complex that selectively mediates MAP kinase activation | Q28281953 | ||
| Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein | Q28290411 | ||
| Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction | Q28293156 | ||
| Candidate gene for the chromosome 1 familial Alzheimer's disease locus | Q28295424 | ||
| Interaction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's beta-amyloid precursor proteins | Q28304287 | ||
| Requirement of the JIP1 scaffold protein for stress-induced JNK activation | Q28505333 | ||
| Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene | Q28507982 | ||
| The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2 | Q28511338 | ||
| IB1, a JIP-1-related nuclear protein present in insulin-secreting cells | Q28574756 | ||
| A cytoplasmic inhibitor of the JNK signal transduction pathway | Q28586970 | ||
| Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3 | Q28588674 | ||
| Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease | Q29614374 | ||
| Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity | Q29616491 | ||
| Neurodegenerative tauopathies | Q29619895 | ||
| Fluorescence resonance energy transfer analysis of cell surface receptor interactions and signaling using spectral variants of the green fluorescent protein | Q31001023 | ||
| Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease | Q33725164 | ||
| The presenilins in Alzheimer's disease--proteolysis holds the key. | Q33763282 | ||
| New insights into the control of MAP kinase pathways | Q33783573 | ||
| The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes | Q33892083 | ||
| IB1 reduces cytokine-induced apoptosis of insulin-secreting cells | Q33896758 | ||
| The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids | Q33958834 | ||
| The Role of presenilins in gamma-secretase activity | Q34116345 | ||
| Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein. | Q34148927 | ||
| Intramembrane proteolysis by presenilins | Q34185772 | ||
| Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene | Q34303468 | ||
| Fluorescence Energy Transfer as a Spectroscopic Ruler | Q34661461 | ||
| Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells | Q35058548 | ||
| The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein | Q36788339 | ||
| Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport | Q37701379 | ||
| Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide | Q40790952 | ||
| A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling | Q40927150 | ||
| Amyloid beta-protein and the genetics of Alzheimer's disease | Q41074945 | ||
| Amyloid, the presenilins and Alzheimer's disease | Q41433661 | ||
| Kunitz protease inhibitor-containing amyloid beta protein precursor immunoreactivity in Alzheimer's disease | Q41644400 | ||
| Mutant genes in familial Alzheimer's disease and transgenic models | Q41733323 | ||
| Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease | Q41751567 | ||
| Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation | Q42527531 | ||
| Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation | Q48141900 | ||
| Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease | Q48142435 | ||
| p38 kinase is activated in the Alzheimer's disease brain | Q48227440 | ||
| Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor. | Q48492125 | ||
| Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis | Q48739094 | ||
| P433 | issue | 5 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | Alzheimer's disease | Q11081 |
| P304 | page(s) | 3767-3775 | |
| P577 | publication date | 2001-11-27 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP). | |
| P478 | volume | 277 |
| Q92237683 | A Role for Drosophila Amyloid Precursor Protein in Retrograde Trafficking of L1-Type Cell Adhesion Molecule Neuroglian |
| Q38720656 | A STRIPAK complex mediates axonal transport of autophagosomes and dense core vesicles through PP2A regulation |
| Q51300908 | A molecular dynamics study of the binary complexes of APP, JIP1, and the cargo binding domain of KLC. |
| Q33661653 | A new molecular explanation for age-related neurodegeneration: the Tyr682 residue of amyloid precursor protein |
| Q24310599 | A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease |
| Q28543167 | APP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functions |
| Q24297668 | APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain |
| Q41045804 | Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration |
| Q44534322 | Amyloid beta protein precursor (AbetaPP), but not AbetaPP-like protein 2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1. |
| Q44548877 | Amyloid beta protein precursor is phosphorylated by JNK-1 independent of, yet facilitated by, JNK-interacting protein (JIP)-1. |
| Q37360497 | Amyloid precursor family proteins are expressed by thymic and lymph node stromal cells but are not required for lymphocyte development |
| Q40168518 | Amyloid precursor protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK 1,2 signaling |
| Q37427458 | Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors |
| Q36863026 | Amyloid precursor protein and presenilin involvement in cell signaling. |
| Q33646390 | Amyloid precursor protein mediates a tyrosine kinase-dependent activation response in endothelial cells |
| Q42389524 | Amyloid precursor protein mediates monocyte adhesion in AD tissue and apoE(-)/(-) mice |
| Q40154388 | Amyloid precursor protein modulates ERK-1 and -2 signaling |
| Q37681861 | Amyloid precursor protein modulates macrophage phenotype and diet-dependent weight gain |
| Q34345797 | Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner. |
| Q34603033 | An intracellular threonine of amyloid-β precursor protein mediates synaptic plasticity deficits and memory loss |
| Q41128390 | Anti-inflammatory Effect of Glucagon Like Peptide-1 Receptor Agonist, Exendin-4, through Modulation of IB1/JIP1 Expression and JNK Signaling in Stroke |
| Q39006798 | ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion |
| Q24305128 | Autosomal recessive hypercholesterolemia protein interacts with and regulates the cell surface level of Alzheimer's amyloid beta precursor protein |
| Q28079729 | Axonal Transport and Neurodegeneration: How Marine Drugs Can Be Used for the Development of Therapeutics |
| Q26827748 | Axonal transport: cargo-specific mechanisms of motility and regulation |
| Q24315799 | BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2 |
| Q33635895 | C-terminal cleavage of the amyloid-beta protein precursor at Asp664: a switch associated with Alzheimer's disease |
| Q28506045 | Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1 |
| Q35913893 | Cytoplasmic tail adaptors of Alzheimer's amyloid-beta protein precursor |
| Q28573591 | DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3 |
| Q34976286 | Death and survival of neuronal cells exposed to Alzheimer's insults |
| Q30858845 | Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus |
| Q58549216 | Early Life Stress and Epigenetics in Late-onset Alzheimer's Dementia: A Systematic Review |
| Q40714164 | Evidence for a role of the nerve growth factor receptor TrkA in tyrosine phosphorylation and processing of beta-APP. |
| Q36882015 | Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role |
| Q28207751 | Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression |
| Q40108106 | Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-beta degrading enzyme neprilysin |
| Q44822089 | Growth factor receptor-bound protein 2 interaction with the tyrosine-phosphorylated tail of amyloid beta precursor protein is mediated by its Src homology 2 domain. |
| Q33224260 | Hyperphosphorylation of JNK-interacting protein 1, a protein associated with Alzheimer disease. |
| Q44489184 | Increased vulnerability to kainic acid-induced epileptic seizures in mice underexpressing the scaffold protein Islet-Brain 1/JIP-1. |
| Q38222320 | Integrated regulation of motor-driven organelle transport by scaffolding proteins |
| Q36156106 | Interaction of ASK1 and the beta-amyloid precursor protein in a stress-signaling complex |
| Q39909606 | Is abnormal axonal transport a cause, a contributing factor or a consequence of the neuronal pathology in Alzheimer's disease? |
| Q37071736 | JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors |
| Q26741279 | JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships |
| Q34761715 | JNK-interacting protein-1 promotes transcription of A beta protein precursor but not A beta precursor-like proteins, mechanistically different than Fe65 |
| Q48205930 | Live-Cell Imaging Reveals Tau Isoforms Imbalance Disrupts Traffic of APP Vesicles in Human Neurons. |
| Q35095136 | MAPKs: new targets for neurodegeneration |
| Q24315684 | Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein |
| Q35760258 | N-terminal kinesins: many and various. |
| Q38102579 | Nanoparticles in the brain: a potential therapeutic system targeted to an early defect observed in many neurodegenerative diseases. |
| Q38002023 | Neurodegeneration in Alzheimer disease: role of amyloid precursor protein and presenilin 1 intracellular signaling |
| Q40650184 | Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway |
| Q42278279 | Paradoxical effect of TrkA inhibition in Alzheimer's disease models |
| Q47577094 | Phosphorylation of KLC1 modifies interaction with JIP1 and abolishes the enhanced fast velocity of APP transport by kinesin-1. |
| Q44367827 | Platelet-derived growth factor induces the beta-gamma-secretase-mediated cleavage of Alzheimer's amyloid precursor protein through a Src-Rac-dependent pathway. |
| Q37804913 | Possible roles of amyloid intracellular domain of amyloid precursor protein |
| Q28201680 | Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription |
| Q28254104 | Proteolytic processing of Alzheimer's β-amyloid precursor protein |
| Q30597672 | Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport |
| Q24311363 | Regulation of FE65 nuclear translocation and function by amyloid beta-protein precursor in osmotically stressed cells |
| Q29619598 | Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals |
| Q42471712 | Regulation of gene expression by the amyloid precursor protein: inhibition of the JNK/c-Jun pathway. |
| Q34178005 | Requirement of JIP1-mediated c-Jun N-terminal kinase activation for obesity-induced insulin resistance |
| Q28202553 | Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory |
| Q37956562 | Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging |
| Q36819386 | Scaffold proteins of MAP-kinase modules. |
| Q36161835 | Similarities and differences between the Wnt and reelin pathways in the forming brain. |
| Q36610341 | Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis |
| Q57462276 | Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors |
| Q52558853 | Structure of APP-C991-99 and implications for role of extra-membrane domains in function and oligomerization. |
| Q27651299 | Structure of the C-terminal phosphotyrosine interaction domain of Fe65L1 complexed with the cytoplasmic tail of amyloid precursor protein reveals a novel peptide binding mode |
| Q37073568 | Substrate specificity of gamma-secretase and other intramembrane proteases |
| Q40475845 | Tau phosphorylation in Alzheimer's disease: potential involvement of an APP-MAP kinase complex. |
| Q28508249 | The axon guidance defect of the telencephalic commissures of the JSAP1-deficient brain was partially rescued by the transgenic expression of JIP1 |
| Q30500831 | The c-jun kinase/stress-activated pathway: regulation, function and role in human disease |
| Q24531382 | The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling |
| Q34622077 | The interaction of Kinesin-1 with its adaptor protein JIP1 can be regulated via proteins binding to the JIP1-PTB domain |
| Q37295364 | The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains |
| Q37634610 | The role of scaffold proteins in JNK signalling |
| Q24292400 | Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc |
| Q24646503 | UNC-51/ATG1 kinase regulates axonal transport by mediating motor-cargo assembly |
| Q24337845 | Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1 |
| Q47774964 | X11alpha modulates secretory and endocytic trafficking and metabolism of amyloid precursor protein: mutational analysis of the YENPTY sequence |
| Q35951529 | Yeast Two-Hybrid Screening for Proteins that Interact with the Extracellular Domain of Amyloid Precursor Protein |
| Q40435410 | c-Jun NH2-terminal kinase-interacting protein-3 facilitates phosphorylation and controls localization of amyloid-beta precursor protein. |
| Q36037957 | β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia |
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