| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.M110286200 |
| P698 | PubMed publication ID | 11877420 |
| P50 | author | Luciano D'Adamio | Q52350188 |
| Philip E Tarr | Q91425500 | ||
| P2093 | author name string | Pier Giuseppe Pelicci | |
| Giuliana Pelicci | |||
| Roberta Roncarati | |||
| P2860 | cites work | c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK | Q24291602 |
| The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein | Q24315811 | ||
| A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction | Q24338592 | ||
| Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation | Q28131755 | ||
| The beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocation | Q28138194 | ||
| A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain | Q28141707 | ||
| Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I | Q28141879 | ||
| Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation | Q28143624 | ||
| A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60 | Q28205099 | ||
| The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene | Q28208729 | ||
| Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases | Q28242035 | ||
| Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain | Q28273268 | ||
| Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction | Q28293156 | ||
| Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3 | Q28588674 | ||
| Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP | Q28592685 | ||
| New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway | Q28608965 | ||
| The p66shc adaptor protein controls oxidative stress response and life span in mammals | Q29614553 | ||
| Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases | Q29618331 | ||
| Amino-terminal modification and tyrosine phosphorylation of [corrected] carboxy-terminal fragments of the amyloid precursor protein in Alzheimer's disease and Down's syndrome brain | Q31853679 | ||
| Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP). | Q33289346 | ||
| Elevated expression of p21ras is an early event in Alzheimer's disease and precedes neurofibrillary degeneration | Q33640174 | ||
| Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues. | Q33652573 | ||
| Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5. | Q33913155 | ||
| The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids | Q33958834 | ||
| An alternative to SH2 domains for binding tyrosine-phosphorylated proteins | Q34292972 | ||
| A portrait of Alzheimer secretases--new features and familiar faces | Q34345559 | ||
| The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein | Q36788339 | ||
| Effects of the beta-amyloid and carboxyl-terminal fragment of Alzheimer's amyloid precursor protein on the production of the tumor necrosis factor-alpha and matrix metalloproteinase-9 by human monocytic THP-1. | Q40812258 | ||
| Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor | Q41640200 | ||
| Ligand-dependent G protein coupling function of amyloid transmembrane precursor | Q42066774 | ||
| Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. | Q42495065 | ||
| Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation | Q42527531 | ||
| Phosphorylation-induced structural changes in the amyloid precursor protein cytoplasmic tail detected by NMR. | Q43556227 | ||
| Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid | Q43715880 | ||
| The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture | Q43735231 | ||
| Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation | Q48141900 | ||
| Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor. | Q48492125 | ||
| Reactivating kinase/p38 phosphorylates tau protein in vitro | Q48677349 | ||
| Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals. | Q48703300 | ||
| Shc signaling in differentiating neural progenitor cells | Q48871945 | ||
| Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease | Q49017768 | ||
| Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and -8. | Q53229491 | ||
| Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases. | Q53333732 | ||
| Phosphorylation Sites on Tau Identified by Nanoelectrospray Mass Spectrometry | Q55919559 | ||
| Shc Binding to Nerve Growth Factor Receptor Is Mediated by the Phosphotyrosine Interaction Domain | Q57270013 | ||
| The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons | Q73406764 | ||
| Auto-inhibition and partner proteins, core-binding factor beta (CBFbeta) and Ets-1, modulate DNA binding by CBFalpha2 (AML1) | Q95811462 | ||
| P433 | issue | 19 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | phosphorylation | Q242736 |
| Amyloid beta (A4) precursor protein | Q14865884 | ||
| Neurotrophic tyrosine kinase, receptor, type 1 | Q14901156 | ||
| Src homology 2 domain-containing transforming protein C3 | Q21498710 | ||
| P1104 | number of pages | 7 | |
| P304 | page(s) | 16798-16804 | |
| P577 | publication date | 2002-03-04 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc | |
| P478 | volume | 277 |
| Q33661653 | A new molecular explanation for age-related neurodegeneration: the Tyr682 residue of amyloid precursor protein |
| Q34685168 | A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function. |
| Q36674481 | A two decade contribution of molecular cell biology to the centennial of Alzheimer's disease: are we progressing toward therapy? |
| Q36840033 | APP Receptor? To Be or Not To Be. |
| Q28543167 | APP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functions |
| Q35870089 | APP is phosphorylated by TrkA and regulates NGF/TrkA signaling |
| Q37902514 | APP physiological and pathophysiological functions: insights from animal models. |
| Q42917696 | APP processing is regulated by cytoplasmic phosphorylation |
| Q39619549 | Activation of amyloid precursor protein processing by growth factors is dependent on Ras GTPase activity. |
| Q36030499 | Adaptor protein 2-mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing. |
| Q36005686 | All in the Family: How the APPs Regulate Neurogenesis |
| Q41045804 | Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration |
| Q44548877 | Amyloid beta protein precursor is phosphorylated by JNK-1 independent of, yet facilitated by, JNK-interacting protein (JIP)-1. |
| Q37360497 | Amyloid precursor family proteins are expressed by thymic and lymph node stromal cells but are not required for lymphocyte development |
| Q40168518 | Amyloid precursor protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK 1,2 signaling |
| Q37427458 | Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors |
| Q36863026 | Amyloid precursor protein and presenilin involvement in cell signaling. |
| Q48617628 | Amyloid precursor protein cross-linking stimulates beta amyloid production and pro-inflammatory cytokine release in monocytic lineage cells |
| Q40597791 | Amyloid precursor protein mediates proinflammatory activation of monocytic lineage cells |
| Q40154388 | Amyloid precursor protein modulates ERK-1 and -2 signaling |
| Q34345797 | Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner. |
| Q34603033 | An intracellular threonine of amyloid-β precursor protein mediates synaptic plasticity deficits and memory loss |
| Q37614648 | Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents. |
| Q24305128 | Autosomal recessive hypercholesterolemia protein interacts with and regulates the cell surface level of Alzheimer's amyloid beta precursor protein |
| Q24312009 | Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage |
| Q34988301 | Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease |
| Q36559668 | Cathepsin Inhibition Prevents Autophagic Protein Turnover and Downregulates Insulin Growth Factor-1 Receptor-Mediated Signaling in Neuroblastoma |
| Q35913893 | Cytoplasmic tail adaptors of Alzheimer's amyloid-beta protein precursor |
| Q33952409 | Dynamic changes of the phosphoproteome in postmortem mouse brains. |
| Q34311248 | EGCG functions through estrogen receptor‐mediated activation of ADAM10 in the promotion of non‐amyloidogenic processing of APP |
| Q92990581 | Effects of the Pentapeptide P33 on Memory and Synaptic Plasticity in APP/PS1 Transgenic Mice: A Novel Mechanism Presenting the Protein Fe65 as a Target |
| Q40714164 | Evidence for a role of the nerve growth factor receptor TrkA in tyrosine phosphorylation and processing of beta-APP. |
| Q30538684 | Fast anterograde transport of herpes simplex virus: role for the amyloid precursor protein of alzheimer's disease |
| Q40591740 | Fe65 is not involved in the platelet-derived growth factor-induced processing of Alzheimer's amyloid precursor protein, which activates its caspase-directed cleavage. |
| Q28207751 | Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression |
| Q40108106 | Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-beta degrading enzyme neprilysin |
| Q44822089 | Growth factor receptor-bound protein 2 interaction with the tyrosine-phosphorylated tail of amyloid beta precursor protein is mediated by its Src homology 2 domain. |
| Q28580671 | Interaction of Mint2 with TrkA is involved in regulation of nerve growth factor-induced neurite outgrowth |
| Q39796602 | Interactions of the NPXY microdomains of the low density lipoprotein receptor-related protein 1. |
| Q34761715 | JNK-interacting protein-1 promotes transcription of A beta protein precursor but not A beta precursor-like proteins, mechanistically different than Fe65 |
| Q45893865 | Monitoring "De Novo"APP synthesis by taking advantage of the reversible effect of cycloheximide |
| Q40006229 | Multisite tyrosine phosphorylation of the N-terminus of Mint1/X11α by Src kinase regulates the trafficking of amyloid precursor protein |
| Q36529555 | Nerve growth factor, neural stem cells and Alzheimer's disease |
| Q38002023 | Neurodegeneration in Alzheimer disease: role of amyloid precursor protein and presenilin 1 intracellular signaling |
| Q34453199 | Novel adaptors of amyloid precursor protein intracellular domain and their functional implications |
| Q92354226 | Phosphorylation Signaling in APP Processing in Alzheimer's Disease |
| Q44367827 | Platelet-derived growth factor induces the beta-gamma-secretase-mediated cleavage of Alzheimer's amyloid precursor protein through a Src-Rac-dependent pathway. |
| Q37804913 | Possible roles of amyloid intracellular domain of amyloid precursor protein |
| Q39319453 | Protein Phosphorylation is a Key Mechanism in Alzheimer's Disease |
| Q28254104 | Proteolytic processing of Alzheimer's β-amyloid precursor protein |
| Q40524598 | Proteolytic processing of amyloid-beta precursor protein by secretases does not require cell surface transport |
| Q40196139 | RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation |
| Q34576437 | Rapamycin promotes beta-amyloid production via ADAM-10 inhibition |
| Q28202553 | Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory |
| Q33257954 | Screening for PTB domain binding partners and ligand specificity using proteome-derived NPXY peptide arrays |
| Q44041873 | Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain. |
| Q27652388 | Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2 |
| Q37073568 | Substrate specificity of gamma-secretase and other intramembrane proteases |
| Q46055931 | Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production. |
| Q41899169 | The amyloid precursor protein intracellular domain-fe65 multiprotein complexes: a challenge to the amyloid hypothesis for Alzheimer's disease? |
| Q24540102 | The amyloid-beta precursor protein: integrating structure with biological function |
| Q37295364 | The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains |
| Q34708261 | The intracellular threonine of amyloid precursor protein that is essential for docking of Pin1 is dispensable for developmental function. |
| Q98386132 | TrkB receptor cleavage by delta-secretase abolishes its phosphorylation of APP, aggravating Alzheimer's disease pathologies |
| Q33754509 | Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo |
| Q36405899 | Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance |
| Q47774964 | X11alpha modulates secretory and endocytic trafficking and metabolism of amyloid precursor protein: mutational analysis of the YENPTY sequence |
| Q35297339 | Y682G Mutation of Amyloid Precursor Protein Promotes Endo-Lysosomal Dysfunction by Disrupting APP-SorLA Interaction. |
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