Elevated expression of p21ras is an early event in Alzheimer's disease and precedes neurofibrillary degeneration

scientific article

Elevated expression of p21ras is an early event in Alzheimer's disease and precedes neurofibrillary degeneration is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/S0306-4522(99)00059-7
P698PubMed publication ID10336054

P2093author name stringHolzer M
Arendt T
Gärtner U
P2860cites workInsulin-like growth factors and insulin-like growth factor binding proteins in cerebrospinal fluid and serum of patients with dementia of the Alzheimer typeQ53201609
Regulation of secretion of Alzheimer amyloid precursor protein by the mitogen-activated protein kinase cascadeQ58112395
Ras-signaling pathways: positive and negative regulation of tau expression in PC12 cellsQ74015471
Neuropathological stageing of Alzheimer-related changesQ27860862
Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control proteinQ28256250
Ras signalling linked to the cell-cycle machinery by the retinoblastoma proteinQ28305440
Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation.Q35616076
Mitotic mechanisms in Alzheimer's disease?Q36236501
ras isoprenylation is required for ras-induced but not for NGF-induced neuronal differentiation of PC12 cellsQ36530493
The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's diseaseQ38611694
Nerve growth factor and ras regulate beta-amyloid precursor protein gene expression in PC12 cellsQ41190133
Dendritic reorganisation in the basal forebrain under degenerative conditions and its defects in Alzheimer's disease. II. Ageing, Korsakoff's disease, Parkinson's disease, and Alzheimer's diseaseQ42477274
Increase of c-fos and ras oncoproteins in the denervated neuropil of the rat dentate gyrusQ45089570
Induction of basic Fibroblast Growth Factor in Alzheimerʼs disease pathologyQ46894345
Hyperphosphorylation of human TAU by brain kinase PK40erk beyond phosphorylation by cAMP-dependent PKA: relation to Alzheimer's diseaseQ48139408
Detection of NGF-like activity in human brain tissue: increased levels in Alzheimer's diseaseQ48270749
Neuronal expression of cycline dependent kinase inhibitors of the INK4 family in Alzheimer's diseaseQ48320192
Aberrancies in signal transduction and cell cycle related events in Alzheimer's disease.Q48330754
Brain glutamate decarboxylase in Parkinson's disease with particular reference to a premortem severity indexQ48482439
Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain.Q48487273
Hepatocyte growth factor (HGF/SF) in Alzheimer's diseaseQ48528548
Regulation of amyloid precursor protein catabolism involves the mitogen-activated protein kinase signal transduction pathwayQ48567917
Insulin-like growth factor-I (IGF-I) immunoreactivity in the Alzheimer's disease temporal cortex and hippocampusQ48591069
Cell cycle markers in the hippocampus in Alzheimer's diseaseQ48671520
Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brainQ48706959
Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditionsQ48786969
Nerve growth factor mRNA and protein levels measured in the same tissue from normal and Alzheimer's disease parietal cortexQ48879964
Increased expression and subcellular translocation of the mitogen activated protein kinase kinase and mitogen-activated protein kinase in Alzheimer's disease.Q53199479
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
P304page(s)1-5
P577publication date1999-01-01
P1433published inNeuroscienceQ15708571
P1476titleElevated expression of p21ras is an early event in Alzheimer's disease and precedes neurofibrillary degeneration
P478volume91

Reverse relations

cites work (P2860)
Q600456145-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer's disease
Q53232860Aberrant expression of nNOS in pyramidal neurons in Alzheimer's disease is highly co-localized with p21ras and p16INK4a.
Q38857243Activation of Ras-ERK Signaling and GSK-3 by Amyloid Precursor Protein and Amyloid Beta Facilitates Neurodegeneration in Alzheimer's Disease
Q39619549Activation of amyloid precursor protein processing by growth factors is dependent on Ras GTPase activity.
Q34286579AlzPathway: a comprehensive map of signaling pathways of Alzheimer's disease
Q35974525Alzheimer's disease as a disorder of dynamic brain self-organization
Q34142269Alzheimer's disease as a disorder of mechanisms underlying structural brain self-organization
Q35708114Alzheimer's disease: the two-hit hypothesis
Q57006022An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity
Q35793508BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease
Q33791646Biomarkers in Alzheimer's disease: past, present and future
Q54738945Cell cycle activation and CNS injury.
Q40120725Cell cycle related signaling in Neuro2a cells proceeds via the receptor for advanced glycation end products
Q37722680Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis
Q42508999Constitutive Cdc25B tyrosine phosphatase activity in adult brain neurons with M phase-type alterations in Alzheimer's disease
Q42467173Constitutive Ras activity induces hippocampal hypertrophy and remodeling of pyramidal neurons in synRas mice
Q44085921Cyclin D1 and cyclin E are co-localized with cyclo-oxygenase 2 (COX-2) in pyramidal neurons in Alzheimer disease temporal cortex
Q27864126Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease
Q34241440Disturbance of neuronal plasticity is a critical pathogenetic event in Alzheimer's disease
Q35083375Dysregulation of mitogen-activated protein kinase signaling pathways in simian immunodeficiency virus encephalitis
Q48435650ERK activation and expression of neuronal cell cycle markers in the hippocampus after entorhinal cortex lesion
Q39316007Exploring the biochemistry of the prenylome and its role in disease through proteomics: progress and potential.
Q42451752Expression of constitutively active p21H-rasval12 in postmitotic pyramidal neurons results in increased dendritic size and complexity.
Q53243973Expression of endothelial and inducible NOS-isoforms is increased in Alzheimer's disease, in APP23 transgenic mice and after experimental brain lesion in rat: evidence for an induction by amyloid pathology.
Q53350076Hyperphosphorylation of RNA polymerase II and reduced neuronal RNA levels precede neurofibrillary tangles in Alzheimer disease.
Q54223105Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer's disease.
Q41328860Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer's brain molecular pathology.
Q34574992Mutation in E1, the ubiquitin activating enzyme, reduces Drosophila lifespan and results in motor impairment
Q37016092Natural antioxidants in Alzheimer's disease
Q34976296Neuroplasticity in Alzheimer's disease
Q91827638Neuroprotective Effect of S-trans, Trans-farnesylthiosalicylic Acid via Inhibition of RAS/ERK Pathway for the Treatment of Alzheimer's Disease
Q34070765Pathological implications of cell cycle re-entry in Alzheimer disease
Q44486768Progressive degeneration of nonphosphorylated neurofilament protein-enriched pyramidal neurons predicts cognitive impairment in Alzheimer's disease: stereologic analysis of prefrontal cortex area 9.
Q26858942Protein prenylation and synaptic plasticity: implications for Alzheimer's disease
Q42338638Retinoschisin is linked to retinal Na/K-ATPase signaling and localization
Q37671001Review: cell cycle aberrations and neurodegeneration
Q39242927SILAC-based proteomic analysis to investigate the impact of amyloid precursor protein expression in neuronal-like B103 cells
Q47795955The identification and characterization of oxidized RNAs in Alzheimer's disease.
Q38094984The senescence hypothesis of disease progression in Alzheimer disease: an integrated matrix of disease pathways for FAD and SAD.
Q24292400Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc
Q47739695Up-regulation of glycohydrolases in Alzheimer's Disease fibroblasts correlates with Ras activation
Q48407971Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease
Q30753189What studies on human longevity tell us about the risk for cancer in the oldest old: data and hypotheses on the genetics and immunology of centenarians

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