Constitutive Cdc25B tyrosine phosphatase activity in adult brain neurons with M phase-type alterations in Alzheimer's disease

scientific article

Constitutive Cdc25B tyrosine phosphatase activity in adult brain neurons with M phase-type alterations in Alzheimer's disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0306-4522(01)00219-6
P698PubMed publication ID11516829

P2093author name stringL Jin
D Nochlin
K Hudson
I Vincent
B Bu
J Husseman
P2860cites workHuman wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinaseQ24311353
Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: Evidence for multiple roles of mitotic cyclinsQ24314904
Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivoQ24315026
Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycleQ24568298
Nuclear localization of cyclin B1 controls mitotic entry after DNA damageQ24683172
Cdc25B and Cdc25C differ markedly in their properties as initiators of mitosisQ24685826
Fresh and nonfibrillar amyloid beta protein(1-40) induces rapid cellular degeneration in aged human fibroblasts: evidence for AbetaP-channel-mediated cellular toxicityQ28145519
Phosphatases and tumorigenesisQ28261948
Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2Q28301582
Identification of functional domains in the neuronal Cdk5 activator proteinQ28303940
Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosisQ29618506
Regulating the onset of mitosisQ33597414
Elevated expression of p21ras is an early event in Alzheimer's disease and precedes neurofibrillary degenerationQ33640174
Proteasome-dependent degradation of human CDC25B phosphataseQ33654863
Systematic identification of mitotic phosphoproteinsQ34422813
Nerve growth factor regulates the expression and activity of p33cdk2 and p34cdc2 kinases in PC12 pheochromocytoma cells.Q34445949
Assembly and cell cycle dynamics of the nuclear laminaQ35464261
Animal cell cycles and their controlQ35671048
The cell cycle Cdc25A tyrosine phosphatase is activated in degenerating postmitotic neurons in Alzheimer's diseaseQ35829694
cdc2 phosphorylation is required for its interaction with cyclin.Q35933286
Redundant cyclin overexpression and gene amplification in breast cancer cellsQ36090819
Inhibition of cyclin-dependent kinase activity triggers neuronal differentiation of mouse neuroblastoma cellsQ36236073
Mitotic mechanisms in Alzheimer's disease?Q36236501
Phosphoproteins are components of mitotic microtubule organizing centersQ36272767
cdc25 is a nuclear protein expressed constitutively throughout the cell cycle in nontransformed mammalian cellsQ36531704
Mitotic controlQ37286966
Role of phosphorylation in p34cdc2 activation: identification of an activating kinaseQ37370012
Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phaseQ37376960
Cell cycle regulation of a Xenopus Wee1-like kinaseQ37378230
Monoclonal antibodies to mitotic cellsQ37611790
The brain-specific activator p35 allows Cdk5 to escape inhibition by p27Kip1 in neurons.Q37647121
cdc25 is one of the MPM-2 antigens involved in the activation of maturation-promoting factorQ40365865
Neuronal cdc2-like kinaseQ40605476
Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transitionQ40793182
Reversible tyrosine phosphorylation and cell cycle controlQ40813399
Mitotic phosphoepitopes precede paired helical filaments in Alzheimer's diseaseQ40843729
Dynamic changes in nuclear architecture during mitosis: on the role of protein phosphorylation in spindle assembly and chromosome segregation.Q41295372
Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1.Q42014638
c-Myc cooperates with activated Ras to induce the cdc2 promoterQ42088710
Plastic neuronal remodeling is impaired in patients with Alzheimer's disease carrying apolipoprotein epsilon 4 alleleQ42528671
Regulation of the cdc25 protein during the cell cycle in Xenopus extractsQ42612101
Control of p34cdc2 ActivationQ46469924
The cdc25 protein contains an intrinsic phosphatase activityQ46716281
Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppressionQ47852578
Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain.Q48158450
The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons.Q48257428
Signal transduction abnormalities in Alzheimer's disease: evidence of a pathogenic stimuliQ48312866
Constitutive Wee1 activity in adult brain neurons with M phase-type alterations in Alzheimer neurodegeneration.Q48492209
Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brainQ48706959
Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditionsQ48786969
Alzheimer's disease neurofibrillary tangles contain mitosis-specific phosphoepitopes.Q48856816
Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseasesQ49140750
A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threadsQ53199877
Structure, function, and regulation of neuronal Cdc2-like protein kinase.Q53200234
Immortal, non-tumourigenic mouse mammary outgrowths express high levels of cyclin B1 and activation of cyclin B1/cdc2 kinase.Q53449725
Dephosphorylation and activation of Xenopusp34 cdc2 protein kinase during the cell cycleQ58997203
Phosphorylation changes associated with the early cell cycle in Xenopus eggsQ69721365
Constitutive overexpression of CDK2 inhibits neuronal differentiation of rat pheochromocytoma PC12 cellsQ71743056
Transcriptional activation of the cdc2 gene is associated with Fas-induced apoptosis of human hematopoietic cellsQ71763217
Over-expression and amplification of the CDC2 gene in leukaemia cellsQ72327032
Centrosomal and cytoplasmic Cdc2/cyclin B1 activation precedes nuclear mitotic eventsQ73896625
Cell cycle dependent subcellular distribution of Cdc25B subtypesQ77811811
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
P304page(s)639-650
P577publication date2001-01-01
P1433published inNeuroscienceQ15708571
P1476titleConstitutive Cdc25B tyrosine phosphatase activity in adult brain neurons with M phase-type alterations in Alzheimer's disease
P478volume105

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