| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/S0168-0102(99)00026-7 |
| P698 | PubMed publication ID | 10413323 |
| P50 | author | Jesusa L Rosales | Q63377111 |
| P2093 | author name string | K Y Lee | |
| R N Johnston | |||
| A W Clark | |||
| K Chapman | |||
| T Fung | |||
| P2860 | cites work | A family of human cdc2-related protein kinases | Q24300226 |
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| p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5 | Q24320432 | ||
| Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 | Q25938983 | ||
| A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding | Q25938984 | ||
| Phosphorylation by neuronal cdc2-like protein kinase promotes dimerization of Tau protein in vitro | Q28253196 | ||
| Hyperphosphorylation of tau in PHF | Q28289907 | ||
| Phosphorylation of the high molecular weight neurofilament protein (NF-H) by Cdk5 and p35 | Q28573095 | ||
| The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation | Q28577018 | ||
| Anti-Hu immunolabeling as an index of neuronal differentiation in human brain tumors: a study of 112 central neuroepithelial neoplasms. | Q32098170 | ||
| Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression | Q33187332 | ||
| Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau. | Q34324670 | ||
| Phosphoprotein phosphatase activities in Alzheimer disease brain | Q34356873 | ||
| Mitotic mechanisms in Alzheimer's disease? | Q36236501 | ||
| Role of cyclins in neuronal differentiation of immortalized hippocampal cells | Q36573600 | ||
| The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease | Q38611694 | ||
| Neurofibrillary tangles of paired helical filaments | Q39759052 | ||
| Molecular dissection of the paired helical filament | Q40416715 | ||
| Neuronal cdc2-like kinase | Q40605476 | ||
| Phosphorylation of paired helical filament tau in Alzheimer's disease neurofibrillary lesions: focusing on phosphatases | Q40928264 | ||
| Neurodegenerative disorders with extensive tau pathology: a comparative study and review | Q41084709 | ||
| Neuronal antinuclear antibody (anti-Hu) in paraneoplastic encephalomyelitis simulating acute polyneuritis | Q41371467 | ||
| Neuronal Cdc2-like kinases: neuron-specific forms of Cdk5. | Q41647408 | ||
| Detection of Phosphorylated Ser262 in Fetal Tau, Adult Tau, and Paired Helical Filament Tau | Q46127208 | ||
| Neurofilaments are part of the high molecular weight complex containing neuronal cdc2-like kinase (nclk). | Q47298416 | ||
| Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration | Q47836277 | ||
| A brain-specific activator of cyclin-dependent kinase 5. | Q48079027 | ||
| Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain | Q48083452 | ||
| Brain protein kinase PK40erk converts TAU into a PHF-like form as found in Alzheimer's disease | Q48266498 | ||
| Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau. | Q48394153 | ||
| Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase | Q48406074 | ||
| Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease | Q48444661 | ||
| Association of neurofilament proteins with neuronal Cdk5 activator | Q48556716 | ||
| Neuronal Cdc2-like kinase (Nclk) binds and phosphorylates the retinoblastoma protein | Q48795524 | ||
| Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain | Q48822557 | ||
| alpha-calcium-calmodulin-dependent kinase II is associated with paired helical filaments of Alzheimer's disease | Q48934721 | ||
| Reduction of calcineurin enzymatic activity in Alzheimer's disease: correlation with neuropathologic changes | Q48958065 | ||
| Interaction of cyclin-dependent kinase 5 (Cdk5) and neuronal Cdk5 activator in bovine brain. | Q49161768 | ||
| Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease | Q51288499 | ||
| Senile dementia of Alzheimer type characterized by laminar neuronal loss exclusively in the hippocampus, parahippocampus and medial occipitotemporal cortex. | Q52060398 | ||
| Rapid Alzheimer-like phosphorylation of tau by the synergistic actions of non-proline-dependent protein kinases and GSK-3. | Q52210516 | ||
| Senile dementia of the Alzheimer type without neocortical neurofibrillary tangles. | Q53189973 | ||
| Proline-directed and non-proline-directed phosphorylation of PHF-tau. | Q53203171 | ||
| Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II. | Q53322724 | ||
| The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity | Q59097192 | ||
| Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5 | Q60603655 | ||
| Molecular characterization of a neuronal-specific protein that stimulates the activity of Cdk5 | Q71689177 | ||
| P433 | issue | 1 | |
| P921 | main subject | Alzheimer's disease | Q11081 |
| P304 | page(s) | 21-29 | |
| P577 | publication date | 1999-05-01 | |
| P1433 | published in | Neuroscience Research | Q15764280 |
| P1476 | title | Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain | |
| P478 | volume | 34 |
| Q28576106 | A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons |
| Q34139509 | A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains |
| Q34279396 | Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles |
| Q40239614 | Abl deregulates Cdk5 kinase activity and subcellular localization in Drosophila neurodegeneration |
| Q35794568 | Absence of the Cdk5 activator p35 causes adult-onset neurodegeneration in the central brain of Drosophila |
| Q37606284 | Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies |
| Q36688393 | Advances in the pathogenesis of Alzheimer's disease: focusing on tau-mediated neurodegeneration |
| Q54379908 | Alterations of cyclin dependent kinase 5 expression and phosphorylation in amyloid precursor protein (APP)-transfected PC12 cells. |
| Q34077155 | CDK5 interacts with Slo and affects its surface expression and kinetics through direct phosphorylation |
| Q52981192 | CRMP1 Interacted with Spy1 During the Collapse of Growth Cones Induced by Sema3A and Acted on Regeneration After Sciatic Nerve Crush. |
| Q37570600 | Calcium in the initiation, progression and as an effector of Alzheimer's disease pathology |
| Q48399038 | Candidate genes, pathways and mechanisms for alcoholism: an expanded convergent functional genomics approach |
| Q33687591 | Cdk5 activity in the brain - multiple paths of regulation |
| Q34537614 | Cdk5 behind the wheel: a role in trafficking and transport? |
| Q30279162 | Cdk5 is a New Rapid Synaptic Homeostasis Regulator Capable of Initiating the Early Alzheimer-Like Pathology |
| Q48300530 | Cdk5 is a key factor in tau aggregation and tangle formation in vivo |
| Q34571448 | Cdk5 phosphorylation of EFhd2 at S74 affects its calcium binding activity |
| Q73748003 | Cdk5/p25(nck5a) interaction with synaptic proteins in bovine brain |
| Q24299163 | Cdk5: multitasking between physiological and pathological conditions |
| Q28200189 | Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry |
| Q42508999 | Constitutive Cdc25B tyrosine phosphatase activity in adult brain neurons with M phase-type alterations in Alzheimer's disease |
| Q37223230 | Crosstalk between Cdk5 and GSK3beta: Implications for Alzheimer's Disease |
| Q24305253 | Cyclin-dependent kinase 5 modulates the transcriptional activity of the mineralocorticoid receptor and regulates expression of brain-derived neurotrophic factor |
| Q34718758 | Cyclin-dependent kinase 5 promotes pancreatic β-cell survival via Fak-Akt signaling pathways. |
| Q48139851 | Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice. |
| Q36494716 | Deregulated Cdk5 activity is involved in inducing Alzheimer's disease |
| Q28578526 | Early growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brain |
| Q64051857 | Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer's disease pathology and cognitive symptoms |
| Q48532158 | Epigenetic modulation of Cdk5 contributes to memory deficiency induced by amyloid fibrils |
| Q56558091 | Fuzhisan, a Chinese herbal medicine, inhibits beta-amyloid-induced neurotoxicity and tau phosphorylation through calpain/Cdk5 pathway in cultured cortical neurons |
| Q35053214 | Gene discovery and validation for neurodegenerative diseases |
| Q28565510 | Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity |
| Q30855123 | Heat shock protein 90: translation from cancer to Alzheimer's disease treatment? |
| Q39836825 | Identification of non-muscle myosin heavy chain as a substrate for Cdk5 and tool for drug screening |
| Q33371464 | Identification of small molecule inhibitors of beta-amyloid cytotoxicity through a cell-based high-throughput screening platform |
| Q43507724 | Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? |
| Q38313548 | Interaction of neuronal Cdc2-like protein kinase with microtubule-associated protein tau. |
| Q38271896 | Invited review: Animal models of tauopathies and their implications for research/translation into the clinic |
| Q28383558 | Involvement of aberrant cyclin-dependent kinase 5/p25 activity in experimental traumatic brain injury |
| Q38108308 | Link between cancer and Alzheimer disease via oxidative stress induced by nitric oxide-dependent mitochondrial DNA overproliferation and deletion |
| Q44491452 | Mitotic-like tau phosphorylation by p25-Cdk5 kinase complex |
| Q35006021 | Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease. |
| Q33871297 | Molecular mechanisms of neurodegeneration in Alzheimer's disease |
| Q28082792 | Neuroprotective Mechanisms Mediated by CDK5 Inhibition |
| Q38173380 | Neuroprotective function of 14-3-3 proteins in neurodegeneration |
| Q39307016 | New Functions of APC/C Ubiquitin Ligase in the Nervous System and Its Role in Alzheimer's Disease |
| Q33483663 | No association of CDK5 genetic variants with Alzheimer's disease risk |
| Q28568204 | Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death |
| Q80940333 | Overexpression of GSK3betaS9A resulted in tau hyperphosphorylation and morphology reminiscent of pretangle-like neurons in the brain of PDGSK3beta transgenic mice |
| Q30613304 | Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25. |
| Q37295067 | Pharmacotherapeutic targets in Alzheimer's disease |
| Q38868081 | Phosphorylation of collapsin response mediator protein-2 disrupts neuronal maturation in a model of adult neurogenesis: Implications for neurodegenerative disorders |
| Q34533775 | Phosphorylation of glutamyl-prolyl tRNA synthetase by cyclin-dependent kinase 5 dictates transcript-selective translational control |
| Q38214594 | Protein phosphorylation in neurodegeneration: friend or foe? |
| Q37117419 | Rapid induction of intraneuronal neurofibrillary tangles in apolipoprotein E-deficient mice |
| Q48411067 | Regional expression of key cell cycle proteins in brain from subjects with amnestic mild cognitive impairment |
| Q36784909 | Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease. |
| Q46167371 | SORLA attenuates EphA4 signaling and amyloid β-induced neurodegeneration |
| Q24628256 | Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice |
| Q34913399 | Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. |
| Q35050284 | Tau neurofibrillary pathology and microtubule stability |
| Q47387876 | The GAIT translational control system |
| Q44406443 | The cyclin-dependent kinase 5 activator, p39, is expressed in stripes in the mouse cerebellum. |
| Q37145919 | The role of tau in neurodegeneration |
| Q36579740 | Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing |
| Q36836607 | Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases. |
| Q42729005 | Yeast as a model system to study tau biology. |
| Q34779285 | p25/CDK5 is partially involved in neuronal injury induced by radiofrequency electromagnetic field exposure. |
| Q53594164 | p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo. |
| Q74224124 | reply: Neurobiologyp25 protein in neurodegeneration |
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