| scholarly article | Q13442814 |
| P2093 | author name string | Harish C Pant | |
| Varsha Shukla | |||
| Susan Skuntz | |||
| P2860 | cites work | Tau pathology in Alzheimer disease and other tauopathies | Q22252520 |
| A family of human cdc2-related protein kinases | Q24300226 | ||
| p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5 | Q24320432 | ||
| Direct evidence of phosphorylated neuronal intermediate filament proteins in neurofibrillary tangles (NFTs): phosphoproteomics of Alzheimer's NFTs | Q24320601 | ||
| SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. | Q24601406 | ||
| Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice | Q24628256 | ||
| Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory | Q24645499 | ||
| Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau | Q24648590 | ||
| Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer's disease | Q27657129 | ||
| Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration | Q28140796 | ||
| p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton | Q28145210 | ||
| Neurotoxicity induces cleavage of p35 to p25 by calpain | Q28145382 | ||
| Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry | Q28200189 | ||
| New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry | Q28290064 | ||
| Cyclin-dependent kinase 5 is required for associative learning | Q28511889 | ||
| Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death | Q28568204 | ||
| A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons | Q28576106 | ||
| The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation | Q28577018 | ||
| Cdk5 is essential for synaptic vesicle endocytosis | Q28579572 | ||
| Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death | Q28587075 | ||
| p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment | Q28589437 | ||
| Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions | Q28591963 | ||
| Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective | Q29614702 | ||
| Tau suppression in a neurodegenerative mouse model improves memory function | Q29615831 | ||
| APP processing and synaptic function | Q29615873 | ||
| Neurodegenerative tauopathies | Q29619895 | ||
| Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression | Q33187332 | ||
| A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease | Q33292510 | ||
| Translating cell biology into therapeutic advances in Alzheimer's disease | Q33678168 | ||
| Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5. | Q33913155 | ||
| A decade of CDK5. | Q34093501 | ||
| A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation | Q34232193 | ||
| Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles | Q34279396 | ||
| Quantitative phosphoproteomic analysis of neuronal intermediate filament proteins (NF-M/H) in Alzheimer's disease by iTRAQ | Q34281634 | ||
| Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease | Q34415666 | ||
| Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs | Q34462500 | ||
| Leisure activities and the risk of amnestic mild cognitive impairment in the elderly | Q34483428 | ||
| Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to crossreaction with tau protein | Q34624802 | ||
| Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics | Q34988116 | ||
| Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5 | Q35084361 | ||
| Oxidative stress in neurodegeneration | Q35224677 | ||
| Identification of Caspase-6-mediated processing of the valosin containing protein (p97) in Alzheimer's disease: a novel link to dysfunction in ubiquitin proteasome system-mediated protein degradation | Q35276123 | ||
| The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism | Q35578655 | ||
| Detection of a Cdc2-related kinase associated with Alzheimer paired helical filaments. | Q35797860 | ||
| Cdk5 deregulation in the pathogenesis of Alzheimer's disease | Q35879533 | ||
| Tau phosphorylation: physiological and pathological consequences | Q35992168 | ||
| cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXK motifs in neurofilament proteins: isolation and characterization | Q36434952 | ||
| Peptides derived from Cdk5 activator p35, specifically inhibit deregulated activity of Cdk5. | Q36831783 | ||
| Caspases as therapeutic targets in Alzheimer's disease: is it time to "cut" to the chase? | Q36974610 | ||
| Distinct pools of beta-amyloid in Alzheimer disease-affected brain: a clinicopathologic study | Q36981858 | ||
| Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations | Q37010838 | ||
| Current approaches in the treatment of Alzheimer's disease | Q37136865 | ||
| Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects | Q37227424 | ||
| Aberrant neurofilament phosphorylation in Alzheimer disease | Q37692419 | ||
| Amyloid precursor protein processing and Alzheimer's disease | Q37860317 | ||
| Interaction of neuronal Cdc2-like protein kinase with microtubule-associated protein tau. | Q38313548 | ||
| Increased expression of cdk5/p25 in N2a cells leads to hyperphosphorylation and impaired axonal transport of neurofilament proteins | Q39739816 | ||
| Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation. | Q40165778 | ||
| Short amyloid-beta (Abeta) immunogens reduce cerebral Abeta load and learning deficits in an Alzheimer's disease mouse model in the absence of an Abeta-specific cellular immune response. | Q40328434 | ||
| Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau. | Q40704620 | ||
| Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease | Q41753192 | ||
| Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease | Q42557471 | ||
| APP processing is regulated by cytoplasmic phosphorylation | Q42917696 | ||
| Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer's disease | Q43117403 | ||
| Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid | Q43715880 | ||
| Cyclin-dependent kinase 5 (cdk5) activation requires interaction with three domains of p35. | Q43867857 | ||
| Intracellular Targets of Paullones. Identification following affinity purification on immobilized inhibitor | Q43966314 | ||
| Colocalization and fluorescence resonance energy transfer between cdk5 and AT8 suggests a close association in pre-neurofibrillary tangles and neurofibrillary tangles | Q44032768 | ||
| Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease | Q44060098 | ||
| A peptide derived from cyclin-dependent kinase activator (p35) specifically inhibits Cdk5 activity and phosphorylation of tau protein in transfected cells | Q44135928 | ||
| Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease | Q44270458 | ||
| Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease | Q44365109 | ||
| Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway. | Q44820147 | ||
| Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer's disease | Q45105706 | ||
| Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles | Q46332461 | ||
| Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons. | Q46733868 | ||
| Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease | Q46765734 | ||
| Cyclin-dependent kinase 5 increases perikaryal neurofilament phosphorylation and inhibits neurofilament axonal transport in response to oxidative stress | Q47436409 | ||
| Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration | Q47836277 | ||
| Alzheimer paired helical filaments. Restoration of the biological activity by dephosphorylation | Q48087390 | ||
| Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain. | Q48158450 | ||
| Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease | Q48247414 | ||
| Cdk5 is a key factor in tau aggregation and tangle formation in vivo | Q48300530 | ||
| p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway | Q48401217 | ||
| Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. | Q48404445 | ||
| Phosphorylated neurofilament antigens in neurofibrillary tangles in Alzheimer's disease. | Q48407350 | ||
| Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration. | Q48492166 | ||
| Activation of MKK6, an upstream activator of p38, in Alzheimer's disease | Q48733235 | ||
| Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction | Q50335730 | ||
| Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease | Q53311596 | ||
| Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II. | Q53322724 | ||
| Activation of the calpain/cdk5/p25 pathway in the girus cinguli in Parkinson's disease. | Q53518705 | ||
| Cyclin-dependent Kinase 5 (Cdk5) Activation Domain of Neuronal Cdk5 Activator | Q58035353 | ||
| Analysis of phosphorylation of tau with antibodies specific for phosphorylation sites | Q71488318 | ||
| Phosphorylation of human tau protein by microtubule-associated kinases: GSK3beta and cdk5 are key participants | Q73131783 | ||
| Alzheimer disease | Q74222937 | ||
| Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein | Q74736370 | ||
| P433 | issue | 8 | |
| P921 | main subject | Alzheimer's disease | Q11081 |
| P304 | page(s) | 655-662 | |
| P577 | publication date | 2012-11-07 | |
| P1433 | published in | Archives of Medical Research | Q15751494 |
| P1476 | title | Deregulated Cdk5 activity is involved in inducing Alzheimer's disease | |
| P478 | volume | 43 |
| Q28388637 | A Tale of the Good and Bad: Remodeling of the Microtubule Network in the Brain by Cdk5 |
| Q34109035 | Altered distribution of the EphA4 kinase in hippocampal brain tissue of patients with Alzheimer's disease correlates with pathology |
| Q26778149 | Alzheimer's Disease: Mechanism and Approach to Cell Therapy |
| Q37053942 | Analysis of the Inhibitory Elements in the p5 Peptide Fragment of the CDK5 Activator, p35, CDKR1 Protein |
| Q97532440 | Brain sterol flux mediated by cytochrome P450 46A1 affects membrane properties and membrane-dependent processes |
| Q38732547 | Calpain-1 and Calpain-2: The Yin and Yang of Synaptic Plasticity and Neurodegeneration |
| Q38213140 | Cdk5 regulates multiple cellular events in neural development, function and disease. |
| Q40801428 | Cdk5-Dependent Activation of Neuronal Inflammasomes in Parkinson's Disease. |
| Q28396052 | Cdk5-FOXO3a axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models |
| Q38656547 | Cdk5-Mcl-1 axis promotes mitochondrial dysfunction and neurodegeneration in Alzheimer's disease model. |
| Q36405673 | Cdk5r1 Overexpression Induces Primary β-Cell Proliferation. |
| Q38213536 | Copper as a key regulator of cell signalling pathways. |
| Q26765530 | Current Research Therapeutic Strategies for Alzheimer's Disease Treatment |
| Q37718997 | Deciphering the molecular profile of plaques, memory decline and neuron loss in two mouse models for Alzheimer's disease by deep sequencing |
| Q38976189 | Divergent and convergent roles for kinases and phosphatases in neurofilament dynamics |
| Q52142981 | Fibrillar Amyloid-β Accumulation Triggers an Inflammatory Mechanism Leading to Hyperphosphorylation of the Carboxyl-Terminal End of Tau Polypeptide in the Hippocampal Formation of the 3×Tg-AD Transgenic Mouse. |
| Q42654233 | Gene Network Construction from Microarray Data Identifies a Key Network Module and Several Candidate Hub Genes in Age-Associated Spatial Learning Impairment |
| Q64248689 | Golgi Complex Dynamics and Its Implication in Prevalent Neurological Disorders |
| Q31123604 | Hippocampal gene expression meta-analysis identifies aging and age-associated spatial learning impairment (ASLI) genes and pathways |
| Q51015642 | Inhibition of c-Jun N-terminal kinase activation reverses Alzheimer disease phenotypes in APPswe/PS1dE9 mice. |
| Q52790624 | Interstitial microdeletion of 17q11.2 is associated with hypotonia, fatigue, intellectual disability, and a subtle facial phenotype in three unrelated patients. |
| Q38202756 | Involvement of 'stress-response' kinase pathways in Alzheimer's disease progression |
| Q64061523 | LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer's disease brains |
| Q97516738 | Metformin Ameliorates Synaptic Defects in a Mouse Model of AD by Inhibiting Cdk5 Activity |
| Q89597137 | Much More Than a Scaffold: Cytoskeletal Proteins in Neurological Disorders |
| Q64103530 | MultiBac: Baculovirus-Mediated Multigene DNA Cargo Delivery in Insect and Mammalian Cells |
| Q89287833 | Multifaceted Regulation of ALDH1A1 by Cdk5 in Alzheimer's Disease Pathogenesis |
| Q48127566 | Novel miR-sc4 regulates the proliferation and migration of Schwann cells by targeting Cdk5r1. |
| Q38936146 | Perspectives for treating Alzheimer's disease: a review on promising pharmacological substances |
| Q57817550 | Phosphorylation, Dephosphorylation, and Multiprotein Assemblies Regulate Dynamic Behavior of Neuronal Cytoskeleton: A Mini-Review |
| Q26860395 | Physiological and pathological phosphorylation of tau by Cdk5 |
| Q34200115 | Prenatal alcohol exposure alters p35, CDK5 and GSK3β in the medial frontal cortex and hippocampus of adolescent mice |
| Q51546743 | Profiling of p5, a 24 Amino Acid Inhibitory Peptide Derived from the CDK5 Activator, p35 CDKR1 Against 70 Protein Kinases. |
| Q34884230 | Protein interaction module-assisted function X (PIMAX) approach to producing challenging proteins including hyperphosphorylated tau and active CDK5/p25 kinase complex |
| Q38214594 | Protein phosphorylation in neurodegeneration: friend or foe? |
| Q37687443 | Protein profiles associated with context fear conditioning and their modulation by memantine |
| Q39043782 | Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses |
| Q28834464 | S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration |
| Q35669383 | Sigma-1 receptor regulates Tau phosphorylation and axon extension by shaping p35 turnover via myristic acid |
| Q34776047 | Soluble alpha-APP (sAPPalpha) regulates CDK5 expression and activity in neurons |
| Q33865294 | Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice |
| Q41780599 | Stress-Induced CDK5 Activation Disrupts Axonal Transport via Lis1/Ndel1/Dynein |
| Q37289231 | Structural basis for the different stability and activity between the Cdk5 complexes with p35 and p39 activators |
| Q30572403 | Suppression of neuroinflammation in forebrain-specific Cdk5 conditional knockout mice by PPARγ agonist improves neuronal loss and early lethality |
| Q27026829 | Synaptic dysfunction and septin protein family members in neurodegenerative diseases |
| Q37288349 | TFP5 prevents 1-methyl-4-phenyl pyridine ion-induced neurotoxicity in mouse cortical neurons |
| Q39304793 | Tale of the Good and the Bad Cdk5: Remodeling of the Actin Cytoskeleton in the Brain. |
| Q38203031 | Tau acts as a mediator for Alzheimer's disease-related synaptic deficits. |
| Q57178723 | Tau-targeting therapies for Alzheimer disease |
| Q48451338 | The Crucial Role of Cyclin-Dependent Kinase-5-Ataxia-Telangiectasia Mutated Axis in ICH-Induced Neuronal Injury of Rat Model |
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| Q48185617 | The miR-15/107 Family of microRNA Genes Regulates CDK5R1/p35 with Implications for Alzheimer's Disease Pathogenesis |
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| Q33702585 | Tibolone modulates neuronal plasticity through regulating Tau, GSK3β/Akt/PI3K pathway and CDK5 p35/p25 complexes in the hippocampus of aged male mice. |
| Q37457439 | Transient enhancement of proliferation of neural progenitors and impairment of their long-term survival in p25 transgenic mice. |
| Q38928927 | Treatment strategies in Alzheimer's disease: a review with focus on selenium supplementation |
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