scholarly article | Q13442814 |
P50 | author | Lisa Kirouac | Q96051689 |
Jaya Padmanabhan | Q96051690 | ||
P2093 | author name string | David H Cribbs | |
Alexander J Rajic | |||
P2860 | cites work | Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules | Q24302556 |
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease | Q24316501 | ||
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory | Q24645499 | ||
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei | Q27860728 | ||
Neuropathological stageing of Alzheimer-related changes | Q27860862 | ||
Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta | Q28139977 | ||
p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected] | Q28212545 | ||
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease | Q28241772 | ||
Cyclin D1 is a nuclear protein required for cell cycle progression in G1 | Q28269145 | ||
Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity | Q28276393 | ||
Candidate gene for the chromosome 1 familial Alzheimer's disease locus | Q28295424 | ||
Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1 | Q28506045 | ||
Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extension | Q28513050 | ||
Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease | Q28854273 | ||
A specific amyloid-beta protein assembly in the brain impairs memory | Q28854597 | ||
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins | Q29547593 | ||
Neurogenic effect of beta-amyloid peptide in the development of neural stem cells. | Q30981855 | ||
Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F x DP, in B-amyloid-induced neuronal death | Q33178580 | ||
Elevated expression of p21ras is an early event in Alzheimer's disease and precedes neurofibrillary degeneration | Q33640174 | ||
The role of cell cycle-mediated events in Alzheimer's disease | Q33723773 | ||
Driven to death: Inhibition of farnesylation increases Ras activity and promotes growth arrest and cell death [corrected] | Q33843725 | ||
Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5. | Q33913155 | ||
Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels | Q33931836 | ||
p44mpk MAP kinase induces aizheimer type alterations in tau function and in primary hippocampal neurons | Q48264016 | ||
Secreted amyloid precursor protein and holo-APP bind amyloid beta through distinct domains eliciting different toxic responses on hippocampal neurons. | Q48307679 | ||
Signal transduction abnormalities in Alzheimer's disease: evidence of a pathogenic stimuli | Q48312866 | ||
Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons | Q48354068 | ||
Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase | Q48406074 | ||
Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease | Q48407971 | ||
The regulation of phosphorylation of tau in SY5Y neuroblastoma cells: the role of protein phosphatases | Q48464116 | ||
Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain. | Q48487273 | ||
Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein | Q48634030 | ||
Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain | Q48706959 | ||
Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions | Q48786969 | ||
Glycogen synthase kinase 3beta phosphorylates tau at both primed and unprimed sites. Differential impact on microtubule binding. | Q51842084 | ||
Increased expression and subcellular translocation of the mitogen activated protein kinase kinase and mitogen-activated protein kinase in Alzheimer's disease. | Q53199479 | ||
Induction of p21ras in Alzheimer pathology. | Q53199609 | ||
Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease. | Q53234381 | ||
Clinical validity of Braak neuropathological staging in the oldest-old | Q53234837 | ||
Amyloid-beta precursor protein mediates neuronal toxicity of amyloid beta through Go protein activation. | Q53291495 | ||
Different fibrillar Abeta 1-42 concentrations induce adult hippocampal neurons to reenter various phases of the cell cycle. | Q53473145 | ||
beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding. | Q54447659 | ||
The APP intracellular domain (AICD) inhibits Wnt signalling and promotes neurite outgrowth. | Q54509670 | ||
Hyperphosphorylation of the cytoskeletal protein Tau by the MAP-kinase PK40erk2: regulation by prior phosphorylation with cAMP-dependent protein kinase A. | Q54601389 | ||
Mitotic signaling by beta-amyloid causes neuronal death | Q73263325 | ||
PD98059 prevents neurite degeneration induced by fibrillar beta-amyloid in mature hippocampal neurons | Q73315889 | ||
Activated mitogenic signaling induces a process of dedifferentiation in Alzheimer's disease that eventually results in cell death. | Q34148259 | ||
Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease. | Q34148953 | ||
Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum? | Q34183637 | ||
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene | Q34303468 | ||
A cdc2-related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline-directed protein kinase associated with microtubule | Q34345777 | ||
In vitro phosphorylation of the cytoplasmic domain of the amyloid precursor protein by glycogen synthase kinase-3beta | Q34393147 | ||
The role of apolipoprotein E in Alzheimer's disease | Q34603092 | ||
Phosphorylation of amyloid precursor protein (APP) at Thr668 regulates the nuclear translocation of the APP intracellular domain and induces neurodegeneration | Q34718043 | ||
Abeta induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624) | Q35740815 | ||
Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration | Q35795163 | ||
Ras trafficking, localization and compartmentalized signalling | Q36043314 | ||
Nuclear translocation of mitogen-activated protein kinase kinase (MEK1) in response to mitogenic stimulation | Q36105057 | ||
Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain | Q36320330 | ||
Preparing Synthetic Aβ in Different Aggregation States | Q37119634 | ||
Evidence for impaired amyloid β clearance in Alzheimer's disease | Q37690374 | ||
Neurodegeneration in Alzheimer disease: role of amyloid precursor protein and presenilin 1 intracellular signaling | Q38002023 | ||
Beta-amyloid-induced neurotoxicity of a hybrid septal cell line associated with increased tau phosphorylation and expression of beta-amyloid precursor protein | Q38343231 | ||
Ras signal triggers β-amyloid precursor protein (APP) expression | Q38627128 | ||
SILAC-based proteomic analysis to investigate the impact of amyloid precursor protein expression in neuronal-like B103 cells | Q39242927 | ||
Is abnormal axonal transport a cause, a contributing factor or a consequence of the neuronal pathology in Alzheimer's disease? | Q39909606 | ||
The binding and phosphorylation of Thr231 is critical for Tau's hyperphosphorylation and functional regulation by glycogen synthase kinase 3beta | Q40097597 | ||
Amyloid precursor protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK 1,2 signaling | Q40168518 | ||
Staging of Alzheimer's disease-related neurofibrillary changes | Q40416705 | ||
Farnesyltransferase inhibitor (L-744,832) restores TGF-beta type II receptor expression and enhances radiation sensitivity in K-ras mutant pancreatic cancer cell line MIA PaCa-2. | Q40691694 | ||
Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein | Q40791095 | ||
Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells | Q40952400 | ||
Unconventional rapid Erk1,2 activation is indispensable for proliferation of the growth factor-independent myeloid leukemic cell line KG1. | Q41041913 | ||
Nerve growth factor and ras regulate beta-amyloid precursor protein gene expression in PC12 cells | Q41190133 | ||
Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells. | Q41423732 | ||
Amyloid, the presenilins and Alzheimer's disease | Q41433661 | ||
Mitosis-specific phosphorylation of amyloid precursor protein at threonine 668 leads to its altered processing and association with centrosomes | Q41441508 | ||
Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state | Q41525580 | ||
Phosphorylation of tau by glycogen synthase kinase 3beta affects the ability of tau to promote microtubule self-assembly | Q42028884 | ||
Cholecystokinin and EGF activate a MAPK cascade by different mechanisms in rat pancreatic acinar cells | Q42447277 | ||
Phosphorylated map kinase (ERK1, ERK2) expression is associated with early tau deposition in neurones and glial cells, but not with increased nuclear DNA vulnerability and cell death, in Alzheimer disease, Pick's disease, progressive supranuclear pa | Q42502827 | ||
Extracellular signal regulated kinases. Localization of protein and mRNA in the human hippocampal formation in Alzheimer's disease | Q42754690 | ||
Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein | Q42827866 | ||
APP processing is regulated by cytoplasmic phosphorylation | Q42917696 | ||
Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3). | Q43516562 | ||
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils | Q43718666 | ||
p42/p44 mitogen-activated protein kinases activation is required for the insulin-like growth factor-I/insulin induced proliferation, but inhibits differentiation, in rat fetal brown adipocytes | Q47974780 | ||
ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo | Q48087583 | ||
Activation of the L voltage-sensitive calcium channel by mitogen-activated protein (MAP) kinase following exposure of neuronal cells to beta-amyloid. MAP kinase mediates beta-amyloid-induced neurodegeneration | Q48095794 | ||
Hyperphosphorylation of human TAU by brain kinase PK40erk beyond phosphorylation by cAMP-dependent PKA: relation to Alzheimer's disease | Q48139408 | ||
Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neurites | Q48233856 | ||
P4510 | describes a project that uses | ImageJ | Q1659584 |
P433 | issue | 2 | |
P921 | main subject | Alzheimer's disease | Q11081 |
neurodegeneration | Q1755122 | ||
P577 | publication date | 2017-03-27 | |
P1433 | published in | eNeuro | Q27726083 |
P1476 | title | Activation of Ras-ERK Signaling and GSK-3 by Amyloid Precursor Protein and Amyloid Beta Facilitates Neurodegeneration in Alzheimer's Disease | |
P478 | volume | 4 |
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