Activation of Ras-ERK Signaling and GSK-3 by Amyloid Precursor Protein and Amyloid Beta Facilitates Neurodegeneration in Alzheimer's Disease

scientific article

Activation of Ras-ERK Signaling and GSK-3 by Amyloid Precursor Protein and Amyloid Beta Facilitates Neurodegeneration in Alzheimer's Disease is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1523/ENEURO.0149-16.2017
P932PMC publication ID5367084
P698PubMed publication ID28374012

P50authorLisa KirouacQ96051689
Jaya PadmanabhanQ96051690
P2093author name stringDavid H Cribbs
Alexander J Rajic
P2860cites workPrimed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubulesQ24302556
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's diseaseQ24316501
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memoryQ24645499
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nucleiQ27860728
Neuropathological stageing of Alzheimer-related changesQ27860862
Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3betaQ28139977
p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]Q28212545
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's diseaseQ28241772
Cyclin D1 is a nuclear protein required for cell cycle progression in G1Q28269145
Aging renders the brain vulnerable to amyloid beta-protein neurotoxicityQ28276393
Candidate gene for the chromosome 1 familial Alzheimer's disease locusQ28295424
Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1Q28506045
Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extensionQ28513050
Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's diseaseQ28854273
A specific amyloid-beta protein assembly in the brain impairs memoryQ28854597
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxinsQ29547593
Neurogenic effect of beta-amyloid peptide in the development of neural stem cells.Q30981855
Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F x DP, in B-amyloid-induced neuronal deathQ33178580
Elevated expression of p21ras is an early event in Alzheimer's disease and precedes neurofibrillary degenerationQ33640174
The role of cell cycle-mediated events in Alzheimer's diseaseQ33723773
Driven to death: Inhibition of farnesylation increases Ras activity and promotes growth arrest and cell death [corrected]Q33843725
Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5.Q33913155
Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vesselsQ33931836
p44mpk MAP kinase induces aizheimer type alterations in tau function and in primary hippocampal neuronsQ48264016
Secreted amyloid precursor protein and holo-APP bind amyloid beta through distinct domains eliciting different toxic responses on hippocampal neurons.Q48307679
Signal transduction abnormalities in Alzheimer's disease: evidence of a pathogenic stimuliQ48312866
Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neuronsQ48354068
Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinaseQ48406074
Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's diseaseQ48407971
The regulation of phosphorylation of tau in SY5Y neuroblastoma cells: the role of protein phosphatasesQ48464116
Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain.Q48487273
Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril proteinQ48634030
Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brainQ48706959
Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditionsQ48786969
Glycogen synthase kinase 3beta phosphorylates tau at both primed and unprimed sites. Differential impact on microtubule binding.Q51842084
Increased expression and subcellular translocation of the mitogen activated protein kinase kinase and mitogen-activated protein kinase in Alzheimer's disease.Q53199479
Induction of p21ras in Alzheimer pathology.Q53199609
Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease.Q53234381
Clinical validity of Braak neuropathological staging in the oldest-oldQ53234837
Amyloid-beta precursor protein mediates neuronal toxicity of amyloid beta through Go protein activation.Q53291495
Different fibrillar Abeta 1-42 concentrations induce adult hippocampal neurons to reenter various phases of the cell cycle.Q53473145
beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding.Q54447659
The APP intracellular domain (AICD) inhibits Wnt signalling and promotes neurite outgrowth.Q54509670
Hyperphosphorylation of the cytoskeletal protein Tau by the MAP-kinase PK40erk2: regulation by prior phosphorylation with cAMP-dependent protein kinase A.Q54601389
Mitotic signaling by beta-amyloid causes neuronal deathQ73263325
PD98059 prevents neurite degeneration induced by fibrillar beta-amyloid in mature hippocampal neuronsQ73315889
Activated mitogenic signaling induces a process of dedifferentiation in Alzheimer's disease that eventually results in cell death.Q34148259
Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease.Q34148953
Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?Q34183637
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 geneQ34303468
A cdc2-related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline-directed protein kinase associated with microtubuleQ34345777
In vitro phosphorylation of the cytoplasmic domain of the amyloid precursor protein by glycogen synthase kinase-3betaQ34393147
The role of apolipoprotein E in Alzheimer's diseaseQ34603092
Phosphorylation of amyloid precursor protein (APP) at Thr668 regulates the nuclear translocation of the APP intracellular domain and induces neurodegenerationQ34718043
Abeta induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624)Q35740815
Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegenerationQ35795163
Ras trafficking, localization and compartmentalized signallingQ36043314
Nuclear translocation of mitogen-activated protein kinase kinase (MEK1) in response to mitogenic stimulationQ36105057
Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domainQ36320330
Preparing Synthetic Aβ in Different Aggregation StatesQ37119634
Evidence for impaired amyloid β clearance in Alzheimer's diseaseQ37690374
Neurodegeneration in Alzheimer disease: role of amyloid precursor protein and presenilin 1 intracellular signalingQ38002023
Beta-amyloid-induced neurotoxicity of a hybrid septal cell line associated with increased tau phosphorylation and expression of beta-amyloid precursor proteinQ38343231
Ras signal triggers β-amyloid precursor protein (APP) expressionQ38627128
SILAC-based proteomic analysis to investigate the impact of amyloid precursor protein expression in neuronal-like B103 cellsQ39242927
Is abnormal axonal transport a cause, a contributing factor or a consequence of the neuronal pathology in Alzheimer's disease?Q39909606
The binding and phosphorylation of Thr231 is critical for Tau's hyperphosphorylation and functional regulation by glycogen synthase kinase 3betaQ40097597
Amyloid precursor protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK 1,2 signalingQ40168518
Staging of Alzheimer's disease-related neurofibrillary changesQ40416705
Farnesyltransferase inhibitor (L-744,832) restores TGF-beta type II receptor expression and enhances radiation sensitivity in K-ras mutant pancreatic cancer cell line MIA PaCa-2.Q40691694
Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor proteinQ40791095
Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cellsQ40952400
Unconventional rapid Erk1,2 activation is indispensable for proliferation of the growth factor-independent myeloid leukemic cell line KG1.Q41041913
Nerve growth factor and ras regulate beta-amyloid precursor protein gene expression in PC12 cellsQ41190133
Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.Q41423732
Amyloid, the presenilins and Alzheimer's diseaseQ41433661
Mitosis-specific phosphorylation of amyloid precursor protein at threonine 668 leads to its altered processing and association with centrosomesQ41441508
Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like stateQ41525580
Phosphorylation of tau by glycogen synthase kinase 3beta affects the ability of tau to promote microtubule self-assemblyQ42028884
Cholecystokinin and EGF activate a MAPK cascade by different mechanisms in rat pancreatic acinar cellsQ42447277
Phosphorylated map kinase (ERK1, ERK2) expression is associated with early tau deposition in neurones and glial cells, but not with increased nuclear DNA vulnerability and cell death, in Alzheimer disease, Pick's disease, progressive supranuclear paQ42502827
Extracellular signal regulated kinases. Localization of protein and mRNA in the human hippocampal formation in Alzheimer's diseaseQ42754690
Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau proteinQ42827866
APP processing is regulated by cytoplasmic phosphorylationQ42917696
Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3).Q43516562
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrilsQ43718666
p42/p44 mitogen-activated protein kinases activation is required for the insulin-like growth factor-I/insulin induced proliferation, but inhibits differentiation, in rat fetal brown adipocytesQ47974780
ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivoQ48087583
Activation of the L voltage-sensitive calcium channel by mitogen-activated protein (MAP) kinase following exposure of neuronal cells to beta-amyloid. MAP kinase mediates beta-amyloid-induced neurodegenerationQ48095794
Hyperphosphorylation of human TAU by brain kinase PK40erk beyond phosphorylation by cAMP-dependent PKA: relation to Alzheimer's diseaseQ48139408
Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neuritesQ48233856
P4510describes a project that usesImageJQ1659584
P433issue2
P921main subjectAlzheimer's diseaseQ11081
neurodegenerationQ1755122
P577publication date2017-03-27
P1433published ineNeuroQ27726083
P1476titleActivation of Ras-ERK Signaling and GSK-3 by Amyloid Precursor Protein and Amyloid Beta Facilitates Neurodegeneration in Alzheimer's Disease
P478volume4

Reverse relations

cites work (P2860)
Q92937324"Amyloid-beta accumulation cycle" as a prevention and/or therapy target for Alzheimer's disease
Q600456145-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer's disease
Q64111898A novel role of HuR in -Epigallocatechin-3-gallate (EGCG) induces tumour cells apoptosis
Q90113025APP Maturation and Intracellular Localization Are Controlled by a Specific Inhibitor of 37/67 kDa Laminin-1 Receptor in Neuronal Cells
Q59336577Active full-length DNA Aβ immunization in 3xTg-AD mice reduces not only amyloid deposition but also tau pathology
Q57168692Amyloid-β interrupts canonical Sonic hedgehog signaling by distorting primary cilia structure
Q33766908Berberine Ameliorates Diabetes-Associated Cognitive Decline through Modulation of Aberrant Inflammation Response and Insulin Signaling Pathway in DM Rats
Q89749533CEPO (carbamylated erythropoietin)-Fc protects hippocampal cells in culture against beta amyloid-induced apoptosis: considering Akt/GSK-3β and ERK signaling pathways
Q50420748Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease.
Q98292629Gamma radiation improves AD pathogenesis in APP/PS1 mouse model by potentiating insulin sensitivity
Q47443049Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP.
Q90433497Influence of hippocampal GABAB receptor inhibition on memory in rats with acute β-amyloid toxicity
Q58733448Investigating the role of P38, JNK and ERK in LPS induced hippocampal insulin resistance and spatial memory impairment: effects of insulin treatment
Q54223105Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer's disease.
Q60046048N-Acetylcysteine Prevents the Spatial Memory Deficits and the Redox-Dependent RyR2 Decrease Displayed by an Alzheimer’s Disease Rat Model
Q91827638Neuroprotective Effect of S-trans, Trans-farnesylthiosalicylic Acid via Inhibition of RAS/ERK Pathway for the Treatment of Alzheimer's Disease
Q60932964Pathogenic Feed-Forward Mechanisms in Alzheimer's and Parkinson's Disease Converge on GSK-3
Q90017061Pharmacological inhibition of glycogen synthase kinase 3 increases operant alcohol self-administration in a manner associated with altered pGSK-3β, protein interacting with C kinase and GluA2 protein expression in the reward pathway of male C57BL/6J
Q92518340Physiological and pathological effects of amyloid-β species in neural stem cell biology
Q89975356Protein Kinase C Isozymes and Autophagy during Neurodegenerative Disease Progression
Q92684821RvE1 treatment prevents memory loss and neuroinflammation in the Ts65Dn mouse model of Down syndrome
Q64916582Small-Molecule SB216763-Loaded Microspheres Repair Peripheral Nerve Injury in Small Gap Tubulization.
Q89228031The Effect of BSA-Based Curcumin Nanoparticles on Memory and Hippocampal MMP-2, MMP-9, and MAPKs in Adult Mice
Q89287765The Transcriptional Regulatory Properties of Amyloid Beta 1-42 may Include Regulation of Genes Related to Neurodegeneration
Q91866908Therapeutic Potential of the Hsp90/Cdc37 Interaction in Neurodegenerative Diseases

Search more.