A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function.

scientific article

A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.C111.219873
P932PMC publication ID3059018
P698PubMed publication ID21266574

P50authorLuciano D'AdamioQ52350188
P2093author name stringHui Zheng
Zilai Wang
Alessia P M Barbagallo
P2860cites workTyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with ShcQ24292400
Amino-terminal region of secreted form of amyloid precursor protein stimulates proliferation of neural stem cellsQ77773293
Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42Q77926799
Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporterQ24337889
Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domainQ24536014
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APPQ26269904
Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesisQ26269915
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptideQ28131750
Mints as adaptors. Direct binding to neurexins and recruitment of munc18Q28141531
A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60Q28205099
SynCAM, a synaptic adhesion molecule that drives synapse assemblyQ28219424
CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexinsQ28288628
Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor proteinQ28513133
Neurobehavioral development, adult openfield exploration and swimming navigation learning in mice with a modified beta-amyloid precursor protein geneQ28513269
Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein geneQ28586800
Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2Q28589908
Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO miceQ28590025
beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activityQ28593175
Signal-dependent membrane protein trafficking in the endocytic pathwayQ29622948
Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivoQ33754509
JNK-interacting protein-1 promotes transcription of A beta protein precursor but not A beta precursor-like proteins, mechanistically different than Fe65Q34761715
Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis.Q35000938
APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viabilityQ35629330
Adaptor protein interactions: modulators of amyloid precursor protein metabolism and Alzheimer's disease risk?Q35635088
Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursorQ35638734
Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice.Q36530142
Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional roleQ36882015
The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domainsQ37295364
Novel mediators of amyloid precursor protein signalingQ39762318
Phosphorylation of a tyrosine in the amyloid-beta protein precursor intracellular domain inhibits Fe65 binding and signaling.Q39883256
The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.Q40106778
Evidence for a role of the nerve growth factor receptor TrkA in tyrosine phosphorylation and processing of beta-APP.Q40714164
Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.Q42495065
Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain.Q44041873
Amyloid beta protein precursor (AbetaPP), but not AbetaPP-like protein 2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1.Q44534322
Growth factor receptor-bound protein 2 interaction with the tyrosine-phosphorylated tail of amyloid beta precursor protein is mediated by its Src homology 2 domain.Q44822089
Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor.Q48492125
Alzheimer amyloid protein precursor enhances proliferation of neural stem cells from fetal rat brainQ72903742
P4510describes a project that usesImageJQ1659584
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)8717-8721
P577publication date2011-01-25
P1433published inJournal of Biological ChemistryQ867727
P1476titleA single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function
P478volume286

Reverse relations

cites work (P2860)
Q33661653A new molecular explanation for age-related neurodegeneration: the Tyr682 residue of amyloid precursor protein
Q28551424APP Is a Context-Sensitive Regulator of the Hippocampal Presynaptic Active Zone
Q39251175APP Protein Family Signaling at the Synapse: Insights from Intracellular APP-Binding Proteins
Q36585916APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses
Q36347215APP intracellular domain acts as a transcriptional regulator of miR-663 suppressing neuronal differentiation.
Q28543167APP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functions
Q35870089APP is phosphorylated by TrkA and regulates NGF/TrkA signaling
Q37902514APP physiological and pathophysiological functions: insights from animal models.
Q41045804Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration
Q30531725Amyloid precursor protein (APP) regulates synaptic structure and function
Q26769909Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
Q37869935Biology and pathophysiology of the amyloid precursor protein
Q34255981Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function.
Q27316665FE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation
Q37935600Functions of the APP gene family in the nervous system: insights from mouse models
Q34251023Knockdown of amyloid precursor protein in zebrafish causes defects in motor axon outgrowth
Q34288710Neddylation dysfunction in Alzheimer's disease
Q37408544Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer's Disease
Q39209681Not just amyloid: physiological functions of the amyloid precursor protein family
Q89544702Opposite changes in APP processing and human Aβ levels in rats carrying either a protective or a pathogenic APP mutation
Q37987144Physiological functions of APP family proteins
Q38109402Redundancy and divergence in the amyloid precursor protein family
Q27687528Structural aspects and physiological consequences of APP/APLP trans-dimerization
Q40874327The APP Intracellular Domain Is Required for Normal Synaptic Morphology, Synaptic Plasticity, and Hippocampus-Dependent Behavior.
Q34708261The intracellular threonine of amyloid precursor protein that is essential for docking of Pin1 is dispensable for developmental function.
Q27026919The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes
Q98386132TrkB receptor cleavage by delta-secretase abolishes its phosphorylation of APP, aggravating Alzheimer's disease pathologies
Q34854001Turnover of amyloid precursor protein family members determines their nuclear signaling capability
Q36405899Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance
Q35297339Y682G Mutation of Amyloid Precursor Protein Promotes Endo-Lysosomal Dysfunction by Disrupting APP-SorLA Interaction.

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