| scholarly article | Q13442814 |
| P2093 | author name string | Martin Korte | |
| Susann Ludewig | |||
| P2860 | cites work | A synaptic model of memory: long-term potentiation in the hippocampus | Q22337276 |
| Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors | Q24294213 | ||
| Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor | Q24317632 | ||
| Homo- and heterodimerization of APP family members promotes intercellular adhesion | Q24337232 | ||
| Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path | Q24538964 | ||
| Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory | Q24645499 | ||
| Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake | Q24656613 | ||
| Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP | Q26269904 | ||
| The Amyloid Precursor Protein-A Novel Player within the Molecular Array of Presynaptic Nanomachines | Q26772807 | ||
| Roles of the amyloid precursor protein family in the peripheral nervous system | Q26825226 | ||
| Dynamic learning and memory, synaptic plasticity and neurogenesis: an update | Q26864054 | ||
| FE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation | Q27316665 | ||
| Structural aspects and physiological consequences of APP/APLP trans-dimerization | Q27687528 | ||
| Amyloid precursor protein dimerization and synaptogenic function depend on copper binding to the growth factor-like domain | Q27694782 | ||
| Cellular functions of the amyloid precursor protein from development to dementia | Q28087171 | ||
| Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein | Q28138703 | ||
| Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory | Q28202553 | ||
| A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60 | Q28205099 | ||
| Short-term synaptic plasticity | Q28217342 | ||
| The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation | Q28245707 | ||
| Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density | Q28284762 | ||
| Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions. | Q45896474 | ||
| Secreted amyloid precursor protein-alpha upregulates synaptic protein synthesis by a protein kinase G-dependent mechanism. | Q45999808 | ||
| Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy. | Q46084355 | ||
| Activity requires soluble amyloid precursor protein alpha to promote neurite outgrowth in neural stem cell-derived neurons via activation of the MAPK pathway. | Q46418672 | ||
| Endogenous secreted amyloid precursor protein-alpha regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory | Q46515073 | ||
| APP homodimers transduce an amyloid-β-mediated increase in release probability at excitatory synapses | Q46616848 | ||
| Soluble amyloid-β precursor protein binds its cell surface receptor in a cooperative fashion with glypican and syndecan proteoglycans | Q46971074 | ||
| Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein li | Q47357147 | ||
| Amyloid Precursor Protein Protects Neuronal Network Function after Hypoxia via Control of Voltage-Gated Calcium Channels. | Q48045724 | ||
| Increase in extracellular NCAM and amyloid precursor protein following induction of long-term potentiation in the dentate gyrus of anaesthetized rats | Q48157101 | ||
| Hypersensitivity to seizures in beta-amyloid precursor protein deficient mice | Q48236519 | ||
| Modular composition and dynamics of native GABAB receptors identified by high-resolution proteomics. | Q48276818 | ||
| APLP1 and APLP2, members of the APP family of proteins, behave similarly to APP in that they associate with NMDA receptors and enhance NMDA receptor surface expression | Q48327983 | ||
| Electrophysiological and cerebrovascular effects of the alpha-secretase-derived form of amyloid precursor protein in young and middle-aged rats | Q48342604 | ||
| Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity. | Q48444707 | ||
| Amyloid precursor protein knockout diminishes synaptic vesicle proteins at the presynaptic active zone in mouse brain | Q48459747 | ||
| Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. | Q48643108 | ||
| Cell-specific expression of beta-amyloid precursor protein isoform mRNAs and proteins in neurons and astrocytes | Q48672944 | ||
| Processing of amyloid precursor protein in human primary neuron and astrocyte cultures. | Q48793487 | ||
| Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease. | Q48920532 | ||
| Amyloid precursor-like protein 1 (APLP1) exhibits stronger zinc-dependent neuronal adhesion than amyloid precursor protein and APLP2. | Q48954585 | ||
| sAβPPα Improves Hippocampal NMDA-Dependent Functional Alterations Linked to Healthy Aging. | Q50706672 | ||
| The role of the low-density lipoprotein receptor-related protein (LRP1) in Alzheimer's A beta generation: development of a cell-based model system. | Q51843480 | ||
| Similar levels of long-term potentiation in amyloid precursor protein -null and wild-type mice in the CA1 region of picrotoxin treated slices. | Q53236126 | ||
| Differential role of APP and APLPs for neuromuscular synaptic morphology and function. | Q53466455 | ||
| Amino-terminal region of the beta-amyloid precursor protein activates mitogen-activated protein kinase | Q70921280 | ||
| Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42 | Q77926799 | ||
| Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development | Q28506956 | ||
| APP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functions | Q28543167 | ||
| APP Is a Context-Sensitive Regulator of the Hippocampal Presynaptic Active Zone | Q28551424 | ||
| Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2 | Q28589908 | ||
| Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice | Q28590025 | ||
| Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus | Q28592777 | ||
| Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein | Q28592893 | ||
| Alzheimer's disease is a synaptic failure | Q29547670 | ||
| The molecular biology of memory storage: a dialogue between genes and synapses | Q29547845 | ||
| APP processing and synaptic function | Q29615873 | ||
| Amyloid precursor protein trafficking, processing, and function | Q29617429 | ||
| Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease | Q30080016 | ||
| Amyloid precursor protein (APP) regulates synaptic structure and function | Q30531725 | ||
| TiGER: a database for tissue-specific gene expression and regulation | Q33341488 | ||
| Neuroanatomical localization and quantification of amyloid precursor protein mRNA by in situ hybridization in the brains of normal, aneuploid, and lesioned mice | Q33575703 | ||
| Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression | Q33622388 | ||
| Alzheimer precursor protein interaction with the Nogo-66 receptor reduces amyloid-beta plaque deposition | Q33756388 | ||
| A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. | Q34049859 | ||
| Genomic organization of the human amyloid beta-protein precursor gene | Q34151473 | ||
| The role of APP and APLP for synaptic transmission, plasticity, and network function: lessons from genetic mouse models | Q34225079 | ||
| Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis | Q34240868 | ||
| Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function. | Q34255981 | ||
| The amyloid precursor protein controls adult hippocampal neurogenesis through GABAergic interneurons | Q34268936 | ||
| Regulation of presynaptic Ca2+, synaptic plasticity and contextual fear conditioning by a N-terminal β-amyloid fragment | Q34383395 | ||
| The APP family of proteins: similarities and differences | Q34610073 | ||
| Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides | Q34631864 | ||
| Time-dependent changes in gene expression induced by secreted amyloid precursor protein-alpha in the rat hippocampus | Q34761829 | ||
| Soluble alpha-APP (sAPPalpha) regulates CDK5 expression and activity in neurons | Q34776047 | ||
| Identification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro | Q35014671 | ||
| APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP. | Q35052570 | ||
| Soluble β-amyloid Precursor Protein Alpha binds to p75 neurotrophin receptor to promote neurite outgrowth | Q35072706 | ||
| Role of key aromatic residues in the ligand-binding domain of alpha7 nicotinic receptors in the agonist action of beta-amyloid | Q35311317 | ||
| Deletion of the amyloid precursor-like protein 1 (APLP1) enhances excitatory synaptic transmission, reduces network inhibition but does not impair synaptic plasticity in the mouse dentate gyrus. | Q35569822 | ||
| Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway. | Q35679568 | ||
| η-Secretase processing of APP inhibits neuronal activity in the hippocampus | Q35760228 | ||
| Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment | Q35957965 | ||
| Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease | Q35980016 | ||
| Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices | Q36342500 | ||
| APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses | Q36585916 | ||
| Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP). | Q36761978 | ||
| Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D-serine homeostasis | Q37348863 | ||
| Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors | Q37427458 | ||
| Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease | Q37633601 | ||
| Posttranslational modifications of amyloid precursor protein : ectodomain phosphorylation and sulfation | Q37841241 | ||
| Role of APP and Aβ in synaptic physiology | Q37878495 | ||
| APP physiological and pathophysiological functions: insights from animal models. | Q37902514 | ||
| Functions of the APP gene family in the nervous system: insights from mouse models | Q37935600 | ||
| Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging | Q37956562 | ||
| Physiological functions of APP family proteins | Q37987144 | ||
| Neurotoxicity of amyloid β-protein: synaptic and network dysfunction | Q38023860 | ||
| Consequences of inhibiting amyloid precursor protein processing enzymes on synaptic function and plasticity | Q38026045 | ||
| D-Amino acids in brain neurotransmission and synaptic plasticity | Q38034082 | ||
| Physiological mechanisms underlying long-term potentiation | Q38201329 | ||
| Cellular and network mechanisms underlying memory impairment induced by amyloid β protein. | Q38340934 | ||
| Impaired theta-gamma coupling in APP-deficient mice. | Q38608328 | ||
| Cellular and System Biology of Memory: Timing, Molecules, and Beyond | Q38767284 | ||
| Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic short-term plasticity | Q39441413 | ||
| Amyloid precursor proteins are constituents of the presynaptic active zone | Q39755134 | ||
| A novel pathway for amyloid precursor protein processing | Q39825039 | ||
| Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2. | Q39898160 | ||
| The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. | Q40106778 | ||
| Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer's disease mouse model. | Q40354888 | ||
| The APP Intracellular Domain Is Required for Normal Synaptic Morphology, Synaptic Plasticity, and Hippocampus-Dependent Behavior. | Q40874327 | ||
| Binding and selective detection of the secretory N-terminal domain of the alzheimer amyloid precursor protein on cell surfaces | Q40971910 | ||
| Metabotropic glutamate receptor subtype mGluR1alpha stimulates the secretion of the amyloid beta-protein precursor ectodomain. | Q41098330 | ||
| Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain | Q41156869 | ||
| Shedding of APP limits its synaptogenic activity and cell adhesion properties. | Q42208784 | ||
| Intracellular accumulation of amyloid-β (Aβ) protein plays a major role in Aβ-induced alterations of glutamatergic synaptic transmission and plasticity. | Q42465835 | ||
| Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. | Q42495065 | ||
| APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms | Q42563807 | ||
| Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines | Q42735982 | ||
| Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses. | Q43236403 | ||
| Enhancement of long-term depression by soluble amyloid β protein in rat hippocampus is mediated by metabotropic glutamate receptor and involves activation of p38MAPK, STEP and caspase-3. | Q43707408 | ||
| Phosphatidylinositol-3-kinase-Akt kinase and p42/p44 mitogen-activated protein kinases mediate neurotrophic and excitoprotective actions of a secreted form of amyloid precursor protein | Q44025529 | ||
| Transient and sustained types of long-term potentiation in the CA1 area of the rat hippocampus | Q44470237 | ||
| Hyperexcitability induced by GABA withdrawal facilitates hippocampal long-term potentiation | Q44897326 | ||
| P921 | main subject | synaptic plasticity | Q1551556 |
| proteolysis | Q33123 | ||
| P304 | page(s) | 161 | |
| P577 | publication date | 2016-01-01 | |
| P1433 | published in | Frontiers in Molecular Neuroscience | Q27721913 |
| P1476 | title | Novel Insights into the Physiological Function of the APP (Gene) Family and Its Proteolytic Fragments in Synaptic Plasticity | |
| P478 | volume | 9 |
| Q47151964 | Amyloid β42 peptide is toxic to non-neural cells in Drosophila yielding a characteristic metabolite profile and the effect can be suppressed by PI3K. |
| Q46240783 | Amyloid-β and tau complexity - towards improved biomarkers and targeted therapies. |
| Q58561394 | Analysis of Motor Function in Amyloid Precursor-Like Protein 2 Knockout Mice: The Effects of Ageing and Sex |
| Q90332891 | Astrocyte-microglial association and matrix composition are common events in the natural history of primary familial brain calcification |
| Q54234721 | Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition. |
| Q58785711 | Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer's Disease |
| Q94502431 | Intracellular Trafficking Mechanisms of Synaptic Dysfunction in Alzheimer's Disease |
| Q36344945 | Isoflurane anesthesia promotes cognitive impairment by inducing expression of β-amyloid protein-related factors in the hippocampus of aged rats. |
| Q60046056 | The Emerging Role of Mechanics in Synapse Formation and Plasticity |
| Q42778244 | The type II transmembrane serine protease matriptase cleaves the amyloid precursor protein and reduces its processing to β amyloid |
Search more.