scholarly article | Q13442814 |
P50 | author | Ulrike Herrmann | Q110135451 |
Fabian C. Roth | Q83018947 | ||
P2093 | author name string | Martin Korte | |
David P Wolfer | |||
Marc Mercken | |||
Meike Hick | |||
Sascha W Weyer | |||
Ulrike C Müller | |||
Jakob-Andreas Tschäpe | |||
Andreas Draguhn | |||
Jan-Philipp Mallm | |||
Marianne Borgers | |||
Lutz Slomianka | |||
P2860 | cites work | Homo- and heterodimerization of APP family members promotes intercellular adhesion | Q24337232 |
Roles of the amyloid precursor protein family in the peripheral nervous system | Q26825226 | ||
Hippocampal network oscillations in APP/APLP2-deficient mice | Q27325718 | ||
Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members | Q28504488 | ||
Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity | Q28511294 | ||
Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein | Q28513133 | ||
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins | Q28574891 | ||
Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the beta-amyloid-precursor protein | Q28587017 | ||
Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2 | Q28589908 | ||
Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice | Q28590025 | ||
Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus | Q28592777 | ||
Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein | Q28592893 | ||
Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment | Q29547294 | ||
Alzheimer's disease is a synaptic failure | Q29547670 | ||
Amyloid precursor protein (APP) regulates synaptic structure and function | Q30531725 | ||
Reduced cerebrospinal fluid levels of alpha-secretase-cleaved amyloid precursor protein in aged rats: correlation with spatial memory deficits | Q31405199 | ||
Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression | Q33622388 | ||
ADAM10 missense mutations potentiate β-amyloid accumulation by impairing prodomain chaperone function | Q33926960 | ||
Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function. | Q34255981 | ||
The APP family of proteins: similarities and differences | Q34610073 | ||
APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP. | Q35052570 | ||
Diurnal patterns of soluble amyloid precursor protein metabolites in the human central nervous system | Q35124855 | ||
Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway. | Q35679568 | ||
Downregulation of amyloid precursor protein inhibits neurite outgrowth in vitro | Q36235391 | ||
Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance | Q36405899 | ||
Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation | Q36462366 | ||
Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice. | Q36530142 | ||
Novel GαS-protein signaling associated with membrane-tethered amyloid precursor protein intracellular domain. | Q36595737 | ||
Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1. | Q36740945 | ||
Behavioral phenotyping strategies for mutant mice | Q37119401 | ||
Destabilization of the postsynaptic density by PSD-95 serine 73 phosphorylation inhibits spine growth and synaptic plasticity | Q37163643 | ||
The upside of APP at synapses | Q37825632 | ||
Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing | Q37854085 | ||
Functions of the APP gene family in the nervous system: insights from mouse models | Q37935600 | ||
Regulation of α-secretase ADAM10 expression and activity | Q37942089 | ||
Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging | Q37956562 | ||
Role of APP for dendritic spine formation and stability | Q37957630 | ||
Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and presenilin | Q37961473 | ||
Physiological functions of APP family proteins | Q37987144 | ||
Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic short-term plasticity | Q39441413 | ||
Amyloid precursor protein 695 associates with assembled NR2A- and NR2B-containing NMDA receptors to result in the enhancement of their cell surface delivery | Q39790331 | ||
The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. | Q40106778 | ||
Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines | Q42735982 | ||
The effects of amyloid precursor protein on postsynaptic composition and activity. | Q43009196 | ||
sAPPalpha antagonizes dendritic degeneration and neuron death triggered by proteasomal stress | Q43062510 | ||
Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses. | Q43236403 | ||
Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions. | Q45896474 | ||
Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production. | Q46055931 | ||
Activity requires soluble amyloid precursor protein alpha to promote neurite outgrowth in neural stem cell-derived neurons via activation of the MAPK pathway. | Q46418672 | ||
Endogenous secreted amyloid precursor protein-alpha regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory | Q46515073 | ||
APP homodimers transduce an amyloid-β-mediated increase in release probability at excitatory synapses | Q46616848 | ||
Excitatory synaptic transmission is depressed in cultured hippocampal neurons of APP/PS1 mice | Q46852627 | ||
A secreted form of the beta-amyloid precursor protein (sAPP695) improves spatial recognition memory in OF1 mice | Q47326030 | ||
Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein li | Q47357147 | ||
Increase in extracellular NCAM and amyloid precursor protein following induction of long-term potentiation in the dentate gyrus of anaesthetized rats | Q48157101 | ||
Genetic targeting of principal neurons in neocortex and hippocampus of NEX-Cre mice | Q48347466 | ||
Hippocampal lesions, species-typical behaviours and anxiety in mice | Q48510605 | ||
Secreted form of beta-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices | Q48659729 | ||
Neto1 associates with the NMDA receptor/amyloid precursor protein complex. | Q51038130 | ||
Decreased α-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's diseas | Q53200551 | ||
Differential role of APP and APLPs for neuromuscular synaptic morphology and function. | Q53466455 | ||
P433 | issue | 1 | |
P921 | main subject | synaptic plasticity | Q1551556 |
P304 | page(s) | 21-37 | |
P577 | publication date | 2014-11-29 | |
P1433 | published in | Acta Neuropathologica | Q343168 |
P1476 | title | Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity | |
P478 | volume | 129 |
Q38913292 | A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis |
Q47728000 | ADAM10 as a therapeutic target for brain diseases: from developmental disorders to Alzheimer's disease |
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Q37594982 | APP Deletion Accounts for Age-Dependent Changes in the Bioenergetic Metabolism and in Hyperphosphorylated CaMKII at Stimulated Hippocampal Presynaptic Active Zones |
Q28551424 | APP Is a Context-Sensitive Regulator of the Hippocampal Presynaptic Active Zone |
Q39251175 | APP Protein Family Signaling at the Synapse: Insights from Intracellular APP-Binding Proteins |
Q36585916 | APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses |
Q34551487 | APP as a Protective Factor in Acute Neuronal Insults |
Q39164553 | APP-A Novel Player within the Presynaptic Active Zone Proteome. |
Q27301267 | Alzheimer's disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression |
Q92589754 | Amyloid Precursor Protein (APP) and GABAergic Neurotransmission |
Q48045724 | Amyloid Precursor Protein Protects Neuronal Network Function after Hypoxia via Control of Voltage-Gated Calcium Channels. |
Q37348863 | Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D-serine homeostasis |
Q41073036 | Amyloid-precursor Like Proteins APLP1 and APLP2 Are Dispensable for Normal Development of the Neonatal Respiratory Network |
Q93119497 | Amyloid-β Oligomers Regulate ADAM10 Synaptic Localization Through Aberrant Plasticity Phenomena |
Q91989576 | Defining the binding interface of Amyloid Precursor Protein (APP) and Contactin3 (CNTN3) by site-directed mutagenesis |
Q35569822 | Deletion of the amyloid precursor-like protein 1 (APLP1) enhances excitatory synaptic transmission, reduces network inhibition but does not impair synaptic plasticity in the mouse dentate gyrus. |
Q54234721 | Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition. |
Q58785711 | Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer's Disease |
Q90680150 | Emerging Alternative Proteinases in APP Metabolism and Alzheimer's Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP |
Q37329676 | Functions of the Alzheimer's Disease Protease BACE1 at the Synapse in the Central Nervous System. |
Q91904075 | Glutamate Receptor Trafficking and Protein Synthesis Mediate the Facilitation of LTP by Secreted Amyloid Precursor Protein-Alpha |
Q91635058 | Hebbian and Homeostatic Synaptic Plasticity-Do Alterations of One Reflect Enhancement of the Other? |
Q41747758 | Identification of Phlogacantholide C as a Novel ADAM10 Enhancer from Traditional Chinese Medicinal Plants. |
Q42082620 | Inhibition of Protease-Activated Receptor 1 Does not Affect Dendritic Homeostasis of Cultured Mouse Dentate Granule Cells |
Q52656382 | Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development. |
Q50094019 | Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease |
Q40364440 | Modulation of BAG3 Expression and Proteasomal Activity by sAPPα Does Not Require Membrane-Tethered Holo-APP. |
Q59854882 | Molecular properties underlying regional vulnerability to Alzheimer's disease pathology |
Q91404770 | New Alzheimer's disease model mouse specialized for analyzing the function and toxicity of intraneuronal Amyloid β oligomers |
Q39209681 | Not just amyloid: physiological functions of the amyloid precursor protein family |
Q37595011 | Novel Insights into the Physiological Function of the APP (Gene) Family and Its Proteolytic Fragments in Synaptic Plasticity |
Q38826557 | Novel roles of amyloid-beta precursor protein metabolites in fragile X syndrome and autism. |
Q93336516 | Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5'-untranslated region: Implications in Alzheimer's disease |
Q37633232 | Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models |
Q92556384 | Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved |
Q59137316 | Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity |
Q36222842 | Region-Specific Differences in Amyloid Precursor Protein Expression in the Mouse Hippocampus |
Q39214249 | Regulation of Alpha-Secretase ADAM10 In vitro and In vivo: Genetic, Epigenetic, and Protein-Based Mechanisms |
Q38929253 | Restoring Soluble Amyloid Precursor Protein α Functions as a Potential Treatment for Alzheimer's Disease. |
Q89747430 | Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer's disease |
Q93046766 | Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons |
Q38911059 | Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function |
Q40874327 | The APP Intracellular Domain Is Required for Normal Synaptic Morphology, Synaptic Plasticity, and Hippocampus-Dependent Behavior. |
Q26772807 | The Amyloid Precursor Protein-A Novel Player within the Molecular Array of Presynaptic Nanomachines |
Q92973684 | The Arctic/Swedish APP mutation alters the impact of chronic stress on cognition in mice |
Q38766310 | The Role of APP in Structural Spine Plasticity |
Q36113757 | The keystone of Alzheimer pathogenesis might be sought in Aβ physiology |
Q90730208 | The β-Secretase BACE1 in Alzheimer's Disease |
Q39145999 | Therapeutic Potential of Secreted Amyloid Precursor Protein APPsα. |
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Q40354888 | Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer's disease mouse model. |