Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity.

scientific article published on 29 November 2014

Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00401-014-1368-X
P698PubMed publication ID25432317
P5875ResearchGate publication ID268986337

P50authorUlrike HerrmannQ110135451
Fabian C. RothQ83018947
P2093author name stringMartin Korte
David P Wolfer
Marc Mercken
Meike Hick
Sascha W Weyer
Ulrike C Müller
Jakob-Andreas Tschäpe
Andreas Draguhn
Jan-Philipp Mallm
Marianne Borgers
Lutz Slomianka
P2860cites workHomo- and heterodimerization of APP family members promotes intercellular adhesionQ24337232
Roles of the amyloid precursor protein family in the peripheral nervous systemQ26825226
Hippocampal network oscillations in APP/APLP2-deficient miceQ27325718
Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family membersQ28504488
Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activityQ28511294
Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor proteinQ28513133
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteinsQ28574891
Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the beta-amyloid-precursor proteinQ28587017
Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2Q28589908
Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO miceQ28590025
Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampusQ28592777
Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor proteinQ28592893
Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairmentQ29547294
Alzheimer's disease is a synaptic failureQ29547670
Amyloid precursor protein (APP) regulates synaptic structure and functionQ30531725
Reduced cerebrospinal fluid levels of alpha-secretase-cleaved amyloid precursor protein in aged rats: correlation with spatial memory deficitsQ31405199
Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expressionQ33622388
ADAM10 missense mutations potentiate β-amyloid accumulation by impairing prodomain chaperone functionQ33926960
Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function.Q34255981
The APP family of proteins: similarities and differencesQ34610073
APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP.Q35052570
Diurnal patterns of soluble amyloid precursor protein metabolites in the human central nervous systemQ35124855
Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway.Q35679568
Downregulation of amyloid precursor protein inhibits neurite outgrowth in vitroQ36235391
Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performanceQ36405899
Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generationQ36462366
Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice.Q36530142
Novel GαS-protein signaling associated with membrane-tethered amyloid precursor protein intracellular domain.Q36595737
Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1.Q36740945
Behavioral phenotyping strategies for mutant miceQ37119401
Destabilization of the postsynaptic density by PSD-95 serine 73 phosphorylation inhibits spine growth and synaptic plasticityQ37163643
The upside of APP at synapsesQ37825632
Regulated intramembrane proteolysis--lessons from amyloid precursor protein processingQ37854085
Functions of the APP gene family in the nervous system: insights from mouse modelsQ37935600
Regulation of α-secretase ADAM10 expression and activityQ37942089
Roles of amyloid precursor protein family members in neuroprotection, stress signaling and agingQ37956562
Role of APP for dendritic spine formation and stabilityQ37957630
Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and presenilinQ37961473
Physiological functions of APP family proteinsQ37987144
Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic short-term plasticityQ39441413
Amyloid precursor protein 695 associates with assembled NR2A- and NR2B-containing NMDA receptors to result in the enhancement of their cell surface deliveryQ39790331
The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.Q40106778
Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spinesQ42735982
The effects of amyloid precursor protein on postsynaptic composition and activity.Q43009196
sAPPalpha antagonizes dendritic degeneration and neuron death triggered by proteasomal stressQ43062510
Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses.Q43236403
Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions.Q45896474
Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production.Q46055931
Activity requires soluble amyloid precursor protein alpha to promote neurite outgrowth in neural stem cell-derived neurons via activation of the MAPK pathway.Q46418672
Endogenous secreted amyloid precursor protein-alpha regulates hippocampal NMDA receptor function, long-term potentiation and spatial memoryQ46515073
APP homodimers transduce an amyloid-β-mediated increase in release probability at excitatory synapsesQ46616848
Excitatory synaptic transmission is depressed in cultured hippocampal neurons of APP/PS1 miceQ46852627
A secreted form of the beta-amyloid precursor protein (sAPP695) improves spatial recognition memory in OF1 miceQ47326030
Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein liQ47357147
Increase in extracellular NCAM and amyloid precursor protein following induction of long-term potentiation in the dentate gyrus of anaesthetized ratsQ48157101
Genetic targeting of principal neurons in neocortex and hippocampus of NEX-Cre miceQ48347466
Hippocampal lesions, species-typical behaviours and anxiety in miceQ48510605
Secreted form of beta-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slicesQ48659729
Neto1 associates with the NMDA receptor/amyloid precursor protein complex.Q51038130
Decreased α-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's diseasQ53200551
Differential role of APP and APLPs for neuromuscular synaptic morphology and function.Q53466455
P433issue1
P921main subjectsynaptic plasticityQ1551556
P304page(s)21-37
P577publication date2014-11-29
P1433published inActa NeuropathologicaQ343168
P1476titleAcute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity
P478volume129

Reverse relations

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