Role of prostacyclin signaling in endothelial production of soluble amyloid precursor protein-α in cerebral microvessels.

scientific article published on 20 November 2015

Role of prostacyclin signaling in endothelial production of soluble amyloid precursor protein-α in cerebral microvessels. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1177/0271678X15618977
P8608Fatcat IDrelease_7whyyt6rgjfdfgkt3e26kkyqxi
P932PMC publication ID5363732
P698PubMed publication ID26661245
P5875ResearchGate publication ID285750627

P50authorTong LuQ50034641
P2093author name stringTongrong He
Zvonimir S Katusic
Livius V d'Uscio
Anantha Vijay R Santhanam
P2860cites workAMPK and PPARdelta agonists are exercise mimeticsQ24652674
Structural Basis for Iloprost as a Dual Peroxisome Proliferator-activated Receptor  /  AgonistQ27670895
Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloproteaseQ28140038
Role of prostacyclin in the cardiovascular response to thromboxane A2Q28192832
An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregationQ28244623
Neuroprotective Sirtuin ratio reversed by ApoE4Q28300666
Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and deltaQ28379553
Induction of prostacyclin/PGI2 synthase expression after cerebral ischemia-reperfusionQ28571311
Peroxisome proliferator-activated receptor delta regulation of miR-15a in ischemia-induced cerebral vascular endothelial injuryQ28593367
Amyloid precursor protein trafficking, processing, and functionQ29617429
More hippocampal neurons in adult mice living in an enriched environmentQ29617733
Peroxisome proliferator-activated receptor delta (PPARdelta )-mediated regulation of preadipocyte proliferation and gene expression is dependent on cAMP signalingQ31537639
Rapid transport of CCL11 across the blood-brain barrier: regional variation and importance of blood cellsQ33603633
Diverse roles of the vasculature within the neural stem cell nicheQ33718137
The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortexQ34067209
Protease nexin-2/amyloid beta-protein precursor limits cerebral thrombosisQ34212770
The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+).Q34242709
Brain endothelial cells produce amyloid {beta} from amyloid precursor protein 770 and preferentially secrete the O-glycosylated formQ34401049
Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursorQ34475374
Endurance factors improve hippocampal neurogenesis and spatial memory in miceQ34546610
Neuroprotective efficacy of the peroxisome proliferator-activated receptor delta-selective agonists in vitro and in vivoQ34590738
Activation of peroxisome proliferator-activated receptor-{delta} enhances regenerative capacity of human endothelial progenitor cells by stimulating biosynthesis of tetrahydrobiopterinQ35126265
TAK1 in brain endothelial cells mediates fever and lethargyQ35627672
Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.Q35897595
The kunitz protease inhibitor domain of protease nexin-2 inhibits factor XIa and murine carotid artery and middle cerebral artery thrombosisQ36106323
Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supplyQ36127114
Activation of peroxisome proliferator-activated receptor β/δ attenuates acute ischemic stroke on middle cerebral ischemia occlusion in rats.Q50667161
Exercise pre-conditioning reduces brain damage in ischemic rats that may be associated with regional angiogenesis and cellular overexpression of neurotrophin.Q51022529
Increased cortical cell loss and prolonged hemodynamic depression after traumatic brain injury in mice lacking the IP receptor for prostacyclin.Q51907454
A quantitative immunocytochemical study of blood-brain barrier to endogenous albumin in cerebral cortex and hippocampus of senescence-accelerated mice (SAM).Q52019496
Regional expression and role of cyclooxygenase-2 following experimental traumatic brain injury.Q52170939
Human endothelial progenitor cells tolerate oxidative stress due to intrinsically high expression of manganese superoxide dismutase.Q53888121
Cyclooxygenase-2–Derived Prostacyclin Regulates Arterial Thrombus Formation by Suppressing Tissue Factor in a Sirtuin-1–Dependent-MannerQ57398730
Platelet coagulation factor XIa-inhibitor, a form of Alzheimer amyloid precursor proteinQ67292492
Vascular trauma and prostacyclin releaseQ70422617
Alzheimer amyloid protein precursor enhances proliferation of neural stem cells from fetal rat brainQ72903742
Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasisQ74516844
The PPARδ-mediated inhibition of angiotensin II-induced premature senescence in human endothelial cells is SIRT1-dependentQ87353450
Vascular effects of prostacyclin: does activation of PPARδ play a role?Q36287741
PPARδ agonist GW501516 prevents uncoupling of endothelial nitric oxide synthase in cerebral microvessels of hph-1 miceQ36326958
Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor proteinQ36404963
Soluble amyloid precursor protein 770 is released from inflamed endothelial cells and activated platelets: a novel biomarker for acute coronary syndromeQ36418965
PPARdelta regulates multiple proinflammatory pathways to suppress atherosclerosisQ36670249
Neurotrophic and neuroprotective effects of hAPP in transgenic miceQ36798319
Angiogenic function of prostacyclin biosynthesis in human endothelial progenitor cellsQ37147002
Multiple Interactions between Peroxisome Proliferators-Activated Receptors and the Ubiquitin-Proteasome System and Implications for Cancer PathogenesisQ37190455
Interactions between APP secretases and inflammatory mediatorsQ37195010
Aging decreases expression and activity of glutathione peroxidase-1 in human endothelial progenitor cellsQ37439217
Endothelium-derived vasoactive factors: I. Endothelium-dependent relaxationQ37450529
Genetic Deletion of Prostacyclin IP Receptor Exacerbates Transient Global Cerebral Ischemia in Aging MiceQ37630989
Mechanisms of vascular dysfunction in mice with endothelium-specific deletion of the PPAR-δ geneQ37656075
Roles of amyloid precursor protein family members in neuroprotection, stress signaling and agingQ37956562
Identification and biology of α-secretase.Q37961730
Peroxisome proliferator-activated receptor delta and cardiovascular diseaseQ38152503
The role of ubiquitin-proteasome in the metabolism of amyloid precursor protein (APP): implications for novel therapeutic strategies for Alzheimer's diseaseQ38236858
ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neuronsQ39672952
A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's diseaseQ39782076
Involvement of a disintegrin and metalloproteinase 10 and 17 in shedding of tumor necrosis factor-alphaQ39797126
Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretinQ39895248
The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.Q40106778
Role of prostaglandins and arachidonic acid derivatives in the coupling of cerebral blood flow to cerebral metabolismQ40263316
The amyloid precursor protein in ischemic brain injury and chronic hypoperfusionQ40779615
Pro-tumor necrosis factor-alpha processing activity is tightly controlled by a component that does not affect notch processingQ41009791
Regulation of the cerebral circulation: role of endothelium and potassium channelsQ41697441
Formation of the collateral circulation is regulated by vascular endothelial growth factor-A and a disintegrin and metalloprotease family members 10 and 17.Q42017593
ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretaseQ42059040
Neuroprotective properties of prostaglandin I2 IP receptor in focal cerebral ischemia.Q42973907
PPARbeta/delta regulates the human SIRT1 gene transcription via Sp1.Q43160117
Cyclooxygenase-1 and bicistronic cyclooxygenase-1/prostacyclin synthase gene transfer protect against ischemic cerebral infarction.Q43984493
Prostacyclin receptor deletion aggravates hippocampal neuronal loss after bilateral common carotid artery occlusion in mouse.Q46369462
Lipopolysaccharide stimulates the secretion of the amyloid precursor protein via a protein kinase C-mediated pathway.Q46603764
M1 receptors play a central role in modulating AD-like pathology in transgenic miceQ46737320
Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone.Q47793632
Protein kinase C activation potentiates the rapid secretion of the amyloid precursor protein from rat cortical synaptosomes.Q48307831
Accumulation of the beta amyloid precursor protein at sites of ischemic injury in rat brain.Q48335889
Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor proteinQ48342880
Increased levels of the Kunitz protease inhibitor-containing beta APP mRNAs in rat brain following neurotoxic damage.Q48369648
Effects of indomethacin upon cerebral hemodynamics of newborn pigsQ48438434
Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortexQ48737468
P433issue1
P921main subjectmicrovesselQ6840468
P304page(s)106-122
P577publication date2015-11-20
P1433published inJournal of Cerebral Blood Flow & MetabolismQ14663525
P1476titleRole of prostacyclin signaling in endothelial production of soluble amyloid precursor protein-α in cerebral microvessels
P478volume37

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cites work (P2860)
Q64927425Effects of Brain-Derived Neurotrophic Factor on MicroRNA Expression Profile in Human Endothelial Progenitor Cells.
Q47853250Effects of senescence and angiotensin II on expression and processing of amyloid precursor protein in human cerebral microvascular endothelial cells
Q42515941Endothelium-specific amyloid precursor protein deficiency causes endothelial dysfunction in cerebral arteries
Q39032252Expression and Processing of Amyloid Precursor Protein in Vascular Endothelium
Q47282106Impairment of amyloid precursor protein alpha-processing in cerebral microvessels of type 1 diabetic mice
Q47837479Pulsatile stretch as a novel modulator of amyloid precursor protein processing and associated inflammatory markers in human cerebral endothelial cells
Q92025973The Role of Eicosanoids in Alzheimer's Disease

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