Effects of senescence and angiotensin II on expression and processing of amyloid precursor protein in human cerebral microvascular endothelial cells

scientific article published on 15 January 2018

Effects of senescence and angiotensin II on expression and processing of amyloid precursor protein in human cerebral microvascular endothelial cells is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID5811245
P698PubMed publication ID29348391

P2093author name stringYujun Pan
Tongrong He
Zvonimir S Katusic
Ruohan Sun
P2860cites workBeta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACEQ22010705
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ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neuronsQ39672952
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The disintegrin ADAM9 indirectly contributes to the physiological processing of cellular prion by modulating ADAM10 activityQ40360129
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sAβPPα is a Potent Endogenous Inhibitor of BACE1.Q40507322
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Hypertension induces brain β-amyloid accumulation, cognitive impairment, and memory deterioration through activation of receptor for advanced glycation end products in brain vasculatureQ42009075
ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretaseQ42059040
Angiotensin II activates nuclear transcription factor-kappaB through AT1 and AT2 receptorsQ44004809
Impairment of amyloid precursor protein alpha-processing in cerebral microvessels of type 1 diabetic miceQ47282106
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in miceQ47315084
BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type miceQ48379491
Hypertension accelerates the progression of Alzheimer-like pathology in a mouse model of the diseaseQ48479574
Substance P activates ADAM9 mRNA expression and induces α-secretase-mediated amyloid precursor protein cleavageQ48713940
Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor ProteinQ48873213
Role of prostacyclin signaling in endothelial production of soluble amyloid precursor protein-α in cerebral microvessels.Q49157255
Blood angiotensin II levels of normal and hypertensive subjectsQ49169103
P433issue1
P304page(s)100-114
P577publication date2018-01-15
P1433published inAgingQ2845875
P1476titleEffects of senescence and angiotensin II on expression and processing of amyloid precursor protein in human cerebral microvascular endothelial cells
P478volume10

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cites work (P2860)
Q90295696Mouse models of Alzheimer's disease cause rarefaction of pial collaterals and increased severity of ischemic stroke
Q99711299New Insights Into Blood-Brain Barrier Maintenance: The Homeostatic Role of β-Amyloid Precursor Protein in Cerebral Vasculature

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