scholarly article | Q13442814 |
P2093 | author name string | Xue Zhang | |
Hui Zheng | |||
Ping Han | |||
Feng Li | |||
Huaxi Xu | |||
Stuart A Lipton | |||
Francesca-Fang Liao | |||
Yun-Wu Zhang | |||
Fei Dou | |||
P2860 | cites work | Tau pathology in Alzheimer disease and other tauopathies | Q22252520 |
Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease | Q24312611 | ||
Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts | Q24675729 | ||
Neurotoxicity induces cleavage of p35 to p25 by calpain | Q28145382 | ||
Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members | Q28504488 | ||
Migration defects of cdk5(-/-) neurons in the developing cerebellum is cell autonomous | Q28507469 | ||
Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein | Q28513133 | ||
A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons | Q28576106 | ||
Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene | Q28586800 | ||
Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the beta-amyloid-precursor protein | Q28587017 | ||
The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity | Q28587197 | ||
Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP | Q28592685 | ||
Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein | Q28592893 | ||
beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity | Q28593175 | ||
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction | Q29547778 | ||
Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses | Q29616076 | ||
Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides | Q32067582 | ||
Cellular and molecular basis of beta-amyloid precursor protein metabolism | Q33854048 | ||
Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures | Q34032447 | ||
Alzheimer's disease: a dysfunction of the amyloid precursor protein(1). | Q34105788 | ||
The beta-amyloid precursor protein (APP) and Alzheimer's disease: does the tail wag the dog? | Q34154668 | ||
Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles | Q34279396 | ||
Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function | Q34296896 | ||
Excitatory amino acids as a final common pathway for neurologic disorders. | Q34321926 | ||
Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5 | Q35084361 | ||
Cdk5: One of the links between senile plaques and neurofibrillary tangles? | Q35116571 | ||
Diversity in the mechanisms of neuronal cell death. | Q35558449 | ||
Cyclin-dependent kinase 5--a neuronal killer? | Q35610041 | ||
Stable-tau overexpression in human neuroblastoma cells: an open door for explaining neuronal death in tauopathies. | Q35700412 | ||
Cdk5: mediator of neuronal death and survival | Q35769666 | ||
Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect? | Q35825892 | ||
Molecular pathways to neurodegeneration | Q35844771 | ||
Cdk5 deregulation in the pathogenesis of Alzheimer's disease | Q35879533 | ||
Balancing neuronal death | Q35889908 | ||
Neurotrophic and neuroprotective effects of hAPP in transgenic mice | Q36798319 | ||
Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo. | Q36858269 | ||
Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport | Q37701379 | ||
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. | Q39173722 | ||
Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells | Q40483602 | ||
The receptor-bound N-terminal ectodomain of the amyloid precursor protein is associated with membrane rafts. | Q40674513 | ||
Calcium regulates the association between mitochondria and a smooth subdomain of the endoplasmic reticulum | Q40854212 | ||
Neuronal necrosis and apoptosis: two distinct events induced by exposure to glutamate or oxidative stress. | Q41308388 | ||
Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives | Q41630805 | ||
A monoclonal antibody to amyloid precursor protein induces neuronal apoptosis | Q41737049 | ||
Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress | Q41830251 | ||
The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells. | Q41941163 | ||
Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease | Q42474769 | ||
Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. | Q42495065 | ||
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils | Q43718666 | ||
Phosphatidylinositol-3-kinase-Akt kinase and p42/p44 mitogen-activated protein kinases mediate neurotrophic and excitoprotective actions of a secreted form of amyloid precursor protein | Q44025529 | ||
Regulation of amyloid precursor protein (APP) phosphorylation and processing by p35/Cdk5 and p25/Cdk5. | Q44157383 | ||
Inhibition of CDK5 is protective in necrotic and apoptotic paradigms of neuronal cell death and prevents mitochondrial dysfunction | Q44627825 | ||
Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome | Q45007178 | ||
Neurotoxic calcium transfer from endoplasmic reticulum to mitochondria is regulated by cyclin-dependent kinase 5-dependent phosphorylation of tau. | Q46448197 | ||
Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress. | Q47710423 | ||
Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles | Q47761619 | ||
Glutamate increases tau phosphorylation in primary neuronal cultures from fetal rat cerebral cortex. | Q48122748 | ||
Hypersensitivity to seizures in beta-amyloid precursor protein deficient mice | Q48236519 | ||
Cdk5 is a key factor in tau aggregation and tangle formation in vivo | Q48300530 | ||
Mouse cortical neurones lacking APP show normal neurite outgrowth and survival responses in vitro | Q48357738 | ||
AbetaPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576. | Q48439872 | ||
Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein. | Q48621031 | ||
Amyloid-beta-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression. | Q52552907 | ||
Age-related distribution of neuropathologic changes in the cerebral cortex of patients with Down's syndrome. Quantitative regional analysis and comparison with Alzheimer's disease. | Q53201936 | ||
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work | Q57897029 | ||
The Alzheimer's disease amyloid precursor protein modulates copper-induced toxicity and oxidative stress in primary neuronal cultures | Q73107254 | ||
p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro | Q74480258 | ||
Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein | Q78525357 | ||
P433 | issue | 50 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | phosphorylation | Q242736 |
P304 | page(s) | 11542-11552 | |
P577 | publication date | 2005-12-01 | |
P1433 | published in | Journal of Neuroscience | Q1709864 |
P1476 | title | Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation | |
P478 | volume | 25 |
Q34232193 | A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation |
Q22251088 | APP binds DR6 to trigger axon pruning and neuron death via distinct caspases |
Q27694738 | APP processing in Alzheimer's disease |
Q35041654 | APP regulates NGF receptor trafficking and NGF-mediated neuronal differentiation and survival |
Q34242416 | Adult hippocampal neurogenesis and its role in Alzheimer's disease |
Q36478423 | Advances in the pathogenesis of Alzheimer's disease: a re-evaluation of amyloid cascade hypothesis |
Q54379908 | Alterations of cyclin dependent kinase 5 expression and phosphorylation in amyloid precursor protein (APP)-transfected PC12 cells. |
Q30492443 | Amyloid precursor protein increases cortical neuron size in transgenic mice |
Q36432966 | Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration |
Q52720530 | BACE1 Mediates HIV-Associated and Excitotoxic Neuronal Damage Through an APP-Dependent Mechanism. |
Q37869935 | Biology and pathophysiology of the amyloid precursor protein |
Q42268906 | Calcium-Sensing Receptor Antagonist NPS 2143 Restores Amyloid Precursor Protein Physiological Non-Amyloidogenic Processing in Aβ-Exposed Adult Human Astrocytes. |
Q46547119 | Calnuc binds to Alzheimer's beta-amyloid precursor protein and affects its biogenesis |
Q53392171 | Cyclin-dependent kinase 5 is associated with risk for Alzheimer's disease in a Dutch population-based study. |
Q39835135 | Decrease of Tau hyperphosphorylation by 17β estradiol requires sphingosine kinase in a glutamate toxicity model. |
Q33566835 | Designing of dual inhibitors for GSK-3β and CDK5: Virtual screening and in vitro biological activities study |
Q48505432 | Effects of endogenous beta-amyloid overproduction on tau phosphorylation in cell culture |
Q40271638 | Endogenous overproduction of beta-amyloid induces tau hyperphosphorylation and decreases the solubility of tau in N2a cells |
Q37069865 | Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders |
Q35541305 | Eukaryotic operon-like transcription of functionally related genes in Drosophila. |
Q33744696 | Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc |
Q48444859 | Fuzhisan Ameliorates the Memory Deficits in Aged SAMP8 Mice via Decreasing Aβ Production and Tau Hyperphosphorylation of the Hippocampus |
Q35679568 | Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway. |
Q51760865 | Homocysteine Increases Tau Phosphorylation, Truncation and Oligomerization. |
Q36067364 | Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors |
Q40170952 | IGF-1-induced processing of the amyloid precursor protein family is mediated by different signaling pathways |
Q34082420 | Increased Human Wildtype Tau Attenuates Axonal Transport Deficits Caused by Loss of App in Mouse Models |
Q41894440 | Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1 |
Q90316651 | Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression |
Q34653599 | Non-selective calcium channel blocker bepridil decreases secondary pathology in mice after photothrombotic cortical lesion |
Q38868081 | Phosphorylation of collapsin response mediator protein-2 disrupts neuronal maturation in a model of adult neurogenesis: Implications for neurodegenerative disorders |
Q26860395 | Physiological and pathological phosphorylation of tau by Cdk5 |
Q37987144 | Physiological functions of APP family proteins |
Q28254104 | Proteolytic processing of Alzheimer's β-amyloid precursor protein |
Q37352348 | Retinoic acid attenuates beta-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model. |
Q37956562 | Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging |
Q90263746 | SNX8 Enhances Non-amyloidogenic APP Trafficking and Attenuates Aβ Accumulation and Memory Deficits in an AD Mouse |
Q34776047 | Soluble alpha-APP (sAPPalpha) regulates CDK5 expression and activity in neurons |
Q37377515 | Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling. |
Q24680465 | The amyloid precursor protein: beyond amyloid |
Q30480131 | The amyloid-beta precursor protein is phosphorylated via distinct pathways during differentiation, mitosis, stress, and degeneration |
Q36113757 | The keystone of Alzheimer pathogenesis might be sought in Aβ physiology |
Q35534062 | The roles of amyloid precursor protein (APP) in neurogenesis: Implications to pathogenesis and therapy of Alzheimer disease |
Q35815964 | p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing |
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