Knock-in of human BACE1 cleaves murine APP and reiterates Alzheimer-like phenotypes

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Knock-in of human BACE1 cleaves murine APP and reiterates Alzheimer-like phenotypes is …
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scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.0433-14.2014
P932PMC publication ID4122804
P698PubMed publication ID25100603
P5875ResearchGate publication ID267756454

P50authorKaja PlucinskaQ58105876
Bettina PlattQ87517043
P2093author name stringGernot Riedel
Lianne Robinson
Michael Siebrecht
Barry Crouch
David Koss
P2860cites workBeta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACEQ22010705
Purification and cloning of amyloid precursor protein beta-secretase from human brainQ22010914
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BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeuticsQ28201876
Control of peripheral nerve myelination by the beta-secretase BACE1Q28264800
A specific amyloid-beta protein assembly in the brain impairs memoryQ28854597
Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the ratQ29619517
Neuronal clearance of amyloid-β by endocytic receptor LRP1.Q29977780
Search strategies in a human water maze analogue analyzed with automatic classification methodsQ30318843
APP transgenic mice for modelling behavioural and psychological symptoms of dementia (BPSD).Q30455082
BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.Q30483997
Morphological and functional reversal of phenotypes in a mouse model of Rett syndromeQ30524829
Brain amyloid-β oligomers in ageing and Alzheimer's diseaseQ30539133
Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteasesQ31032457
Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generationQ32063777
BACE1 is the major beta-secretase for generation of Abeta peptides by neuronsQ32063781
Adult-generated hippocampal neurons allow the flexible use of spatially precise learning strategiesQ33440592
Identification of beta-secretase (BACE1) substrates using quantitative proteomicsQ33521280
Cross-talk of membrane lipids and Alzheimer-related proteinsQ33592538
BACE1 and BACE2 enzymatic activities in Alzheimer's diseaseQ33643141
Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer's disease mouse modelQ33677169
Olfactory memory is impaired in a triple transgenic model of Alzheimer diseaseQ43331593
Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.Q43955854
Beta-secretase protein and activity are increased in the neocortex in Alzheimer diseaseQ44132132
Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer diseaseQ44270458
Specific BACE1 genotypes provide additional risk for late‐onset alzheimer disease in APOE ε4 carriersQ44411872
BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changesQ44686140
Store-operated Ca2+ entry in hippocampal neurons: Regulation by protein tyrosine phosphatase PTP1B.Q44708136
Transgenic BACE expression in mouse neurons accelerates amyloid plaque pathologyQ44780939
Spatial learning impairments in PLB1Triple knock-in Alzheimer mice are task-specific and age-dependent.Q45924774
Amyloid beta protein is internalized selectively by hippocampal field CA1 and causes neurons to accumulate amyloidogenic carboxyterminal fragments of the amyloid precursor proteinQ46142184
Learning decreases A beta*56 and tau pathology and ameliorates behavioral decline in 3xTg-AD mice.Q46765311
Early intraneuronal accumulation and increased aggregation of phosphorylated Abeta in a mouse model of Alzheimer's diseaseQ48112174
Spatial learning and memory impairment and increased locomotion in a transgenic amyloid precursor protein mouse model of Alzheimer's disease.Q48145768
Age-dependent changes in hippocampal synaptic transmission and plasticity in the PLB1Triple Alzheimer mouseQ48164227
Aged Tg2576 mice are impaired on social memory and open field habituation testsQ48317805
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteinsQ48601563
BACE1 gene deletion: impact on behavioral function in a model of Alzheimer's disease.Q51906403
The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brainQ74290658
Coomassie staining as loading control in Western blot analysis.Q33780688
Dissecting the behaviour of transgenic mice: is it the mutation, the genetic background, or the environment?Q33933978
Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic miceQ34067152
Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepinesQ34246061
Search strategies used by APP transgenic mice during navigation in the Morris water mazeQ34340670
Total protein analysis as a reliable loading control for quantitative fluorescent Western blottingQ34983533
Hippocampal neurogenesis levels predict WATERMAZE search strategies in the aging brainQ35005389
A dynamic relationship between intracellular and extracellular pools of AbetaQ35070713
Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice.Q35623033
Intraneuronal Abeta42 accumulation in human brain.Q35793325
BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic miceQ35809329
Morris water maze search strategy analysis in PDAPP mice before and after experimental traumatic brain injuryQ35878754
Secretome protein enrichment identifies physiological BACE1 protease substrates in neuronsQ36103683
Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloidQ36246858
APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease.Q36451896
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expressionQ36609033
The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimer's DiseaseQ37108142
Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic miceQ37137534
BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampusQ37309641
BACE1 regulates voltage-gated sodium channels and neuronal activityQ37355641
Simple behavioral assessment of mouse olfactionQ37365567
Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain.Q37389332
Long-term home cage activity scans reveal lowered exploratory behaviour in symptomatic female Rett miceQ37453590
Intracellular accumulation of amyloid-Beta - a predictor for synaptic dysfunction and neuron loss in Alzheimer's diseaseQ37765478
Which memory task for my mouse? A systematic review of spatial memory performance in the Tg2576 Alzheimer's mouse modelQ37874061
The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and BeyondQ37987919
The anatomical bases of semantic retrieval deficits in early Alzheimer's diseaseQ38394432
Distinct neuroanatomical bases of episodic and semantic memory performance in Alzheimer's disease.Q38456827
Extent and neural basis of semantic memory impairment in mild cognitive impairmentQ38480669
Atlas of transgenic Tet-Off Ca2+/calmodulin-dependent protein kinase II and prion protein promoter activity in the mouse brainQ39959510
Role of hippocampal signaling pathways in long-term memory formation of a nonassociative learning task in the ratQ40416447
Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted miceQ41428934
Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.Q42239487
Gene structure and organization of the human beta-secretase (BACE) promoter.Q42459613
Mutations in the open reading frame of the beta-site APP cleaving enzyme (BACE) locus are not a common cause of Alzheimer's disease.Q42664113
Housekeepers for accurate transcript expression analysis in Alzheimer's disease autopsy brain tissueQ42838569
P4510describes a project that usesImageJQ1659584
P433issue32
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
P304page(s)10710-10728
P577publication date2014-08-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleKnock-in of human BACE1 cleaves murine APP and reiterates Alzheimer-like phenotypes
P478volume34

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cites work (P2860)
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