BACE1 activity regulates cell surface contactin-2 levels

scientific article published on 09 January 2014

BACE1 activity regulates cell surface contactin-2 levels is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1001667182
P356DOI10.1186/1750-1326-9-4
P932PMC publication ID3899608
P698PubMed publication ID24405708
P5875ResearchGate publication ID259649799

P2093author name stringDoo Yeon Kim
Dora M Kovacs
Carla D'Avanzo
Matthias Hebisch
Vivek Gautam
P2860cites workBeta-secretase protein and activity are increased in the neocortex in Alzheimer diseaseQ44132132
alpha- and beta-secretase: profound changes in Alzheimer's disease.Q44225451
Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1).Q44243372
Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer diseaseQ44270458
Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesisQ48217048
Transgenic mice expressing F3/contactin from the TAG-1 promoter exhibit developmentally regulated changes in the differentiation of cerebellar neuronsQ48443241
Bace1 modulates myelination in the central and peripheral nervous system.Q53588736
Clustering and functional cooperation of Ng-CAM and axonin-1 in the substratum-contact area of growth conesQ71139272
TAG-1 can mediate homophilic binding, but neurite outgrowth on TAG-1 requires an L1-like molecule and beta 1 integrinsQ71618287
Distinct subpopulations of sensory afferents require F11 or axonin-1 for growth to their target layers within the spinal cord of the chickQ74112983
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACEQ22010705
Purification and cloning of amyloid precursor protein beta-secretase from human brainQ22010914
Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1Q24321543
Cell-cell adhesion by homophilic interaction of the neuronal recognition molecule axonin-1Q28261021
Control of peripheral nerve myelination by the beta-secretase BACE1Q28264800
The adhesion molecule TAG-1 is required for proper migration of the superficial migratory stream in the medulla but not of cortical interneuronsQ28505851
The axonal glycoprotein TAG-1 is an immunoglobulin superfamily member with neurite outgrowth-promoting activityQ28576557
A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesisQ28587599
Impairment of learning and memory in TAG-1 deficient mice associated with shorter CNS internodes and disrupted juxtaparanodesQ28588262
Alzheimer's disease is a synaptic failureQ29547670
Transient axonal glycoprotein-1 (TAG-1) and laminin-alpha1 regulate dynamic growth cone behaviors and initial axon direction in vivoQ30481597
BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.Q30483997
Contactins: emerging key roles in the development and function of the nervous systemQ30484262
BACE1 deficiency causes altered neuronal activity and neurodegenerationQ30495458
BACE1: the beta-secretase enzyme in Alzheimer's diseaseQ33202614
Identification of beta-secretase (BACE1) substrates using quantitative proteomicsQ33521280
The cell neural adhesion molecule contactin-2 (TAG-1) is beneficial for functional recovery after spinal cord injury in adult zebrafishQ34533737
Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complexQ35105866
The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulbQ35717366
Secretome protein enrichment identifies physiological BACE1 protease substrates in neuronsQ36103683
The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivoQ36122127
A direct interaction of axonin-1 with NgCAM-related cell adhesion molecule (NrCAM) results in guidance, but not growth of commissural axons.Q36327022
β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defectsQ36385744
The Alzheimer's disease beta-secretase enzyme, BACE1.Q36397690
Axonin-1/TAG-1 is required for pathfinding of granule cell axons in the developing cerebellumQ36569955
BACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channelsQ36860349
Palmitoylation of amyloid precursor protein regulates amyloidogenic processing in lipid raftsQ37032450
BACE1 regulates voltage-gated sodium channels and neuronal activityQ37355641
The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potentialQ37614747
The precision of axon targeting of mouse olfactory sensory neurons requires the BACE1 proteaseQ40534733
Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelinationQ40687892
Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunitQ41839372
P304page(s)4
P577publication date2014-01-09
P1433published inMolecular NeurodegenerationQ15817329
P1476titleBACE1 activity regulates cell surface contactin-2 levels
P478volume9

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cites work (P2860)
Q47368687Beta secretase activity in peripheral nerve regeneration
Q53397736Click chemistry-mediated biotinylation reveals a function for the protease BACE1 in modulating the neuronal surface glycoproteome.
Q55283766Contactin-2, a synaptic and axonal protein, is reduced in cerebrospinal fluid and brain tissue in Alzheimer's disease.
Q48333335Contactin-2/TAG-1, active on the front line for three decades
Q61804442Contactins in the central nervous system: role in health and disease
Q35551929Discovery of new candidate genes related to brain development using protein interaction information
Q90572097Exploring Potential Biomarkers Underlying Pathogenesis of Alzheimer's Disease by Differential Co-expression Analysis
Q47433086Expression of Gas1 in Mouse Brain: Release and Role in Neuronal Differentiation.
Q64096066High-throughput epitope profiling of antibodies in the plasma of Alzheimer's disease patients using random peptide microarrays
Q36869427Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease
Q36804007Neurological dysfunctions associated with altered BACE1-dependent Neuregulin-1 signaling
Q26745419Regulating Axonal Responses to Injury: The Intersection between Signaling Pathways Involved in Axon Myelination and The Inhibition of Axon Regeneration
Q26865296Regulation of development and cancer by the R2B subfamily of RPTPs and the implications of proteolysis
Q37316706Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons.
Q26744544Synaptic Cell Adhesion Molecules in Alzheimer's Disease
Q35879747Synaptotagmins interact with APP and promote Aβ generation
Q48451297Tripchlorolide Attenuates β-amyloid Generation via Suppressing PPARγ-Regulated BACE1 Activity in N2a/APP695 Cells
Q90131522β-Secretase BACE1 Is Required for Normal Cochlear Function
Q51765619β-Secretase BACE1 Promotes Surface Expression and Function of Kv3.4 at Hippocampal Mossy Fiber Synapses.

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