APP mouse models for Alzheimer's disease preclinical studies

scientific article published on August 2017

APP mouse models for Alzheimer's disease preclinical studies is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.15252/EMBJ.201797397
P932PMC publication ID5579350
P698PubMed publication ID28768718

P50authorBart De StrooperQ4865062
John Anthony HardyQ6237755
Bengt WinbladQ66000726
Takaomi C SaidoQ88385095
Shoko HashimotoQ88475584
Kenichi NagataQ89236299
Hiroki SasaguriQ90452901
Per NilssonQ59558074
Takashi SaitoQ42776201
P2093author name stringRobert Vassar
P2860cites workAlzheimer's therapy targeting the β-secretase enzyme BACE1: Benefits and potential limitations from the perspective of animal model studiesQ38812007
Genomics of Alzheimer Disease: A Review.Q38822996
Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions.Q38827921
Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic MiceQ22242267
TREM2 Variants in Alzheimer's DiseaseQ22250873
A mutation in APP protects against Alzheimer’s disease and age-related cognitive declineQ22251083
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor proteinQ22251280
Alzheimer mechanisms and therapeutic strategiesQ22252311
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's diseaseQ24312938
Mutation of the mouse klotho gene leads to a syndrome resembling ageingQ24328782
Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer modelQ24603560
Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's diseaseQ24672501
Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic miceQ24681736
Analysis of Amyloid Precursor Protein Function in Drosophila melanogasterQ26738294
The amyloid hypothesis of Alzheimer's disease at 25 yearsQ26749528
Genome Engineering with TALE and CRISPR Systems in NeuroscienceQ26752488
Toward more predictive genetic mouse models of Alzheimer's diseaseQ26771883
The Amyloid Precursor Protein-A Novel Player within the Molecular Array of Presynaptic NanomachinesQ26772807
Clearance systems in the brain-implications for Alzheimer diseaseQ26801541
Self-propagation of pathogenic protein aggregates in neurodegenerative diseasesQ26996441
The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foesQ27026919
Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Abeta sequenceQ48915342
Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.Q48933018
Single App knock-in mouse models of Alzheimer's disease.Q50670713
Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse modelsQ50702084
AZD3293: Pharmacokinetic and Pharmacodynamic Effects in Healthy Subjects and Patients with Alzheimer's Disease.Q51371177
Potential Link between Amyloid β-Protein 42 and C-terminal Fragment γ 49–99 of β-Amyloid Precursor ProteinQ51837859
Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques.Q53203663
Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice.Q53219233
Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.Q53335187
TREM2 and Neurodegenerative DiseaseQ57418387
Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch)Q57849311
Ubiquitin-Dependent And Independent Signals In Selective AutophagyQ38599451
Induced pluripotent stem cells as a discovery tool for Alzheimer׳s diseaseQ38605546
Beyond γ-secretase activity: The multifunctional nature of presenilins in cell signalling pathwaysQ38615871
Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cellsQ38666481
The Cellular Phase of Alzheimer's DiseaseQ38731102
Defeating Alzheimer's disease and other dementias: a priority for European science and societyQ38778638
Network abnormalities and interneuron dysfunction in Alzheimer diseaseQ38796950
Alzheimer's disease: experimental models and realityQ39057135
The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the "amyloid cascade hypothesis".Q39068135
Unfolded protein response signaling by transcription factor XBP-1 regulates ADAM10 and is affected in Alzheimer's disease.Q39069488
Cognitive deficits in single App knock-in mouse modelsQ39138139
Targeting neoantigens to augment antitumour immunityQ39149196
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.Q39173722
The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patientsQ39222469
Innate immunity in Alzheimer's disease: the relevance of animal models?Q39314130
Differential effects between γ-secretase inhibitors and modulators on cognitive function in amyloid precursor protein-transgenic and nontransgenic miceQ39398322
The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neuronsQ39884306
Hypoxia Affects Neprilysin Expression Through Caspase Activation and an APP Intracellular Domain-dependent Mechanism.Q40263247
FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproductionQ40737559
Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequenceQ40789635
CCN1/CYR61 overexpression in hepatic stellate cells induces ER stress-related apoptosisQ40930580
Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression.Q41138030
Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor proteinQ41788034
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau proteinQ42491661
A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activityQ43793656
Aβ secretion and plaque formation depend on autophagyQ44061458
BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's diseaseQ44722202
Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice.Q45251288
Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors.Q45256092
The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing.Q45901500
Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer's disease.Q45927250
Abeta43 is more frequent than Abeta40 in amyloid plaque cores from Alzheimer disease brains.Q46003834
Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic MiceQ46143430
Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.Q46380915
Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model.Q46384417
Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse BrainQ46412402
Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutationQ46814179
Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila.Q46959740
Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesisQ48217048
Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch typeQ48265529
Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in miceQ48308608
PLD3 gene and processing of APP.Q48337321
Age-dependent decline of neprilysin in Alzheimer's disease and normal brain: inverse correlation with A beta levels.Q48373220
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.Q48404445
Brain/MINDS: A Japanese National Brain Project for Marmoset NeuroscienceQ48441682
Lessons from a failed γ-secretase Alzheimer trialQ48449453
Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon agingQ48463232
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteinsQ48601563
ScaleS: an optical clearing palette for biological imaging.Q48651783
Demonstration of Amyloid Deposits and Neurofibrillary Changes in Whole Brain SectionsQ48764154
Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathologyQ48773231
Metabolic regulation of brain Abeta by neprilysinQ48869458
Rarity of the Alzheimer disease-protective APP A673T variant in the United StatesQ27346292
The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humansQ27697610
The antibody aducanumab reduces Aβ plaques in Alzheimer’s diseaseQ28005463
Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse modelsQ28119018
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domainQ28141707
Comparison of the genomes of human and mouse lays the foundation of genome zoologyQ28185769
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's diseaseQ28241772
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor proteinQ28260479
Activity-dependent p25 generation regulates synaptic plasticity and Aβ-induced cognitive impairmentQ28590111
The Evolution of Brains from Early Mammals to HumansQ28709606
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunctionQ29547778
Decreased clearance of CNS beta-amyloid in Alzheimer's diseaseQ29616534
High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formationQ29616564
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse modelQ29617937
Clinical and biomarker changes in dominantly inherited Alzheimer's diseaseQ29619940
Genomic variants, genes, and pathways of Alzheimer's disease: An overviewQ30240093
Alzheimer's diseaseQ30251865
Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic modelQ30478167
BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.Q30483997
Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transportQ30597672
Metabolism of amyloid beta peptide and pathogenesis of Alzheimer's disease. Towards presymptomatic diagnosis, prevention and therapyQ31031764
Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generationQ32063777
Alzheimer's disease: clinical trials and drug developmentQ33349401
Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APPQ33771562
Endoplasmic reticulum stress mediates amyloid β neurotoxicity via mitochondrial cholesterol traffickingQ33826820
Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrumQ33870467
BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over timeQ33970104
Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flowQ34042902
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivoQ34063772
Probing the biology of Alzheimer's disease in miceQ34206962
Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein productionQ34280406
Brain endothelial cells produce amyloid {beta} from amyloid precursor protein 770 and preferentially secrete the O-glycosylated formQ34401049
Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse modelsQ34418781
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenesQ34452028
The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregationQ34467463
National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's diseaseQ34635272
Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor proteinQ35065215
An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's diseaseQ35084401
Systematic review of the relationship between amyloid-β levels and measures of transgenic mouse cognitive deficit in Alzheimer's diseaseQ35137134
Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategiesQ35152946
η-Secretase processing of APP inhibits neuronal activity in the hippocampusQ35760228
Quantitation of amyloid beta-protein (A beta) in the cortex during aging and in Alzheimer's disease.Q35765178
BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic miceQ35809329
The mechanism of γ-Secretase dysfunction in familial Alzheimer diseaseQ36000134
A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic miceQ36027275
Amyloid deposition and advanced age fails to induce Alzheimer's type progression in a double knock-in mouse modelQ36040886
Pathophysiological roles of amyloidogenic carboxy-terminal fragments of the beta-amyloid precursor protein in Alzheimer's diseaseQ36094025
Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease.Q36106832
Rodent models for Alzheimer's disease drug discovery.Q36117249
Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid depositsQ36278396
Familial Alzheimer's disease mutations differentially alter amyloid β-protein oligomerizationQ36415249
Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's diseaseQ36564159
Mutation in the 3'untranslated region of APP as a genetic determinant of cerebral amyloid angiopathyQ36695844
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathologyQ36724967
Mobility and subcellular localization of endogenous, gene-edited Tau differs from that of over-expressed human wild-type and P301L mutant TauQ37064222
Differential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein-specific antibodiesQ37235627
Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controlsQ37259426
BACE1 regulates voltage-gated sodium channels and neuronal activityQ37355641
Store-Operated Calcium Channel Complex in Postsynaptic Spines: A New Therapeutic Target for Alzheimer's Disease Treatment.Q37445085
Bidirectional Crosstalk between Lymphatic Endothelial Cell and T Cell and Its Implications in Tumor ImmunityQ37625551
Differential contribution of APP metabolites to early cognitive deficits in a TgCRND8 mouse model of Alzheimer's diseaseQ37665855
'Too much good news' - are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease?Q37764575
Cerebral cortical development in rodents and primatesQ37974428
Cognitive components in mice and humans: combining genetics and touchscreens for medical translationQ38116667
Amyloid precursor protein and neural developmentQ38222924
Alzheimer's disease genetics: from the bench to the clinicQ38225911
A molecular web: endoplasmic reticulum stress, inflammation, and oxidative stress.Q38239644
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue17
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
protein precursorQ258658
membrane proteinQ423042
animal disease modelQ64732998
biomedical investigative techniqueQ66648976
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)2473-2487
P577publication date2017-08-01
2017-09-01
P1433published inThe EMBO JournalQ1278554
P1476titleAPP mouse models for Alzheimer's disease preclinical studies
P478volume36

Reverse relations

cites work (P2860)
Q64101612A Cautionary Tale: Endogenous Biotinylated Proteins and Exogenously-Introduced Protein A Cause Antibody-Independent Artefacts in Western Blot Studies of Brain-Derived Proteins
Q90732117A Human Embryonic Stem Cell Model of Aβ-Dependent Chronic Progressive Neurodegeneration
Q64265088Aberrant Excitatory-Inhibitory Synaptic Mechanisms in Entorhinal Cortex Microcircuits During the Pathogenesis of Alzheimer's Disease
Q61811401Age-related Disturbances in DNA (hydroxy)methylation in APP/PS1 Mice
Q91045286Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer's disease
Q93248642All (animal) models (of neurodegeneration) are wrong. Are they also useful?
Q64088896Alzheimer Aβ Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAKα3 Neurons by Secretion
Q91877796Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer's Disease
Q61811494Amyloid β perturbs elevated heme flux induced with neuronal development
Q64068921Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer's disease
Q91526804Amyloid-β-independent regulators of tau pathology in Alzheimer disease
Q93018574An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain
Q57143848Animal models of neurodegenerative diseases
Q64068852ApoE4: an emerging therapeutic target for Alzheimer's disease
Q90697479Astaxanthin Ameliorated Parvalbumin-Positive Neuron Deficits and Alzheimer's Disease-Related Pathological Progression in the Hippocampus of AppNL-G-F/NL-G-F Mice
Q96129239Biophysical studies of protein misfolding and aggregation in in vivo models of Alzheimer's and Parkinson's diseases
Q90929220Brain organoids: a next step for humanized Alzheimer's disease models?
Q90396209Can mouse models mimic sporadic Alzheimer's disease?
Q42371397Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants
Q64110888Cell Type-Specific Human APP Transgene Expression by Hippocampal Interneurons in the Tg2576 Mouse Model of Alzheimer's Disease
Q100307290Cerebrospinal fluid sTREM2 in Alzheimer's disease: comparisons between clinical presentation and AT classification
Q57040842Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice
Q90587999Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis
Q92501586Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model
Q53397508Critical review: involvement of endoplasmic reticulum stress in the aetiology of Alzheimer's disease.
Q91410950Dementia in Down syndrome: unique insights for Alzheimer disease research
Q57471358ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease
Q92187874Early Cognitive and Behavioral Deficits in Mouse Models for Tauopathy and Alzheimer's Disease
Q64946332Early-Onset Molecular Derangements in the Olfactory Bulb of Tg2576 Mice: Novel Insights Into the Stress-Responsive Olfactory Kinase Dynamics in Alzheimer's Disease.
Q47234302Endoplasmic reticulum stress responses in mouse models of Alzheimer disease: overexpression paradigm versus knock-in paradigm
Q48043354Exceptional in vivo catabolism of neurodegeneration-related aggregates
Q64067761Experimental Pharmacology in Transgenic Rodent Models of Alzheimer's Disease
Q92964504Exploring the efficacy of natural products in alleviating Alzheimer's disease
Q92572573Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice
Q50039492Gamma oscillations in the entorhinal-hippocampal circuit underlying memory and dementia.
Q47332864Gasotransmitter hydrogen sulfide signaling in neuronal health and disease
Q54965183Generation of App knock-in mice reveals deletion mutations protective against Alzheimer's disease-like pathology.
Q60935279Genomics: New Light on Alzheimer's Disease Research
Q57160792Herpes simplex virus-1 specifically targets human CD1d antigen presentation to enhance its pathogenicity
Q61444197Heterochromatic genome instability and neurodegeneration sharing similarities with Alzheimer's disease in old Bmi1+/- mice
Q58761831Human Alzheimer's disease gene expression signatures and immune profile in APP mouse models: a discrete transcriptomic view of Aβ plaque pathology
Q90754253Imbalance in the response of pre- and post-synaptic components to amyloidopathy
Q93158341Immune Signaling in Neurodegeneration
Q55365163Immunotherapy to improve cognition and reduce pathological species in an Alzheimer's disease mouse model.
Q93000628Intracellular Calcium Dysregulation by the Alzheimer's Disease-Linked Protein Presenilin 2
Q52310735Lack of human-like extracellular sortilin neuropathology in transgenic Alzheimer's disease model mice and macaques.
Q96952556Leveraging preclinical models for the development of Alzheimer disease therapeutics
Q90390163M1 muscarinic receptor is a key target of neuroprotection, neuroregeneration and memory recovery by i-Extract from Withania somnifera
Q90206387Microglia in Alzheimer Disease: Well-Known Targets and New Opportunities
Q55073016Microglia in Alzheimer's Disease: Activated, Dysfunctional or Degenerative.
Q92483746Modeling Alzheimer's disease with iPSC-derived brain cells
Q59549217Modeling Alzheimer’s disease brains in vitro
Q92000754Modeling and Targeting Alzheimer's Disease With Organoids
Q90295696Mouse models of Alzheimer's disease cause rarefaction of pial collaterals and increased severity of ischemic stroke
Q91199030Neural oscillations during cognitive processes in an App knock-in mouse model of Alzheimer's disease pathology
Q90359231Neurodegenerative diseases: model organisms, pathology and autophagy
Q64933464Neuroinflammation in mouse models of Alzheimer's disease.
Q93379781Neuroinflammatory Cytokines Induce Amyloid Beta Neurotoxicity through Modulating Amyloid Precursor Protein Levels/Metabolism
Q91404770New Alzheimer's disease model mouse specialized for analyzing the function and toxicity of intraneuronal Amyloid β oligomers
Q50072580Noncoding RNAs in Alzheimer's disease
Q58787421Novel Quantitative Analyses of Spontaneous Synaptic Events in Cortical Pyramidal Cells Reveal Subtle Parvalbumin-Expressing Interneuron Dysfunction in a Knock-In Mouse Model of Alzheimer's Disease
Q90162258Overview of Transgenic Mouse Models for Alzheimer's Disease
Q64279068Partial Identification of Amyloid-β Degrading Activity in Human Serum
Q98163701Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer's-like mouse models
Q47135235Practical considerations for choosing a mouse model of Alzheimer's disease
Q91890979Preclinical Models of Alzheimer's Disease: Relevance and Translational Validity
Q52721951Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression.
Q58800414Protein Co-Aggregation Related to Amyloids: Methods of Investigation, Diversity, and Classification
Q60926571Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration
Q57800439Questions concerning the role of amyloid-β in the definition, aetiology and diagnosis of Alzheimer's disease
Q89174583Reagent Validation to Facilitate Experimental Reproducibility
Q58027500Rodent models for Alzheimer disease
Q50288922Role of Copper in the Onset of Alzheimer's Disease Compared to Other Metals.
Q55365674Sex Differences in Healthspan Predict Lifespan in the 3xTg-AD Mouse Model of Alzheimer's Disease.
Q89501868Sleep and EEG Power Spectral Analysis in Three Transgenic Mouse Models of Alzheimer's Disease: APP/PS1, 3xTgAD, and Tg2576
Q93134029Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression
Q89253294Spontaneous development of Alzheimer's disease-associated brain pathology in a Shugoshin-1 mouse cohesinopathy model
Q46257963Studies for Improving a Rat Model of Alzheimer's Disease: Icv Administration of Well-Characterized β-Amyloid 1-42 Oligomers Induce Dysfunction in Spatial Memory.
Q92501860Tau binding protein CAPON induces tau aggregation and neurodegeneration
Q91797951Tau- but not Aß -pathology enhances NMDAR-dependent depotentiation in AD-mouse models
Q92055304Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice
Q54977832The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade.
Q59806753The Emerging Role of Altered Cerebellar Synaptic Processing in Alzheimer's Disease
Q90275177The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques
Q88947004The biomedical challenge of neurodegenerative disorders: an opportunity for cannabinoid-based therapies to improve on the poor current therapeutic outcomes
Q89980820The clinical promise of biomarkers of synapse damage or loss in Alzheimer's disease
Q49823902The mitochondrial transcription factor TFAM in neurodegeneration: emerging evidence and mechanisms
Q88427169The role of adult hippocampal neurogenesis in brain health and disease
Q64109478Ultrastructural evidence of microglial heterogeneity in Alzheimer's disease amyloid pathology
Q55019485Using Drosophila Models of Amyloid Toxicity to Study Autophagy in the Pathogenesis of Alzheimer's Disease.
Q57471412Whole brain imaging reveals distinct spatial patterns of amyloid beta deposition in three mouse models of Alzheimer's disease

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