Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation

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Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation is …
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scholarly articleQ13442814

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P356DOI10.1128/MCB.14.12.8420
P3181OpenCitations bibliographic resource ID3156778
P932PMC publication ID359381
P698PubMed publication ID7969176
P5875ResearchGate publication ID15230416

P2093author name stringM Xu
A S Yee
H Piwnica-Worms
C Y Peng
K A Sheppard
P2860cites workJNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domainQ24308838
Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activationQ24318303
Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2FQ24320151
The retinoblastoma protein binds to a family of E2F transcription factorsQ24320199
The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and EQ28257000
Isolation of the Rb-related p130 through its interaction with CDK2 and cyclinsQ28257012
Inhibition of cell proliferation by p107, a relative of the retinoblastoma proteinQ28260016
Differential regulation of E2F transactivation by cyclin/cdk2 complexesQ28612933
Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinaseQ28612948
Regulation of retinoblastoma protein functions by ectopic expression of human cyclinsQ29618320
E2F: a link between the Rb tumor suppressor protein and viral oncoproteinsQ29618375
Transforming gene product of Rous sarcoma virus phosphorylates tyrosineQ29620005
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like propertiesQ29620009
A cDNA encoding a pRB-binding protein with properties of the transcription factor E2FQ29620241
The E2F transcription factor is a cellular target for the RB proteinQ29620422
E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factorQ33856709
Phosphorylation-dependent activation of the adenovirus-inducible E2F transcription factor in a cell-free systemQ33860609
A- and B-type cyclins differentially modulate substrate specificity of cyclin-cdk complexesQ34050417
Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F.Q34063326
Expression of transcription factor E2F1 induces quiescent cells to enter S phaseQ34354875
Phosphorylation independent activation of human cyclin-dependent kinase 2 by cyclin A in vitroQ34435398
Transcriptional repression by the Rb-related protein p107.Q34436464
Cyclin A and the retinoblastoma gene product complex with a common transcription factorQ34756189
The retinoblastoma protein as a transcriptional repressorQ35632949
Advances in RNA polymerase II transcriptionQ35673499
Transcription factor E2F binds DNA as a heterodimerQ36248768
The regulation of transcription by phosphorylationQ36377421
The transcription factor E2F-1 mediates the autoregulation of RB gene expressionQ36643356
Cloning, chromosomal location, and characterization of mouse E2F1Q36647938
A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoterQ36676009
Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppressionQ36685714
Cell cycle analysis of E2F in primary human T cells reveals novel E2F complexes and biochemically distinct forms of free E2F.Q36689847
Biological function of the retinoblastoma protein requires distinct domains for hyperphosphorylation and transcription factor bindingQ36706168
An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcriptionQ36765388
The adenovirus-inducible factor E2F stimulates transcription after specific DNA bindingQ36765954
Transcription factor E2F is required for efficient expression of the hamster dihydrofolate reductase gene in vitro and in vivoQ36795598
Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 geneQ36821079
The HIP1 binding site is required for growth regulation of the dihydrofolate reductase gene promoterQ36962702
A new component of the transcription factor DRTF1/E2F.Q38321048
Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct mannerQ38325589
Association of cdk2 Kinase with the Transcription Factor E2F During S PhaseQ38330343
The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated mannerQ38331104
Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F.Q38331115
Interaction of p107 with cyclin A independent of complex formation with viral oncoproteinsQ38331144
The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding proteinQ38334727
The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2FQ38334818
A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathwayQ38340261
Nuclear factor E2F mediates basic transcription and trans-activation by E1a of the human MYC promoterQ38344934
A genetic analysis of the E2F1 gene distinguishes regulation by Rb, p107, and adenovirus E4.Q40656289
Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma proteinQ40656395
DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle controlQ40762422
Interactions of the p107 and Rb proteins with E2F during the cell proliferation responseQ40872245
Promoter interaction of the E1A-inducible factor E2F and its potential role in the formation of a multi-component complexQ41345323
Cell cycle regulation of the human cdc2 geneQ41523467
Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2FQ41591490
Retinoblastoma protein switches the E2F site from positive to negative elementQ41613404
Identification of a growth suppression domain within the retinoblastoma gene productQ41619792
A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex.Q41644025
Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A.Q41678631
Cell cycle-specific association of E2F with the p130 E1A-binding proteinQ42804203
Mechanisms of p34cdc2 regulationQ43182453
Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family membersQ44269566
Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA.Q44697855
The retinoblastoma protein region required for interaction with the E2F transcription factor includes the T/E1A binding and carboxy-terminal sequencesQ46784209
Identification of a cellular transcription factor involved in E1A trans-activationQ48366187
The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2FQ52162406
Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factorQ52480364
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)8420-31
P577publication date1994-12-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleCyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation
P478volume14