Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor

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Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor is …
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P6179Dimensions Publication ID1011437035
P356DOI10.1038/NATURE09856
P3181OpenCitations bibliographic resource ID3314899
P932PMC publication ID3046811
P698PubMed publication ID21350482
P5875ResearchGate publication ID50196484

P50authorElisabeth BinderQ19414380
Bekh BradleyQ57057855
Tanja JovanovicQ90222361
Victor MayQ90734134
Varun KilaruQ91320383
Karen M. BraasQ113869322
Seth D NorrholmQ114444895
Kristina B MercerQ114444896
Kimberly A KerleyQ114444898
Sayamwong E HammackQ117270899
Donna J ToufexisQ117270900
Kerry J. ResslerQ30509274
P2093author name stringAmanda J Myers
Alicia K Smith
Anzhelika Engel
Manuel Ramirez
Amy Mahan
P2860cites workRole of PACAP in the physiology and pathology of the sympathoadrenal system.Q37019460
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Emotional memory: in search of systems and synapsesQ40715927
Light-enhanced startle: further pharmacological and behavioral characterizationQ43893899
Effect of Darkness on Acoustic Startle in Vietnam Veterans With PTSDQ45335062
Noncompensation in peptide/receptor gene expression and distinct behavioral phenotypes in VIP- and PACAP-deficient miceQ48400890
Double Dissociation between the Involvement of the Bed Nucleus of the Stria Terminalis and the Central Nucleus of the Amygdala in Startle Increases Produced by Conditioned versus Unconditioned FearQ48579580
Mental health problems, use of mental health services, and attrition from military service after returning from deployment to Iraq or AfghanistanQ51920790
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Mediation of PACAP–like neuropeptide transmission by coactivation of Ras/Raf and cAMP signal transduction pathways in DrosophilaQ59075588
Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cellsQ69772725
Comparison of the PTSD Symptom Scale-Interview Version and the Clinician-Administered PTSD scaleQ73852161
New insights into the central PACAPergic system from the phenotypes in PACAP- and PACAP receptor-knockout miceQ95802870
Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adultsQ24649595
Behavioral despair in mice: a primary screening test for antidepressantsQ28258027
Differential signal transduction by five splice variants of the PACAP receptorQ28566746
Chronic stress increases pituitary adenylate cyclase-activating peptide (PACAP) and brain-derived neurotrophic factor (BDNF) mRNA expression in the bed nucleus of the stria terminalis (BNST): roles for PACAP in anxiety-like behaviorQ28578421
Sex differences in corticotropin-releasing factor receptor signaling and trafficking: potential role in female vulnerability to stress-related psychopathologyQ28583583
Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1.Q29417150
How the neurocircuitry and genetics of fear inhibition may inform our understanding of PTSD.Q30456148
Estrogen promotes stress sensitivity in a prefrontal cortex-amygdala pathwayQ30473246
Plastic synaptic networks of the amygdala for the acquisition, expression, and extinction of conditioned fearQ30476116
Impaired fear inhibition is a biomarker of PTSD but not depressionQ30476607
Risk and resilience: genetic and environmental influences on development of the stress response.Q30482099
Why we think plasticity underlying Pavlovian fear conditioning occurs in the basolateral amygdalaQ33684057
Pituitary adenylate cyclase-activating polypeptide is a sympathoadrenal neurotransmitter involved in catecholamine regulation and glucohomeostasisQ33898110
Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individualsQ34013528
Steroid hormones: effect on brain development and functionQ34238504
The epidemiology of posttraumatic stress disorder: what is the extent of the problem?Q34331013
The role of the amygdala in fear and anxietyQ34401070
The neurocircuitry of fear, stress, and anxiety disordersQ34660882
Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery.Q35006651
Neuronal signalling of fear memoryQ35924365
Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research--past, present, and futureQ36571175
Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor geneQ36744321
Neuroprotection: a comparative view of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptideQ36826706
Neurotrophic effects of PACAP in the cerebellar cortex.Q36838035
Localization, characterization and function of pituitary adenylate cyclase-activating polypeptide during brain developmentQ36919194
Response variation following trauma: a translational neuroscience approach to understanding PTSD.Q36962671
P433issue7335
P407language of work or nameEnglishQ1860
P921main subjectpost-traumatic stress disorderQ202387
Adenylate cyclase activating polypeptide 1Q6591522
ADCYAP1Q14907479
ADCYAP1R1Q17709847
P304page(s)492-497
P577publication date2011-02-01
P1433published inNatureQ180445
P1476titlePost-traumatic stress disorder is associated with PACAP and the PAC1 receptor
P478volume470

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Q36229576Prediction of Possible Biomarkers and Novel Pathways Conferring Risk to Post-Traumatic Stress Disorder
Q47918167Prevalence of probable posttraumatic stress disorder and determination of its relationship with everyday functioning in children and adolescents by using generalized estimating equations
Q36838744Pro- and anti-mitogenic actions of pituitary adenylate cyclase-activating polypeptide in developing cerebral cortex: potential mediation by developmental switch of PAC1 receptor mRNA isoforms
Q46025538Problematic alcohol use associates with sodium channel and clathrin linker 1 (SCLT1) in trauma-exposed populations.
Q84078371Psychiatric disorders: the stresses of womanhood
Q50641735Psychiatry: A molecular shield from trauma
Q26861658Psychosocial stress and asthma morbidity
Q35144047Putting the 'epi' into epigenetics research in psychiatry
Q34615776Quantitative forecasting of PTSD from early trauma responses: a Machine Learning application
Q46249249Quantitative trait loci for growth and body size in the nine-spined stickleback Pungitius pungitius L.
Q52603393Recent Genetics and Epigenetics Approaches to PTSD.
Q43825293Recent Trauma is Associated with Antiretroviral Failure and HIV Transmission Risk Behavior Among HIV-Positive Women and Female-Identified Transgenders
Q30442231Recent progress in understanding the pathophysiology of post-traumatic stress disorder: implications for targeted pharmacological treatment
Q35669220Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38.
Q30399924Regulation of bed nucleus of the stria terminalis PACAP expression by stress and corticosterone
Q33606810Relaxin' the brain: a case for targeting the nucleus incertus network and relaxin-3/RXFP3 system in neuropsychiatric disorders
Q37670707Relaxin-3/RXFP3 networks: an emerging target for the treatment of depression and other neuropsychiatric diseases?
Q30458749Review of biological mechanisms and pharmacological treatments of comorbid PTSD and substance use disorder
Q36276059Role of DNA Methylation on the Expression of the Anthracycline Metabolizing Enzyme AKR7A2 in Human Heart
Q64071408Role of the Bed Nucleus of the Stria Terminalis in PTSD: Insights From Preclinical Models
Q47116478Sex Differences in Trauma-Related Psychopathology: a Critical Review of Neuroimaging Literature (2014-2017).
Q37163160Sex dependent influence of a functional polymorphism in steroid 5-α-reductase type 2 (SRD5A2) on post-traumatic stress symptoms
Q35934683Sex differences in DNA methylation may contribute to risk of PTSD and depression: a review of existing evidence
Q35120303Sex differences in PTSD resilience and susceptibility: Challenges for animal models of fear learning
Q36961553Sex differences in anxiety and depression clinical perspectives
Q36775163Sex differences in anxiety disorders: Interactions between fear, stress, and gonadal hormones
Q30445153Sex differences in fear conditioning in posttraumatic stress disorder
Q35765589Sex differences in sensitivity to the depressive-like effects of the kappa opioid receptor agonist U-50488 in rats
Q48895095Sex-dependent and differential responses to acute restraint stress of corticotropin-releasing factor-producing neurons in the rat paraventricular nucleus, central amygdala, and bed nucleus of the stria terminalis
Q99637192Sex-specific effects of the histone variant H2A.Z on fear memory, stress-enhanced fear learning and hypersensitivity to pain
Q98196747Single nucleotide polymorphisms in tinnitus patients exhibiting severe distress
Q35981371Social subordination produces distinct stress-related phenotypes in female rhesus monkeys
Q96348444Splice-specific deficiency of the PTSD-associated gene PAC1 leads to a paradoxical age-dependent stress behavior
Q64949779Stress Across Generations: DNA Methylation as a Potential Mechanism Underlying Intergenerational Effects of Stress in Both Post-traumatic Stress Disorder and Pre-clinical Predator Stress Rodent Models.
Q36595175Stress Increases Voluntary Alcohol Intake, but Does not Alter Established Drinking Habits in a Rat Model of Posttraumatic Stress Disorder
Q35879689Stress and Bronchodilator Response in Children with Asthma
Q34613768Stress and asthma: novel insights on genetic, epigenetic, and immunologic mechanisms
Q42375831Stress, ADCYAP1R1, and Childhood Asthma. No Sigh of Relief
Q37618525Stress-related disorders, pituitary adenylate cyclase-activating peptide (PACAP)ergic system, and sex differences
Q42537382Stress: a possible link between genetics, epigenetics, and childhood asthma
Q38429410Susceptibility and Resilience to Posttraumatic Stress Disorder-like Behaviors in Inbred Mice
Q38509927Systematic Review on Post-Traumatic Stress Disorder Among Survivors of the Wenchuan Earthquake.
Q38334909Systems biology approach to understanding post-traumatic stress disorder
Q47699005TACR1 gene polymorphism and sex differences in postoperative nausea and vomiting
Q27016155Targeting memory processes with drugs to prevent or cure PTSD
Q91717863Targeting the PAC1 Receptor for Neurological and Metabolic Disorders
Q33583121The Combination of Long-term Ketamine and Extinction Training Contributes to Fear Erasure by Bdnf Methylation
Q47884557The Effects of Prior Stress on Anxiety-Like Responding to Intra-BNST Pituitary Adenylate Cyclase Activating Polypeptide in Male and Female Rats.
Q59166447The Formation of a Neural Fear Network in Posttraumatic Stress Disorder
Q28396166The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders
Q34236353The Imprinted Brain: How Genes Set the Balance Between Autism and Psychosis
Q34532319The N-Terminal HSDCIF Motif Is Required for Cell Surface Trafficking and Dimerization of Family B G Protein Coupled Receptor PAC1
Q89510221The Neuroprotective and Biomarker Potential of PACAP in Human Traumatic Brain Injury
Q28081561The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: Posttraumatic Stress Disorder Enters the Age of Large-Scale Genomic Collaboration
Q26799558The Research Domain Criteria (RDoC) Project and Studies of Risk and Resilience in Maltreated Children
Q95270126The Role of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Signaling in the Hippocampal Dentate Gyrus
Q30455815The anxiety spectrum and the reflex physiology of defense: from circumscribed fear to broad distress
Q90168060The autism-mutated ADNP plays a key role in stress response
Q30383734The central amygdala as an integrative hub for anxiety and alcohol use disorders
Q47776566The clandestine organs of the endocrine system
Q35985454The early life social environment and DNA methylation: DNA methylation mediating the long-term impact of social environments early in life
Q37974947The early‐life social environment and DNA methylation
Q51308838The expression of PAC1 increases in the degenerative thymus and low dose PACAP protects female mice from cyclophosphamide induced thymus atrophy
Q36915482The functional serotonin 1a receptor promoter polymorphism, rs6295, is associated with psychiatric illness and differences in transcription
Q24607129The genetic basis of addictive disorders
Q92587631The glucocorticoid receptor-FKBP51 complex contributes to fear conditioning and posttraumatic stress disorder
Q38435969The potential of epigenetics in stress-enhanced fear learning models of PTSD.
Q30437494Towards new approaches to disorders of fear and anxiety
Q38162818Translational approaches to anxiety: focus on genetics, fear extinction and brain imaging
Q46156583Trauma Exposure, PTSD, and Parenting in a Community Sample of Low-Income, Predominantly African American Mothers and Children.
Q38167041Understanding posttraumatic stress disorder: insights from the methylome.
Q37916954Understanding risk for psychopathology through imaging gene-environment interactions
Q33732168Update in asthma 2013
Q33635597Utilization of machine learning for prediction of post-traumatic stress: a re-examination of cortisol in the prediction and pathways to non-remitting PTSD
Q61809620VPAC1 receptors play a dominant role in PACAP-induced vasorelaxation in female mice
Q30300050Validation of candidate anxiety disorder genes using a carbon dioxide challenge task
Q39300491Women in recovery from PTSD have similar inflammation and quality of life as non-traumatized controls
Q36438099Yak whole-genome resequencing reveals domestication signatures and prehistoric population expansions
Q85288968[Psychological trauma as risk for delayed psychiatric disorders: epigenetic mechanisms]
Q54941845β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking.

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