The topical antimicrobial zinc pyrithione is a heat shock response inducer that causes DNA damage and PARP-dependent energy crisis in human skin cells

scientific article

The topical antimicrobial zinc pyrithione is a heat shock response inducer that causes DNA damage and PARP-dependent energy crisis in human skin cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1030383910
P356DOI10.1007/S12192-009-0145-6
P8608Fatcat IDrelease_lvtvfxrt4vdgrcyik6mmjjjpry
P932PMC publication ID2866994
P698PubMed publication ID19809895
P5875ResearchGate publication ID26876814

P2093author name stringChristopher M Cabello
Georg T Wondrak
Sarah D Lamore
P2860cites workThe cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growthQ24646381
Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testingQ28140019
Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin diseaseQ28298870
Induction by synaptic zinc of heat shock protein-70 in hippocampus after kainate seizuresQ28370935
A simple technique for quantitation of low levels of DNA damage in individual cellsQ29014320
Effects of zinc acetate on splenocytes of endotoxemic mice: enhanced immune response, reduced apoptosis, and increased expression of heat shock protein 70.Q31812548
Poly(APD-ribosyl)ation, a DNA damage-driven protein modification and regulator of genomic instabilityQ34132736
A multicenter randomized trial of ketoconazole 2% and zinc pyrithione 1% shampoos in severe dandruff and seborrheic dermatitisQ34163879
Zinc pyrithione in alcohol-based products for skin antisepsis: persistence of antimicrobial effectsQ34390001
Synthesis and anticancer properties of water-soluble zinc ionophoresQ34551766
What is the 'true' function of skin?Q34627005
Zinc protects endothelial cells from hydrogen peroxide via Nrf2-dependent stimulation of glutathione biosynthesisQ34655936
Environmental pollutants and skin cancerQ34871465
Hsp70B' regulation and functionQ35981119
Poly(ADP-ribose) polymerases: managing genome stabilityQ36060144
Endogenous UVA-photosensitizers: mediators of skin photodamage and novel targets for skin photoprotectionQ36390337
Let the sun shine in: mechanisms and potential for therapeutics in skin photodamage.Q36829902
Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stressQ37010338
The experimental chemotherapeutic N6-furfuryladenosine (kinetin-riboside) induces rapid ATP depletion, genotoxic stress, and CDKN1A(p21) upregulation in human cancer cell linesQ37130026
Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatinQ37261069
Significance of heat shock proteins in the skin upon UV exposureQ37410681
Pyrithione, a zinc ionophore, inhibits NF-kappaB activationQ38527829
Overexpression of methionine sulfoxide reductases A and B2 protects MOLT-4 cells against zinc-induced oxidative stressQ39948976
Inhibition of poly(ADP-ribose) polymerase (PARP) influences the mode of sulfur mustard (SM)-induced cell death in HaCaT cellsQ40043023
NQO1-activated phenothiazinium redox cyclers for the targeted bioreductive induction of cancer cell apoptosisQ40113045
Induction of the 72-kilodalton heat shock protein and protection from ultraviolet B-induced cell death in human keratinocytes by repetitive exposure to heat shock or 15-deoxy-delta(12,14)-prostaglandin J2.Q40298208
Poly ADP-ribose polymerase (PARP) inhibitors transiently protect leukemia cells from alkylating agent induced cell death by three different effectsQ40620765
Alkylating DNA damage stimulates a regulated form of necrotic cell deathQ40903823
Percutaneous absorption of zinc pyridinethione in monkeysQ41415992
Updated in vivo Methods for Evaluating Topical Antimicrobial Agents on Human SkinQ41502751
Molecular cloning and expression of a cDNA encoding an apoptotic endonuclease DNase gammaQ41898310
Studies on cytotoxic and genotoxic effects of N-hydroxypyridine-2-thione (Omadine) in L5178Y mouse lymphoma cellsQ44170432
DNA damage by carbonyl stress in human skin cellsQ44271857
Proteins of the extracellular matrix are sensitizers of photo-oxidative stress in human skin cellsQ44553529
Comparative percutaneous absorption of pyrithionesQ45234938
Zinc pyrithione induces apoptosis and increases expression of Bim.Q46448392
Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extractsQ46791777
Evaluation of the genotoxic potential of zinc pyrithione in the Salmonella mutagenicity (Ames) assay, CHO/HGPRT gene mutation assay and mouse micronucleus assayQ50160936
Zinc induces ERK-dependent cell death through a specific Ras isoform.Q51803492
H2AX phosphorylation after UV irradiation is triggered by DNA repair intermediates and is mediated by the ATR kinase.Q53331348
The roles of poly(ADP-ribose)-metabolizing enzymes in alkylation-induced cell death.Q54550534
Structural characterization of bis(N-oxopyridine-2-thionato)zinc(II)Q56428284
Zinc pyrithione (Zinc Omadine) allergyQ70071126
Regulation of hsp70 synthesis induced by cupric sulfate and zinc sulfate in thermotolerant HeLa cellsQ72694996
Effects of cadmium and zinc on solar-simulated light-irradiated cells: potential role of zinc-metallothionein in zinc-induced genoprotectionQ74762793
Embryotoxicity of zinc pyrithione, an antidandruff chemical, in fishQ77850170
SAFETY EVALUATION OF ZINC 2-PYRIDINETHIOL 1-OXIDE IN A SHAMPOO FORMULATIONQ78345264
PARP-1-induced cell death through inhibition of the MEK/ERK pathway in MNNG-treated HeLa cellsQ81166510
A double-blind randomized vehicle-controlled clinical trial investigating the effect of ZnPTO dose on the scalp vs. antidandruff efficacy and antimycotic activityQ81316413
Activation of molecular adaptation to sunlight--a new approach to photoprotectionQ81503069
PhotoprotectionQ81803201
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
DNA damageQ5205747
P304page(s)309-22
P577publication date2010-05-01
P1433published inCell Stress & ChaperonesQ13458649
P1476titleThe topical antimicrobial zinc pyrithione is a heat shock response inducer that causes DNA damage and PARP-dependent energy crisis in human skin cells
P478volume15

Reverse relations

cites work (P2860)
Q38786525A Topical Zinc Ionophore Blocks Tumorigenic Progression in UV-exposed SKH-1 High-risk Mouse Skin
Q39439229Antineoplastic activity of ouabain and pyrithione zinc in acute myeloid leukemia
Q33870883Autophagic-lysosomal dysregulation downstream of cathepsin B inactivation in human skin fibroblasts exposed to UVA.
Q38476996Climbazole increases expression of cornified envelope proteins in primary keratinocytes.
Q41901385Curcuma purpurascens BI. rhizome accelerates rat excisional wound healing: involvement of Hsp70/Bax proteins, antioxidant defense, and angiogenesis activity
Q37189245D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis
Q28297100DCPIP (2,6-dichlorophenolindophenol) as a genotype-directed redox chemotherapeutic targeting NQO1*2 breast carcinoma
Q38912188Effects of non-toxic zinc exposure on human epidermal keratinocytes.
Q41679806Evaluation of mutagenic and antimicrobial properties of brown propolis essential oil from the Brazilian Cerrado biome
Q42707898Interference of CuO nanoparticles with metal homeostasis in hepatocytes under sub-toxic conditions
Q28546512Moles of a Substance per Cell Is a Highly Informative Dosing Metric in Cell Culture
Q36656212Phenotypic identification of the redox dye methylene blue as an antagonist of heat shock response gene expression in metastatic melanoma cells
Q40707513Phytotoxicity evaluation of some commonly used shampoos using Brassica napus L.
Q64100289Protective effects of novel derivatives of vitamin D3 and lumisterol against UVB-induced damage in human keratinocytes involve activation of Nrf2 and p53 defense mechanisms
Q34402583Proteomic Identification of Cathepsin B and Nucleophosmin as Novel UVA‐Targets in Human Skin Fibroblasts
Q37706728Repurposing an antidandruff agent to treating cancer: zinc pyrithione inhibits tumor growth via targeting proteasome-associated deubiquitinases.
Q35113995Resveratrol prevents epigenetic silencing of BRCA-1 by the aromatic hydrocarbon receptor in human breast cancer cells
Q47807724Systematic Quantification of Population Cell Death Kinetics in Mammalian Cells.
Q35602551The Tryptophan-Derived Endogenous Aryl Hydrocarbon Receptor Ligand 6-Formylindolo[3,2-b]Carbazole Is a Nanomolar UVA Photosensitizer in Epidermal Keratinocytes
Q35013756The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death
Q22061955The redox antimalarial dihydroartemisinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosis
Q35823218Thiostrepton is an inducer of oxidative and proteotoxic stress that impairs viability of human melanoma cells but not primary melanocytes
Q37010298UVA causes dual inactivation of cathepsin B and L underlying lysosomal dysfunction in human dermal fibroblasts
Q34216402Zinc pyrithione impairs zinc homeostasis and upregulates stress response gene expression in reconstructed human epidermis

Search more.