Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice

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Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1476-5381.2010.00826.X
P932PMC publication ID2962821
P698PubMed publication ID20718744
P5875ResearchGate publication ID45706741

P2093author name stringYing Feng
Wei Dou
Yu Shen
Song Zhang
Ying Leng
Jian-hua Shen
Jun-hua Chen
Su-ling Huang
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11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stressQ36833926
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Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient miceQ42459262
Glucocorticoids down-regulate glucose uptake capacity and insulin-signaling proteins in omental but not subcutaneous human adipocytes.Q42462690
Increased expression of 11beta-hydroxysteroid dehydrogenase type 1 in type 2 diabetic myotubesQ42484332
Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null miceQ43730363
Immunosuppressive effect of emodin, a free radical generatorQ43810833
Aloe emodin suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture.Q44036377
Effects of the 11 beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes.Q44273298
Subcutaneous adipose 11 beta-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in Pima Indians and CaucasiansQ44467081
Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strainsQ44576264
Regulation of 11beta-HSD genes in human adipose tissue: influence of central obesity and weight lossQ44741685
11beta-hydroxysteroid dehydrogenase type 1 activity in lean and obese males with type 2 diabetes mellitusQ45050691
Cortisol secretion in relation to body fat distribution in obese premenopausal womenQ45252138
Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11beta-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone.Q45285404
Diet-induced type II diabetes in C57BL/6J miceQ45730735
In vivo pharmacokinetics comparisons of icariin, emodin and psoralen from gan-kang granules and extracts of herba Epimedii, Nepal dock root, Ficus hirta yahl.Q46005172
Hypoglycaemic and hypolipidaemic effects of emodin and its effect on L-type calcium channels in dyslipidaemic-diabetic ratsQ46373869
Hormonal regulation of hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytesQ46404958
An all atom force field for simulations of proteins and nucleic acidsQ46625508
Development and application of a scintillation proximity assay (SPA) for identification of selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.Q46717961
Sub-chronic administration of the 11beta-HSD1 inhibitor, carbenoxolone, improves glucose tolerance and insulin sensitivity in mice with diet-induced obesityQ46787475
Effect of dexamethasone on glucose tolerance and fat metabolism in a diet-induced obesity mouse modelQ46920977
Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 reduces food intake and weight gain but maintains energy expenditure in diet-induced obese miceQ47341892
Carbenoxolone treatment attenuates symptoms of metabolic syndrome and atherogenesis in obese, hyperlipidemic mice.Q51463179
Emodin inhibits TNF-alpha-induced human aortic smooth-muscle cell proliferation via caspase- and mitochondrial-dependent apoptosis.Q53476116
Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis.Q53579867
Discovery of adamantane ethers as inhibitors of 11beta-HSD-1: Synthesis and biological evaluation.Q53584635
Anti-inflammatory effects of emodin from ventilago leiocarpaQ71693452
Emodin-induced inhibition of growth and DNA damage in the Helicobacter pyloriQ74173332
Glucocorticoids and neuroendocrine functionQ74345554
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectobesityQ12174
natural productQ901227
hydroxysteroidQ2157080
P304page(s)113-26
P577publication date2010-09-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleEmodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice
P478volume161

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