Screening of a natural compound library identifies emodin, a natural compound from Rheum palmatum Linn that inhibits DPP4.

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Screening of a natural compound library identifies emodin, a natural compound from Rheum palmatum Linn that inhibits DPP4. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.7717/PEERJ.3283
P932PMC publication ID5428354
P698PubMed publication ID28507818

P2093author name stringChao Zhang
Peng Wu
Fang Zhang
Min Li
Wenjie Liu
Zhaokai Wang
Longhe Yang
Hu Fan
P2860cites workAnti-diabetic effect of a traditional Chinese medicine formula.Q51352693
Design, synthesis and biological evaluation of 4-fluoropyrrolidine-2-carbonitrile and octahydrocyclopenta[b]pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors.Q53462796
Emodin ameliorates high glucose induced-podocyte epithelial-mesenchymal transition in-vitro and in-vivo.Q53576886
Emodin-induced inhibition of growth and DNA damage in the Helicobacter pyloriQ74173332
Emodin protects against diabetic cardiomyopathy by regulating the AKT/GSK-3β signaling pathway in the rat modelQ85331689
Bioassay-guided isolation of DPP-4 inhibitory fractions from extracts of submerged cultured of Inonotus obliquusQ85906676
Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese miceQ24627436
Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IVQ27644485
8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetesQ27649174
Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetesQ28262769
Biology of incretins: GLP-1 and GIPQ29617302
Chinese herbal medicines for type 2 diabetes mellitusQ31097067
Immune reponses in human mesangial cells regulated by emodin from Polygonum hypoleucum OhwiQ32101822
Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9.Q33368655
A new dipeptide naphthylamidase hydrolyzing glycyl-prolyl-beta-naphthylamideQ34661843
Effect of diacerein on insulin secretion and metabolic control in drug-naive patients with type 2 diabetes: a randomized clinical trialQ35060231
Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV.Q35189265
Emodin regulates glucose utilization by activating AMP-activated protein kinaseQ36635928
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitusQ37141727
Berry and Citrus Phenolic Compounds Inhibit Dipeptidyl Peptidase IV: Implications in Diabetes ManagementQ37171907
Emodin, an 11β-hydroxysteroid dehydrogenase type 1 inhibitor, regulates adipocyte function in vitro and exerts anti-diabetic effect in ob/ob miceQ37729480
Diabetes is an inflammatory disease: evidence from traditional Chinese medicinesQ37825944
Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer.Q38130366
The distinct mechanisms of the antitumor activity of emodin in different types of cancer (Review).Q38142749
Pharmacology, physiology, and mechanisms of action of dipeptidyl peptidase-4 inhibitorsQ38248682
Astragalus polysaccharides decreased the expression of PTP1B through relieving ER stress induced activation of ATF6 in a rat model of type 2 diabetesQ39838494
The role of β cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugsQ41849970
Antihyperglycemic effect of catalpol in streptozotocin-induced diabetic ratsQ43046471
Anti-diabetic effects of emodin involved in the activation of PPARgamma on high-fat diet-fed and low dose of streptozotocin-induced diabetic miceQ43287880
Aloe emodin suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture.Q44036377
1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic propertiesQ44474559
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetesQ45212807
Hypoglycaemic and hypolipidaemic effects of emodin and its effect on L-type calcium channels in dyslipidaemic-diabetic ratsQ46373869
The protection of Rhein lysinate to liver in diabetic mice induced by high-fat diet and streptozotocinQ46873961
NTP Toxicology and Carcinogenesis Studies of EMODIN (CAS NO. 518-82-1) Feed Studies in F344/N Rats and B6C3F1 Mice.Q47409195
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectRheum palmatumQ1109580
P304page(s)e3283
P577publication date2017-05-10
P1433published inPeerJQ2000010
P1476titleScreening of a natural compound library identifies emodin, a natural compound from Rheum palmatum Linn that inhibits DPP4.
P478volume5

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cites work (P2860)
Q64226372Polyalthia Clerodane Diterpene Potentiates Hypoglycemia via Inhibition of Dipeptidyl Peptidase 4
Q49940117Tackling dipeptidyl peptidase IV in neurological disorders
Q90291678The perceptions of natural compounds against dipeptidyl peptidase 4 in diabetes: from in silico to in vivo

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