LYN proto-oncogene, Src family tyrosine kinase

mammalian protein found in Homo sapiens

Wikidata entity: Q2463389



P682 biological process ... Q210861 (cell differentiation) cell differentiation
P682 biological process ... Q242736 (phosphorylation) phosphorylation
P682 biological process ... Q179217 (blood coagulation) blood coagulation
P682 biological process ... Q14818018 (cellular response to DNA damage stimulus) cellular response to DNA damage stimulus
P682 biological process ... Q14819456 (platelet degranulation) platelet degranulation
P682 biological process ... Q14819467 (platelet activation) platelet activation
P682 biological process ... Q14819471 (leukocyte migration) leukocyte migration
P682 biological process ... Q14819846 (positive regulation of protein phosphorylation) positive regulation of protein phosphorylation
P682 biological process ... Q14819849 (inflammatory response) inflammatory response
P682 biological process ... Q14820585 (growth hormone receptor signaling pathway via JAK-STAT) growth hormone receptor signaling pathway via JAK-STAT
P682 biological process ... Q14820890 (response to peptide hormone) response to peptide hormone
P682 biological process ... Q14820916 (response to organic cyclic compound) response to organic cyclic compound
P682 biological process ... Q14851938 (cellular response to retinoic acid) cellular response to retinoic acid
P682 biological process ... Q14851946 (regulation of protein phosphorylation) regulation of protein phosphorylation
P682 biological process ... Q14851952 (intracellular signal transduction) intracellular signal transduction
P682 biological process ... Q14852019 (positive regulation of Ras protein signal transduction) positive regulation of Ras protein signal transduction
P682 biological process ... Q14907336 (regulation of platelet aggregation) regulation of platelet aggregation
P682 biological process ... Q14911761 (regulation of erythrocyte differentiation) regulation of erythrocyte differentiation
P682 biological process ... Q14911811 (immune response-regulating cell surface receptor signaling pathway) immune response-regulating cell surface receptor signaling pathway
P682 biological process ... Q14912444 (positive regulation of mast cell proliferation) positive regulation of mast cell proliferation
P682 biological process ... Q14912571 (negative regulation of toll-like receptor 2 signaling pathway) negative regulation of toll-like receptor 2 signaling pathway
P682 biological process ... Q14914499 (positive regulation of dendritic cell apoptotic process) positive regulation of dendritic cell apoptotic process
P682 biological process ... Q14916317 (immune system process) immune system process
P682 biological process ... Q15314472 (regulation of mast cell degranulation) regulation of mast cell degranulation
P682 biological process ... Q15323358 (negative regulation of toll-like receptor 4 signaling pathway) negative regulation of toll-like receptor 4 signaling pathway
P682 biological process ... Q15328828 (peptidyl-tyrosine autophosphorylation) peptidyl-tyrosine autophosphorylation
P682 biological process ... Q15331818 (Fc receptor mediated stimulatory signaling pathway) Fc receptor mediated stimulatory signaling pathway
P682 biological process ... Q15331821 (negative regulation of myeloid leukocyte differentiation) negative regulation of myeloid leukocyte differentiation
P682 biological process ... Q15331824 (Fc receptor mediated inhibitory signaling pathway) Fc receptor mediated inhibitory signaling pathway
P682 biological process ... Q15331828 (response to sterol depletion) response to sterol depletion
P682 biological process ... Q15331838 (regulation of mast cell activation) regulation of mast cell activation
P682 biological process ... Q15331849 (regulation of B cell receptor signaling pathway) regulation of B cell receptor signaling pathway
P682 biological process ... Q15331854 (regulation of release of sequestered calcium ion into cytosol) regulation of release of sequestered calcium ion into cytosol
P682 biological process ... Q15331857 (positive regulation of Fc receptor mediated stimulatory signaling pathway) positive regulation of Fc receptor mediated stimulatory signaling pathway
P682 biological process ... Q15331860 (positive regulation of stress-activated protein kinase signaling cascade) positive regulation of stress-activated protein kinase signaling cascade
P682 biological process ... Q15331864 (negative regulation of mast cell proliferation) negative regulation of mast cell proliferation
P682 biological process ... Q15331867 (regulation of monocyte chemotaxis) regulation of monocyte chemotaxis
P682 biological process ... Q15331910 (positive regulation of B cell receptor signaling pathway) positive regulation of B cell receptor signaling pathway
P682 biological process ... Q21095173 (stimulatory C-type lectin receptor signaling pathway) stimulatory C-type lectin receptor signaling pathway
P682 biological process ... Q21097219 (negative regulation of intracellular signal transduction) negative regulation of intracellular signal transduction
P682 biological process ... Q21121974 (positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process) positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
P682 biological process ... Q14852020 (response to axon injury) response to axon injury
P682 biological process ... Q14852033 (erythrocyte differentiation) erythrocyte differentiation
P682 biological process ... Q14859928 (oligodendrocyte development) oligodendrocyte development
P682 biological process ... Q14860214 (positive regulation of oligodendrocyte progenitor proliferation) positive regulation of oligodendrocyte progenitor proliferation
P682 biological process ... Q14860518 (regulation of inflammatory response) regulation of inflammatory response
P682 biological process ... Q14860559 (positive regulation of phosphorylation) positive regulation of phosphorylation
P682 biological process ... Q14860834 (response to amino acid) response to amino acid
P682 biological process ... Q14860865 (negative regulation of protein phosphorylation) negative regulation of protein phosphorylation
P682 biological process ... Q14863362 (transmembrane receptor protein tyrosine kinase signaling pathway) transmembrane receptor protein tyrosine kinase signaling pathway
P682 biological process ... Q14863380 (B cell homeostasis) B cell homeostasis
P682 biological process ... Q14863427 (B cell receptor signaling pathway) B cell receptor signaling pathway
P682 biological process ... Q14863711 (negative regulation of ERK1 and ERK2 cascade) negative regulation of ERK1 and ERK2 cascade
P682 biological process ... Q14863968 (Fc-gamma receptor signaling pathway involved in phagocytosis) Fc-gamma receptor signaling pathway involved in phagocytosis
P682 biological process ... Q14864036 (negative regulation of MAP kinase activity) negative regulation of MAP kinase activity
P682 biological process ... Q14864368 (neuron projection development) neuron projection development
P682 biological process ... Q14864446 (negative regulation of B cell proliferation) negative regulation of B cell proliferation
P682 biological process ... Q14864869 (positive regulation of glial cell proliferation) positive regulation of glial cell proliferation
P682 biological process ... Q14865169 (viral process) viral process
P682 biological process ... Q14865394 (T cell costimulation) T cell costimulation
P682 biological process ... Q14865493 (dendritic cell differentiation) dendritic cell differentiation
P682 biological process ... Q14865614 (tolerance induction to self antigen) tolerance induction to self antigen
P682 biological process ... Q14331037 (positive regulation of peptidyl-tyrosine phosphorylation) positive regulation of peptidyl-tyrosine phosphorylation
P682 biological process ... Q14599399 (negative regulation of cell population proliferation) negative regulation of cell population proliferation
P682 biological process ... Q14599419 (response to hormone) response to hormone
P682 biological process ... Q14599765 (response to insulin) response to insulin
P682 biological process ... Q14633891 (positive regulation of cell population proliferation) positive regulation of cell population proliferation
P682 biological process ... Q14758919 (positive regulation of cell migration) positive regulation of cell migration
P682 biological process ... Q14762273 (positive regulation of phosphatidylinositol 3-kinase activity) positive regulation of phosphatidylinositol 3-kinase activity
P682 biological process ... Q14905484 (regulation of cell adhesion mediated by integrin) regulation of cell adhesion mediated by integrin
P682 biological process ... Q14905487 (ephrin receptor signaling pathway) ephrin receptor signaling pathway
P682 biological process ... Q14906042 (histamine secretion by mast cell) histamine secretion by mast cell
P682 biological process ... Q14907233 (positive regulation of tyrosine phosphorylation of STAT protein) positive regulation of tyrosine phosphorylation of STAT protein
P682 biological process ... Q14865650 (negative regulation of immune response) negative regulation of immune response
P682 biological process ... Q14874299 (Fc-epsilon receptor signaling pathway) Fc-epsilon receptor signaling pathway
P682 biological process ... Q14875284 (regulation of cytokine production) regulation of cytokine production
P682 biological process ... Q14877485 (regulation of ERK1 and ERK2 cascade) regulation of ERK1 and ERK2 cascade
P682 biological process ... Q14878196 (cellular response to heat) cellular response to heat
P682 biological process ... Q14878347 (regulation of B cell apoptotic process) regulation of B cell apoptotic process
P682 biological process ... Q14885627 (lipopolysaccharide-mediated signaling pathway) lipopolysaccharide-mediated signaling pathway
P682 biological process ... Q14887714 (adaptive immune response) adaptive immune response
P682 biological process ... Q14890579 (response to carbohydrate) response to carbohydrate
P682 biological process ... Q14902449 (cellular response to extracellular stimulus) cellular response to extracellular stimulus
P682 biological process ... Q3630494 (protein autophosphorylation) protein autophosphorylation
P682 biological process ... Q7251493 (protein phosphorylation) protein phosphorylation
P682 biological process ... Q14330803 (response to toxic substance) response to toxic substance
P682 biological process ... Q14330967 (central nervous system development) central nervous system development
P682 biological process ... Q14330979 (positive regulation of neuron projection development) positive regulation of neuron projection development
P682 biological process ... Q14330982 (positive regulation of phosphatidylinositol 3-kinase signaling) positive regulation of phosphatidylinositol 3-kinase signaling
P682 biological process ... Q14330986 (peptidyl-tyrosine phosphorylation) peptidyl-tyrosine phosphorylation
P682 biological process ... Q428253 (innate immune response) innate immune response
P682 biological process ... Q828130 (signal transduction) signal transduction
P682 biological process ... Q919283 (hemopoiesis) hemopoiesis
P681 cell component ... Q83181 (Golgi apparatus) Golgi apparatus
P681 cell component ... Q220599 (cytosol) cytosol
P681 cell component ... Q79899 (cytoplasm) cytoplasm
P681 cell component ... Q424178 (membrane raft) membrane raft
P681 cell component ... Q14819224 (mitochondrial intermembrane space) mitochondrial intermembrane space
P681 cell component ... Q15331809 (integrin alpha2-beta1 complex) integrin alpha2-beta1 complex
P681 cell component ... Q29548 (plasma membrane) plasma membrane
P681 cell component ... Q40260 (nucleus) nucleus
P681 cell component ... Q24629101 (glutamatergic synapse) glutamatergic synapse
P681 cell component ... Q27918504 (postsynaptic specialization, intracellular component) postsynaptic specialization, intracellular component
P681 cell component ... Q14860783 (mast cell granule) mast cell granule
P681 cell component ... Q14860954 (mitochondrial membranes) mitochondrial membranes
P681 cell component ... Q14349455 (membrane) membrane
P681 cell component ... Q14349519 (intracellular membrane-bounded organelle) intracellular membrane-bounded organelle
P681 cell component ... Q14905148 (extrinsic component of cytoplasmic side of plasma membrane) extrinsic component of cytoplasmic side of plasma membrane
P681 cell component ... Q1140236 (mitochondrial crista) mitochondrial crista
P681 cell component ... Q4374336 (postsynaptic density) postsynaptic density
P681 cell component ... Q14330632 (perinuclear region of cytoplasm) perinuclear region of cytoplasm
P681 cell component ... Q903634 (extracellular exosome) extracellular exosome
P702 encoded by ... Q15331874 (LYN) LYN
P703 found in taxon ... Q15978631 (Homo sapiens) Homo sapiens
P527 has part(s) ... Q24719835 (tyrosine-protein kinase, catalytic domain) tyrosine-protein kinase, catalytic domain
P527 has part(s) ... Q24738472 (tyrosine-protein kinase, active site) tyrosine-protein kinase, active site
P527 has part(s) ... Q24740842 (serine-threonine/tyrosine-protein kinase, catalytic domain) serine-threonine/tyrosine-protein kinase, catalytic domain
P527 has part(s) ... Q24768234 (protein kinase domain) protein kinase domain
P527 has part(s) ... Q24769051 (protein kinase, ATP binding site) protein kinase, ATP binding site
P527 has part(s) ... Q24771787 (SH3 domain) SH3 domain
P527 has part(s) ... Q24780316 (SH2 domain) SH2 domain
P527 has part(s) ... Q41796899 (Tyrosine-protein kinase Lyn, SH3 domain) Tyrosine-protein kinase Lyn, SH3 domain
P527 has part(s) ... Q41797003 (Tyrosine-protein kinase Lyn, SH2 domain) Tyrosine-protein kinase Lyn, SH2 domain
P31 instance of ... Q8054 (protein) protein
P680 molecular function ... Q167149 (protein binding) protein binding
P680 molecular function ... Q14819233 (signaling receptor binding) signaling receptor binding
P680 molecular function ... Q14820641 (protein kinase activity) protein kinase activity
P680 molecular function ... Q14840131 (transferase activity) transferase activity
P680 molecular function ... Q22312857 (protein-containing complex binding) protein-containing complex binding
P680 molecular function ... Q30104989 (phosphorylation-dependent protein binding) phosphorylation-dependent protein binding
P680 molecular function ... Q14860365 (nucleotide binding) nucleotide binding
P680 molecular function ... Q14860862 (phosphoprotein binding) phosphoprotein binding
P680 molecular function ... Q14863082 (kinase activity) kinase activity
P680 molecular function ... Q14863338 (protein tyrosine kinase activity) protein tyrosine kinase activity
P680 molecular function ... Q14864502 (glycosphingolipid binding) glycosphingolipid binding
P680 molecular function ... Q14864724 (gamma-tubulin binding) gamma-tubulin binding
P680 molecular function ... Q14865298 (SH3 domain binding) SH3 domain binding
P680 molecular function ... Q14599289 (enzyme binding) enzyme binding
P680 molecular function ... Q14633861 (integrin binding) integrin binding
P680 molecular function ... Q14633869 (ubiquitin protein ligase binding) ubiquitin protein ligase binding
P680 molecular function ... Q14817981 (ATP binding) ATP binding
P680 molecular function ... Q14873985 (non-membrane spanning protein tyrosine kinase activity) non-membrane spanning protein tyrosine kinase activity
P680 molecular function ... Q14878379 (platelet-derived growth factor receptor binding) platelet-derived growth factor receptor binding
P680 molecular function ... Q14897681 (ephrin receptor binding) ephrin receptor binding
P680 molecular function ... Q14901685 (transmembrane transporter binding) transmembrane transporter binding
P361 part of ... Q24726164 (Protein kinase-like domain superfamily) Protein kinase-like domain superfamily
P361 part of ... Q41797170 (SH3-like domain superfamily) SH3-like domain superfamily
P361 part of ... Q41797956 (SH2 domain superfamily) SH2 domain superfamily
P361 part of ... Q50261758 (Src family kinases (SFKs) [cytosol]) Src family kinases (SFKs) [cytosol]
P361 part of ... Q83130430 (Tyrosine-protein kinase, catalytic domain, protein family) Tyrosine-protein kinase, catalytic domain, protein family
P361 part of ... Q83137014 (Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family) Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family
P361 part of ... Q83138186 (Protein kinase domain, protein family) Protein kinase domain, protein family
P361 part of ... Q83140574 (SH3 domain, protein family) SH3 domain, protein family
P361 part of ... Q83164644 (SH2 domain, protein family) SH2 domain, protein family
P361 part of ... Q83170843 (Tyrosine-protein kinase Lyn, SH2 domain, protein family) Tyrosine-protein kinase Lyn, SH2 domain, protein family
P361 part of ... Q83172436 (Tyrosine-protein kinase Lyn, SH3 domain, protein family) Tyrosine-protein kinase Lyn, SH3 domain, protein family
P361 part of ... Q95352684 (Tyrosine-protein kinase, active site, protein family) Tyrosine-protein kinase, active site, protein family
P361 part of ... Q95354221 (Protein kinase, ATP binding site, protein family) Protein kinase, ATP binding site, protein family
P129 physically interacts with ... Q7394936 (SU6656) SU6656
P129 physically interacts with ... Q799775 (bafetinib) bafetinib
P129 physically interacts with ... Q894611 (bosutinib) bosutinib

External Ids
P705Ensembl protein IDENSP00000428424
P705Ensembl protein IDENSP00000428924
P705Ensembl protein IDENSP00000428313
P646Freebase ID/m/03cpykh
P6366Microsoft Academic ID (discontinued)175818844
P10283OpenAlex IDC175818844
P638PDB structure ID3A4O
P638PDB structure ID1W1F
P638PDB structure ID1WA7
P637RefSeq protein IDNP_001104567
P637RefSeq protein IDNP_002341
P637RefSeq protein IDXP_011515831
P637RefSeq protein IDXP_016868904
P637RefSeq protein IDXP_016868905
P352UniProt protein IDP07948

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log id: 2958879