| review article | Q7318358 |
| scholarly article | Q13442814 |
| P2093 | author name string | Puneet Bharill | |
| Robert J Shmookler Reis | |||
| Srinivas Ayyadevara | |||
| Cagdas Tazearslan | |||
| P2860 | cites work | Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals | Q73711170 |
| Characterization of a life-extending mutation in age-2, a new aging gene in Caenorhabditis elegans | Q77371029 | ||
| Charging the batteries to heal wounds through PI3K | Q80143380 | ||
| Analysis of intact phosphoinositides in biological samples | Q83189880 | ||
| Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9 | Q21563331 | ||
| Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase | Q24310456 | ||
| Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family | Q24602369 | ||
| Suppression of aging in mice by the hormone Klotho | Q24650916 | ||
| New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen | Q24811634 | ||
| Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm | Q25255758 | ||
| p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans | Q27315174 | ||
| A C. elegans mutant that lives twice as long as wild type | Q27861054 | ||
| Regulation of longevity and stress resistance by Sch9 in yeast | Q27929987 | ||
| Functional interaction between beta-catenin and FOXO in oxidative stress signaling | Q28115106 | ||
| Genetic pathways that regulate ageing in model organisms | Q28138437 | ||
| Synthesis and function of 3-phosphorylated inositol lipids | Q28200755 | ||
| Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein | Q28211215 | ||
| A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results | Q28271230 | ||
| Docking interactions in protein kinase and phosphatase networks | Q28271644 | ||
| Direct isolation of longevity mutants in the nematodeCaenorhabditis elegans | Q63951801 | ||
| Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging | Q63951809 | ||
| Genes that regulate both development and longevity in Caenorhabditis elegans | Q28611326 | ||
| daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans | Q28611331 | ||
| daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans | Q28611332 | ||
| The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway | Q28611339 | ||
| Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B | Q28646376 | ||
| Extended longevity in mice lacking the insulin receptor in adipose tissue | Q29614549 | ||
| The p66shc adaptor protein controls oxidative stress response and life span in mammals | Q29614553 | ||
| Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans | Q29616003 | ||
| IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice | Q29616382 | ||
| A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans | Q29617059 | ||
| Two neurons mediate diet-restriction-induced longevity in C. elegans | Q29617239 | ||
| A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function | Q29618026 | ||
| Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor | Q29619759 | ||
| Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling | Q29619762 | ||
| Activated AKT/PKB signaling in C. elegans uncouples temporally distinct outputs of DAF-2/insulin-like signaling | Q33259341 | ||
| Lifespan regulation by evolutionarily conserved genes essential for viability | Q33281293 | ||
| Positive feedback between transcriptional and kinase suppression in nematodes with extraordinary longevity and stress resistance | Q33428996 | ||
| Regulation of C. elegans life-span by insulinlike signaling in the nervous system | Q33920458 | ||
| JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. | Q33934548 | ||
| The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans | Q33966277 | ||
| Membrane transport in Caenorhabditis elegans: an essential role for VPS34 at the nuclear membrane | Q34078775 | ||
| Extending the lifespan of long-lived mice | Q34102936 | ||
| Interacting genes in nematode dauer larva formation | Q34281914 | ||
| JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling | Q34410199 | ||
| Extended life-span and stress resistance in the Drosophila mutant methuselah | Q34477849 | ||
| Stress resistance as a determinate of C. elegans lifespan | Q34547047 | ||
| Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction | Q34595363 | ||
| An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. | Q34602710 | ||
| Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans. | Q34605166 | ||
| Receptors for insulin and insulin-like growth factor-1 and insulin receptor substrate-1 mediate pathways that regulate islet function | Q34650009 | ||
| Brain IRS2 signaling coordinates life span and nutrient homeostasis | Q34653913 | ||
| Remarkable longevity and stress resistance of nematode PI3K-null mutants | Q34712507 | ||
| Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies | Q34869635 | ||
| Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism | Q34945194 | ||
| Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans | Q35554316 | ||
| Life span and stress resistance of Caenorhabditis elegans are differentially affected by glutathione transferases metabolizing 4-hydroxynon-2-enal | Q35675232 | ||
| Wnt signaling regulates pancreatic beta cell proliferation | Q35741102 | ||
| Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis | Q35781497 | ||
| Long-lived alpha MUPA transgenic mice exhibit increased mitochondrion-mediated apoptotic capacity | Q35833046 | ||
| Broad spectrum detoxification: the major longevity assurance process regulated by insulin/IGF-1 signaling? | Q36017390 | ||
| Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans | Q36277196 | ||
| Evolutionary conservation of regulated longevity assurance mechanisms | Q36570563 | ||
| Quantitative trait loci define genes and pathways underlying genetic variation in longevity | Q36571054 | ||
| Stress resistance in long-lived mouse models | Q36589616 | ||
| Signalling through Class I PI3Ks in mammalian cells | Q36628574 | ||
| Genome-wide identification of conserved longevity genes in yeast and worms | Q36663334 | ||
| RTK/Ras/MAPK signaling | Q37020699 | ||
| FOXO transcription factors in ageing and cancer. | Q37048803 | ||
| The regulation and function of Class III PI3Ks: novel roles for Vps34. | Q37063618 | ||
| Current overview of the role of Akt in cancer studies via applied immunohistochemistry | Q37104138 | ||
| The RSK factors of activating the Ras/MAPK signaling cascade | Q37175280 | ||
| Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans | Q37187457 | ||
| DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA. | Q38331301 | ||
| The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling | Q38515423 | ||
| The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor | Q40091020 | ||
| Phosphatidylinositol ether lipid analogues that inhibit AKT also independently activate the stress kinase, p38alpha, through MKK3/6-independent and -dependent mechanisms. | Q40107095 | ||
| Insulin receptor substrates mediate distinct biological responses to insulin-like growth factor receptor activation in breast cancer cells. | Q40219858 | ||
| Insulin-like growth factor I induces preferential degradation of insulin receptor substrate-2 through the phosphatidylinositol 3-kinase pathway in human neuroblastoma cells | Q40375832 | ||
| Signaling via the insulin-like growth factor-I receptor: does it differ from insulin receptor signaling? | Q41194565 | ||
| The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans | Q41711470 | ||
| Regulation of lifespan by sensory perception in Caenorhabditis elegans | Q41711479 | ||
| The C. elegans ortholog of mammalian Ku70, interacts with insulin-like signaling to modulate stress resistance and life span. | Q41762353 | ||
| An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans | Q41834228 | ||
| PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans | Q44731575 | ||
| Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene. | Q45939084 | ||
| Healthy Animals with Extreme Longevity | Q46120835 | ||
| Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan | Q46366442 | ||
| The p38 signal transduction pathway participates in the oxidative stress-mediated translocation of DAF-16 to Caenorhabditis elegans nuclei | Q46485828 | ||
| Lifespan extension in hypomorphic daf-2 mutants of Caenorhabditis elegans is partially mediated by glutathione transferase CeGSTP2-2. | Q46814115 | ||
| C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span | Q47068907 | ||
| SMK-1, an essential regulator of DAF-16-mediated longevity | Q47069047 | ||
| RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination | Q47069128 | ||
| C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO. | Q47069277 | ||
| Extended life-span conferred by cotransporter gene mutations in Drosophila. | Q47070414 | ||
| Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans | Q48581848 | ||
| 14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans. | Q51959154 | ||
| Targeted neuronal gene expression and longevity in Drosophila. | Q52584602 | ||
| The spe-10 mutant has longer life and increased stress resistance. | Q54065456 | ||
| Role of mutator alleles in adaptive evolution. | Q54564129 | ||
| CpG DNA Activates Survival in Murine Macrophages through TLR9 and the Phosphatidylinositol 3-Kinase-Akt Pathway | Q56879956 | ||
| P433 | issue | 10 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 1075-83 | |
| P577 | publication date | 2009-10-01 | |
| P1433 | published in | Biochimica et Biophysica Acta | Q864239 |
| P1476 | title | Extreme-longevity mutations orchestrate silencing of multiple signaling pathways | |
| P478 | volume | 1790 |
| Q35711379 | A narrow quantitative trait locus in C. elegans coordinately affects longevity, thermotolerance, and resistance to paraquat |
| Q33784965 | A recent global selective sweep on the age-1 phosphatidylinositol 3-OH kinase regulator of the insulin-like signaling pathway within Caenorhabditis remanei. |
| Q36130861 | Effects of ADARs on small RNA processing pathways in C. elegans |
| Q35169881 | Expression level drives the pattern of selective constraints along the insulin/Tor signal transduction pathway in Caenorhabditis |
| Q39366426 | Extreme Depletion of PIP3 Accompanies the Increased Life Span and Stress Tolerance of PI3K-null C. elegans Mutants |
| Q34630640 | Genetic Studies Reveal the Role of the Endocrine and Metabolic Systems in Aging |
| Q47813385 | How regularities of mortality statistics explain why we age despite having potentially ageless somatic stem cells |
| Q33817242 | Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species |
| Q34275041 | Integrating evolutionary and molecular genetics of aging. |
| Q36005664 | Mechanistic insights into aging, cell-cycle progression, and stress response. |
| Q47819372 | Recent Advances in the Systems Biology of Aging |
| Q38429799 | Reproducible effects of the mitochondria-targeted plastoquinone derivative SkQ1 on Drosophila melanogaster lifespan under different experimental scenarios |
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