Common variants near MC4R are associated with fat mass, weight and risk of obesity

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Common variants near MC4R are associated with fat mass, weight and risk of obesity is …
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P6179Dimensions Publication ID1026795787
P356DOI10.1038/NG.140
P3181OpenCitations bibliographic resource ID1761
P932PMC publication ID2669167
P698PubMed publication ID18454148
P5875ResearchGate publication ID5329789

P50authorFrancis CollinsQ336658
Heinz Erich WichmannQ1517116
Philippe FroguelQ3379857
Michael BoehnkeQ6828710
Gonçalo AbecasisQ16001382
Frank B. HuQ18062122
Sarah TeichmannQ19501099
Nilesh SamaniQ19665717
George Davey SmithQ21003878
Andrew KeniryQ57090144
Alexander S DoneyQ57327614
Ruth J. LoosQ58867501
Paul ElliottQ59262666
Sheila RodwellQ7493142
Stephen O'RahillyQ7610127
Christian GiegerQ28039312
Peter VollenweiderQ28039313
Thomas IlligQ28039315
Inês BarrosoQ28039326
Miles ParkesQ28050120
Marjo-Riitta JärvelinQ28050155
Inga ProkopenkoQ28050160
David J. HunterQ21066148
Andrew Tym HattersleyQ21165208
David SchlessingerQ28039331
Claudia LaminaQ28050004
Serena SannaQ28050036
Massimo ManginoQ28050045
Manuela UdaQ28050070
Nicole SoranzoQ28050073
Jaakko TuomilehtoQ28050079
Paul ScheetQ28050083
Vincent MooserQ28050088
Rhian GwilliamQ28050117
Eleftheria ZegginiQ21258788
Murielle BochudQ21264436
Leif GroopQ27214742
Stephen ChanockQ27662321
Panos DeloukasQ28037258
Thomas MeitingerQ28039310
Emmanouil DermitzakisQ59420022
Karen L MohlkeQ59812940
Michael N WeedonQ59940078
Mark CaulfieldQ29642451
Gérard WaeberQ29839423
Cyrus CooperQ29839772
André ScheragQ29999935
Johannes HebebrandQ30000133
Anke HinneyQ30004428
Christian DinaQ30170217
Cecilia LindgrenQ30347705
David M. EvansQ30348322
Michael InouyeQ56508850
Benjamin F. VoightQ56864510
Nicholas J. WarehamQ56936055
Anne U JacksonQ57063641
Alistair Scott HallQ37624871
Chris WallaceQ37624906
Fredrik KarpeQ37624990
Richard B HayesQ37632158
Rachel M FreathyQ37632866
Kevin B. JacobsQ37632947
Colin PalmerQ42603882
Nicholas J. TimpsonQ30348324
Eleanor WheelerQ30435129
Sarah E. HuntQ30504323
Robert N. LubenQ30506463
Willem H. OuwehandQ32540518
Jonathan MarchiniQ32653370
Giuseppe AlbaiQ32985041
Cristen J. WillerQ37389746
Toby JohnsonQ37389769
Jacques S BeckmannQ53075920
Tim FraylingQ54627337
Simon C PotterQ55314032
Sven BergmannQ55590536
Joel HirschhornQ56277942
Ken K OngQ61160886
Mark McCarthyQ62733235
Amanda J BennettQ63353374
Susan RingQ63368034
David P StrachanQ64858751
David MeyreQ75175280
Lu QiQ76570566
Susan E. HankinsonQ76570836
Peter KraftQ77526208
Subhajyoti DeQ87191265
Wendy L McArdleQ87944939
Patricia B MunroeQ88350963
Nigel William RaynerQ89006350
Manjinder S SandhuQ90261665
Elizabeth K SpeliotesQ91795503
Andrew D MorrisQ92527781
Holly E SyddallQ92789196
Jing Hua ZhaoQ96085216
Dawn WaterworthQ96102528
Konstantinos PapadakisQ96162735
Katherine S ElliottQ100761852
Ralph McGinnisQ102388869
Sonja BerndtQ109521956
Jennifer JolleyQ114270722
Kijoung SongQ114293123
Stephane CauchiQ114293165
Iris M HeidQ114293465
Ramaiah NagarajaQ114300800
Antony P. AttwoodQ114332521
Joshua C RandallQ115679234
Kay-Tee KhawQ28356290
Sadaf FarooqiQ28528161
Anneli PoutaQ28805352
Andy NessQ29575343
P2093author name stringBlanca Herrera
Christopher J Groves
Jonathan H Tobias
Katharine R Owen
Alexandra C Nica
Matthew J Neville
Xin Yuan
David Hadley
Shengxu Li
Helen N Lyon
Morris Brown
Wraight
John M Connell
Ian Day
Jilur Ghori
Matthew A Sims
Carla I Ganz Vogel
Martin Ridderstrale
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A frameshift mutation in human MC4R is associated with a dominant form of obesityQ28285286
Variation in FTO contributes to childhood obesity and severe adult obesityQ28301922
Targeted disruption of the melanocortin-4 receptor results in obesity in miceQ28302831
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetesQ28680760
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P433issue6
P407language of work or nameEnglishQ1860
P921main subjectobesityQ12174
P304page(s)768-75
P577publication date2008-06-01
P1433published inNature GeneticsQ976454
P1476titleCommon variants near MC4R are associated with fat mass, weight and risk of obesity
P478volume40

Reverse relations

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Q34649752From obesity genetics to the future of personalized obesity therapy
Q35549920GENES AS INSTRUMENTS FOR STUDYING RISK BEHAVIOR EFFECTS: AN APPLICATION TO MATERNAL SMOKING AND OROFACIAL CLEFTS
Q64063049Gene Lifestyle Interactions With Relation to Obesity, Cardiometabolic, and Cardiovascular Traits Among South Asians
Q37154693Gene X environment interaction of vigorous exercise and body mass index among male Vietnam-era twins
Q33759896Gene expression profiling in whole blood identifies distinct biological pathways associated with obesity
Q55347185Gene polymorphisms of TNF-238G/A, TNF-308G/A, IL10-1082G/A, TNFAIP3, and MC4R and comorbidity occurrence in a Romanian population with psoriasis.
Q34916970Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry
Q36467059Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals
Q36933049Gene-environment interaction and obesity
Q34314297Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study
Q37149301Gene-gene and gene-environment interactions: new insights into the prevention, detection and management of coronary artery disease
Q35653364Genes and lifestyle factors in obesity: results from 12,462 subjects from MONICA/KORA.
Q33651950Genes, emotions and gut microbiota: The next frontier for the gastroenterologist
Q28084624Genetic & epigenetic approach to human obesity
Q34981947Genetic Effects of FTO and MC4R Polymorphisms on Body Mass in Constitutional Types.
Q35153836Genetic and lifestyle causal beliefs about obesity and associated diseases among ethnically diverse patients: a structured interview study
Q35243264Genetic and phenotypic variation in UGT2B17, a testosterone-metabolizing enzyme, is associated with BMI in males
Q35015765Genetic approaches to understanding human obesity.
Q38340326Genetic association studies of obesity in Africa: a systematic review
Q45817465Genetic association study between antipsychotic-induced weight gain and the melanocortin-4 receptor gene
Q46902624Genetic association study of WNT10B polymorphisms with BMD and adiposity parameters in Danish and Belgian males
Q33599821Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions
Q35575747Genetic associations with metabolic syndrome and its quantitative traits by race/ethnicity in the United States
Q35606938Genetic determinants for gestational diabetes mellitus and related metabolic traits in Mexican women
Q33937715Genetic determinants of pubertal timing in the general population.
Q33798871Genetic factors associated with risk of metabolic syndrome and hepatocellular carcinoma
Q38137370Genetic factors in exercise adoption, adherence and obesity
Q37967053Genetic influences in childhood obesity: recent progress and recommendations for experimental designs
Q35757116Genetic link between obesity and MMP14-dependent adipogenic collagen turnover
Q28751939Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth
Q33883760Genetic markers of obesity risk: stronger associations with body composition in overweight compared to normal-weight children
Q33842319Genetic polymorphisms in the hypothalamic pathway in relation to subsequent weight change--the DiOGenes study
Q43471415Genetic predisposition to obesity and lifestyle factors--the combined analyses of twenty-six known BMI- and fourteen known waist:hip ratio (WHR)-associated variants in the Finnish Diabetes Prevention Study
Q34641489Genetic predisposition to obesity leads to increased risk of type 2 diabetes
Q33669117Genetic research into bipolar disorder: the need for a research framework that integrates sophisticated molecular biology and clinically informed phenotype characterization
Q37319321Genetic resistance to diet-induced obesity in chromosome substitution strains of mice
Q40215113Genetic risk clustering increases children's body weight at 2 years of age - the STEPS Study
Q28390241Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study
Q51333739Genetic risk score does not predict the outcome of obesity surgery.
Q36111952Genetic risk sum score comprised of common polygenic variation is associated with body mass index
Q38243023Genetic strategies to understand physiological pathways regulating body weight
Q37300015Genetic susceptibility to obesity and diet intakes: association and interaction analyses in the Malmö Diet and Cancer Study
Q34237799Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies
Q38214522Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond
Q33434477Genetic variance in the adiponutrin gene family and childhood obesity.
Q28071337Genetic variants influencing effectiveness of exercise training programmes in obesity - an overview of human studies
Q35683670Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
Q43299076Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study
Q89060260Genetics and Epigenetics of Eating Disorders
Q35541780Genetics and epigenetics of obesity
Q28072893Genetics of Common Antipsychotic-Induced Adverse Effects
Q26745624Genetics of Insulin Resistance and the Metabolic Syndrome
Q50900394Genetics of Obesity.
Q35107260Genetics of Obesity: What have we Learned?
Q41490210Genetics of body fat mass and related traits in a pig population selected for leanness
Q35104978Genetics of childhood obesity
Q36734032Genetics of obesity and type 2 diabetes in African Americans.
Q38078821Genetics of type 2 diabetes and potential clinical implications
Q37680443Genome metabolome integrated network analysis to uncover connections between genetic variants and complex traits: an application to obesity
Q33943947Genome wide association study identifies KCNMA1 contributing to human obesity
Q35955956Genome wide association study: searching for genes underlying body mass index in the Chinese
Q59797397Genome-Wide Association Studies of Estimated Fatty Acid Desaturase Activity in Serum and Adipose Tissue in Elderly Individuals: Associations with Insulin Sensitivity
Q28943380Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity
Q37078854Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course
Q24654676Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
Q35794058Genome-wide association of BMI in African Americans
Q33904445Genome-wide association of anthropometric traits in African- and African-derived populations
Q21092459Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution
Q37464290Genome-wide association scans for secondary traits using case-control samples
Q37883249Genome-wide association studies (GWAS): impact on elucidating the aetiology of diabetes.
Q34061654Genome-wide association studies and heritability estimates of body mass index related phenotypes in Bangladeshi adults
Q37339440Genome-wide association studies for atherosclerotic vascular disease and its risk factors
Q38089855Genome-wide association studies for the identification of biomarkers in metabolic diseases
Q33704021Genome-wide association study and follow-up analysis of adiposity traits in Hispanic Americans: the IRAS Family Study
Q28307044Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
Q50587017Genome-wide association study identifies common variants associated with pharmacokinetics of psychotropic drugs.
Q29614414Genome-wide association study identifies eight loci associated with blood pressure
Q24629653Genome-wide association study identifies five loci associated with lung function
Q34981439Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche
Q34612326Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women
Q36718615Genome-wide association study of body mass index in 23 000 individuals with and without asthma
Q33956859Genome-wide association study of exercise behavior in Dutch and American adults
Q35596257Genome-wide association study of height and body mass index in Australian twin families
Q28303894Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
Q38468183Genome-wide linkage scan for resistance to muscle fatigue
Q33641349Genome-wide meta-analysis for serum calcium identifies significantly associated SNPs near the calcium-sensing receptor (CASR) gene
Q34606096Genomewide association studies: history, rationale, and prospects for psychiatric disorders
Q37394261Genomic Variants Associated with Resistance to High Fat Diet Induced Obesity in a Primate Model.
Q33999488Genomic insights into early-onset obesity
Q29614590Genotype imputation
Q29614880Genotype imputation for genome-wide association studies
Q37156125Genotype-imputation accuracy across worldwide human populations
Q84020832Getting biological about the genetics of diabetes
Q34629745Gut microbiome, obesity, and metabolic dysfunction
Q35629619HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes
Q28730908Heparanase affects food intake and regulates energy balance in mice
Q40666599Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity
Q47391623High allelic burden of four obesity SNPs is associated with poorer weight loss outcomes following gastric bypass surgery
Q48206917High-fat diet leads to a decreased methylation of the Mc4r gene in the obese BFMI and the lean B6 mouse lines
Q33385257How does body fat influence bone mass in childhood? A Mendelian randomization approach
Q39009925How mice are indispensable for understanding obesity and diabetes genetics
Q34137857Human behavioral informatics in genetic studies of neuropsychiatric disease: multivariate profile-based analysis
Q37634967Human genetics illuminates the paths to metabolic disease
Q37366385Human obesity as a heritable disorder of the central control of energy balance
Q34029265Hyperhomocysteinemia is independently associated with albuminuria in the population-based CoLaus study
Q47176455INSIG2 rs7566605 single nucleotide variant and global DNA methylation index levels are associated with weight loss in a personalized weight reduction program.
Q57848895Identification and Functional Characterization of Novel Mutations in the Melanocortin-4 Receptor
Q34306097Identification and validation of copy number variants using SNP genotyping arrays from a large clinical cohort
Q34506670Identification of allelic heterogeneity at type-2 diabetes loci and impact on prediction
Q37416947Identification of genetic loci involved in diabetes using a rat model of depression.
Q99418434Identification of pleiotropic loci underlying hip bone mineral density and trunk lean mass
Q36208196Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis
Q34463688Impact of obesity-related genes in Spanish population
Q45921270Impact of variation near MC4R on whole-body fat distribution, liver fat, and weight loss.
Q35835431Implication of European-derived adiposity loci in African Americans
Q33933066Implications of central obesity-related variants in LYPLAL1, NRXN3, MSRA, and TFAP2B on quantitative metabolic traits in adult Danes
Q40061670Improving power of association tests using multiple sets of imputed genotypes from distributed reference panels.
Q34505622Increased power of mixed models facilitates association mapping of 10 loci for metabolic traits in an isolated population
Q35203410Indications for potential parent-of-origin effects within the FTO gene
Q35045396Influence of common variants in FTO and near INSIG2 and MC4R on growth curves for adiposity in African- and European-American youth
Q35730107Influence of genomic variation in FTO at 16q12.2, MC4R at 18q22 and NRXN3 at 14q31 genes on breast cancer risk
Q51036928Influence of physical inactivity on associations between single nucleotide polymorphisms and genetic predisposition to childhood obesity.
Q34971477Inherited destiny? Genetics and gestational diabetes mellitus
Q34238637Inhibition of the central melanocortin system decreases brown adipose tissue activity
Q26781353Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits
Q37430426Integrating post-genomic approaches as a strategy to advance our understanding of health and disease.
Q36116735Intelligence: shared genetic basis between Mendelian disorders and a polygenic trait
Q45814301Interaction between Social/Psychosocial Factors and Genetic Variants on Body Mass Index: A Gene-Environment Interaction Analysis in a Longitudinal Setting
Q47100788Interaction between TCF7L2 polymorphism and dietary fat intake on high density lipoprotein cholesterol
Q35682529Interaction between common variants of FTO and MC4R is associated with risk of PCOS.
Q34414737Interaction between genetic predisposition to adiposity and dietary protein in relation to subsequent change in body weight and waist circumference
Q44081455Interaction between obesity-related genes, FTO and MC4R, associated to an increase of breast cancer risk.
Q35832628Interaction of smoking and obesity susceptibility loci on adolescent BMI: The National Longitudinal Study of Adolescent to Adult Health
Q33708369Interactions between genetic factors that predict diabetes and dietary factors that ultimately impact on risk of diabetes
Q36923268Interactions with the MC4R rs17782313 variant, mental stress and energy intake and the risk of obesity in Genome Epidemiology Study
Q37822862Investigation of Mendelian forms of obesity holds out the prospect of personalized medicine
Q33750073Investigation of a genome wide association signal for obesity: synthetic association and haplotype analyses at the melanocortin 4 receptor gene locus
Q40234047Investigation of the locus near MC4R with childhood obesity in Americans of European and African ancestry
Q33531795Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort
Q30907369Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults
Q37296850Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?
Q37301357Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry
Q35757223Large copy-number variations are enriched in cases with moderate to extreme obesity.
Q33525709Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS).
Q24623878Large, rare chromosomal deletions associated with severe early-onset obesity
Q28272915Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Q90606935Late onset obesity in mice with targeted deletion of potassium inward rectifier Kir7.1 from cells expressing the melanocortin-4 receptor
Q38475978Latest approaches for the treatment of obesity.
Q30528003Leisure time activities in adolescence in the presence of susceptibility genes for obesity: risk or resilience against overweight in adulthood? The HUNT study
Q24644972Leptin at 14 y of age: an ongoing story
Q26865174Leptin signaling and leptin resistance
Q33559765Life course variations in the associations between FTO and MC4R gene variants and body size
Q34122862Life-course analysis of a fat mass and obesity-associated (FTO) gene variant and body mass index in the Northern Finland Birth Cohort 1966 using structural equation modeling
Q36930898Lifetime Socioeconomic Status, Historical Context, and Genetic Inheritance in Shaping Body Mass in Middle and Late Adulthood
Q42637379Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene
Q29614868LocusZoom: regional visualization of genome-wide association scan results
Q34166360Longitudinal replication studies of GWAS risk SNPs influencing body mass index over the course of childhood and adulthood
Q82419180Look into the future through the past
Q58571530Low Salivary Amylase Gene () Copy Number Is Associated with Obesity and Gut Abundance in Mexican Children and Adults
Q98177580MC4R Variant rs17782313 Associates With Increased Levels of DNAJC27, Ghrelin, and Visfatin and Correlates With Obesity and Hypertension in a Kuwaiti Cohort
Q92215615MC4R and ENPP1 gene polymorphisms and their implication in maternal and neonatal risk for obesity
Q86575428MC4R rs17782313 gene polymorphism was associated with glycated hemoglobin independently of its effect on BMI in Japanese: the Shimane COHRE study
Q28296094MC4R rs489693: a clinical risk factor for second generation antipsychotic-related weight gain?
Q34103316MC4R variant is associated with BMI but not response to resistance training in young females.
Q92722923MC4R variants rs12970134 and rs17782313 are associated with obese polycystic ovary syndrome patients in the Western region of Saudi Arabia
Q24310708MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family
Q51418900Macronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese Europeans.
Q30488409Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers
Q35080341Maternal and offspring adiposity-related genetic variants and gestational weight gain
Q42315518MeQTL analysis of childhood obesity links epigenetics with a risk SNP rs17782313 near MC4R from meta-analysis
Q34989340Meal frequencies modify the effect of common genetic variants on body mass index in adolescents of the northern Finland birth cohort 1986
Q38381406Melanocortin Receptor-4 Gene Polymorphisms in Glioblastoma Patients Treated with Concomitant Radio-Chemotherapy
Q28580846Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat
Q27013622Melanocortin receptor accessory proteins in adrenal disease and obesity
Q57775014Melanocortin-4 Receptor Gene Mutations in a Dutch Cohort of Obese Children
Q51703197Melanocortin-4 receptor gene variants in Chilean families: association with childhood obesity and eating behavior.
Q34489633Melanocortin-4 receptor mutations and polymorphisms do not affect weight loss after bariatric surgery
Q37593898Melanocortin-4 receptor-regulated energy homeostasis
Q21296811Mendelian Randomisation Study of Childhood BMI and Early Menarche
Q36900949Mendelian randomization in nutritional epidemiology
Q37967484Mendelian randomization: application to cardiovascular disease
Q34142739Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Q35785297Meta-analysis identifies common variants associated with body mass index in east Asians
Q30669834Meta-analysis of genome-wide association data identifies novel susceptibility loci for obesity
Q34211781Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index
Q21092465Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size
Q90714102Metabolic and Addiction Indices in Patients on Opioid Agonist Medication-Assisted Treatment: A Comparison of Buprenorphine and Methadone
Q34851773Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants
Q38643942Metabolic biomarkers and gallstone disease - a population-based study
Q38301656Metabolic regulation and energy homeostasis through the primary Cilium
Q38536898Metabolic side effects and pharmacogenetics of second-generation antipsychotics in children
Q26770483Metabolic signals in sleep regulation: recent insights
Q33691139Metabolic syndrome: from epidemiology to systems biology
Q42416673Missing heritability and GWAS utility
Q58910968Mixed Modeling with Whole Genome Data
Q34562414Modelling BMI trajectories in children for genetic association studies
Q35107257Molecular basis of obesity: current status and future prospects
Q36904053Molecular genetic aspects of weight regulation
Q42152091Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity
Q37213116Mouse models for the central melanocortin system.
Q21183892Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease
Q33864624Multicenter dizygotic twin cohort study confirms two linkage susceptibility loci for body mass index at 3q29 and 7q36 and identifies three further potential novel loci
Q88538370Multiple genetic variations confer risks for obesity and type 2 diabetes mellitus in arab descendants from UAE
Q34314273Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits
Q33420094Mutations in genes involved in nonsense mediated decay ameliorate the phenotype of sel-12 mutants with amber stop mutations in Caenorhabditis elegans
Q37263858Mutations in ligands and receptors of the leptin-melanocortin pathway that lead to obesity
Q37726409Mutations in melanocortin-4 receptor and human obesity.
Q21144997NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium
Q37149232Narrowing down the role of common variants in the genetic predisposition to obesity
Q34244188Neural innervation of white adipose tissue and the control of lipolysis
Q37284868Neural melanocortin receptors in obesity and related metabolic disorders
Q26752744Neuroendorine and Epigentic Mechanisms Subserving Autonomic Imbalance and HPA Dysfunction in the Metabolic Syndrome
Q58584067New Insights Regarding Genetic Aspects of Childhood Obesity: A Minireview
Q34998766New insights into nutrition and cognitive neuroscience
Q36541220New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Q36068914New targets to treat obesity and the metabolic syndrome
Q37921910New type 2 diabetes risk genes provide new insights in insulin secretion mechanisms
Q37693953Next-generation sequence analysis of genes associated with obesity and nonalcoholic fatty liver disease-related cirrhosis in extreme obesity
Q46194547No Association of Obesity and Type 2 Diabetes Mellitus Related Genetic Variants With Colon Cancer
Q33410654Non-replication of an association of CTNNBL1 polymorphisms and obesity in a population of Central European ancestry
Q33358134Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes
Q37581270Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial.
Q34505634Novel common copy number variation for early onset extreme obesity on chromosome 11q11 identified by a genome-wide analysis
Q44324263Novel variants in the MC4R and LEPR genes among severely obese children from the Iberian population
Q36510373Nutritional regulation of genome-wide association obesity genes in a tissue-dependent manner
Q33659676Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study
Q35568124Obesity and diabetes genetic variants associated with gestational weight gain
Q38020893Obesity and eating behaviour in children and adolescents: contribution of common gene polymorphisms
Q38357876Obesity and genomics: role of technology in unraveling the complex genetic architecture of obesity
Q34725000Obesity gene NEGR1 associated with white matter integrity in healthy young adults
Q33388521Obesity genes: so close and yet so far...
Q36997859Obesity genomics: assessing the transferability of susceptibility loci across diverse populations
Q24633541Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus
Q37126358Obesity polymorphisms identified in genome-wide association studies interact with n-3 polyunsaturated fatty acid intake and modify the genetic association with adiposity phenotypes in Yup'ik people
Q30514020Obesity susceptibility loci and dietary intake in the Look AHEAD Trial
Q35575819Obesity susceptibility loci in Qataris, a highly consanguineous Arabian population
Q38637859Obesity, More than a 'Cosmetic' Problem. Current Knowledge and Future Prospects of Human Obesity Genetics
Q36167403Obesity-Related Genetic Variants and their Associations with Physical Activity
Q84733015Obesity-induced diabetes in mouse strains treated with gold thioglucose: a novel animal model for studying β-cell dysfunction
Q40379647Obesity-related genetic polymorphisms and adiposity indices in a young Italian population.
Q36931200Obesity-related genetic variants, human pigmentation, and risk of melanoma
Q34005097Obesity-related genomic loci are associated with type 2 diabetes in a Han Chinese population
Q34456240Obesity-susceptibility loci and their influence on adiposity-related traits in transition from adolescence to adulthood--the HUNT study
Q26853442Obesity: interactions of genome and nutrients intake
Q46814792On the choice of parameterisation and priors for the Bayesian analyses of Mendelian randomisation studies.
Q47607244On the origin of obesity: identifying the biological, environmental and cultural drivers of genetic risk among human populations
Q37986642Oxidative stress and inflammation interactions in human obesity
Q27024024Pathogenesis of the metabolic syndrome: insights from monogenic disorders
Q38842714Pharmacogenetic Associations of Antipsychotic Drug-Related Weight Gain: A Systematic Review and Meta-analysis
Q37926893Pharmacogenetics of antipsychotic-induced weight gain: review and clinical implications.
Q38217628Pharmacogenetics of second-generation antipsychotics
Q55309789Phenotype and genotype predictors of BMI variability among European adults.
Q36247856Physical Activity and Sedentary Behaviors Modify the Association between Melanocortin 4 Receptor Gene Variant and Obesity in Chinese Children and Adolescents
Q40034465Physical activity attenuates genetic effects on BMI: Results from a study of Chinese adult twins
Q33687186Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study
Q37877244Planning a genome-wide association study: points to consider
Q51338079Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals.
Q37069270Polymorphisms in the NPY2R gene show significant associations with BMI that are additive to FTO, MC4R, and NPFFR2 gene effects
Q42285622Population genetic analyses of susceptibility to increased body weight
Q28681745Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium
Q35167237Population sequencing of two endocannabinoid metabolic genes identifies rare and common regulatory variants associated with extreme obesity and metabolite level
Q34861754Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes
Q89811253Potential role of the melanocortin signaling system interference in the excess weight gain associated to some antiretroviral drugs in people living with HIV
Q31006720Practical Experience of the Application of a Weighted Burden Test to Whole Exome Sequence Data for Obesity and Schizophrenia
Q41584472Precision Nutrition: A Review of Personalized Nutritional Approaches for the Prevention and Management of Metabolic Syndrome
Q38723256Prediction of Adulthood Obesity Using Genetic and Childhood Clinical Risk Factors in the Cardiovascular Risk in Young Finns Study
Q46685596Preliminary findings on the influence of FTO rs9939609 and MC4R rs17782313 polymorphisms on resting energy expenditure, leptin and thyrotropin levels in obese non-morbid premenopausal women.
Q33556631Prevalence of loss-of-function FTO mutations in lean and obese individuals
Q39956554Prognostic significance of FTO genotype in the development of obesity in Japanese: the J-SHIPP study
Q37698685Progress in the genetics of common obesity and type 2 diabetes
Q33389080Proper analysis of secondary phenotype data in case-control association studies
Q28656219Quality control and conduct of genome-wide association meta-analyses
Q100316505RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice
Q38084443Rare-variant genome-wide association studies: a new frontier in genetic analysis of complex traits
Q46440360Recapitulation of genome-wide association studies on body mass index in the Korean population
Q53495655Recent Advances in Human Genetics and Epigenetics of Adiposity: Pathway to Precision Medicine?
Q38587726Recent Progress in the Understanding of Obesity: Contributions of Genome-Wide Association Studies
Q35855592Recent advances in obesity: genetics and beyond
Q36063735Recent advances in understanding and mitigating adipogenic and metabolic effects of antipsychotic drugs
Q33607966Recent progress in the genetics of common obesity
Q37845744Recent progress in the study of the genetics of height
Q37446959Relationships between FTO rs9939609, MC4R rs17782313, and PPARγ rs1801282 polymorphisms and the occurrence of selected metabolic and hormonal disorders in middle-aged and elderly men - a preliminary study.
Q58721314Relevance of polymorphisms in MC4R and BDNF in short normal stature
Q91014092Repeat length variations in polyglutamine disease-associated genes affect body mass index
Q36285142Replication and extension of association between common genetic variants in SIM1 and human adiposity
Q24648857Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden
Q24288830Replication in Genome-Wide Association Studies
Q54592226Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations.
Q43594171Replication of association between a common variant near melanocortin-4 receptor gene and obesity-related traits in Asian Sikhs
Q36837758Replication of established common genetic variants for adult BMI and childhood obesity in Greek adolescents: the TEENAGE study
Q44279111Replication of genetic effects of MC4R polymorphisms on body mass index in a Korean population.
Q34705195Replication of genetic variants from genome-wide association studies with metabolic traits in an island population of the Adriatic coast of Croatia
Q57848876Replication of the SH2B1 rs7498665 Association with Obesity in a Belgian Study Population
Q37844489Revisiting Mendelian disorders through exome sequencing
Q29617365Richness of human gut microbiome correlates with metabolic markers
Q48218831Robust analysis of secondary phenotypes in case-control genetic association studies
Q33566642Robust estimation for secondary trait association in case-control genetic studies
Q43556898Role of BMI-associated loci identified in GWAS meta-analyses in the context of common childhood obesity in European Americans
Q33693925Rs12970134 near MC4R is associated with appetite and beverage intake in overweight and obese children: A family-based association study in Chinese population
Q34595193Rs4074134 near BDNF gene is associated with type 2 diabetes mellitus in Chinese Han population independently of body mass index
Q34248203Rs7206790 and rs11644943 in FTO gene are associated with risk of obesity in Chinese school-age population
Q33404436SLC6A3 and body mass index in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
Q33893009Science of self-preservation: how melanocortin action in the brain modulates body weight, blood pressure, and ischemic damage
Q39195923Scientometric analysis of the world-wide research efforts concerning Leishmaniasis
Q57051330Searching for Factors Raising the Incidence of Metabolic Syndrome Among 45-60-Year-Old Women
Q51298739Selected variants of the melanocortin 4 receptor gene (MC4R) do not confer susceptibility to female pattern hair loss.
Q37401173Selecting instruments for Mendelian randomization in the wake of genome-wide association studies
Q42326799Sequencing of Lp-PLA2-encoding PLA2G7 gene in 2000 Europeans reveals several rare loss-of-function mutations
Q35989586Serum 25-Hydroxyvitamin D Status and Longitudinal Changes in Weight and Waist Circumference: Influence of Genetic Predisposition to Adiposity.
Q49054214Sex-dependent associations of genetic variants identified by GWAS with indices of adiposity and obesity risk in a Chinese children population.
Q47260649Sex-specific effects of weight-affecting gene variants in a life course perspective--The HUNT Study, Norway
Q34765317Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits
Q92542571Sexual Dimorphism of a Genetic Risk Score for Obesity and Related Traits among Chinese Patients with Type 2 Diabetes
Q34284034Sexual dimorphism in offspring glucose-sensitive hypothalamic gene expression and physiological responses to maternal high-fat diet feeding
Q37623593Sexual dimorphisms in genetic loci linked to body fat distribution
Q38862130Single Gene and Syndromic Causes of Obesity: Illustrative Examples
Q33493156Single gold nanoparticles counter: an ultrasensitive detection platform for one-step homogeneous immunoassays and DNA hybridization assays
Q33509634Single nucleotide polymorphisms in obesity-related genes and all-cause and cause-specific mortality: a prospective cohort study
Q24646434Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
Q35857783Smokeless weight loss
Q31110205Statistical and biological gene-lifestyle interactions of MC4R and FTO with diet and physical activity on obesity: new effects on alcohol consumption
Q85434292Strong influence of variants near MC4R on adiposity in children and adults: a cross-sectional study in Indian population
Q34017742Studies of metabolic phenotypic correlates of 15 obesity associated gene variants
Q34592844Study of 11 BMI-associated loci identified in GWAS for associations with central obesity in the Chinese children
Q34074346Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty
Q35400880Targeting microRNAs in obesity
Q42022420Test for association of common variants in GRM7 with alcohol consumption
Q45925200The A-allele of the common FTO gene variant rs9939609 complicates weight maintenance in severe obese patients.
Q53690182The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women.
Q51734241The Clinical Efficacy of Prostate Cancer Screening in Worldwide and Iran: Narrative Review.
Q49481418The Complex Relationship between Antipsychotic-Induced Weight Gain and Therapeutic Benefits: A Systematic Review and Implications for Treatment.
Q92702880The Effect Sizes of PPARγ rs1801282, FTO rs9939609, and MC4R rs2229616 Variants on Type 2 Diabetes Mellitus Risk among the Western Saudi Population: A Cross-Sectional Prospective Study
Q28296207The FTO gene and measured food intake in children
Q37168391The Geisinger MyCode community health initiative: an electronic health record-linked biobank for precision medicine research.
Q36355571The Genetics of Pediatric Obesity.
Q50092000The Genetics of Physical Activity.
Q44483893The Heinz Nixdorf Recall study
Q33467104The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts
Q92835657The MC4R genetic variants are associated with lower visceral fat accumulation and higher postprandial relative increase in carbohydrate utilization in humans
Q38964926The MC4R genotype is associated with postpartum weight reduction and glycemic changes among women with prior gestational diabetes: longitudinal analysis
Q30859265The PsyCoLaus study: methodology and characteristics of the sample of a population-based survey on psychiatric disorders and their association with genetic and cardiovascular risk factors
Q94561726The Role of Genetic Variation of BMI, Body Composition, and Fat Distribution for Mental Traits and Disorders: A Look-Up and Mendelian Randomization Study
Q28067395The Role of PVH Circuits in Leptin Action and Energy Balance
Q33815387The architecture of gene regulatory variation across multiple human tissues: the MuTHER study
Q34228008The association of fasting insulin, glucose, and lipids with bone mass in adolescents: findings from a cross-sectional study
Q33801241The association of insertions/deletions (INDELs) and variable number tandem repeats (VNTRs) with obesity and its related traits and complications
Q92861752The association of the fat mass and obesity-associated gene (FTO) rs9939609 polymorphism and the severe obesity in a Brazilian population
Q24562954The bigger picture of FTO: the first GWAS-identified obesity gene
Q34360518The biology of FTO: from nucleic acid demethylase to amino acid sensor
Q36948291The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women
Q33624290The common rs9939609 variant of the fat mass and obesity-associated gene is associated with obesity risk in children and adolescents of Beijing, China
Q37422176The continuum of causality in human genetic disorders
Q41997918The contribution of genetics and environment to obesity
Q28116061The cytosolic chaperone Hsc70 promotes traffic to the cell surface of intracellular retained melanocortin-4 receptor mutants
Q47226621The effect of GWAS identified BMI loci on changes in body weight among middle-aged Danes during a five-year period.
Q41885752The effect of fat mass on educational attainment: examining the sensitivity to different identification strategies
Q37293511The effect of neurohormonal factors, epigenetic factors, and gut microbiota on risk of obesity.
Q34712198The emerging genetic architecture of type 2 diabetes
Q46196924The fat mass and obesity-associated (FTO) gene is associated with intramuscular fat content and growth rate in the pig.
Q38050689The genetic and epigenetic basis of type 2 diabetes and obesity
Q22251027The genetic contribution to non-syndromic human obesity
Q88080077The genetics of human obesity
Q56475358The genetics of human obesity
Q34402855The genetics of insulin resistance: Where's Waldo?
Q26830784The genetics of major depression
Q85172563The genetics of obesity
Q33886816The genetics of obesity and the metabolic syndrome
Q34005975The genetics of obesity: FTO leads the way.
Q36192017The heterogeneity of the cigarette price effect on body mass index
Q26828382The hunger genes: pathways to obesity
Q39852586The impact of genetic variants on BMI increase during childhood versus adulthood.
Q38038868The impact of intronic single nucleotide polymorphisms and ethnic diversity for studies on the obesity gene FTO.
Q86189097The impact of obesity-related SNP on appetite and energy intake
Q89455263The influence of polymorphisms of fat mass and obesity (FTO, rs9939609) and vitamin D receptor (VDR, BsmI, TaqI, ApaI, FokI) genes on weight loss by diet and exercise interventions in non-diabetic overweight/obese Asian Indians in North India
Q104104090The interaction between dietary approaches to stop hypertension and MC4R gene variant in predicting cardiovascular risk factors
Q44011691The joint effect of cigarette smoking and polymorphisms on LRP5, LEPR, near MC4R and SH2B1 genes on metabolic syndrome susceptibility in Taiwan
Q36003378The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.
Q34372347The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits
Q39206121The missense variation landscape of FTO, MC4R, and TMEM18 in obese children of African Ancestry.
Q35919282The multi-systemic nature of diabetes mellitus: Genotype or phenotype?
Q39653152The obesity-associated Fto gene is a transcriptional coactivator
Q28742979The obesity-associated polymorphisms FTO rs9939609 and MC4R rs17782313 and endometrial cancer risk in non-Hispanic white women
Q41512645The prevalence of melanocortin-4 receptor gene mutations in Slovak obese children and adolescents
Q87026094The role of common and rare MC4R variants and FTO polymorphisms in extreme form of obesity
Q24631490The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI
Q40036840The search for putative unifying genetic factors for components of the metabolic syndrome
Q39986129The serum leptin level and body mass index in Melanesian and Micronesian Solomon Islanders: focus on genetic factors and urbanization
Q33971259The use of genome-wide eQTL associations in lymphoblastoid cell lines to identify novel genetic pathways involved in complex traits
Q64959470Three at one swoop!
Q22251108Thrift: a guide to thrifty genes, thrifty phenotypes and thrifty norms
Q33688133Towards the clinical implementation of pharmacogenetics in bipolar disorder.
Q38953433Tumour biology of obesity-related cancers: understanding the molecular concept for better diagnosis and treatment.
Q28943490Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups
Q36464788Type 2 Diabetes Genetics: Beyond GWAS.
Q37885799Type 2 diabetes and obesity: genomics and the clinic
Q36311846Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration
Q38046073Unraveling the brain regulation of appetite: lessons from genetics
Q33586820Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach
Q37436398Use of cell lines in the investigation of pharmacogenetic loci
Q21144978Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes
Q37292880Using gene expression to investigate the genetic basis of complex disorders
Q57106334Using genetic loci to understand the relationship between adiposity and psychological distress: a Mendelian Randomization study in the Copenhagen General Population Study of 53 221 adults
Q37181834Using linkage analysis to identify quantitative trait loci for sleep apnea in relationship to body mass index.
Q41931960Using multiple genetic variants as instrumental variables for modifiable risk factors
Q33725093Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks
Q37016538Validation of candidate genes associated with cardiovascular risk factors in psychiatric patients
Q40838204Validation of obesity susceptibility loci identified by genome-wide association studies in early childhood in South Brazilian children.
Q35971017Variability in the heritability of body mass index: a systematic review and meta-regression
Q33698696Variant rs9939609 in the FTO gene is associated with body mass index among Chinese children
Q37105383Variants near MC4R are associated with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes
Q44398082Variation at diabetes- and obesity-associated Loci may mirror neutral patterns of human population diversity and diabetes prevalence in India
Q30578282Variation at the melanocortin 4 receptor gene and response to weight-loss interventions in the diabetes prevention program
Q35091801Variation in the MC4R gene is associated with bone phenotypes in elderly Swedish women
Q33359578Variations in the ghrelin receptor gene associate with obesity and glucose metabolism in individuals with impaired glucose tolerance
Q38026994What can genetics tell us about the cause of fixed airflow obstruction?
Q42909074What the Genetic Background of Individuals with Asthma and Obesity Can Reveal: Is β2-Adrenergic Receptor Gene Polymorphism Important?
Q37980673Who should we target for diabetes prevention and diabetes risk reduction?
Q34698823Whole genome scanning and association mapping identified a significant association between growth and a SNP in the IFABP-a gene of the Asian seabass
Q37537912Whole-genome pathway analysis on 132,497 individuals identifies novel gene-sets associated with body mass index
Q87089092[Novel achievements in development and application of GPCR-peptides]
Q28749907Pathogenesis of adolescent idiopathic scoliosis in girls - a double neuro-osseous theory involving disharmony between two nervous systems, somatic and autonomic expressed in the spine and trunk: possible dependency on sympathetic nervous system and

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