P2X7 receptor-Pannexin1 complex: pharmacology and signaling

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P2X7 receptor-Pannexin1 complex: pharmacology and signaling is …
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scholarly articleQ13442814

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P356DOI10.1152/AJPCELL.00228.2008
P3181OpenCitations bibliographic resource ID1396562
P932PMC publication ID2544446
P698PubMed publication ID18596211
P5875ResearchGate publication ID5255607

P50authorEliana ScemesQ38328617
P2093author name stringD C Spray
A Roque
R Iglesias
G Dahl
A P Alberto
S Locovei
P2860cites workPannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptorQ24306745
Pannexin1 channels contain a glycosylation site that targets the hexamer to the plasma membraneQ24338217
Proteomic and functional evidence for a P2X7 receptor signalling complexQ24535912
A ubiquitous family of putative gap junction moleculesQ28140991
Molecular physiology of P2X receptorsQ28203477
Pannexin: to gap or not to gap, is that a question?Q28248565
P2X receptors as cell-surface ATP sensors in health and diseaseQ28255603
Pannexin membrane channels are mechanosensitive conduits for ATPQ28276454
Pannexin1 is expressed by neurons and glia but does not form functional gap junctionsQ48410095
Differential assembly of rat purinergic P2X7 receptor in immune cells of the brain and peripheryQ48907038
P2X7 purinoceptor expression in Xenopus oocytes is not sufficient to produce a pore-forming P2Z-like phenotypeQ48955005
Extracellular ATP4- promotes cation fluxes in the J774 mouse macrophage cell lineQ70023884
Functional evidence of distinct ATP activation sites at the human P2X(7) receptorQ28343332
Pannexins, a family of gap junction proteins expressed in brainQ28567263
The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)Q28568856
The Pro-451 to Leu polymorphism within the C-terminal tail of P2X7 receptor impairs cell death but not phospholipase D activation in murine thymocytesQ28584701
Cutting edge: a natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptorQ28587973
Cutting edge: the nucleotide receptor P2X7 contains multiple protein- and lipid-interaction motifs including a potential binding site for bacterial lipopolysaccharideQ28589722
Modulation of intercellular communication in macrophages: possible interactions between GAP junctions and P2 receptorsQ28590048
ATP-induced pore formation in the plasma membrane of rat peritoneal mast cellsQ28678688
ATP induces nucleotide permeability in rat mast cellsQ28678698
Functional connexin “hemichannels”: A critical appraisalQ29030321
Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complexQ30479449
The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins.Q30913735
Extracellular ATP induces a large nonselective conductance in macrophage plasma membranesQ33661244
Pannexin 1 in erythrocytes: function without a gapQ34650659
Activation of ERK1/2 by extracellular nucleotides in macrophages is mediated by multiple P2 receptors independently of P2X7-associated pore or channel formation.Q35545223
The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste budsQ35748758
Evolution of gap junction proteins--the pannexin alternative.Q36085400
Purine and pyrimidine receptorsQ36765468
Gap junctional proteins of animals: the innexin/pannexin superfamilyQ36824309
Trafficking dynamics of glycosylated pannexin 1 proteinsQ36860965
P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signalingQ36981083
Connexin and pannexin mediated cell-cell communication.Q37218997
Potent block of Cx36 and Cx50 gap junction channels by mefloquineQ37485123
Extracellular ATP: effects, sources and fateQ39500098
Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteinsQ40070137
Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathwayQ40205467
Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes.Q40457389
Are second messengers crucial for opening the pore associated with P2X7 receptor?Q40506943
P2X7 receptor cell surface expression and cytolytic pore formation are regulated by a distal C-terminal regionQ40681894
The P2X(7) receptor-mediated phospholipase D activation is regulated by both PKC-dependent and PKC-independent pathways in a rat brain-derived Type-2 astrocyte cell line, RBA-2.Q40762645
Effects of divalent cations, protons and calmidazolium at the rat P2X7 receptorQ41080074
Are there functional gap junctions or junctional hemichannels in macrophages?Q41189158
Differential activation of cation channels and non-selective pores by macrophage P2z purinergic receptors expressed in Xenopus oocytes.Q41468237
Nucleotide receptorsQ41541504
Evidence that the gap junction protein connexin-43 is the ATP-induced pore of mouse macrophagesQ41684592
Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannelsQ43854350
Synthesis, biological activity and molecular modeling studies of 1,2,3,4-tetrahydroisoquinoline derivatives as conformationally constrained analogues of KN62, a potent antagonist of the P2X7-receptor containing a tyrosine moietyQ44012680
Functional hemichannels in astrocytes: a novel mechanism of glutamate release.Q44433358
Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calciumQ46858670
Modulation of membrane channel currents by gap junction protein mimetic peptides: size mattersQ47278817
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
pharmacologyQ128406
P304page(s)C752-60
P577publication date2008-09-01
P1433published inAmerican Journal of Physiology - Cell PhysiologyQ2227080
P1476titleP2X7 receptor-Pannexin1 complex: pharmacology and signaling
P478volume295

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