The P2X7 receptor drives microglial activation and proliferation: a trophic role for P2X7R pore

scientific article published in March 2009

The P2X7 receptor drives microglial activation and proliferation: a trophic role for P2X7R pore is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.5512-08.2009
P932PMC publication ID6665035
P698PubMed publication ID19321774

P50authorKim L PowellQ56845661
Christopher A ReidQ56850335
Mastura MonifQ81294421
P2093author name stringMegan L Smart
David A Williams
P2860cites workInterleukin 1 is processed and released during apoptosisQ24315035
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Microglia and neuroinflammation: a pathological perspectiveQ24799838
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Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivoQ27860578
Neuronal P2X7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systemsQ28215870
Tissue distribution of the P2X7 receptorQ28254153
Receptors for purines and pyrimidinesQ28283941
Functional role of gap junctions in cytokine-induced leukocyte adhesion to endothelium in vivoQ28506489
A plethora of presynaptic proteins associated with ATP-storing organelles in cultured astrocytesQ28564872
The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)Q28568856
Altered cytokine production in mice lacking P2X(7) receptorsQ28586061
ATP induces nucleotide permeability in rat mast cellsQ28678698
Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complexQ30479449
Cytolytic P2X purinoceptors.Q33592245
Reactive microgliosisQ33604483
Dynamic selectivity filters in ion channelsQ33731015
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Extracellular ATP and P2X7 receptors in neurodegenerationQ34768762
Prospects for rational development of pharmacological gap junction channel blockersQ35007602
Purinergic modulation of interleukin-1 beta release from microglial cells stimulated with bacterial endotoxinQ36376502
High Ca(2+)-phosphate transfection efficiency enables single neuron gene analysisQ39128633
A novel recombinant plasma membrane-targeted luciferase reveals a new pathway for ATP secretionQ40412183
P2X7 receptor cell surface expression and cytolytic pore formation are regulated by a distal C-terminal regionQ40681894
Microglial activation and dopaminergic cell injury: an in vitro model relevant to Parkinson's disease.Q40773870
Cytotoxicity of microgliaQ40870381
Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementiaQ40896306
Chemokines induce migration and changes in actin polymerization in adult rat brain microglia and a human fetal microglial cell line in vitroQ40980153
Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitisQ41433234
Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptorQ41559800
Stimulation of Ca(2+) influx through ATP receptors on rat brain synaptosomes: identification of functional P2X(7) receptor subtypesQ43263816
ATP mediates calcium signaling between astrocytes and microglial cells: modulation by IFN-gammaQ43600966
Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity.Q43715908
Involvement of P2X7 receptors in the regulation of neurotransmitter release in the rat hippocampusQ44030451
Microglial activation and recruitment, but not proliferation, suffice to mediate neurodegenerationQ44055767
Activation of presynaptic P2X7-like receptors depresses mossy fiber-CA3 synaptic transmission through p38 mitogen-activated protein kinase.Q44067005
P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's diseaseQ44292875
Reversible inhibition of intercellular junctional communication by glycyrrhetinic acidQ44325495
Differential co-localisation of the P2X7 receptor subunit with vesicular glutamate transporters VGLUT1 and VGLUT2 in rat CNS.Q44714746
Production and release of neuroprotective tumor necrosis factor by P2X7 receptor-activated microglia.Q44723151
Glu496 to Ala polymorphism in the P2X7 receptor impairs ATP-induced IL-1 beta release from human monocytesQ44788647
Increased morphological diversity of microglia in the activated hypothalamic supraoptic nucleus.Q44895554
P2X7 receptor inhibition improves recovery after spinal cord injuryQ44982503
Effects of carbenoxolone on alveolar fluid clearance and lung inflammation in the rat.Q45041330
Macrophage-induced neurotoxicity is mediated by glutamate and attenuated by glutaminase inhibitors and gap junction inhibitorsQ46614579
Cellular localization of P2X7 receptor mRNA in the rat brainQ46821425
Apoptotic pathways mobilized in microglia and neurones as a consequence of chromogranin A-induced microglial activationQ48149106
Modulation of the purinergic P2X7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain.Q48180638
Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer diseaseQ48186602
Comparative MR analysis of the entorhinal cortex and hippocampus in diagnosing Alzheimer diseaseQ48285881
Hippocampal and entorhinal cortex atrophy in frontotemporal dementia and Alzheimer's diseaseQ48298121
Gap junction hemichannel-mediated release of glutathione from cultured rat astrocytesQ48310232
Mechanisms of cell death in Alzheimer disease--immunopathology.Q48330745
Development of microglia in the postnatal rat hippocampusQ48344574
Upregulated expression of purinergic P2X(7) receptor in Alzheimer disease and amyloid-beta peptide-treated microglia and in peptide-injected rat hippocampusQ48378167
Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer diseaseQ48394474
Morphology of reactive microglia in the injured cerebral cortex. Fractal analysis and complementary quantitative methodsQ48623708
Nonuniform distribution of Ca2+ channel subtypes on presynaptic terminals of excitatory synapses in hippocampal culturesQ48728265
The P2X(7) receptor from Xenopus laevis: formation of a large pore in Xenopus oocytesQ48865628
ATP4- permeabilizes the plasma membrane of mouse macrophages to fluorescent dyes.Q50902451
Co-release of noradrenaline and ATP from cultured sympathetic neurons.Q51630641
Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner.Q53278044
Microglia: Intrinsic immuneffector cell of the brainQ56029409
New expression of myelomonocytic antigens by microglia and perivascular cells following lethal motor neuron injuryQ68768348
[Microglia: origin and development]Q74270494
Two different ionotropic receptors are activated by ATP in rat microgliaQ78157427
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectmicrogliaQ1622829
P304page(s)3781-3791
P577publication date2009-03-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleThe P2X7 receptor drives microglial activation and proliferation: a trophic role for P2X7R pore
P478volume29

Reverse relations

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