DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane

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DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.16.4.1770
P3181OpenCitations bibliographic resource ID3251658
P932PMC publication ID231163
P698PubMed publication ID8657152

P50authorMichiyuki MatsudaQ51727894
P2093author name stringM Matsuda
M Shibuya
K Nagashima
S Tanaka
H Hasegawa
T Kurata
N Gotoh
E Kiyokawa
P2860cites workC3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteinsQ24305258
A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent mannerQ24318312
Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activityQ24558728
Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA librariesQ24563818
CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cellsQ24610534
Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathwaysQ24613828
Two species of human CRK cDNA encode proteins with distinct biological activitiesQ24629936
An analysis of vertebrate mRNA sequences: intimations of translational controlQ24642530
Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3GQ24651040
Signal transduction from the extracellular matrixQ24675031
Protein modules and signalling networksQ27860694
Efficient selection for high-expression transfectants with a novel eukaryotic vectorQ27860810
Association of Ash/Grb-2 with dynamin through the Src homology 3 domainQ28250199
CLUSTAL: a package for performing multiple sequence alignment on a microcomputerQ28293854
The SH3 domain of Crk binds specifically to a conserved proline-rich motif in Eps15 and Eps15RQ28304242
SH2 and SH3 domains as molecular adhesives: the interactions of Crk and AblQ28307277
A novel viral oncogene with structural similarity to phospholipase CQ28307371
The proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cellsQ28609032
Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of CrkQ28609801
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinaseQ28646514
Integrins and signal transduction pathways: the road takenQ29547895
Modular binding domains in signal transduction proteinsQ29617351
The GTPase dynamin binds to and is activated by a subset of SH3 domainsQ29618141
Affinity and specificity requirements for the first Src homology 3 domain of the Crk proteinsQ30193419
Cellular proteins binding to the first Src homology 3 (SH3) domain of the proto-oncogene product c-Crk indicate Crk-specific signaling pathwaysQ30193501
Crk interacts with tyrosine-phosphorylated p116 upon T cell activationQ30193645
The C-terminal SH3 domain of the mouse c-Crk protein negatively regulates tyrosine-phosphorylation of Crk associated p130 in rat 3Y1 cells.Q30194289
Structure and function of the SH3 domainQ30194603
Identification and Characterization of a High-Affinity Interaction Between v-Crk and Tyrosine-Phosphorylated Paxillin in CT10-Transformed FibroblastsQ30194902
Both the SH2 and SH3 domains of human CRK protein are required for neuronal differentiation of PC12 cellsQ30194957
The product of the cellular crk gene consists primarily of SH2 and SH3 regionsQ30195339
Tyrosine-phosphorylated epidermal growth factor receptor and cellular p130 provide high affinity binding substrates to analyze Crk-phosphotyrosine-dependent interactions in vitroQ30195371
Mutagenic analysis of the v-crk oncogene: requirement for SH2 and SH3 domains and correlation between increased cellular phosphotyrosine and transformationQ30195822
Binding of Transforming Protein, P47 gag-crk , to a Broad Range of Phosphotyrosine-containing ProteinsQ30195844
pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for CrkQ30452729
Signal transduction through integrins: a central role for focal adhesion kinase?Q30464970
Focal adhesion kinase and associated proteinsQ30465310
Signal transduction in T lymphocytes using a conditional allele of SosQ33871535
Epidermal growth factor-receptor mutant lacking the autophosphorylation sites induces phosphorylation of Shc protein and Shc-Grb2/ASH association and retains mitogenic activityQ34914079
Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activityQ35722860
Human Colon Carcinoma Ki-ras2 Oncogene and Its Corresponding Proto-OncogeneQ36946669
Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.Q39481540
Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifsQ41334070
The hunt for Ras targetsQ59095565
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectcell morphologyQ66568582
P304page(s)1770-6
P577publication date1996-04-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleDOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane
P478volume16

Reverse relations

cites work (P2860)
Q34623781A Minimal Rac Activation Domain in the Unconventional Guanine Nucleotide Exchange Factor Dock180
Q24296060A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs
Q24535521A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activation
Q24539212A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling
Q30008856A pre-metazoan origin of the CRK gene family and co-opted signaling network
Q34048799Activation of Cdc42 is necessary for sustained oscillations of Ca2+ and PIP2 stimulated by antigen in RBL mast cells
Q35570177Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans
Q22007972Activation of Rac1 by a Crk SH3-binding protein, DOCK180
Q40525953Activation of Rac1 by paxillin-Crk-DOCK180 signaling complex is antagonized by Rap1 in migrating NBT-II cells
Q36854898Activation of Rac1 by the guanine nucleotide exchange factor Dck1 is required for invasive filamentous growth in the pathogen Candida albicans
Q27657391Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor
Q34324446Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells
Q30168248Activation of the focal adhesion kinase signaling pathway by structural alterations in the carboxyl-terminal region of c-Crk II.
Q30307290Alterations in the focal adhesion kinase/Src signal transduction pathway correlate with increased migratory capacity of prostate carcinoma cells
Q33940235An appetite for apoptotic cells? Controversies and challenges
Q24304056An isoform of GTPase regulator DOCK4 localizes to the stereocilia in the inner ear and binds to harmonin (USH1C)
Q24313047Ankyrin repeat domain 28 (ANKRD28), a novel binding partner of DOCK180, promotes cell migration by regulating focal adhesion formation
Q47071234Antisocial, an intracellular adaptor protein, is required for myoblast fusion in Drosophila
Q35719265Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems
Q30277892Apoptotic cell recognition receptors and scavenger receptors
Q30167608Apoptotic regulation by the Crk adapter protein mediated by interactions with Wee1 and Crm1/exportin
Q28298373B cell antigen receptor signaling induces the formation of complexes containing the Crk adapter proteins
Q28257171BCR/ABL-induced leukemogenesis causes phosphorylation of Hef1 and its association with Crkl
Q28144317Beta 1-integrin-mediated cell signaling in T lymphocytes
Q30008899Binding Mechanism of the N-Terminal SH3 Domain of CrkII and Proline-Rich Motifs in cAbl
Q28306511C-terminal SH3 domain of CrkII regulates the assembly and function of the DOCK180/ELMO Rac-GEF
Q39750201C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment.
Q24336487C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180
Q24311510CAS/Crk coupling serves as a "molecular switch" for induction of cell migration
Q30306838CAS/Crk signalling mediates uptake of Yersinia into human epithelial cells
Q24291780CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration
Q39749591CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans
Q64900712CRKII overexpression promotes the in vitro proliferation, migration and invasion potential of murine hepatocarcinoma Hca-P cells.
Q38112644Cbl-family proteins as regulators of cytoskeleton-dependent phenomena
Q35107552Cell and molecular biology of myoblast fusion
Q30437225Cell migration is regulated by platelet-derived growth factor receptor endocytosis
Q29616711Cell migration: Rho GTPases lead the way
Q30439052Characterization of a novel interaction between ELMO1 and ERM proteins
Q33891506Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways
Q30433781Clearance of apoptotic cells: implications in health and disease
Q54231841Comparison of normal human skin gene expression using cDNA microarrays.
Q30176172Constitutive association of EGF receptor with the CrkII-23 mutant that inhibits transformation of NRK cells by EGF and TGF-beta
Q33744987Control of cell migration during Caenorhabditis elegans development
Q30157305Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration
Q41942048Crk and CrkL adaptor proteins: networks for physiological and pathological signaling
Q30155850Crk and CrkL present with different expression and significance in epithelial ovarian carcinoma
Q30167857Crk family adaptors-signalling complex formation and biological roles
Q48185910Crk proteins transduce FGF signaling to promote lens fiber cell elongation
Q30175335CrkL mediates Ras-dependent activation of the Raf/ERK pathway through the guanine nucleotide exchange factor C3G in hematopoietic cells stimulated with erythropoietin or interleukin-3.
Q30175868DEF-1, a novel Src SH3 binding protein that promotes adipogenesis in fibroblastic cell lines
Q24304336DOCK2 mediates T cell receptor-induced activation of Rac2 and IL-2 transcription
Q28182054DOCK4, a GTPase activator, is disrupted during tumorigenesis
Q28116715DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV
Q30008878Dedicator of Cytokinesis 2 in Cell Signaling Regulation and Disease Development
Q30485463Dictyostelium Dock180-related RacGEFs regulate the actin cytoskeleton during cell motility
Q22253384Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation
Q24678407Disruption of a novel member of a sodium/hydrogen exchanger family and DOCK3 is associated with an attention deficit hyperactivity disorder-like phenotype
Q42374728Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy
Q30157067Distinct roles for Crk adaptor isoforms in actin reorganization induced by extracellular signals
Q28187402Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration
Q28296792Dock180-ELMO cooperation in Rac activation
Q52671777Dock2 in the development of inflammation and cancer.
Q28267493Dock4 is regulated by RhoG and promotes Rac-dependent cell migration
Q34596325Dock6, a Dock-C subfamily guanine nucleotide exchanger, has the dual specificity for Rac1 and Cdc42 and regulates neurite outgrowth
Q53175756Dock7: a GEF for Rho-family GTPases and a novel myosin VI-binding partner in neuronal PC12 cells.
Q37230539Drosophila ELMO/CED-12 interacts with Myoblast city to direct myoblast fusion and ommatidial organization
Q24676790Drosophila myoblast city encodes a conserved protein that is essential for myoblast fusion, dorsal closure, and cytoskeletal organization
Q24623558ELMO1 and Dock180, a bipartite Rac1 guanine nucleotide exchange factor, promote human glioma cell invasion
Q27340506Early mechanisms of pathobiology are revealed by transcriptional temporal dynamics in hippocampal CA1 neurons of prion infected mice
Q52655711Ecdysone regulates morphogenesis and function of Malpighian tubules in Drosophila melanogaster through EcR-B2 isoform.
Q47153678Efferocytosis creates a tumor microenvironment supportive of tumor survival and metastasis
Q48193673Efferocytosis of dying cells differentially modulate immunological outcomes in tumor microenvironment.
Q37255353Engineering a multi-nucleated myotube, the role of the actin cytoskeleton
Q30445079Engulfment of apoptotic cells: signals for a good meal
Q57754194Enhancement of guanine-nucleotide exchange activity of C3G for Rap1 by the expression of Crk, CrkL, and Grb2
Q55055558Epidermal growth factor-dependent dissociation of CrkII proto-oncogene product from the epidermal growth factor receptor in human glioma cells.
Q24648256ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration
Q33744526Essential genes for myoblast fusion in Drosophila embryogenesis
Q30176064Evidence that DOCK180 up-regulates signals from the CrkII-p130(Cas) complex
Q21261467Examination of NRCAM, LRRN3, KIAA0716, and LAMB1 as autism candidate genes
Q92661891FAK-Dependent Cell Motility and Cell Elongation
Q34300201Focal adhesions require catalytic activity of Src family kinases to mediate integrin-matrix adhesion
Q34056991Function of Rho family proteins in actin dynamics during phagocytosis and engulfment
Q26998955Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers
Q24633334GEF what? Dock180 and related proteins help Rac to polarize cells in new ways
Q74543058GEF without a Dbl domain?
Q30436337GRASP and IPCEF promote ARF-to-Rac signaling and cell migration by coordinating the association of ARNO/cytohesin 2 with Dock180.
Q31150208Genetic and functional evidence for a locus controlling otitis media at chromosome 10q26.3.
Q37112620Genetic control of muscle development: learning from Drosophila
Q43762442Guidance of cell migration by the Drosophila PDGF/VEGF receptor
Q28512928Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration
Q24550885Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase
Q33314672Host-pathogen systems biology: logical modelling of hepatocyte growth factor and Helicobacter pylori induced c-Met signal transduction
Q38284377I'm coming to GEF you: Regulation of RhoGEFs during cell migration
Q28203896Identification and kinetic analysis of the interaction between Nck-2 and DOCK180
Q27219697Identification of a Drosophila homologue to vertebrate Crk by interaction with MBC
Q32066807Identification of novel Drosophila neural precursor genes using a differential embryonic head cDNA screen
Q30442947Identification of two signaling submodules within the CrkII/ELMO/Dock180 pathway regulating engulfment of apoptotic cells.
Q24649740Identification of tyrosine residues on ELMO1 that are phosphorylated by the Src-family kinase Hck.
Q40051860Identification, Characterization, and Structure of Tm16 from Trichuris muris
Q35563190Immunohistochemichal Assessment of the CrkII Proto-oncogene Expression in Common Malignant Salivary Gland Tumors and Pleomorphic Adenoma
Q28296782In vitro guanine nucleotide exchange activity of DHR-2/DOCKER/CZH2 domains
Q24533233Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes.
Q35547365Integrin signaling to the actin cytoskeleton.
Q30448862Integrin-mediated mechanotransduction pathway of low-intensity continuous ultrasound in human chondrocytes
Q30423615Integrins and extracellular matrix in mechanotransduction
Q28281847Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins
Q30009578Interaction of crk with Myosin-1c participates in fibronectin-induced cell spreading
Q37998461Interplay of polarity proteins and GTPases in T-lymphocyte function.
Q28272714Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction
Q40313652Involvement of adaptor protein Crk in malignant feature of human ovarian cancer cell line MCAS.
Q30175432Involvement of the adapter protein CRKL in integrin-mediated adhesion
Q30009282Iterative tyrosine phosphorylation controls non-canonical domain utilization in Crk.
Q24680571Listeria monocytogenes exploits normal host cell processes to spread from cell to cell
Q30453539Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src
Q24532348Membrane recruitment of DOCK180 by binding to PtdIns(3,4,5)P3
Q30175408Membrane-targeting of signalling molecules by SH2/SH3 domain-containing adaptor proteins
Q30009961Models of crk adaptor proteins in cancer
Q30165527Molecular and immunohistochemical analysis of signaling adaptor protein Crk in human cancers
Q27668010Multiple Factors Confer Specific Cdc42 and Rac Protein Activation by Dedicator of Cytokinesis (DOCK) Nucleotide Exchange Factors
Q34574378Muscle differentiation: how two cells become one.
Q58795841Mutations in dock1 disrupt early Schwann cell development
Q24596003Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes
Q37147237Myoblast fusion in fly and vertebrates: new genes, new processes and new perspectives.
Q33787549Myoblast fusion: when it takes more to make one.
Q30481422Myoblasts and macrophages share molecular components that contribute to cell-cell fusion
Q30443470Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling
Q22010788Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins
Q53198380Overexpression of dedicator of cytokinesis I (Dock180) in ovarian cancer correlated with aggressive phenotype and poor patient survival.
Q37592539PVR plays a critical role via JNK activation in thorax closure during Drosophila metamorphosis
Q24646926Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis
Q42752703Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation
Q30416374Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion
Q28274831Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor
Q30009346Phosphorylation of Dok1 by Abl family kinases inhibits CrkI transforming activity
Q30175229Phosphorylation of tyrosine residues 31 and 118 on paxillin regulates cell migration through an association with CRK in NBT-II cells
Q33937108Plexina1 autoinhibition by the plexin sema domain.
Q37119206Prenylation and membrane localization of Cdc42 are essential for activation by DOCK7.
Q44163313Presenilin-binding protein forms aggresomes in monkey kidney COS-7 cells.
Q38579028Pressure activates colon cancer cell adhesion via paxillin phosphorylation, Crk, Cas, and Rac1.
Q30156056Proteins that bind the Src homology 3 domain of CrkI have distinct roles in Crk transformation
Q74014180Rac and roll over the corpses
Q43966859Rac is activated by erythropoietin or interleukin-3 and is involved in activation of the Erk signaling pathway
Q30433703Rac1 is essential for basement membrane-dependent epiblast survival
Q30009085Reciprocal regulation of Abl kinase by Crk Y251 and Abi1 controls invasive phenotypes in glioblastoma
Q36306178Reduced DOCK4 expression leads to erythroid dysplasia in myelodysplastic syndromes.
Q30157247Regulation of focal adhesion and cell migration by ANKRD28-DOCK180 interaction
Q34612747Rho GTPase signalling pathways in the morphological changes associated with apoptosis.
Q37891679Rho-guanine nucleotide exchange factors during development: Force is nothing without control
Q24310774RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo
Q30009052Role of CrkII Signaling in RANKL-Induced Osteoclast Differentiation and Function
Q50335857Role of CrkII in Fcgamma receptor-mediated phagocytosis
Q62590792Role of DOCK2 and DOCK180 in fetal thymus colonization
Q30175238Role of the β1 integrin molecule in T-cell activation and migration
Q33834442Roles of protein tyrosine phosphatases in cell migration and adhesion
Q40887859SCAR/WAVE and Arp2/3 are crucial for cytoskeletal remodeling at the site of myoblast fusion
Q40195229Shigella IpgB1 promotes bacterial entry through the ELMO-Dock180 machinery.
Q37723999Small-GTPase-associated signaling by the guanine nucleotide exchange factors CpDock180 and CpCdc24, the GTPase effector CpSte20, and the scaffold protein CpBem1 in Claviceps purpurea
Q40433184Spatial and functional heterogeneity of sphingolipid-rich membrane domains
Q33771789Stress signaling in Drosophila
Q27659933Structural Basis of Membrane Targeting by the Dock180 Family of Rho Family Guanine Exchange Factors (Rho-GEFs)
Q97529790Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state
Q30175390T cell activation stimulates the association of enzymatically active tyrosine-phosphorylated ZAP-70 with the Crk adapter proteins
Q28264262T cell receptor-mediated tyrosine phosphorylation of Cas-L, a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3G
Q30165409Target-assisted iterative screening reveals novel interactors for PSD95, Nedd4, Src, Abl and Crk proteins
Q48320240The Arabidopsis SPIKE1 gene is required for normal cell shape control and tissue development
Q24672486The CDM superfamily protein MBC directs myoblast fusion through a mechanism that requires phosphatidylinositol 3,4,5-triphosphate binding but is independent of direct interaction with DCrk
Q33924971The Caenorhabditis elegans gonad: a test tube for cell and developmental biology
Q47614378The Candida albicans ELMO homologue functions together with Rac1 and Dck1, upstream of the MAP Kinase Cek1, in invasive filamentous growth
Q36495318The Cbl family proteins: ring leaders in regulation of cell signaling
Q24656195The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport
Q30009834The Drosophila DOCK family protein sponge is involved in differentiation of R7 photoreceptor cells
Q33573218The Rac-specific exchange factors Dock1 and Dock5 are dispensable for the establishment of the glomerular filtration barrier in vivo
Q30424414The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons.
Q57838274The Small Yeast GTPase Rho5 and Its Dimeric GEF Dck1/Lmo1 Respond to Glucose Starvation
Q30175936The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway
Q77796080The discovery and validation of new drug targets in cancer
Q35912786The engulfment process of programmed cell death in caenorhabditis elegans
Q37721163The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion.
Q30175889The functional role of CrkII in actin cytoskeleton organization and mitogenesis
Q22010844The human homologue of Caenorhabditis elegans CED-6 specifically promotes phagocytosis of apoptotic cells
Q33834236The molecular mechanism of programmed cell death in C. elegans
Q38346520The opsonin MFG-E8 is a ligand for the alphavbeta5 integrin and triggers DOCK180-dependent Rac1 activation for the phagocytosis of apoptotic cells.
Q37257352The rho-specific guanine nucleotide exchange factor Dbs regulates breast cancer cell migration
Q39726277The role of Crk/Dock180/Rac1 pathway in the malignant behavior of human ovarian cancer cell SKOV3.
Q37388703The ubiquitin-proteasome system regulates focal adhesions at the leading edge of migrating cells.
Q35172313The β1-integrin-p-FAK-p130Cas-DOCK180-RhoA-vinculin is a novel regulatory protein complex at the apical ectoplasmic specialization in adult rat testes
Q39743634Translocation of CrkL to focal adhesions mediates integrin-induced migration downstream of Src family kinases
Q35693138Tuning protein autoinhibition by domain destabilization
Q24646756Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation
Q24301883Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex
Q54976938Upregulation of multiple signaling pathways by Dock5 deletion in epithelial cells.
Q37135603Visualizing new dimensions in Drosophila myoblast fusion
Q36749738Zizimin and Dock guanine nucleotide exchange factors in cell function and disease.
Q28142034alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells
Q37403951c-Abl and insulin receptor signalling

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