Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation

scientific article published on 29 January 2013

Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M112.410423
P932PMC publication ID3605628
P698PubMed publication ID23362269
P5875ResearchGate publication ID235383553

P50authorYoshinori FukuiQ57167803
Jean-François CôtéQ89637925
Akihiko NishikimiQ39867863
P2093author name stringYasunori Kanaho
Fumiyuki Sanematsu
Yoshihiko Tanaka
Tsunaki Hongu
Mayuki Watanabe
P2860cites workCED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migrationQ24291780
Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complexQ24301883
A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosisQ24306318
An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signalingQ24310171
STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cellsQ24534351
A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signallingQ24539212
DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membraneQ24650136
Molecular mechanisms of N-formyl-methionyl-leucyl-phenylalanine-induced superoxide generation and degranulation in mouse neutrophils: phospholipase D is dispensableQ42531338
5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxisQ42805401
Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signalQ42818777
Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos.Q42828551
Differential Roles of WAVE1 and WAVE2 in Dorsal and Peripheral Ruffle Formation for Fibroblast Cell MigrationQ44612166
T helper type 2 differentiation and intracellular trafficking of the interleukin 4 receptor-alpha subunit controlled by the Rac activator Dock2.Q50889452
MacropinocytosisQ58323386
Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinaseQ72237914
DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxisQ24683000
Structural Basis of Membrane Targeting by the Dock180 Family of Rho Family Guanine Exchange Factors (Rho-GEFs)Q27659933
Multiple Factors Confer Specific Cdc42 and Rac Protein Activation by Dedicator of Cytokinesis (DOCK) Nucleotide Exchange FactorsQ27668010
Cell migration: integrating signals from front to backQ27860670
DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1Q28182421
Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migrationQ28187402
Identification and kinetic analysis of the interaction between Nck-2 and DOCK180Q28203896
Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activityQ28214812
Phospholipase DQ28253553
Phospholipase D: a lipid centric reviewQ28270831
Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-alphaQ28302448
Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migrationQ28512928
DOCK2 is essential for antigen-induced translocation of TCR and lipid rafts, but not PKC-theta and LFA-1, in T cellsQ28593591
PIP2 and PIP3: complex roles at the cell surfaceQ28609413
Guanine nucleotide exchange factors for Rho GTPases: turning on the switchQ29618403
Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signalingQ30443470
Rac1-null mouse embryonic fibroblasts are motile and respond to platelet-derived growth factorQ30477161
A dynamin-cortactin-Arp2/3 complex mediates actin reorganization in growth factor-stimulated cellsQ30477658
CtBP1/BARS is an activator of phospholipase D1 necessary for agonist-induced macropinocytosisQ30486803
Sequential signaling in plasma-membrane domains during macropinosome formation in macrophagesQ30489942
The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivoQ33372285
Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation.Q33794944
Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteinsQ34143927
Heterogeneity of phosphatidic acid levels and distribution at the plasma membrane in living cells as visualized by a Föster resonance energy transfer (FRET) biosensorQ34285394
Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinasesQ34321861
Differential requirement for DOCK2 in migration of plasmacytoid dendritic cells versus myeloid dendritic cellsQ34736661
Foot and mouth: podosomes, invadopodia and circular dorsal rufflesQ35887297
Phosphatidic acid- and phosphatidylserine-binding proteinsQ36453653
Get off my back! Rapid receptor internalization through circular dorsal ruffles.Q36673646
Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasisQ37041152
DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4.Q39657420
Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis.Q39867658
Opening up on ELMO regulation: New insights into the control of Rac signaling by the DOCK180/ELMO complexQ40647051
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)8092-8100
P577publication date2013-01-29
P1433published inJournal of Biological ChemistryQ867727
P1476titlePhosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation
P478volume288

Reverse relations

cites work (P2860)
Q91936025A real-time, click chemistry imaging approach reveals stimulus-specific subcellular locations of phospholipase D activity
Q34044529Cellular and physiological roles for phospholipase D1 in cancer
Q36268883DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation
Q30582096DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation
Q28066088Diacylglycerol Kinases: Shaping Diacylglycerol and Phosphatidic Acid Gradients to Control Cell Polarity
Q38713729ELMO proteins transduce G protein-coupled receptor signal to control reorganization of actin cytoskeleton in chemotaxis of eukaryotic cells
Q47593066G-Protein Gα13 Functions with Abl Kinase to Regulate Actin Cytoskeletal Reorganization
Q101476135Genetic analyses in mouse fibroblast and melanoma cells demonstrate novel roles for PDGF-AB ligand and PDGF receptor alpha
Q38196631Insights into the biological functions of Dock family guanine nucleotide exchange factors
Q58586388Macropinocytosis: New Insights Into Its Underappreciated Role in Innate Immune Cell Surveillance
Q61811029Phosphatidic Acid: From Pleiotropic Functions to Neuronal Pathology
Q37665324Phospholipase D (PLD) drives cell invasion, tumor growth and metastasis in a human breast cancer xenograph model
Q47386895Proliferative and metastatic roles for Phospholipase D in mouse models of cancer.
Q37721163The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion.
Q38936522The life cycle of phagosomes: formation, maturation, and resolution
Q28082479The phospholipase D superfamily as therapeutic targets
Q36909364The transcription factors Slug (SNAI2) and Snail (SNAI1) regulate phospholipase D (PLD) promoter in opposite ways towards cancer cell invasion
Q27345292p53 Down regulates PDGF-induced formation of circular dorsal ruffles in rat aortic smooth muscle cells

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