Opening up on ELMO regulation: New insights into the control of Rac signaling by the DOCK180/ELMO complex

scientific article published on September 2011

Opening up on ELMO regulation: New insights into the control of Rac signaling by the DOCK180/ELMO complex is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4161/SGTP.2.5.17716
P932PMC publication ID3265818
P698PubMed publication ID22292130
P5875ResearchGate publication ID221793407

P50authorJean-François CôtéQ89637925
P2093author name stringManishha Patel
Ariane Pelletier
P2860cites workSuccessful allogeneic hematopoietic stem cell transplantation for DOCK8 deficiencyQ57014639
Activation of Rac1 by a Crk SH3-binding protein, DOCK180Q22007972
CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migrationQ24291780
A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFsQ24296060
PH domain of ELMO functions in trans to regulate Rac activation via Dock180Q24299119
Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complexQ24301883
The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18Q24303678
ELMOD2 is an Arl2 GTPase-activating protein that also acts on ArfsQ24303801
The mammalian formin FHOD1 is activated through phosphorylation by ROCK and mediates thrombin-induced stress fibre formation in endothelial cellsQ24309382
An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signalingQ24310171
RhoG activates Rac1 by direct interaction with the Dock180-binding protein ElmoQ24310774
DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cellsQ24319212
Combined immunodeficiency associated with DOCK8 mutationsQ24622094
GEF what? Dock180 and related proteins help Rac to polarize cells in new waysQ24633334
Identification of tyrosine residues on ELMO1 that are phosphorylated by the Src-family kinase Hck.Q24649740
Endogenous RhoG is dispensable for integrin-mediated cell spreading but contributes to Rac-independent migration.Q24655225
Mechanism of activation of the Formin protein Daam1Q24657453
DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxisQ24683000
The human formin FHOD1 contains a bipartite structure of FH3 and GTPase-binding domains required for activationQ27652093
Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensorQ27657391
Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migrationQ28187402
The formin/diaphanous-related protein, FHOS, interacts with Rac1 and activates transcription from the serum response elementQ28190692
Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activityQ28214812
In vitro guanine nucleotide exchange activity of DHR-2/DOCKER/CZH2 domainsQ28296782
Elmo1 inhibits ubiquitylation of Dock180Q28298756
Rac activation and inactivation control plasticity of tumor cell movementQ28299776
Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMOQ28300130
Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migrationQ28512928
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factorsQ29547630
Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivoQ30417167
The novel Cdc42 guanine nucleotide exchange factor, zizimin1, dimerizes via the Cdc42-binding CZH2 domainQ30433928
Characterization of a novel interaction between ELMO1 and ERM proteinsQ30439052
BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac moduleQ30444833
The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivoQ33372285
A common set of engulfment genes mediates removal of both apoptotic and necrotic cell corpses in C. elegansQ33930492
Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteinsQ34143927
MOCA induces membrane spreading by activating Rac1.Q34289337
Differential requirement for DOCK2 in migration of plasmacytoid dendritic cells versus myeloid dendritic cellsQ34736661
The Rac1 exchange factor Dock5 is essential for bone resorption by osteoclastsQ36268888
Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factorsQ36322667
The Elmo family forms an ancient group of actin-regulating proteinsQ37324042
Actin dynamics at the leading edge: from simple machinery to complex networks.Q37598394
Fifteen formins for an actin filament: a molecular view on the regulation of human formins.Q37681690
An evolutionarily conserved autoinhibitory molecular switch in ELMO proteins regulates Rac signalingQ39277685
DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4.Q39657420
C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment.Q39750201
Shigella IpgB1 promotes bacterial entry through the ELMO-Dock180 machinery.Q40195229
Activation of the Rac-binding partner FHOD1 induces actin stress fibers via a ROCK-dependent mechanismQ42799513
The regulation of mDia1 by autoinhibition and its release by Rho*GTP.Q43192533
Structural and mechanistic insights into the interaction between Rho and mammalian Dia.Q46466555
An Elmo-like protein associated with myosin II restricts spurious F-actin events to coordinate phagocytosis and chemotaxisQ50617939
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)268-275
P577publication date2011-09-01
P1433published inSmall GTPases (journal)Q15709529
P1476titleOpening up on ELMO regulation: New insights into the control of Rac signaling by the DOCK180/ELMO complex
P478volume2

Reverse relations

cites work (P2860)
Q43919117A barley Engulfment and Motility domain containing protein modulates Rho GTPase activating protein HvMAGAP1 function in the barley powdery mildew interaction
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Q36235313A shortcut from GPCR signaling to Rac-mediated actin cytoskeleton through an ELMO/DOCK complex
Q34968578Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion
Q35172911ClipR-59 interacts with Elmo2 and modulates myoblast fusion
Q37344247Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity
Q37580974Dock protein family in brain development and neurological disease
Q64255333Down Regulation of the Expression of ELMO3 by COX2 Inhibitor Suppresses Tumor Growth and Metastasis in Non-Small-Cell Lung Cancer
Q37309896Drosophila importin-7 functions upstream of the Elmo signaling module to mediate the formation and stability of muscle attachments
Q38713729ELMO proteins transduce G protein-coupled receptor signal to control reorganization of actin cytoskeleton in chemotaxis of eukaryotic cells
Q37012072ELMO1 Directly Interacts with Gβγ Subunit to Transduce GPCR Signaling to Rac1 Activation in Chemotaxis.
Q91944405ELMO2 association with Gαi2 regulates pancreatic cancer cell chemotaxis and metastasis
Q38976339ELMO3 predicts poor outcome in T1 laryngeal cancer.
Q43207153ELMO3: a direct driver of cancer metastasis?
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Q41837669Elmo2 Is a Regulator of Insulin-dependent Glut4 Membrane Translocation.
Q57455036Emerging roles of the neural adaptor FE65 in neurite outgrowth
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Q38079579Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis.
Q37534894Knockdown of ELMO3 Suppresses Growth, Invasion and Metastasis of Colorectal Cancer
Q42717310NSCLC metastasis: going with ELMO3.
Q52333038Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1.
Q42752703Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation
Q30575111SILAC-based proteomic quantification of chemoattractant-induced cytoskeleton dynamics on a second to minute timescale
Q30009212The SH3 regulatory domain of the hematopoietic cell kinase Hck binds ELMO via its polyproline motif.
Q57838274The Small Yeast GTPase Rho5 and Its Dimeric GEF Dck1/Lmo1 Respond to Glucose Starvation
Q37721163The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion.
Q89493913Two Autism/Dyslexia Linked Variations of DOCK4 Disrupt the Gene Function on Rac1/Rap1 Activation, Neurite Outgrowth, and Synapse Development

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