ELMO1 Directly Interacts with Gβγ Subunit to Transduce GPCR Signaling to Rac1 Activation in Chemotaxis.

scientific article published on 12 May 2016

ELMO1 Directly Interacts with Gβγ Subunit to Transduce GPCR Signaling to Rac1 Activation in Chemotaxis. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.7150/JCA.15118
P932PMC publication ID4910590
P698PubMed publication ID27313788

P50authorXuehua XuQ59677668
P2093author name stringTian Jin
Miao Pan
Youhong Wang
P2860cites workInvolvement of chemokine receptors in breast cancer metastasisQ24290909
A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFsQ24296060
PH domain of ELMO functions in trans to regulate Rac activation via Dock180Q24299119
Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complexQ24301883
An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signalingQ24310171
RhoG activates Rac1 by direct interaction with the Dock180-binding protein ElmoQ24310774
A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signallingQ24539212
GEF what? Dock180 and related proteins help Rac to polarize cells in new waysQ24633334
Rho GTPases: biochemistry and biologyQ27860645
Cellular motility driven by assembly and disassembly of actin filamentsQ27860676
Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migrationQ28187402
International Union of Pharmacology. XXX. Update on chemokine receptor nomenclatureQ28201568
Getting to the site of inflammation: the leukocyte adhesion cascade updatedQ29547271
The C-terminal polyproline-containing region of ELMO contributes to an increase in the life-time of the ELMO-DOCK complex.Q30010187
Capping protein regulatory cycle driven by CARMIL and V-1 may promote actin network assembly at protruding edgesQ30409560
Chemotaxis in neutrophil-like HL-60 cellsQ33615267
LTB4 is a signal-relay molecule during neutrophil chemotaxisQ34077159
A Gβγ effector, ElmoE, transduces GPCR signaling to the actin network during chemotaxis.Q34134773
P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophilsQ34461899
The CXC chemokine receptor 4 ligands ubiquitin and stromal cell-derived factor-1α function through distinct receptor interactionsQ35312229
Chemotaxis: signalling the way forwardQ35887290
The engulfment process of programmed cell death in caenorhabditis elegansQ35912786
Association between Gαi2 and ELMO1/Dock180 connects chemokine signalling with Rac activation and metastasisQ36815468
Chemotaxis, chemokine receptors and human disease.Q37034783
Actin dynamics at the leading edge: from simple machinery to complex networks.Q37598394
Sphingosine-1-phosphate and lymphocyte egress from lymphoid organsQ37965743
An evolutionarily conserved autoinhibitory molecular switch in ELMO proteins regulates Rac signalingQ39277685
C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment.Q39750201
Opening up on ELMO regulation: New insights into the control of Rac signaling by the DOCK180/ELMO complexQ40647051
Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42.Q52102307
P433issue8
P921main subjectG protein-coupled receptorQ38173
chemotaxisQ658145
P304page(s)973-983
P577publication date2016-05-12
P1433published inJournal of CancerQ6294901
P1476titleELMO1 Directly Interacts with Gβγ Subunit to Transduce GPCR Signaling to Rac1 Activation in Chemotaxis
P478volume7

Reverse relations

cites work (P2860)
Q92410553A current view of G protein-coupled receptor - mediated signaling in pulmonary hypertension: finding opportunities for therapeutic intervention
Q50435350Cell adhesion controlled by adhesion G protein-coupled receptor GPR124/ADGRA2 is mediated by a protein complex comprising intersectins and Elmo-Dock.
Q38713729ELMO proteins transduce G protein-coupled receptor signal to control reorganization of actin cytoskeleton in chemotaxis of eukaryotic cells
Q47999919Epidermal activation of the small GTPase Rac1 in psoriasis pathogenesis.
Q38957364Gβγ Pathways in Cell Polarity and Migration Linked to Oncogenic GPCR Signaling: Potential Relevance in Tumor Microenvironment
Q93349664How do chemokines navigate neutrophils to the target site: Dissecting the structural mechanisms and signaling pathways
Q37534894Knockdown of ELMO3 Suppresses Growth, Invasion and Metastasis of Colorectal Cancer
Q57821602Silencing ELMO3 Inhibits the Growth, Invasion, and Metastasis of Gastric Cancer
Q58115610Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion

Search more.