The pharmacokinetic behavior of the soy isoflavone metabolite S-(-)equol and its diastereoisomer R-(+)equol in healthy adults determined by using stable-isotope-labeled tracers

scientific article

The pharmacokinetic behavior of the soy isoflavone metabolite S-(-)equol and its diastereoisomer R-(+)equol in healthy adults determined by using stable-isotope-labeled tracers is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3945/AJCN.2009.27981
P8608Fatcat IDrelease_6jnpfxjfengjnntyb5if4zwkue
P932PMC publication ID2744624
P698PubMed publication ID19710188
P5875ResearchGate publication ID26770172

P2093author name stringXueheng Zhao
James E Heubi
Pinky Jha
Nadine M Brown
Kenneth Dr Setchell
P2860cites workThe identification of the weak oestrogen equol [7-hydroxy-3-(4'-hydroxyphenyl)chroman] in human urineQ24531190
Enantioselective synthesis of S-equol from dihydrodaidzein by a newly isolated anaerobic human intestinal bacteriumQ24557533
Interindividual variation in metabolism of soy isoflavones and lignans: influence of habitual diet on equol production by the gut microfloraQ28143631
Interaction of phytoestrogens with estrogen receptors alpha and betaQ28212740
Gut bacterial metabolism of the soy isoflavone daidzein: exploring the relevance to human healthQ28236996
Method of defining equol-producer status and its frequency among vegetariansQ28253168
Urinary equol excretion with a soy challenge: influence of habitual dietQ28264036
Soymilk or progesterone for prevention of bone loss--a 2 year randomized, placebo-controlled trialQ33205929
Liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of estradiol and estrone in human plasmaQ33430674
The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavonesQ34162974
Nonsteroidal estrogens of dietary origin: possible roles in hormone-dependent diseaseQ34258149
S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial floraQ34417374
Variations in phytoestrogen content between different mill dates of the same diet produces significant differences in the time of vaginal opening in CD-1 mice and F344 rats but not in CD Sprague-Dawley ratsQ36264552
Estimated Asian adult soy protein and isoflavone intakesQ36590662
Animal models impacted by phytoestrogens in commercial chow: implications for pathways influenced by hormonesQ43606362
Metabolism of the soybean isoflavone glycoside genistin in vitro by human gut bacteria and the effect of prebioticsQ44586040
Phytoestrogens modulate binding response of estrogen receptors alpha and beta to the estrogen response elementQ44685845
Equol is a novel anti-androgen that inhibits prostate growth and hormone feedbackQ44697356
Dietary phytoestrogens accelerate the time of vaginal opening in immature CD-1 mice.Q44731546
Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and betaQ44798276
Consumption of Lactobacillus acidophilus and Bifidobacterium longum do not alter urinary equol excretion and plasma reproductive hormones in premenopausal womenQ44949327
Lactobacillus gasseri: effects on mouse intestinal flora enzyme activity and isoflavonoids in the caecum and plasmaQ45143871
Isolation and identification of equol-producing bacterial strains from cultures of pig faecesQ45357436
Acute and subchronic toxicity and genotoxicity of SE5-OH, an equol-rich product produced by Lactococcus garvieaeQ46539586
Microbial and dietary factors are associated with the equol producer phenotype in healthy postmenopausal womenQ49043125
Administration of equol-producing bacteria alters the equol production status in the Simulator of the Gastrointestinal Microbial Ecosystem (SHIME).Q49088621
Decreased serum total cholesterol concentration is associated with high intake of soy products in Japanese men and women.Q50627921
Metabolic phenotype of isoflavones differ among female rats, pigs, monkeys, and women.Q51810532
Soya--a dietary source of the non-steroidal oestrogen equol in man and animals.Q53805250
Steroid and phyto-oestrogen binding to sheep uterine receptors in vitroQ70342780
Affinity of rabbit uterine oestradiol receptor for phyto-oestrogens and its use in a competitive protein-binding radioassay for plasma coumestrolQ70346583
Conjugation of Lignans in human urineQ72886777
Bioavailability, disposition, and dose-response effects of soy isoflavones when consumed by healthy women at physiologically typical dietary intakesQ73209056
Analysis of soy isoflavone conjugation in vitro and in human blood using liquid chromatography-mass spectrometryQ73462668
Bioavailability of soybean isoflavones from aglycone and glucoside forms in American womenQ73490346
Wheat bran and soy protein feeding do not alter urinary excretion of the isoflavan equol in premenopausal womenQ73587217
Estrogenic activity of some isoflavone derivativesQ73631798
Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplementsQ73707852
Soy isoflavone aglycones are absorbed faster and in higher amounts than their glucosides in humansQ73924402
Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailabilityQ74529751
Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humansQ74535186
Pharmacokinetics of the glucuronide and sulfate conjugates of genistein and daidzein in men and women after consumption of a soy beverageQ74666546
Antioxidant activities of isoflavones and their biological metabolites in a liposomal systemQ77094970
Clinical characteristics and pharmacokinetics of purified soy isoflavones: single-dose administration to healthy menQ77386775
Usual dietary consumption of soy foods and its correlation with the excretion rate of isoflavonoids in overnight urine samples among Chinese women in ShanghaiQ77396515
Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver beta-glucosidase activityQ77408444
Antioxidant efficacy of phytoestrogens in chemical and biological model systemsQ77593106
Dietary intake and sources of isoflavones among JapaneseQ77881860
Safety and pharmacokinetics of purified soy isoflavones: single-dose administration to postmenopausal womenQ78424847
Comparing the pharmacokinetics of daidzein and genistein with the use of 13C-labeled tracers in premenopausal womenQ78829975
Sulfation of the isoflavones genistein and daidzein in human and rat liver and gastrointestinal tractQ79147472
Production of phytoestrogen S-equol from daidzein in mixed culture of two anaerobic bacteriaQ79364064
Plasma phytoestrogens are not altered by probiotic consumption in postmenopausal women with and without a history of breast cancerQ80397108
Increased probiotic yogurt or resistant starch intake does not affect isoflavone bioavailability in subjects consuming a high soy dietQ80682248
Influence of inulin on plasma isoflavone concentrations in healthy postmenopausal womenQ81153063
Chemical synthesis of [(13)c]daidzeinQ83466872
P4510describes a project that usesstable isotopeQ878130
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectpharmacokineticsQ323936
stable isotopeQ878130
P304page(s)1029-37
P577publication date2009-10-01
P1433published inAmerican Journal of Clinical NutritionQ7713500
P1476titleThe pharmacokinetic behavior of the soy isoflavone metabolite S-(-)equol and its diastereoisomer R-(+)equol in healthy adults determined by using stable-isotope-labeled tracers
P478volume90

Reverse relations

cites work (P2860)
Q35914108Acute benefits of the microbial-derived isoflavone metabolite equol on arterial stiffness in men prospectively recruited according to equol producer phenotype: a double-blind randomized controlled trial.
Q35643914Analysis of urinary estrogens, their oxidized metabolites, and other endogenous steroids by benchtop orbitrap LCMS versus traditional quadrupole GCMS.
Q39032494Calcium-41: a technology for monitoring changes in bone mineral
Q33908755Cautions and research needs identified at the equol, soy, and menopause research leadership conference
Q64059737Characterization and bioactivity of self-assembled anti-angiogenic chondroitin sulfate-ES2-AF nanoparticle conjugate
Q35670918Comparative effects of R- and S-equol and implication of transactivation functions (AF-1 and AF-2) in estrogen receptor-induced transcriptional activity.
Q38663475Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis.
Q36235285Endogenous and exogenous equol are antiestrogenic in reproductive tissues of apolipoprotein e-null mice
Q36655771Equol inhibits growth, induces atresia, and inhibits steroidogenesis of mouse antral follicles in vitro
Q37512708Equol production changes over time in postmenopausal women
Q29248888Equol, a Dietary Daidzein Gut Metabolite Attenuates Microglial Activation and Potentiates Neuroprotection In Vitro
Q33908748Equol, via dietary sources or intestinal production, may ameliorate estrogen deficiency-induced bone loss
Q24594674Equol: history, chemistry, and formation
Q24594626Equol: pharmacokinetics and biological actions
Q35048199Estrogen receptor and PI3K/Akt signaling pathway involvement in S-(-)equol-induced activation of Nrf2/ARE in endothelial cells
Q35992562Impact of equol-producing capacity and soy-isoflavone profiles of supplements on bone calcium retention in postmenopausal women: a randomized crossover trial
Q35234941Impact of perinatal exposure to equol enantiomers on reproductive development in rodents
Q42944121Mammary gland differentiation by early life exposure to enantiomers of the soy isoflavone metabolite equol
Q30841046Pharmaco- and toxicokinetics of selected exogenous and endogenous estrogens: a review of the data and identification of knowledge gaps
Q48106159Pharmacokinetics and safety profile of single-dose administration of an estrogen receptor β-selective phytoestrogenic (phytoSERM) formulation in perimenopausal and postmenopausal women
Q37697453Pharmacokinetics of equol, a soy isoflavone metabolite, changes with the form of equol (dietary versus intestinal production) in ovariectomized rats
Q36993533Possible role of S-equol on bone loss via amelioration of inflammatory indices in ovariectomized mice
Q36902122Potentiation of brain mitochondrial function by S-equol and R/S-equol estrogen receptor β-selective phytoSERM treatments
Q38314044Protective effects of equol and their polyphenolic isomers against dermal aging: microarray/protein evidence with clinical implications and unique delivery into human skin
Q61817344Screening dietary biochanin A, daidzein, equol and genistein for their potential to increase DHA biosynthesis in rainbow trout (Oncorhynchus mykiss)
Q35335557Soy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer risk
Q24628910The chemopreventive action of equol enantiomers in a chemically induced animal model of breast cancer
Q34005314The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems
Q47442621The phytoestrogens daidzein and equol inhibit the drug transporter BCRP/ABCG2 in breast cancer cells: potential chemosensitizing effect

Search more.