Soy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer risk

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Soy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer risk is …
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scholarly articleQ13442814

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P356DOI10.3945/AJCN.111.019638
P932PMC publication ID3192476
P698PubMed publication ID21955647
P5875ResearchGate publication ID51678352

P2093author name stringKenneth D R Setchell
Xueheng Zhao
James E Heubi
Eileen C King
Nadine M Brown
Mark J Messina
Stephanie L Lindley
P2860cites workEquol: pharmacokinetics and biological actionsQ24594626
Soy food intake and breast cancer survivalQ24609611
The pharmacokinetic behavior of the soy isoflavone metabolite S-(-)equol and its diastereoisomer R-(+)equol in healthy adults determined by using stable-isotope-labeled tracersQ24653795
Method of defining equol-producer status and its frequency among vegetariansQ28253168
Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor betaQ28283637
Effects of dietary daidzein and its metabolite, equol, at physiological concentrations on the growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in ovariectomized athymic miceQ46884616
Metabolic phenotype of isoflavones differ among female rats, pigs, monkeys, and women.Q51810532
The health implications of soy infant formula.Q51937060
Soybeans inhibit mammary tumors in models of breast cancerQ68567028
Dietary genistein exerts estrogenic effects upon the uterus, mammary gland and the hypothalamic/pituitary axis in ratsQ73087939
Bioavailability, disposition, and dose-response effects of soy isoflavones when consumed by healthy women at physiologically typical dietary intakesQ73209056
Analysis of soy isoflavone conjugation in vitro and in human blood using liquid chromatography-mass spectrometryQ73462668
Exposure of infants to phyto-oestrogens from soy-based infant formulaQ73499013
Phyto-oestrogens in soy-based infant formulaQ73699617
Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplementsQ73707852
Urinary pharmacokinetics of the glucuronide and sulfate conjugates of genistein and daidzeinQ73742435
Genistein inhibits growth of estrogen-independent human breast cancer cells in culture but not in athymic miceQ73924390
HPLC analysis of isoflavonoids and other phenolic agents from foods and from human fluidsQ74279576
Daidzein and genistein glucuronides in vitro are weakly estrogenic and activate human natural killer cells at nutritionally relevant concentrationsQ74453434
Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailabilityQ74529751
Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humansQ74535186
Physiological concentrations of dietary genistein dose-dependently stimulate growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in athymic nude miceQ77123340
Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivoQ77220395
Clinical characteristics and pharmacokinetics of purified soy isoflavones: single-dose administration to healthy menQ77386775
Isoflavone content of infant formulas and the metabolic fate of these phytoestrogens in early lifeQ77665033
Isoflavones in human breast milk and other biological fluidsQ77665039
Pasta naturally enriched with isoflavone aglycons from soy germ reduces serum lipids and improves markers of cardiovascular riskQ81332096
Perspectives on the soy-breast cancer relationQ83596916
Phytoestrogens and breast cancer: a complex storyQ28295155
Genistein stimulates growth of human breast cancer cells in a novel, postmenopausal animal model, with low plasma estradiol concentrationsQ28302033
Natural S-equol decreases bone resorption in postmenopausal, non-equol-producing Japanese women: a pilot randomized, placebo-controlled trialQ28303727
Dietary genistein negates the inhibitory effect of letrozole on the growth of aromatase-expressing estrogen-dependent human breast cancer cells (MCF-7Ca) in vivoQ30438048
Breast cancer risk with postmenopausal hormonal treatmentQ33223014
Effect of oral isoflavone supplementation on vascular endothelial function in postmenopausal women: a meta-analysis of randomized placebo-controlled trialsQ33516196
Effects of isoflavones on breast density in pre- and post-menopausal women: a systematic review and meta-analysis of randomized controlled trialsQ33590487
Phytoestrogens: the "natural" selective estrogen receptor modulators?Q33700680
Soy isoflavones versus placebo in the treatment of climacteric vasomotor symptoms: systematic review and meta-analysisQ34115114
Nonsteroidal estrogens of dietary origin: possible roles in hormone-dependent diseaseQ34258149
Is soy consumption good or bad for the breast?Q34308323
Effect of soy isoflavones on breast cancer recurrence and death for patients receiving adjuvant endocrine therapyQ34334503
Soy isoflavones--benefits and risks from nature's selective estrogen receptor modulators (SERMs).Q34402868
S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial floraQ34417374
The health consequences of early soy consumptionQ34553043
Equol improves menopausal symptoms in Japanese womenQ34619714
Epidemiology of soy exposures and breast cancer riskQ34734223
Soy consumption and prostate cancer risk in men: a revisit of a meta-analysisQ34943276
The pharmacokinetics of S-(-)equol administered as SE5-OH tablets to healthy postmenopausal womenQ35004789
Soy isoflavones and risk of cancer recurrence in a cohort of breast cancer survivors: the Life After Cancer Epidemiology studyQ36315926
Phytoestrogens and cardiovascular diseaseQ36507677
Nutrition and physical activity during and after cancer treatment: an American Cancer Society guide for informed choicesQ36668720
Soy isoflavones, estrogen therapy, and breast cancer risk: analysis and commentaryQ36744585
Selective estrogen receptor modulators and phytoestrogensQ36984515
Glucuronidation of the soyabean isoflavones genistein and daidzein by human liver is related to levels of UGT1A1 and UGT1A9 activity and alters isoflavone response in the MCF-7 human breast cancer cell lineQ39989392
Dietary estrogens--a probable cause of infertility and liver disease in captive cheetahsQ41318795
Genotoxicity assessment of S-equol in bacterial mutation, chromosomal aberration, and rodent bone marrow micronucleus testsQ42874928
Soy food consumption and breast cancer prognosisQ43569297
Animal models impacted by phytoestrogens in commercial chow: implications for pathways influenced by hormonesQ43606362
Mammographic breast density during hormone replacement therapy: effects of continuous combination, unopposed transdermal and low-potency estrogen regimensQ43622091
Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice.Q43973983
Solvent extraction selection in the determination of isoflavones in soy foodsQ44148630
Breast cell proliferation in postmenopausal women during HRT evaluated through fine needle aspiration cytology.Q44425874
Variations in isoflavone levels in soy foods and soy protein isolates and issues related to isoflavone databases and food labelingQ44488707
Single-dose and steady-state pharmacokinetic studies of S-equol, a potent nonhormonal, estrogen receptor β-agonist being developed for the treatment of menopausal symptomsQ44866925
Soy processing influences growth of estrogen-dependent breast cancer tumorsQ44886527
Clinical characteristics and pharmacokinetics of purified soy isoflavones: multiple-dose administration to men with prostate neoplasiaQ44961760
Soy processing affects metabolism and disposition of dietary isoflavones in ovariectomized BALB/c miceQ46773787
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectbreast cancerQ128581
P304page(s)1284-1294
P577publication date2011-09-28
P1433published inAmerican Journal of Clinical NutritionQ7713500
P1476titleSoy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer risk
P478volume94

Reverse relations

cites work (P2860)
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Q29248888Equol, a Dietary Daidzein Gut Metabolite Attenuates Microglial Activation and Potentiates Neuroprotection In Vitro
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Q56672310Use of isoflavone supplements is associated with reduced postmenopausal breast cancer risk

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