Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia

scientific article

Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2006PNAS..10312469G
P356DOI10.1073/PNAS.0603029103
P932PMC publication ID1567903
P698PubMed publication ID16891421
P5875ResearchGate publication ID6896330

P50authorJoseph BuxbaumQ15428933
Nick CraddockQ18685542
Vahram HaroutunianQ47157894
Valentina Escott-PriceQ56528787
Lesley JonesQ56855569
Nicholas BrayQ57419559
Nadine NortonQ96190598
George KirovQ30004103
Michael C O'DonovanQ30410265
Peter HolmansQ37649643
Stanley ZammitQ37651777
Dobril IvanovQ42683162
Stuart MacgregorQ42711014
P2093author name stringNigel Williams
Michael J Owen
Ivan Nikolov
Lyudmila Georgieva
Hywel Williams
Jennifer Wilkinson
Kenneth L Davis
Tim Peirce
P2860cites workInference of population structure using multilocus genotype dataQ24548114
Failure of spinal cord oligodendrocyte development in mice lacking neuregulinQ24554441
Neuregulin 1 and susceptibility to schizophreniaQ24616921
The glial growth factors deficiency and synaptic destabilization hypothesis of schizophreniaQ24798030
Haploview: analysis and visualization of LD and haplotype mapsQ27860955
Schizophrenia: genes at last?Q28260969
Olig transcription factors are expressed in oligodendrocyte and neuronal cells in human fetal CNSQ28280124
DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signalingQ28282412
Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophreniaQ47820010
The basic helix-loop-helix factor olig2 is essential for the development of motoneuron and oligodendrocyte lineages.Q48546876
Olig2 overexpression induces the in vitro differentiation of neural stem cells into mature oligodendrocytesQ48715127
Myelin-associated mRNA and protein expression deficits in the anterior cingulate cortex and hippocampus in elderly schizophrenia patientsQ48738469
Electron microscopy of oligodendroglia in severe mental illness.Q48772850
Differential rates of psychiatric disorders in adults with Down's syndrome compared with other mentally handicapped adults.Q50305372
Interstitial deletion of chromosome 21q and schizophrenia susceptibility.Q50766897
Oligodendroglial density in the prefrontal cortex in schizophrenia and mood disorders: a study from the Stanley Neuropathology Consortium.Q51943076
Pedigree disequilibrium tests for multilocus haplotypes.Q52010978
The ErbB4 neuregulin receptor mediates suppression of oligodendrocyte maturation.Q52047054
Support for genetic variation in neuregulin 1 and susceptibility to schizophrenia.Q53654455
Olig2 directs astrocyte and oligodendrocyte formation in postnatal subventricular zone cells.Q53662277
Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools.Q53668847
Convergent Evidence for 2′,3′-Cyclic Nucleotide 3′-Phosphodiesterase as a Possible Susceptibility Gene for SchizophreniaQ57279160
Design of Case-controls Studies with Unscreened ControlsQ58132458
Evaluation of Nyholt’s Procedure for Multiple Testing Correction – Author’s ReplyQ59590791
Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous systemQ73555176
Optimal temperature selection for mutation detection by denaturing HPLC and comparison to single-stranded conformation polymorphism and heteroduplex analysisQ78077743
Microarray analysis of postmortem temporal cortex from patients with schizophreniaQ80502608
Evaluation of Nyholt's procedure for multiple testing correctionQ81105171
Expression pattern of the transcription factor Olig2 in response to brain injuries: implications for neuronal repairQ28285265
The involvement of ErbB4 with schizophrenia: association and expression studiesQ28290653
Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factorsQ28592141
Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connectionQ28594759
affy--analysis of Affymetrix GeneChip data at the probe levelQ29547353
Abnormalities of myelination in schizophrenia detected in vivo with MRI, and post-mortem with analysis of oligodendrocyte proteins.Q30819593
Schizophrenia and Nogo: elevated mRNA in cortex, and high prevalence of a homozygous CAA insertQ30869659
Regional and cellular gene expression changes in human Huntington's disease brainQ33233457
A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each otherQ33909759
Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophreniaQ33941953
Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humansQ34152058
Oligodendrocyte dysfunction in schizophrenia and bipolar disorderQ34246905
Prefrontal abnormality of schizophrenia revealed by DNA microarray: impact on glial and neurotrophic gene expressionQ34367536
The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessonsQ34498146
An 'oligarchy' rules neural developmentQ34750265
Molecular and cellular evidence for an oligodendrocyte abnormality in schizophreniaQ35014711
White matter changes in schizophrenia: evidence for myelin-related dysfunctionQ35125866
DNA methylation status of SOX10 correlates with its downregulation and oligodendrocyte dysfunction in schizophrenia.Q38325560
Variations in myelin and oligodendrocyte-related gene expression across multiple brain regions in schizophrenia: a gene ontology studyQ38519890
Mind glue: implications of glial cell biology for psychiatryQ40782511
Process outgrowth in oligodendrocytes is mediated by CNP, a novel microtubule assembly myelin proteinQ41888821
Combinatorial profiles of oligodendrocyte-selective classes of transcriptional regulators differentially modulate myelin basic protein gene expression.Q42810403
No association between schizophrenia and polymorphisms in COMT in two large samplesQ46681218
P433issue33
P407language of work or nameEnglishQ1860
P921main subjectoligodendrocyteQ916698
schizophreniaQ41112
P304page(s)12469-74
P577publication date2006-08-15
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleConvergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia
P478volume103

Reverse relations

cites work (P2860)
Q26770756A New Outlook on Mental Illnesses: Glial Involvement Beyond the Glue
Q49629866A Novel Ultrasensitive In Situ Hybridization Approach to Detect Short Sequences and Splice Variants with Cellular Resolution
Q35014891A cytogenetic abnormality and rare coding variants identify ABCA13 as a candidate gene in schizophrenia, bipolar disorder, and depression
Q33785737A systematic enhancer screen using lentivector transgenesis identifies conserved and non-conserved functional elements at the Olig1 and Olig2 locus
Q35832061AKT/GSK3 signaling pathway and schizophrenia
Q81038294Adaptive evolution of genes underlying schizophrenia
Q26773159Advancements in the Underlying Pathogenesis of Schizophrenia: Implications of DNA Methylation in Glial Cells
Q28250481An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia
Q42698412An examination of single nucleotide polymorphism selection prioritization strategies for tests of gene-gene interaction
Q48953087Association of white matter deficits with clinical symptoms in antipsychotic-naive first-episode schizophrenia: an optimized VBM study using 3T.
Q37002050Basic helix-loop-helix transcription factor NEUROG1 and schizophrenia: effects on illness susceptibility, MRI brain morphometry and cognitive abilities
Q27313562Bovine exome sequence analysis and targeted SNP genotyping of recessive fertility defects BH1, HH2, and HH3 reveal a putative causative mutation in SMC2 for HH3
Q40437176Currently recognized genes for schizophrenia: High-resolution chromosome ideogram representation.
Q34531769Disturbed macro-connectivity in schizophrenia linked to oligodendrocyte dysfunction: from structural findings to molecules
Q51893653Effect of a functional single nucleotide polymorphism in the 2',3'-cyclic nucleotide 3'-phosphodiesterase gene on the expression of oligodendrocyte-related genes in schizophrenia.
Q36491749Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development
Q36484847Expression of oligodendrocyte-associated genes in dorsolateral prefrontal cortex of patients with schizophrenia
Q59812978Genetic and Epigenetic Alterations Underlie Oligodendroglia Susceptibility and White Matter Etiology in Psychiatric Disorders
Q35153945Genetic neuropathology of schizophrenia: new approaches to an old question and new uses for postmortem human brains
Q34603780Genetic underpinnings of white matter 'connectivity': heritability, risk, and heterogeneity in schizophrenia
Q91938001Genomics of the OLIG family of a bHLH transcription factor associated with oligo dendrogenesis
Q38373219Glia-related genes and their contribution to schizophrenia
Q91194418Glial cells in schizophrenia: a unified hypothesis
Q37546096Glial cells in schizophrenia: pathophysiological significance and possible consequences for therapy
Q38665790Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia
Q33516442Imaging genetics of structural brain connectivity and neural integrity markers
Q50803888Integrated genetic and genomic approach in the SingaporeTranslational and Clinical Research in Psychosis Study: an overview.
Q38091301Inverse cancer comorbidity: a serendipitous opportunity to gain insight into CNS disorders
Q37800531Linking oligodendrocyte and myelin dysfunction to neurocircuitry abnormalities in schizophrenia
Q37564007Linking white and grey matter in schizophrenia: oligodendrocyte and neuron pathology in the prefrontal cortex
Q35808940Loss of erbB signaling in oligodendrocytes alters myelin and dopaminergic function, a potential mechanism for neuropsychiatric disorders
Q34639446Molecular dissection of NRG1-ERBB4 signaling implicates PTPRZ1 as a potential schizophrenia susceptibility gene
Q36672435Morphine effects on striatal transcriptome in mice
Q34680959Myelin, copper, and the cuprizone model of schizophrenia
Q36591201Myelination-related genes are associated with decreased white matter integrity in schizophrenia
Q37076200Neuregulin 1 genotype and schizophrenia
Q31111596Neuroimaging studies of children with serious emotional disturbances: a selective review
Q41430196Neurotoxocarosis alters myelin protein gene transcription and expression
Q95270886Novel Treatment Strategies Targeting Myelin and Oligodendrocyte Dysfunction in Schizophrenia
Q89747364Novel genetic susceptibility loci identified by family based whole exome sequencing in Han Chinese schizophrenia patients
Q37517222Oligodendrocyte development and the onset of myelination in the human fetal brain
Q24289198Oligodendrocyte genes, white matter tract integrity, and cognition in schizophrenia
Q64062621Oligodendrocytes: Potential of Discovering New Treatment Targets
Q28221773PADB: published association database
Q81437003Positive association between OLIG2 and schizophrenia in the Chinese Han population
Q38885740Psychiatric disorders biochemical pathways unraveled by human brain proteomics
Q36482035Regulatory module network of basic/helix-loop-helix transcription factors in mouse brain
Q48567155Risk variant of oligodendrocyte lineage transcription factor 2 is associated with reduced white matter integrity
Q38183367Schizophrenia: susceptibility genes and oligodendroglial and myelin related abnormalities
Q37069461Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2.
Q95324293Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains
Q37389123Sonic hedgehog promotes generation and maintenance of human forebrain Olig2 progenitors
Q33282297The genetics of brain wiring: from molecule to mind
Q38210119The myelin membrane-associated enzyme 2',3'-cyclic nucleotide 3'-phosphodiesterase: on a highway to structure and function
Q33392711Ultraconserved elements in the Olig2 promoter
Q37896626Understanding aberrant white matter development in schizophrenia: an avenue for therapy?
Q30597641What does anisotropy measure? Insights from increased and decreased anisotropy in selective fiber tracts in schizophrenia
Q36169035White matter abnormalities and animal models examining a putative role of altered white matter in schizophrenia
Q36793946White matter in learning, cognition and psychiatric disorders

Search more.