Adaptive evolution of genes underlying schizophrenia

scientific article published on 01 November 2007

Adaptive evolution of genes underlying schizophrenia is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1098/RSPB.2007.0876
P932PMC publication ID2288689
P698PubMed publication ID17785269

P50authorBernard CrespiQ14941842
Steve DorusQ89463042
P2093author name stringKyle Summers
P2860cites workAVPR1a and SLC6A4 gene polymorphisms are associated with creative dance performanceQ21092500
Localizing recent adaptive evolution in the human genomeQ21145227
A map of recent positive selection in the human genomeQ21563624
An RNA gene expressed during cortical development evolved rapidly in humansQ22122233
Molecular evolution of FOXP2, a gene involved in speech and languageQ22122513
Microcephalin, a Gene Regulating Brain Size, Continues to Evolve Adaptively in HumansQ22337066
Molecular evolution of microcephalin, a gene determining human brain sizeQ22337145
Reconstructing the evolutionary history of microcephalin, a gene controlling human brain sizeQ22337146
DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutationQ24305439
LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophreniaQ24324059
The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locusQ24533481
Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophreniaQ24562939
Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophreniaQ24670103
The PANTHER database of protein families, subfamilies, functions and pathwaysQ24795605
Molecular heterosis: a reviewQ26810050
PAML: a program package for phylogenetic analysis by maximum likelihoodQ27861096
Gene regulation by hypoxia and the neurodevelopmental origin of schizophreniaQ28236058
Molecular genetic studies of schizophreniaQ28242041
AHI1, a pivotal neurodevelopmental gene, and C6orf217 are associated with susceptibility to schizophreniaQ28245905
The genetics and biology of DISC1--an emerging role in psychosis and cognitionQ28252172
Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophreniaQ28263630
The NPAS3 gene--emerging evidence for a role in psychiatric illnessQ28265950
Replication of genetic association studies between markers at the Epsin 4 gene locus and schizophrenia in two Han Chinese samplesQ28270772
A neuregulin 1 variant associated with abnormal cortical function and psychotic symptomsQ28270982
A polymorphism in the PDLIM5 gene associated with gene expression and schizophreniaQ28276196
Abnormal cerebellar development and axonal decussation due to mutations in AHI1 in Joubert syndromeQ28278080
Family-based association study of Epsin 4 and SchizophreniaQ28290620
Evaluation of an improved branch-site likelihood method for detecting positive selection at the molecular levelQ29547731
Positive natural selection in the human lineageQ29614585
Natural selection on protein-coding genes in the human genomeQ29615352
Accelerated evolution of nervous system genes in the origin of Homo sapiensQ29618491
Psychosis: a costly by-product of social brain evolution in Homo sapiens.Q30353231
Schizophrenia: the illness that made us humanQ30431179
Positive selection within the Schizophrenia-associated GABA(A) receptor beta(2) geneQ33285476
Widespread positive selection in synonymous sites of mammalian genesQ33285587
Evidence for positive selection and population structure at the human MAO-A geneQ33894576
Evidence of positive selection acting at the human dopamine receptor D4 gene locusQ33897512
Contrasting effects of natural selection on human and chimpanzee CC chemokine receptor 5Q33938551
Accelerated protein evolution and origins of human-specific features: Foxp2 as an exampleQ33963696
Association between FOXP2 polymorphisms and schizophrenia with auditory hallucinations.Q33994158
A strong signature of balancing selection in the 5' cis-regulatory region of CCR5.Q34075062
Schizophrenia and HLA: a reviewQ34133109
Association study of the dysbindin (DTNBP1) gene in schizophrenia from the Japanese populationQ80022949
Association between the CCR5 32-bp deletion allele and late onset of schizophreniaQ82714513
Meta-analysis of association between ApoE epsilon4 allele and schizophreniaQ82981983
Schizophrenia and cancer risk: can the CCR5-delta 32 chemokine receptor gene mutation play a role?Q83212805
Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphismQ34144158
Population-based association analyses of the HOPA12bp polymorphism for schizophrenia and hypothyroidismQ34292812
Schizophrenia-an evolutionary enigma?Q34307794
Schizophrenia as one extreme of a sexually selected fitness indicatorQ34332457
Accelerated evolution of the pituitary adenylate cyclase-activating polypeptide precursor gene during human originQ34575442
Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia.Q34578123
Accelerated evolution of conserved noncoding sequences in humansQ34578926
Resolving the paradox of common, harmful, heritable mental disorders: which evolutionary genetic models work best?Q34580529
Association between a promoter variant in the monoamine oxidase A gene and schizophrenia.Q35089415
Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophreniaQ35221473
Meat-adaptive genes and the evolution of slower aging in humansQ35752606
Phenotype of schizophrenia: a review and formulationQ35875976
"A gene for...": the nature of gene action in psychiatric disordersQ36182565
Is the dysbindin gene (DTNBP1) a susceptibility gene for schizophrenia?Q36258629
The role of the phosphatidylinositide 3-kinase-protein kinase B pathway in schizophreniaQ36376582
Genomic insights into positive selectionQ36523414
Role of DISC1 in neural development and schizophreniaQ36720430
Positive selection in MAOA gene is human exclusive: determination of the putative amino acid change selected in the human lineageQ42635050
A case-control study of the relationship between the metabotropic glutamate receptor 3 gene and schizophrenia in the Chinese populationQ43670595
Ethnic heterogeneity in allele variation in the DRD4 gene in schizophrenia.Q44132357
Serotonin transporter gene polymorphism and schizoid personality traits in the patients with psychosis and psychiatrically well subjectsQ44312615
Dopamine D4 receptor gene (DRD4) variants and schizophrenia: meta-analysesQ44369831
Identification of a high-risk haplotype for the dystrobrevin binding protein 1 (DTNBP1) gene in the Irish study of high-density schizophrenia familiesQ44894348
Polymorphisms in the serotonin transporter and monoamine oxidase A genes and their relationship to personality traits measured by the Temperament and Character Inventory and NEO Five-Factor Inventory in healthy volunteersQ45006282
Evidence for a common biological basis of the Absorption trait, hallucinogen effects, and positive symptoms: epistasis between 5-HT2a and COMT polymorphismsQ46555897
Identification of first candidate genes for creativity: a pilot studyQ46887424
The geographic distribution of monoamine oxidase haplotypes supports a bottleneck during the dispersion of modern humans from AfricaQ46932739
Association of Neuregulin 1 with schizophrenia and bipolar disorder in a second cohort from the Scottish populationQ47399632
Association of the HOPA12bp allele with a large X-chromosome haplotype and positive symptom schizophreniaQ47702365
Recent origin of HLA-DRB1 alleles and implications for human evolutionQ47768279
Genome-wide linkage scan of schizophrenia: a cross-isolate study.Q47829678
Schizophrenia as a consequence of brain evolutionQ48486531
Is schizophrenia the price that Homo sapiens pays for language?Q48532706
The association of the HOPA(12bp) polymorphism with schizophrenia in the NIMH Genetics Initiative for Schizophrenia sample.Q51906900
Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder.Q51915251
Schizotypal personality traits in nonpsychotic relatives are associated with positive symptoms in psychotic probands.Q51946378
Investigation of a candidate gene for schizophrenia on Xq13 previously associated with mental retardation and hypothyroidism.Q51975730
Recent divergence of the HLA-DRB1*04 allelic lineage from the DRB1*0701 lineage after the separation of the human and chimpanzee species.Q52842406
Selective sweeps in the human genome: a starting point for identifying genetic differences between modern humans and chimpanzees.Q52842542
GABRB2 Association with Schizophrenia: Commonalities and Differences Between Ethnic Groups and Clinical SubtypesQ57258788
Extreme individual marker FST values do not imply population-specific selection in humans: the NRG1 exampleQ57305140
Schizotypal dimensions in normals and schizophrenic patients: a comparison with other clinical samplesQ60646646
P433issue1627
P921main subjectschizophreniaQ41112
adaptive evolutionQ113049937
P1104number of pages10
P304page(s)2801-2810
P577publication date2007-11-01
P1433published inProceedings of the Royal Society BQ2625424
P1476titleAdaptive evolution of genes underlying schizophrenia
P478volume274

Reverse relations

cites work (P2860)
Q36835294'Finitics'. A plea for biological realism
Q46245691A common haplotype of DRD3 affected by recent positive selection is associated with protection from schizophrenia
Q28655504A dual comparative approach: integrating lines of evidence from human evolutionary neuroanatomy and neurodevelopmental disorders
Q93065173A method for genome-wide genealogy estimation for thousands of samples
Q33539809A recombination hotspot in a schizophrenia-associated region of GABRB2
Q37607938Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility.
Q46306295Ancestral resurrection of anthropoid estrogen receptor β demonstrates functional consequences of positive selection.
Q33746823Candidate gene associations with mood disorder, cognitive vulnerability, and fronto-limbic volumes.
Q90598616Commentary on: "Host-parasite interaction associated with major mental illness". Why we need integrative explanations based on evolutionary theory
Q34345299Creativity, psychosis and human evolution: The exemplar case of neuregulin 1 gene
Q42145626Decoding the molecular evolution of human cognition using comparative genomics
Q26782139Diametrical diseases reflect evolutionary-genetic tradeoffs: Evidence from psychiatry, neurology, rheumatology, oncology and immunology
Q37433965Disease consequences of human adaptation.
Q38846088Evidence of a Conserved Molecular Response to Selection for Increased Brain Size in Primates
Q28657468Evolutionary conservation in genes underlying human psychiatric disorders
Q30986287FOXP2 gene and language impairment in schizophrenia: association and epigenetic studies
Q28593528From PPROM to caul: The evolution of membrane rupture in mammals.
Q30914210Genome-wide scan for signatures of human population differentiation and their relationship with natural selection, functional pathways and diseases
Q35533902Genomic and network patterns of schizophrenia genetic variation in human evolutionary accelerated regions
Q33382735Genomic convergence analysis of schizophrenia: mRNA sequencing reveals altered synaptic vesicular transport in post-mortem cerebellum
Q35960747Genomic sister-disorders of neurodevelopment: an evolutionary approach
Q95579823How evolutionary psychiatry can advance psychopharmacology
Q28744614Human brain evolution: harnessing the genomics (r)evolution to link genes, cognition, and behavior
Q38259827Mitochondrial dysfunction in schizophrenia: an evolutionary perspective
Q26745243Molecular Signatures of Natural Selection for Polymorphic Genes of the Human Dopaminergic and Serotonergic Systems: A Review
Q34381421Nonhuman primate models in the genomic era: a paradigm shift.
Q36367450Paradox of schizophrenia genetics: is a paradigm shift occurring?
Q28259472Paternal age effect mutations and selfish spermatogonial selection: causes and consequences for human disease
Q39170724Positive Traits in the Bipolar Spectrum: The Space between Madness and Genius
Q57132733Positive and balancing selection on gene associated with psychiatric disorders and human-unique personality traits
Q28285118Psychosis and autism as diametrical disorders of the social brain
Q43192078Psychosis endophenotypes in schizophrenia and bipolar disorder
Q55168713Recently evolved human-specific methylated regions are enriched in schizophrenia signals.
Q33707645Relating schizotypy and personality to the phenomenology of creativity
Q36288960Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia.
Q21284097Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation
Q34786420Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: cytomegalovirus, influenza, herpes simplex, rubella, and Toxoplasma gondii.
Q35144224Schizophrenia, cancer and obstetric complications in an evolutionary perspective-an empirically based hypothesis
Q37011584Schizophrenia, psychiatric genetics, and Darwinian psychiatry: an evolutionary framework
Q36148471Systematic Integration of Brain eQTL and GWAS Identifies ZNF323 as a Novel Schizophrenia Risk Gene and Suggests Recent Positive Selection Based on Compensatory Advantage on Pulmonary Function
Q38259558The Duality of Schizotypy: Is it Both Dimensional and Categorical?
Q37730425The adaptive brain in mental health: overcoming inherited risk factors.
Q33809026The dystrobrevin-binding protein 1 gene: features and networks
Q36493625The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D).
Q35960713The great opportunity: Evolutionary applications to medicine and public health
Q37791205The origins and evolution of genetic disease risk in modern humans
Q28756691The role of positive selection in determining the molecular cause of species differences in disease
Q36744352Using Evolutionary Theory to Guide Mental Health Research.

Search more.